Category: pyrimidines

Transition-metal-free synthesis of pyrimidines from lignin β-O-4 segments via a one-pot multi-component reaction was written by Zhang, Bo;Guo, Tenglong;Li, Zhewei;Kuhn, Fritz E.;Lei, Ming;Zhao, Zongbao K.;Xiao, Jianliang;Zhang, Jian;Xu, Dezhu;Zhang, Tao;Li, Changzhi. And the article was included in Nature Communications in 2022.Name: 4,6-Diphenylpyrimidin-2-amine This article mentions the following:

In this work, the synthesis of pyrimidines from lignin β-O-4 model compounds, the most abundant segment in lignin, mediated by NaOH through a one-pot multi-component cascade reaction is reported. Mechanism study suggests that the transformation starts by NaOH-induced deprotonation of Cα-H bond in β-O-4 model compounds, and involves highly coupled sequential cleavage of C-O bonds, alc. dehydrogenation, aldol condensation, and dehydrogenative aromatization. This strategy features transition-metal free catalysis, a sustainable universal approach, no need of external oxidant/reductant, and an efficient one-pot process, thus providing an unprecedented opportunity for N-containing aromatic heterocyclic compounds synthesis from biorenewable feedstock. With this protocol, an important marine alkaloid meridianin derivative can be synthesized, emphasizing the application feasibility in pharmaceutical synthesis. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Name: 4,6-Diphenylpyrimidin-2-amine).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they constitute an important class of natural and synthetic compounds exhibiting diverse useful biological activities that hold attractive potential for clinical translation as therapeutic agents in alleviation of a myriad of diseases. Pyrimidine derivatives have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.Name: 4,6-Diphenylpyrimidin-2-amine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Comparison and prioritization of antibiotics in a reservoir and its inflow rivers of Beijing, China was written by Hu, Jingrun;Qi, Dianqing;Chen, Qian;Sun, Weiling. And the article was included in Environmental Science and Pollution Research in 2022.Product Details of 1220-83-3 This article mentions the following:

The occurrence of antibiotics in drinking water resources, like reservoirs, is of considerable concern due to their potential risks to ecosystem, human health, and antimicrobial resistance development. Here, we quantified 83 antibiotics in water and sediments of wet and dry seasons from the Miyun reservoir and its inflow rivers in Beijing, China. Twenty-four antibiotics were detected in water with concentrations of ND-11.6 ng/L and 19 antibiotics were observed in sediments with concentrations of ND-6.50 ng/g. Sulfonamides (SAs) were the dominated antibiotics in water in two seasons. SAs and quinolones (QNs) in wet season and macrolides (MLs) and QNs in dry season predominated in sediments. The reservoir and inflow rivers showed significant differences in antibiotic concentrations and compositions in water and sediments. As an important input source of reservoir, the river water showed significantly higher total antibiotic concentrations than those in the reservoir. In contrast, the reservoir sediments are the sink of antibiotics, and had higher total antibiotic concentrations compared with rivers. A prioritization approach based on the overall risk scores and detection frequencies of antibiotics was developed, and 3 (sulfaguanidine, anhydroerythromycin, and sulfamethoxazole) and 5 (doxycycline, sulfadiazine, clarithromycin, roxithromycin, and flumequine) antibiotics with high and moderate priority, resp., were screened. The study provides a comprehensive insight of antibiotics in the Miyun Reservoir and its inflow rivers, and is significant for future monitoring and pollution mitigation of antibiotics. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Product Details of 1220-83-3).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. The pyrimidine derivatives can easily interact with enzymes, genetic materials, and bio components within the cell. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Product Details of 1220-83-3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthesis and Antimicrobial Activity of Azolyl Pyrimidinyl Acetamides was written by N., Hussain Basha;T., Rekha;Guda, Dinneswara Reddy;Padmaja, Adivireddy;Padmavathi, V.. And the article was included in Polycyclic Aromatic Compounds in 2022.HPLC of Formula: 40230-24-8 This article mentions the following:

A variety of azolyl pyrimidinyl acetamides I (X = O, S, NH; Ar = Ph, 2-furyl, 4-pyridyl, etc.) were prepared from azolyl glycinate and 4,6-diaryl/heteroarylpyrimidinyl-2-amines in the presence of DMAP under ultrasonication. Nitrophenyl, pyridinyl and indolyl substituted thiazolyl pyrimidinyl acetamides, I (X = S; Ar = 4-O₂NC₆H₄), I (X = S; Ar = 4-pyridyl), I (X = S; Ar = 3-indolyl) and imidazolyl pyrimidinyl acetamides I (X = NH; Ar = 4-O₂NC₆H₄), I (X = NH; Ar = 4-pyridyl), I (X = NH; Ar = 3-indolyl) showed excellent antibacterial activity against B. subtilis and MBC is 2xMIC. The compounds, I (X = S; Ar = 4-O₂NC₆H₄), I (X = NH; Ar = 4-O₂NC₆H₄) and I (X = NH; Ar = 4-pyridyl) and also showed excellent antifungal activity against A. niger and MFC is 2xMIC. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8HPLC of Formula: 40230-24-8).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they constitute an important class of natural and synthetic compounds exhibiting diverse useful biological activities that hold attractive potential for clinical translation as therapeutic agents in alleviation of a myriad of diseases. Therapy for fungal infections is based mainly on four classes of antifungals: azoles, echinocandins, polyenes, and pyrimidine analogs.HPLC of Formula: 40230-24-8

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Divergent Solution-Phase Synthesis of Diarylpyrimidine Libraries as Selective A₃ Adenosine Receptor Antagonists was written by Yaziji, Vicente;Coelho, Alberto;El Maatougui, Abdelaziz;Brea, Jose;Loza, M. Isabel;Garcia-Mera, Xerardo;Sotelo, Eddy. And the article was included in Journal of Combinatorial Chemistry in 2009.Electric Literature of C16H13N3 This article mentions the following:

A practical and divergent solution-phase synthetic strategy has been optimized to prepare a highly diverse library of 2,4-diaryl- and 2,6-diarylpyrimidines. Structural elaboration of the starting heterocyclic scaffolds was accomplished by exploiting the potential for diversity offered by the Suzuki-Miyaura cross-coupling reaction. These studies enabled the identification of structurally simple, highly potent, and selective A₃ adenosine receptor antagonists. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Electric Literature of C16H13N3).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Electric Literature of C16H13N3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthesis of amido sulfonamido heteroaromatics under ultrasonication and their antimicrobial activity was written by Gari Divya, Kuppi Reddy;Lakshmi Teja, Gaddam;Yamini, Gudi;Padmaja, Adivireddy;Padmavathi, Venkatapuram. And the article was included in Chemistry & Biodiversity in 2019.Formula: C16H13N3 This article mentions the following:

A convenient and facile methodol. for N-sulfonylation of heteroaryl amines with Et chlorosulfonylacetate in the presence of dispersed sodium in THF under ultrasonication is reported. The corresponding heteroaryl sulfonamido esters are directly condensed with heteroaryl amines to get amido sulfonamido heteroaromatics in the presence of a mild base in THF under ultrasonication. Utilization of easy reaction conditions, shorter reaction times, and isolation of products in high yields under ultrasonication make this process as economically viable. The compounds 12c, 12d, 12f and 13f are potential antibacterial agents against B. subtilis and the compounds 12f, 13c and 13f are potential antifungal agents against A. niger. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Formula: C16H13N3).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Formula: C16H13N3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electro-organic synthesis of new pyrimidine and uracil derivatives was written by Davarani, Saied Saeed Hosseiny;Fumani, Neda Sheijooni;Vahidi, Siavash;Tabatabaei, Mohammad-Ali;Arvin-Nezhad, Hamid. And the article was included in Journal of Heterocyclic Chemistry in 2010.Application of 54030-56-7 This article mentions the following:

Electrochem. oxidation of catechols was studied in the presence of 6-aminopyrimidine derivatives as nucleophiles in aqueous solution using cyclic voltammetry. This efficient electro-organic synthesis was successfully performed at carbon rod electrodes in an undivided cell under controlled potential conditions to give dihydroxyaryl-substituted aminopyrimidinones and dihydroxypyrimido[4,5-b]indolones in good yields and purity. In the experiment, the researchers used many compounds, for example, 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7Application of 54030-56-7).

6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Application of 54030-56-7

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Two-, three-, and four-bond N-F spin-spin coupling constants in fluoroazines was written by Del Bene, Janet E.;Alkorta, Ibon;Elguero, Jose. And the article was included in Molecular Physics in 2010.Formula: C4HF3N2 This article mentions the following:

Ab initio EOM-CCSD calculations were performed to investigate 2-, 3- and 4-bond ¹⁵N-¹⁹F coupling constants in mono-, di-, and trifluoroazines. ²J(N-F) values are neg. and are dominated by the Fermi-contact (FC) term. Absolute values of ²J(N-F) tend to decrease as the number of N atoms in the ring increases, and may also be influenced by the number and positions of C-F bonds. ³J(N-F) values are pos. with three exceptions, are usually dominated by the FC term, and also tend to decrease as the number of N atoms increases. The three mols. which have neg. values of ³J(N-F) have dominant neg. paramagnetic-spin orbit (PSO) terms, and are structurally similar insofar as they have an intervening C-F bond between the N and the coupled F. ⁴J(N-F) values are neg. because the PSO, FC, and spin-dipole (SD) terms are neg., with only one exception. Four mols. have significantly greater values of ⁴J(N-F). These are structurally similar with the coupled N bonded to two other N atoms. The computed EOM-CCSD ⁿJ(N-F) coupling constants are in good agreement with the few exptl. values that are available. In the experiment, the researchers used many compounds, for example, 4,5,6-Trifluoropyrimidine (cas: 17573-78-3Formula: C4HF3N2).

4,5,6-Trifluoropyrimidine (cas: 17573-78-3) belongs to pyrimidine derivatives. The pyrimidine derivatives can easily interact with enzymes, genetic materials, and bio components within the cell. Therapy for fungal infections is based mainly on four classes of antifungals: azoles, echinocandins, polyenes, and pyrimidine analogs.Formula: C4HF3N2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Predicting mass loadings of sulfamonomethoxine, sulfamethoxazole, and lincomycin discharged into surface waters in Japanese river catchments was written by Hanamoto, Seiya;Yamamoto-Ikemoto, Ryoko;Tanaka, Hiroaki. And the article was included in Science of the Total Environment in 2021.Related Products of 1220-83-3 This article mentions the following:

Japanese strategies for the management of livestock waste suggest effluent discharge from livestock farms as major pathways of entry of veterinary antibiotics into surface waters. To aid control of their sources, we developed a model for predicting annual loads of antibiotics discharged into surface waters as effluent from livestock farms, sewage treatment plants, and households, using population, usage, excretion, removal, and fraction of livestock waste treated as wastewater. To verify the model, we monitored three antibiotics which are much used for livestock in Japan and are stable during river transport-i.e., sulfamonomethoxine (SMM), sulfamethoxazole (SMX), and lincomycin (LCM)-over one year in the Oyodo River, which has the most active swine farming area in Japan in its catchment. Concentrations and mass flows of SMM and SMX showed a sharp peak in winter, and those of LCM were also higher in winter than in summer in the river. Annual mass flows observed in the river and reported in three other Japanese rivers were within a range of 1/2 to 2 times the model estimates Effluent from swine farms contributed largely to mass flows of SMM and LCM in the rivers, while human wastewater from sewage treatment plants and households contributed partly to substantially to those of SMX. Estimated contributions of surface runoff from agricultural land to the annual mass flows in the rivers were < 1%, in agreement with the prediction made by limiting sources to effluent. Although other locations and antibiotics should be studied in the future, this first attempt at modeling the load of veterinary antibiotics discharged from livestock farms provides a new perspective on how to reduce movement of these compounds into surface waters in catchments where wastewater treatment is or could be used in managing livestock waste. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Related Products of 1220-83-3).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Related Products of 1220-83-3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

An exhaustive investigation on antibiotics contamination from livestock farms within sensitive reservoir water area: Spatial density, source apportionment and risk assessment was written by Zhang, Keqiang;Ruan, Rong;Zhang, Zulin;Zhi, Suli. And the article was included in Science of the Total Environment in 2022.Computed Properties of C11H12N4O3S This article mentions the following:

Although the studies on antibiotic contamination are common at present, large-scale sampling studies drawing highly representative conclusions are still scarce. This study conducted a comprehensive investigation on a total of 1183 samples from 70 livestock farms within a sensitive area around reservoir waters. 45 types of antibiotics belonging to 5 different classes were monitored. This is the first anal. to comprehensively investigate the d. distribution, source apportionment, ecol. and health risk of antibiotics in an entire area of sensitive waters. The results showed that the layer manure samples had highest detection rate of antibiotics (0.0 %-96.1 %, average value = 30.7 %) followed by pig manure samples. Oxytetracycline had the highest concentration of 712.16 mg/kg in a pig manure sample. Different from using antibiotic concentration as a proxy for pollution level, the spatial d. was calculated by averaging antibiotic concentration to area and converting different livestock to pig equivalent The spatial d. of pig equivalent can more realistically reflect the pollution caused by different breeds of livestocks. It was shown that the pig farms contributed higher to total antibiotic d. than the layer and cattle farms did. After assessed, a few antibiotics (oxytetracycline, chlorotetracycline and tetracycline) have posed high ecol. risks to soil around the farms. However, none of them caused hazard quotient (HQ) risk and carcinogenic risk (CR) to human health in the water of reservoir. Children were more likely to be at hazard risk than adults. Antibiotic mass fluctuation rules were analyzed along the chain (feed �livestock waste �soil �surface water). Feed, livestock waste and soil had similar diversity, but the antibiotic concentrations continued to decline, implying the possible sources of antibiotic residues were similar. Thus, it is important to reduce unnecessary antibiotic use to prevent the potential long-term risk of antibiotics. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Computed Properties of C11H12N4O3S).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.Computed Properties of C11H12N4O3S

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Protonation constants of 2-amino-pyrimidine derivatives was written by Al-Hajjar, F.;Dagga, F. Abu;Hameed, Z.. And the article was included in Annual Research Report – Kuwait Institute for Scientific Research in 1977.Electric Literature of C16H13N3 This article mentions the following:

The basicity constants of I (R = H, 4-Me, 4-Cl, 3-Br, 4-MeO, 4-NO₂, 3-NO₂) and II were correlated linearly with Hammett σ constants I (R = 4-NO₂, 3-NO₂) were most basic; I (R = 4-MeO) was least basic. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Electric Literature of C16H13N3).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they constitute an important class of natural and synthetic compounds exhibiting diverse useful biological activities that hold attractive potential for clinical translation as therapeutic agents in alleviation of a myriad of diseases. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.Electric Literature of C16H13N3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia