Category: pyrimidines

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 34289-60-6, name is 4,6-Dimethylpyrimidin-2-ol hydrochloride. This compound has unique chemical properties. The synthetic route is as follows. Safety of 4,6-Dimethylpyrimidin-2-ol hydrochloride

Add 160 mg (1 mmol) to a 100 mL eggplant bottle 2-hydroxy-4,6-dimethylpyrimidine hydrochloride, 318 mg (3 mmol) benzaldehyde and 0.1 mL (1.2 mmol) concentrated hydrochloric acid,Anhydrous ethanol (40 mL) was added to dissolve the reaction, and the mixture was heated under reflux at 80 C for 24h.After the reaction is completed, the solvent is distilled off under reduced pressure.Add a saturated sodium bicarbonate aqueous solution and stir to remove the acid.The crude product was washed with water and dried and purified by column chromatography (methanol: dichloromethane = 1:10).0.21 g of 2-hydroxy-4,6-distyrylpyrimidine was obtained in a yield of 70%.

With the rapid development of chemical substances, we look forward to future research findings about 34289-60-6.

Reference:
Patent; Ocean University of China; Jiang Tao; Zhang Lijuan; Tong Sheng; Zhang Meng; (30 pag.)CN105198820; (2019); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 444731-75-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 444731-75-3, name is N-(2-Chloropyrimidin-4-yl)-N,2,3-trimethyl-2H-indazol-6-amine, molecular formula is C14H14ClN5, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Procedure 5 To a stirred suspension of the product of Intermediate Example 4 (1.0 g, 3.6 mmol) in 10 mL of CH3CN, was added 5-amino-2- methylbenzenesulfonamide (0.70 g, 3.8 mmol, I.Oequiv) at room temperature. The reaction mixture was heated at reflux for 3 h, then 4 M HCI in 1,4-dioxane (18 (at)L, 0.076 mmol) was added in one portion. After 20 h, the suspension was cooled to room temperature, and filtered. The resulting solid was washed with 10 mL of CH3CN and dried in the air to yield 1.3 g (73%) of 5-((at)4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl}amino)-2- methyl benzenesulfonamide monohydrochloride as an off-white solid.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 444731-75-3, N-(2-Chloropyrimidin-4-yl)-N,2,3-trimethyl-2H-indazol-6-amine.

Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; KUMAR, Rakesh; WO2005/105094; (2005); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 63200-54-4 , The common heterocyclic compound, 63200-54-4, name is 2,4-Dichloro-5H-pyrrolo[3,2-d]pyrimidine, molecular formula is C6H3Cl2N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Into a 50 ml_ vial was placed 2,4-dichloro-5H-pyrrolo[3,2-c/]pyrimidine [CAS 63200-54-4] (1 g, 5.319 mmol), DMF (10 ml_), DIPEA (2.75 ml_, 16 mmol) and benzyl bromide (0.7 ml_, 5.85 mmol). The vial was sealed and shaken for 16 hours at room temperature. The solvents were removed under reduced pressure. The crude was purified via silica gel column chromatography using a heptane to ethyl acetate gradient. The best fractions were pooled and the solvents were removed under reduced pressure to afford B. LC-MS (M+H) m/z = 278

The synthetic route of 63200-54-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; JANSSEN R&D IRELAND; MC GOWAN, David Craig; LAST, Stefaan Julien; PIETERS, Serge Maria Aloysius; EMBRECHTS, Werner; JONCKERS, Tim Hugo Maria; RABOISSON, Pierre Jean-Marie Bernard; WO2014/56953; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 89284-85-5 , The common heterocyclic compound, 89284-85-5, name is Methyl 2,5,6-trichloropyrimidine-4-carboxylate, molecular formula is C6H3Cl3N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A mixture of I (1.5 g, 6.2 mmol) and (rac) 3-hydroxymethylmorpholine (875 mg, 7.4 mmol) with DIPEA ( 1.6 ml_, 9.3 mmol) in EtOH (30 mL) was heated at 75C for 1 h 30 min. The mixture was cooled down to rt and solvents were removed in vacuo. The oily residue was redisolved in DCM (20 mL), washed with sat. solution of NaHC03 (3 x 20 mL), brine (30 mL), dried over Na2S04 and concentrated in vacuo. Required product, intermediate II (1.860 g, 93%) was used further without additional purifications.

The synthetic route of 89284-85-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; FUNDACION CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III; PASTOR FERNANDEZ, Joaquin; FERNANDEZ-CAPETILLO RUIZ, Oscar; MARTINEZ GONZALEZ, Sonia; BLANCO APARICIO, Carmen; RICO FERREIRA, Maria del Rosario; TOLEDO LAZARO, Luis Ignacio; RODRIGUEZ ARISTEGUI, Sonsoles; MURGA COSTA, Matilde; VARELA BUSTO, Carmen; LOPEZ CONTRERAS, Andres Joaquin; RENNER, Oliver; NIETO SOLER, Maria; CEBRIAN MUNOZ, David Alvaro; WO2014/140644; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 6320-15-6 ,Some common heterocyclic compound, 6320-15-6, molecular formula is C6H7ClN2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Preparatory Example 74 4, 6-Dimethoxy-3- (perfluoroethyl) -1H-pyrazolo [3, 4-d] pyrimidine (Scheme 13) Step 1. 1- (4-Chloro-2, 6-dimethoxypyrimidin-5-yl) -2, 2, 3, 3, 3-pentafluoropropan-1-oneTo a stirred solution of 4-chloro-2, 6-dimethoxypyrimidine (0.50 g, 2.86 mmol) in THF (30 mL) at -30under N2was added 2, 2, 6, 6-tetramethylpiperidinylmagnesium chloride lithium chloride complex (1.5 M in THF, 1.4 mL, 2.86 mmol) dropwise. The reaction solution was stirred at -30for 2 h whereupon a copper (I) cyanide di (lithium chloride) complex solution (1 M in THF, 2.86 mL, 2.86 mmol) was added dropwise. The reaction mixture was stirred for an additional 30 min at -30whereupon 2, 2, 3, 3, 3-pentafluoropropanoic anhydride (1.78 g, 5.7 mmol) was added. The reaction mixture allowed to gradually warm to RT and was stirred for 16 h. The resulting mixture was quenched with sat. aq. sodium bicarbonate (50 mL) , diluted with water (50 mL) and extracted with EtOAc (3 x 50 mL) . The combined organic layers were washed with brine (1 x 30 mL) , dried over Na2SO4, filtered, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (0-10ethyl acetate in hexanes) to afford the title compound as an oil.1H NMR (400 MHz, CDCl3) delta: 4.11 (s, 3H) , 4.10 (s, 3H) .

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 6320-15-6, 4-Chloro-2,6-dimethoxypyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; MERCK SHARP & DOHME CORP.; MSD R&D (CHINA) CO. LTD.; SHEN, Dong-Ming; DWYER, Michael; SINZ, Christopher J.; WANG, Deping; STACHEL, Shawn; PAONE, Daniel; NOMLAND, Ashley; BERGER, Richard; CHEN, Yili; QIAN, Yimin; XU, Shimin; HU, Chunmei; (212 pag.)WO2016/192083; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 3680-69-1 ,Some common heterocyclic compound, 3680-69-1, molecular formula is C6H4ClN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A mixture of 249 4-chloro-7H-pyrrolo[2,3-d]pyrimidine (500 g, 3255.84 mmol) and 250 NIS (805.74 g, 3581.43 mmol) in 21 DMF (3.3 L) was stirred at rt for 3 hrs. The mixture was poured into ice water (20 L) and resulting solid was filtered, washed with saturated sodium thiosulphate solution (4×2.5 L), water (4×2.5 L) and dried under vacuum to afford the 237 title compound as an off white solid (780 g, 85.8%). 1HNMR (400 MHz, DMSO-d6): 7.94 (s, 1H), 8.59 (s, 1H). LCMS m/z=279.6 [MH]+

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,3680-69-1, its application will become more common.

