Category: pyrimidines

Borsari, Chiara published the artcileSecond-generation tricyclic pyrimido-pyrrolo-oxazine mTOR inhibitor with predicted blood-brain barrier permeability, Recommanded Product: 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)pyrimidin-2-amine, the publication is RSC Medicinal Chemistry (2021), 12(4), 579-583, database is CAplus and MEDLINE.

Highly selective mTOR inhibitors have been discovered through the exploration of the heteroaromatic ring engaging the binding affinity region in mTOR kinase. Compound 11 showed predicted BBB permeability in a MDCK-MDR1 permeability in vitro assay, being the first pyrimido-pyrrolo-oxazine with potential application in the treatment of neurol. disorders.

RSC Medicinal Chemistry published new progress about 944401-58-5. 944401-58-5 belongs to pyrimidines, auxiliary class Trifluoromethyl,Pyrimidine,Fluoride,Boronic acid and ester,Amine,Boronate Esters,Boronic acid and ester,, name is 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)pyrimidin-2-amine, and the molecular formula is C11H15BF3N3O2, Recommanded Product: 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)pyrimidin-2-amine.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/Pyrimidine,
Pyrimidine – Wikipedia

Novosjolova, Irina published the artcile2-Methoxypyridine as a Thymidine Mimic in Watson-Crick Base Pairs of DNA and PNA: Synthesis, Thermal Stability, and NMR Structural Studies, Name: 2-(N-(2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)ethyl)-2-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamido)acetic acid, the publication is ChemBioChem (2017), 18(21), 2165-2170, database is CAplus and MEDLINE.

The development of nucleic acid base-pair analogs that use new modes of mol. recognition is important both for fundamental research and practical applications. The goal of this study was to evaluate 2-methoxypyridine as a cationic thymidine mimic in the A-T base pair. The hypothesis was that including protonation in the Watson-Crick base pairing scheme would enhance the thermal stability of the DNA double helix without compromising the sequence selectivity. DNA and peptide nucleic acid (PNA) sequences containing the new 2-methoxypyridine nucleobase (P) were synthesized and studied by using UV thermal melting and NMR spectroscopy. Introduction of P nucleobase caused a loss of thermal stability of ≈10°C in DNA-DNA duplexes and ≈20° C in PNA-DNA duplexes over a range of mildly acidic to neutral pH. Despite the decrease in thermal stability, the NMR structural studies showed that P-A formed the expected protonated base pair at pH 4.3. Our study demonstrates the feasibility of cationic unnatural base pairs; however, future optimization of such analogs will be required.

ChemBioChem published new progress about 169396-92-3. 169396-92-3 belongs to pyrimidines, auxiliary class Pyrimidine,Carboxylic acid,Amine,Amide,Others,PNA, name is 2-(N-(2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)ethyl)-2-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamido)acetic acid, and the molecular formula is C26H26N4O7, Name: 2-(N-(2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)ethyl)-2-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamido)acetic acid.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/Pyrimidine,
Pyrimidine – Wikipedia

Novosjolova, Irina published the artcile2-Methoxypyridine as a Thymidine Mimic in Watson-Crick Base Pairs of DNA and PNA: Synthesis, Thermal Stability, and NMR Structural Studies, HPLC of Formula: 186046-81-1, the publication is ChemBioChem (2017), 18(21), 2165-2170, database is CAplus and MEDLINE.

The development of nucleic acid base-pair analogs that use new modes of mol. recognition is important both for fundamental research and practical applications. The goal of this study was to evaluate 2-methoxypyridine as a cationic thymidine mimic in the A-T base pair. The hypothesis was that including protonation in the Watson-Crick base pairing scheme would enhance the thermal stability of the DNA double helix without compromising the sequence selectivity. DNA and peptide nucleic acid (PNA) sequences containing the new 2-methoxypyridine nucleobase (P) were synthesized and studied by using UV thermal melting and NMR spectroscopy. Introduction of P nucleobase caused a loss of thermal stability of ≈10°C in DNA-DNA duplexes and ≈20° C in PNA-DNA duplexes over a range of mildly acidic to neutral pH. Despite the decrease in thermal stability, the NMR structural studies showed that P-A formed the expected protonated base pair at pH 4.3. Our study demonstrates the feasibility of cationic unnatural base pairs; however, future optimization of such analogs will be required.

ChemBioChem published new progress about 186046-81-1. 186046-81-1 belongs to pyrimidines, auxiliary class Pyrimidine,Carboxylic acid,Amine,Benzene,Amide,Others,PNA,, name is 2-(N-(2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)ethyl)-2-(4-(((benzhydryloxy)carbonyl)amino)-2-oxopyrimidin-1(2H)-yl)acetamido)acetic acid, and the molecular formula is C39H35N5O8, HPLC of Formula: 186046-81-1.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/Pyrimidine,
Pyrimidine – Wikipedia

Bennett, Frank published the artcilePyridofuran substituted pyrimidine derivatives as HCV replication (replicase) inhibitors, Related Products of pyrimidines, the publication is Bioorganic & Medicinal Chemistry Letters (2012), 22(15), 5144-5149, database is CAplus and MEDLINE.

Introduction of nitrogen atom into the benzene ring of a previously identified HCV replication (replicase) benzofuran inhibitor I (X = CH), resulted in the discovery of the more potent pyridofuran analog I (X = N). Subsequent introduction of small alkyl and alkoxy ligands into the pyridine ring resulted in further improvements in replicon potency. Replacement of the 4-chloro moiety on the pyrimidine core with a Me group, and concomitant mono-alkylation of the C-2 amino moiety resulted in the identification of several inhibitors with desirable characteristics. Nucleoside inhibitor II (R = CF₃, R¹ = Et, R² = H; R = cyclopropyl, R¹ = OEt, R² = Me), from the mono-substituted pyridofuran and inhibitor 50 from the disubstituted series displayed excellent potency, selectivity (GAPDH/MTS CC₅₀) and PK parameters in all species studied, while the selectivity in the thymidine incorporation assay (DNA·CC₅₀) was low.

Bioorganic & Medicinal Chemistry Letters published new progress about 56-05-3. 56-05-3 belongs to pyrimidines, auxiliary class Pyrimidine,Chloride,Amine,API, name is 2-Amino-4,6-dichloropyrimidine, and the molecular formula is C4H3Cl2N3, Related Products of pyrimidines.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/Pyrimidine,
Pyrimidine – Wikipedia

Patel, Navin B. published the artcileSynthesis of newer 5-benzylidene-2,4-thiazolidinediones as potential antimicrobials, Name: 2-Amino-4,6-dichloropyrimidine, the publication is Indian Journal of Research in Pharmacy and Biotechnology (2014), 2(1), 993-1001, 9 pp., database is CAplus.

A series of 5-benzylidene-2,4-thiazolidinediones I (R = 5-methylthiazol-2-ylamino, 6-fluorobenzothiazol-2-ylamino, 6-nitrobenzothiazol-2-ylamino, etc.) were synthesized and evaluated for antimycobacterial and antimicrobial activity. In vitro antimycobacterial activity was carried out against (M. tuberculosis) H₃₇Rv strain using Lowenstein-Jensen medium and antimicrobial activity against two Gram pos. bacteria (S. aureus, S. pyogenes), two Gram neg. bacteria (E. coli, P. aeruginosa) and three fungal species (C. albicans, A. niger, A. clavatus) using the broth microdilution method. The compounds I (R = 5-methylthiazol-2-amino, 6-fluorobenzothiazol-2-ylamino, 4-nitrobenzothiazol-2-ylamino, 5-nitrobenzothiazol-2-ylamino, 6-methylbenzothiazol-2-ylamino, 4,6-dimethoxypyrimidin-2-ylamino) exhibited promising antimicrobial activity, whereas compounds I (R = 6-methylbenzothiazol-2-ylamino) showed very good antimycobacterial activity.

Indian Journal of Research in Pharmacy and Biotechnology published new progress about 56-05-3. 56-05-3 belongs to pyrimidines, auxiliary class Pyrimidine,Chloride,Amine,API, name is 2-Amino-4,6-dichloropyrimidine, and the molecular formula is C4H3Cl2N3, Name: 2-Amino-4,6-dichloropyrimidine.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/Pyrimidine,
Pyrimidine – Wikipedia

Rayavarapu, Suresh published the artcileA modular approach towards functionalized highly stable self-complementary quadruple hydrogen bonded systems, Product Details of C4H3Cl2N3, the publication is Organic & Biomolecular Chemistry (2017), 15(47), 10087-10094, database is CAplus and MEDLINE.

Self-complementary quadruple hydrogen bonded systems have shown potential as key building blocks for developing various supramol. polymers. Opportunities for the introduction of multiple functionalities would further augment, in principle, their application potential. Herein, we report a novel modular approach to simultaneously introduce two closely aligned side chains into AADD-type self-complementary quadruple hydrogen-bonding systems. Dithiane-tethered ureidopyrimidinone has been used as a reactive intermediate to efficiently attach closely aligned side chains by simply reacting with amines to form highly stable mol. duplexes. These duplexes featuring AADD-type arrays of hydrogen bonding codes are highly stable in non-polar solvents (K_dim > 1.9 x 10⁷ M^-1 in CDCl₃) as well as in polar solvents (K_dim > 10⁵ in 10% DMSO-d₆/CDCl₃). Another notable feature of these self-assembling systems is their insensitivity to prototropy-related issues owing to their prototropic degeneracy, which will enhance their application potential in supramol. chem.

Organic & Biomolecular Chemistry published new progress about 56-05-3. 56-05-3 belongs to pyrimidines, auxiliary class Pyrimidine,Chloride,Amine,API, name is 2-Amino-4,6-dichloropyrimidine, and the molecular formula is C4H3Cl2N3, Product Details of C4H3Cl2N3.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/Pyrimidine,
Pyrimidine – Wikipedia

Sako, Magoichi published the artcileReductive Cleavage of Heteroaryl C-Halogen Bonds by Iodotrimethylsilane. Facile and Regioselective Dechlorination of Antibiotic Pyrrolnitrin, Product Details of C5H6N2O2, the publication is Journal of Organic Chemistry (2001), 66(10), 3610-3612, database is CAplus and MEDLINE.

The authors describe regioselective dechlorination of antibiotic pyrrolnitrin (I) via reductive cleavage of heteroaryl C-halogen bonds by iodotrimethylsilane. Reductive cleavage of the C-halo bond proceeds smoothly, efficiently and chemoselectively even under mild conditions with halo uridines and pyrimidines.

Journal of Organic Chemistry published new progress about 608-34-4. 608-34-4 belongs to pyrimidines, auxiliary class Pyrimidine,Amide, name is 3-Methylpyrimidine-2,4(1H,3H)-dione, and the molecular formula is C5H6N2O2, Product Details of C5H6N2O2.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/Pyrimidine,
Pyrimidine – Wikipedia

King, F. E. published the artcileNew potential chemotherapeutic agents. VI. Derivatives of 2,4-diazaacridine, Application of 2-(Dimethylamino)pyrimidine-4,6-diol, the publication is Journal of the Chemical Society (1947), 726-34, database is CAplus and MEDLINE.

cf. C.A. 41, 3107d. Because of the interest in chemotherapy in compounds having a structural resemblance to riboflavin, attention has been turned to 2′,3′,4,5-quinolinopyrimidine, which has been designated 2,4-diazaacridine (cf. Conrad and Reinbach, Ber. 34, 1341(1901)), and especially to derivatives containing basic side chains. Mercaptobarbituric acid (I) (5 g.), 4.5 g. Et₂N(CH₂)₃NH₂, and about 2 mols. freshly prepared Pb(OH)₂ in iso-AmOH, refluxed 15 hrs., give 78% 2-(3-diethylaminopropylamino)-4,6-dihydroxypyrimidine (II), analyzed as the picrolonate, with 1 mol. H₂O (0.5 mol. lost at 100°, 1 mol. at 150°), yellow, m. 235° (decomposition). I (14.4 g.) and 8.4 g. NaHCO₃ in 200 cc. H₂O, shaken 30 min. with 12.6 g. Me₂SO₄ at room temperature, give 72% 4,6-dihydroxy-2-methylmercaptopyrimidine (III); 10 g. crude III and 3.9 g. Et₂N(CH₂)₃NH₂, heated 30 min. at 180°, give 92% II. EtO₂CCH₂CH₂COCl (6 g.) and 5.2 g. Et₂N(CH₂)₃NH₂ in ether at 0° give 60% α-carbethoxy N-(3-diethylaminopropyl)acetamide, b_0.05 115°, did not react with CO(NH₂)₂ in the presence of EtONa in EtOH (6 hrs.). EtO₂CCH₂C(OEt):NH.HCl (6 g.) and 4.2 g. Et₂N(CH₂)₃NH₂ in 100 cc. EtOH 12 hrs. at room temperature give Et₂N(CH₂)₃NHC(:NH)CH₂CO₂Et, whose picrolonate, with 1 mol. H₂O, yellow, m. 125-30°; this could not be condensed with H₂NCO₂Et. The action of Et₂N(CH₂)₃NH₂ on EtO₂CCH₂CONHCONH₂ gives barbituric acid and not Et₂N(CH₂)₂NHCOCH₂CONHCONH₂, which might have been cyclized to a pyrimidine. 2,4,6-Trichloropyrimidine (IV) (3 g.), added to 11 g. PhCH₂OH and 1.15 g. Na in 100 cc. PhMe (after formation of the alcoholate) and the mixture refluxed 2 hrs., gives 63% of the 2,4,6-tris(benzyloxy) derivative, m. 62-4°; the action of Na in liquid NH₃ does not give a pure compound; hydrogenation in AcOH over Pd-charcoal gives 84% barbituric acid. IV (18 g.) in 100 cc. Me₂CO, cautiously treated with 13 g. Et₂N(CH₂)₃NH₂ with cooling, gives 72% 2,6-dichloro-4-(3-diethylaminopropylamino)pyrimidine (V); HCl salt m. 149°; picrate, bright yellow, m. 162°; picrolonate, yellow, m. 164°. V (3.1 g.) and 10 cc. concentrated HCl, heated on the steam bath 12 hrs., give 76% of the di-HCl salt, m. 253° (decomposition), of 6-chloro-4-(3-diethylaminopropylamino)-2-hydroxypyrimidine; picrate, yellow, m. 209° (decomposition). V (6.25 g.), added in 10 portions to PhCH₂ONa (from 13 g. PhCH₂OH and 1.4 g. Na) in 100 cc. PhMe and the mixture heated 2 hrs., gives 80% 4-(3-diethylaminopropylamino)-2,6-bis(benzyloxy)pyrimidine (VI), m. 68° (dipicrate, m. 156°); crude VI in AcOH, hydrogenated over Pd-charcoal at room temperature and atm. pressure (4 hrs.), gives 4-(3-diethylaminopropylamino)-2,6-dihydroxypyrimidine (VII), apparently with 3 mols. AcOH, very hygroscopic; picrolonate m. 186° (decomposition); 1 of the 2 mols. of H₂O is lost at 100° and the 2nd at 130°. VII and p-ClC₆H₄N₂Cl give 57% of the 5-(p-chlorophenylazo) derivative, with 2 mols. H₂O (1 lost at 100°), yellow, m. 151° (decomposition) (dipicrate, m. 205° (decomposition)); catalytic reduction over RaneyNi gives a product rapidly oxidized in the air. Although VII was devoid of antimalarial activity, the 5-Me analog was also prepared but it was also inactive. 2,4,6-Trichloro-5-methylpyrimidine (19.7 g.) in 100 cc. Me₂CO, cautiously treated with 13 g. Et₂N(CH₂)₃NH₂ in 100 cc. Me₂CO and cooled to 4°, gives 60% of the HCl salt (VIII), m. 193-5°, of 2,6-dichloro-4-(3-diethylaminopropylamino)-5-methylpyrimidine, whose picrate m. 163°. VIII and PhCH₂ONa give the 2,6-bis(benzyloxy) derivative (IX), an oil (tripicrate, m. 141-2°). Hydrogenation of IX in AcOH over Pd-charcoal at room temperature and atm. pressure gives 7.2 g. 4-(3-diethylaminopropylamino)-2,6-dihydroxy-5-methylpyrimidine, as the triacetate (with 1 mol. H₂O); dipicrate, yellow, m. 183-4° (decomposition); picrolonate, yellow, m. 223° (decomposition). 4,6-Dichloro-2-methylaminopyrimidine (X) (4.4 g.) and PhCH₂ONa (from 1.15 g. Na) in 150 cc. PhMe, heated 1 hr. at 100°, give 27.5% 4-chloro-2-methylamino-6-(benzyloxy)pyrimidine, m. 120°; if the reaction mixture is refluxed 4 hrs., there results 61% 2-methylamino-4,6-bis(benzyloxy)pyrimidine, m. 101°; reduction (8 hrs.) in AcOH over Pd-charcoal gives 66.6% 2-methylamino-4,6-dihydroxypyrimidine (XI), with 0.5 mol. EtOH and 2/3 mols. H₂O, m. above 310°. 2,6-Dichloro-4-methylaminopyrimidine (6 g.) and PhCH₂ONa in 75 cc. PhMe, refluxed 3 hrs., give 69% 4-methylamino-2,6-bis(benzyloxy)pyrimidine, m. 118°; reduction (2.5 hrs.) in AcOH gives 98.8% 4-methylamino-2,6-dihydroxypyrimidine (XIA), m. 302° (decomposition). IV (15 g.) and 27 cc. 33% Me₂NH in 75 cc. EtOH give 48% 2,6-dichloro-4-dimethylaminopyrimidine (XII), m. 113°; with PhCH₂ONa in PhMe (refluxed 1 hr.), there results 69.5% 4-dimethylamino-2,6-bis(benzyloxy)pyrimidine, m. 79°; catalytic reduction gives 77% 4-dimethylamino-2,6-dihydroxypyrimidine, m. 320° (decomposition). The alc. mother liquor from XII yields 35% 4,6-dichloro-2-dimethylaminopyrimidine (XIII), m. 102-3°. XIII (3.5 g.) and PhCH₂ONa (from 0.84 g. Na) in 50 cc. PhMe, heated 1 hr. at 100°, give 73% 4-chloro-2-dimethylamino-6-(benzyloxy)pyrimidine, m. 84°; when refluxed 3 hrs., there results 69.5% 2-dimethylamino-4,6-bis(benzyloxy)pyrimidine, whose picrate, yellow, m. 176°; catalytic reduction gives 73% 2-dimethylamino-4,6-dihydroxypyrimidine, yellow, m. 320° (decomposition). IV (5.75 g.) in 90 cc. Me₂CO and the NH:C(NH₂)₂ from 6 g. of the HCl salt in 10 cc. H₂O, on standing 15 min., give 53% 2,6-dichloro-4-guanidinopyrimidine, m. 325° (decomposition); the mother liquor apparently contains an addnl. 43%; PhCH₂ONa in PhMe, heated 2 hrs. at 100°, gives 61% 6-chloro-4-guanidino-2-(benzyloxy)pyrimidine, m. 170° (picrate, yellow, m. 250° (decomposition)); refluxed in PhMe 8 hrs., there results 78% 4-guanidino-2,6-bis(benzyloxy)pyrimidine, characterized as the picrate, m. 200°; reduction yields 38% 4-guanidino-2,6-dihydroxypyrimidine (XIV), m. 300°. Malonylguanidine, CH:C(OH).N:C(NH₂).N:C(OH), (2 g.) and 3 g. o-H₂NC₆H₄CHO in 100 cc. H₂O containing 5 cc. HCl, heated 1 hr. on the steam bath, give 69.5% 3-amino-1-hydroxy-2,4-diazaacridine, analyzed as the HCl salt (with 2 mols. H₂O), m. above 310°; the free base, m. above 310°, gives a pale yellow solution in NaOH with a strong greenish blue fluorescence. 4-Amino-2,6-dihydroxypyrimidine and o-H₂NC₆H₄CHO give 61% 1,3-dihydroxy-2,4-diazaacridine (XV) (cf. Conrad and Reinbach, loc. cit.), which crystallizes with 1 mol. AcOH. 2,4-Diamino-6-hydroxypyrimidine (3 g.) in 100 cc. H₂O and 10 cc. AcOH, treated with 3 g. o-H₂NC₆H₄CHO in 10 cc. EtOH and refluxed 30 min., gives 35% (XVI) with 0.5 mol. H₂O, bright yellow, m. above 330°; its solutions exhibit a vivid blue fluorescence; HCl salt, biscuit-colored, m. above 310°. XI and o-H₂NC₆H₄CHO give 63.5% 3-methylamino-1-hydroxy-2,4-diazaacridine, with 4/3 mols. H₂O, pale yellow, m. above 310°; its solutions have a marked green-blue fluorescence; XIA gives XV. XIV gives 81% of the 1-guanidino analog of XV, m. above 310°; di-HCl salt, with 1.5 mols. H₂O, m. above 310°; at 120° it forms the mono-HCl salt, with 1 mol. H₂O; picrate, yellow, with 1.5 mols. H₂O, m. 230° (decomposition). The 3-(3-diethylaminopropylamino) analog of XV, obtained as a reddish oil, analyzed as the meconate (50% yield), with 5 mols. H₂O (2.5 mols. lost at 100°), pale yellow, m. 180° (decomposition); the picrate, with 1 mol. EtOH, m. 222° (decomposition) and could not be further purified. Barbituric acid (3.9 g.) and 3.9 g. 2,4-(O₂N)₂C₆H₃CHO in 150 cc. boiling H₂O give 71.5 g. of the 2,4-dinitrobenzylidene derivative, orange, m. above 310°; 2,4-H₂N(O₂N)C₆H₃CHO in dilute EtOH gives 64.5% 6-nitro-1,3-dihydroxy-2,4-diazaacridine, with 1 mol. EtOH, cream, m. above 310°; it forms an orange Na salt; in AcOH, it shows a blue fluorescence; the NO₂ group could not be reduced. These compounds were only slightly active or inactive when tested in vitro against Staphylococcus aureus.

Journal of the Chemical Society published new progress about 5738-14-7. 5738-14-7 belongs to pyrimidines, auxiliary class Pyrimidine,Amine,Alcohol,Pyrimidine, name is 2-(Dimethylamino)pyrimidine-4,6-diol, and the molecular formula is C6H9N3O2, Application of 2-(Dimethylamino)pyrimidine-4,6-diol.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/Pyrimidine,
Pyrimidine – Wikipedia

Almeida, D. published the artcileN-site de-methylation in pyrimidine bases as studied by low energy electrons and ab initio calculations, Computed Properties of 608-34-4, the publication is Physical Chemistry Chemical Physics (2013), 15(27), 11431-11440, database is CAplus and MEDLINE.

Electron transfer and dissociative electron attachment to 3-methyluracil (3meU) and 1-methylthymine (1meT) yielding anion formation were studied in atom-mol. collision and electron attachment experiments, resp. The former was studied in the collision energy range 14-100 eV whereas the latter in the 0-15 eV incident electron energy range. In the present studies, emphasis is given to the reaction channel resulting in the loss of the Me group from the N-sites with the extra charge located on the pyrimidine ring. This particular reaction channel has neither been approached in the context of dissociative electron attachment nor in atom-mol. collisions yet. Quantum chem. calculations were performed to provide some insight into the dissociation mechanism involved along the N-CH₃ bond reaction coordinate. The calculations provide support to the threshold value derived from the electron transfer measurements, allowing for a better understanding of the role of the potassium cation as a stabilizing agent in the collision complex. The present comparative study gives insight into the dynamics of the decaying transient anion and more precisely into the competition between dissociation and auto-detachment.

Physical Chemistry Chemical Physics published new progress about 608-34-4. 608-34-4 belongs to pyrimidines, auxiliary class Pyrimidine,Amide, name is 3-Methylpyrimidine-2,4(1H,3H)-dione, and the molecular formula is C5H6N2O2, Computed Properties of 608-34-4.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/Pyrimidine,
Pyrimidine – Wikipedia

Sugiyama, Toru published the artcileSynthesis of PNA using a Fmoc/Boc protecting group strategy, COA of Formula: C11H15N3O5, the publication is Nucleic Acids Research Supplement (2002), 145-146, database is CAplus.

A symposium on the authors’ work. Syntheses of PNA monomers whose nucleobases are protected with Boc group are described. To overcome the solubility problem of carboxymethyl-guanine derivative, the 2-trimethylsilylethyl group was introduced at O⁶ as a second protecting group.

Nucleic Acids Research Supplement published new progress about 172405-16-2. 172405-16-2 belongs to pyrimidines, auxiliary class Pyrimidine,Carboxylic acid,Amine,Amide, name is 2-(4-((tert-Butoxycarbonyl)amino)-2-oxopyrimidin-1(2H)-yl)acetic acid, and the molecular formula is C4H4N2O2, COA of Formula: C11H15N3O5.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/Pyrimidine,
Pyrimidine – Wikipedia