Reference:
Patent; CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC.; Strohbach, Joseph Walter; Limburg, David Christopher; Mathias, John Paul; Thorarensen, Atli; Denny, Rajiah Aldrin; Zapf, Christoph Wolfgang; Elbaum, Daniel; Gavrin, Lori Krim; Efremov, Ivan Viktorovich; (159 pag.)US2018/141954; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 947533-45-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.947533-45-1, name is 2-bromo-5-fluoropyrimidine, molecular formula is C4H2BrFN2, molecular weight is 176.97, as common compound, the synthetic route is as follows.

In a 40 mL vial, chloro(2-dicyclohexylphosphino-2′,4′,6′-triisopropyl- l,l ‘-biphenyl)[2-(2-aminoethyl)phenyl)]palladium(II) (0.025 g, 0.031 mmol), tert-butyl 3-((6-methoxy-2-(methylthio)-5-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2- yl)pyrimidin-4-yl)arnino)piperidine-l-carboxylate (0.15 g, 0.312 mmol), 2-bromo-5- fluoropyrimidine (0.083 g, 0.468 mmol) and CuCl (0.031 g, 0.312 mmol) were combined, then purged with argon. Then degassed DMF (3 mL) followed by CS2CO3 (0.407 g, 1.249 mmol) were added to the vial. The reaction was then heated at 100 C for 18 h. The mixture was cooled, diluted with ethyl acetate, washed with water, dried (Na2SC>4), filtered and the solvent was evaporated under reduced pressure. The material was purified by column chromatography on silica gel (0-100% EtOAc in hexanes) to afford the desired product. MS (m z) = 451 (M+H).

The chemical industry reduces the impact on the environment during synthesis 947533-45-1, I believe this compound will play a more active role in future production and life.

Reference:
Patent; MERCK SHARP & DOHME CORP.; SEGANISH, W. Michael; BRUMFIELD, Stephanie Nicole; LIM, Jongwon; MATASI, Julius, J.; MCELROY, William, T.; TULSHIAN, Dean, B.; LAVEY, Brian, J.; ALTMAN, Michael, D.; GIBEAU, Craig, R.; LAMPE, John William; METHOT, Joey; ZHU, Liang; WO2013/66729; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 4316-93-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 4316-93-2, name is 4,6-Dichloro-5-nitropyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

Step 1: A solution of dibenzylamine (10.2 g) in dichloromethane (30 mL) is dripped into a solution of 4,6-dichloro-5-nitropyrimidine (10 g) in dichloromethane (70 mL) on an ice bath. Then triethylamine (14.4 mL) is added, and the mixture is stirred for 1 hour. Water is added to the reaction mixture, the organic layer is washed with a saturated aqueous sodium chloride solution and dried over anhydrous sodium sulfate, and the solvent is concentrated under reduced pressure to obtain N,N-dibenzyl-6-chloro-5-nitropyrimidine-4-amine (19.2 g).

According to the analysis of related databases, 4316-93-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ACERTA PHARMA B.V.; HAMDY, Ahmed; ROTHBAUM, Wayne; IZUMI, Raquel; LANNUTTI, Brian; COVEY, Todd; ULRICH, Roger; JOHNSON, Dave; BARF, Tjeerd; KAPTEIN, Allard; (745 pag.)WO2016/24232; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 29274-24-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 29274-24-6, name is 5-Chloropyrazolo[1,5-a]pyrimidine. A new synthetic method of this compound is introduced below.

5-Aryl/heteroaryl-ethynyl-pyrazolo[1 ,5-a]pyrimidines (51 )[00143] Under a strong stream of argon, aryltrimethylsilylacetylene, 5-chloro- pyrazolo[1 ,5-a]pyrimidine (1 equivalent), PdCI2(PPh3J2 (5 mol %) and copper (I) iodide (5 mol %) are placed in a vial containing DMF. The mixture is flushed thoroughly with argon and Et3N (4 equivalents) is added through the septum. The reaction mixture is warmed to 60 0C and TBAF (1.1 equivalent) in DMF is added dropwise. The mixture is stirred at 60 0C for 3h, the solvent is evaporated and the residue is purified by flash column chromatography to give the desired product. Yields 20-60%.; Example 1 3-Pyrazolo[1,5-a]pyrimidin-5-ylethynyl-benzonitrile[00177] According to General Procedure 1 , 3-[(trimethylsilyl)ethynyl]benzonitrile is reacted with 5-chloro-pyrazolo[1 ,5-a]pyrimidine to provide the title compound in good yield.1H NMR (CDCI3, TMS) delta: 6.76, 6.98, 7.53, 7.72, 7.88, 8.19, 8.69.LC/MS: (M+H)= 245

At the same time, in my other blogs, there are other synthetic methods of this type of compound,29274-24-6, 5-Chloropyrazolo[1,5-a]pyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; MERZ PHARMA GMBH & CO. KGaA; HENRICH, Markus; WEIL, Tanja; NAGEL, Jens; GRAVIUS, Andreas; MUeLLER, Sibylle; KAUSS, Valerjans; ZEMRIBO, Ronalds; FOTINS, Juris; WO2010/63487; (2010); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 183438-24-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 183438-24-6, name is 5-Bromo-2-iodopyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

To a clean and dry reactor containing 20.04 g of isopropyl 2-bromo-3-cyclopentyl-1-methyl-1H-indole-6-carboxylate, 1.06 g of Pd(TFP)2Cl2 (3 mol %) and 0.76 g of tri(2-furyl)phosphine (6 mol %) was charged 8.35 g of triethylamine (1.5 equivalent), 39.38 g of CH3CN at 23±10 C. under nitrogen or argon and started agitation for 10 min 9.24 g of 4,4,5,5-tetramethyl-1,3,2-dioxaborolane was charged into the reactor. The mixture was heated to reflux (ca. 81-83 C.) and stirred for 6 h until the reaction completed. The batch was cooled to 30±5 C. and quenched with a mixture of 0.99 g of water in 7.86 g of CH3CN. 17.24 g of 5-bromo-2-iodopyrimidine and 166.7 g of degassed aqueous potassium phosphate solution (pre-prepared from 46.70 g of K3PO4 and 120 g of H2O) was charged subsequently under argon or nitrogen. The content was heated to reflux (ca. 76-77 C.) for 2 h until the reaction completed. 4.5 g of 1-methylimidazole was charged into the reactor at 70 C. The batch was cooled to 20±3 C. over 0.5 h and hold at 20±3 C. for at least 1 h. The solid was collected by filtration. The wet cake was first rinsed with 62.8 g of 2-propanol, followed by 200 g of H2O. The solid was dried under vacuum at the temperature below 50 C. [0095] Into a dry and clean reactor was charged dried I, 10 wt % Norit SX Ultra and 5 V of THF. The content was heated at 60±5 C. for at least 1 h. After the content was cooled to 35±5 C., the carbon was filtered off and rinsed with 3 V of THF. The filtrate was charged into a clean reactor containing 1-methylimidazole (10 wt % relative to I). After removal of 5 V of THF by distillation, the content was then cooled to 31±2 C. After the agitation rate was adjusted to over 120 rpm, 2.5 V of water was charged over a period of at least 40 minutes while maintaining the content temperature at 31±2 C. After the content was agitated at 31±2 C. for additional 20 min, 9.5 V of water was charged into the reactor over a period of at least 30 minutes at 31±2 C. The batch was then cooled to about 25±3 C. and stirred for additional 30 minutes. The solid was collected and rinsed with 3 V of water. The wet product I was dried under vacuum at the temperature below 50 C. (19.5 g, 95 wt %, 76% yield).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 183438-24-6, 5-Bromo-2-iodopyrimidine.

Reference:
Patent; Boehringer Ingelheim International GmbH; LI, Zhibin; YANG, Bing-Shiou; YIP, Kazuhiko; US2013/261134; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia