Category: pyrimidines

Prabhakar, Virupakshi; Kondra, Sudhakar Babu; Maddula, Srinivasula Reddy; Parandhama, G.; Latha, J. published the artcile< Synthesis, structural elucidation of novel thieno [2,3-d] pyrimidine core unit containing 1,2,4-triazoles and thiophenes as potent antimicrobial activity>, Name: 2,4-Dichlorothieno[2,3-d]pyrimidine, the main research area is thiophenylboronic acid chloro arylthienotriazolopyrimidine Suzuki coupling; thiophenyl arylthienotriazolopyrimidine preparation antibacterial antifungal activity SAR.

Several new thieno[2,3-d]pyrimidine derivatives 3-substituted phenyl-5-(thiophen-2-yl)thieno[3,2-e] [1,2,4]triazolo[4,3-c]pyrimidines I [R = Ph, 3-pyridyl, 1H-indol-2-yl, etc.] were synthesized starting from thieno[2,3-d]pyrimidine-2,4-diol. The characterization of the newly synthesized compounds I was established by IR, 1H NMR, 13C NMR and mass spectral anal. The final compounds I were screened for their antibacterial activity against Bacillus subtilis and Staphylococcus aureus from Gram pos. group of bacteria and Escherichia coli and Klebsiella pneumonia from Gram neg. group of bacteria and antifungal activity against Candida albicans and Aspergillus flavus. Antibacterial and antifungal activities were evaluated and compared with the standard drugs. From antibacterial and antifungal activity screening results, it was observed that compounds I [R = 3-pyridyl, 1H-indol-2-yl, 4-F3CC6H5] possessed good activity.

Organic Chemistry: Current Research published new progress about Antibacterial agents. 18740-39-1 belongs to class pyrimidines, and the molecular formula is C6H2Cl2N2S, Name: 2,4-Dichlorothieno[2,3-d]pyrimidine.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Chang, P.; Chiang, Kwei-Che published the artcile< 5-Hydroxypyrimidines. II. Synthesis of 2-substituted 4,5-dihydroxypyrimidines>, Recommanded Product: 5-Hydroxypyrimidin-4(3H)-one, the main research area is .

V reacts with HCO2Et gives PhCH2OCH(CHO)CO2Et (X), which condenses with various amidines [RC(:NH)NH2] to 2-R-substituted-5-benzyloxy-4-hydroxypyridines (XI, R), converted by H in the presence of Pd to XII(R). [N:CR.N:C(OH).C(OCH2Ph):CH (XI) and N:CR.N:C(OH).C(OH):CH (XII) are designated by the Roman numeral, followed by R.] XI and XII are stable, high-melting solids, the latter giving the same pos. color tests as III (except that the FeCl3-NH3 colors are different), and reducing 2,6-dichlorophenolindophenol rapidly. When a suspension of NaOMe (from 2.8 g. powd. Na and 10 ml. anhydrous MeOH in 100 ml. dry Et2O) is treated with a 20 g. V and 14 g. HCO2Et with stirring at room temperature during 2 hrs., and stirred 4 hrs. more, the mixture turns from light to orange yellow and a white amorphous solid seps.; after 2 days, 40 ml. H2O, then 12 ml. dilute HOAc are added, the Et2O layer is dried, distilled, and the fraction b1 110-33° or b4 140-53° redistilled, giving 79% X, b1 128-30°, b4 149°, n20D 1.5200, which turns blue-violet with FeCl3. No X is obtained with powd. Na used directly, and solutions of Na in MeOH or EtOH give only 15-20% X. Urea (1.2 g.) added to 0.92 g. Na in 30 ml. anhydrous EtOH, 4.5 g. X stirred in during 1 hr. at room temperature, the mixture heated 4 hrs. on steam, cooled, the solids dissolved by addition of H2O, and the mixture acidified with 6 ml. HOAc gives 70% XI(OH), m. 283° (20% aqueous HOAc)(decomposition). X and IX at room temperature give 78% XI(NH2), m. 243° (20% aqueous HOAc) (decomposition); X and MeC(:NH)NH2.HCl (at 60°) give 93% XI(Me), fine needles from H2O, m. 186°; and NH2CSNH2 [or NH2C(:NH)SEt.HBr, loss of Et occurring during the condensation] and X (at room temperature) give 92% XI(SH), long needles from EtOH, m. 225-6° (decomposition). XI(SEt), m. 189-90°, is obtained by adding 2 ml. EtBr to 0.5 g. XI(SH) in 15 ml. 10% NaOH, heating 3 hrs. on steam, cooling, acidifying with dilute HCl, and recrystallizing the precipitate from EtOH, yield 53.6%. Boiling XI(SH or SEt) in dilute NH4OH with Raney Ni yields XI(H) [83% from XI(SH)], needles, m. 98-9°. Hydrogenation of XI(OH) (0.5 g.) in 30 ml. 5% NaOH containing Pd at room temperature and atm. pressure required 30 min.; acidification of the filtered mixture precipitated XII(OH) (isobarbituric acid), m. 310° (decomposition) (from H2O), yield quant.; addition of XII(OH) to 5% AgNO3 results in immediate precipitation of black metallic Ag. Hydrogenation of XI(NH2) (in HCO2H) gives a quant. yield of XII(NH2) unmelted at 340°. Similarly, XI(Me) is converted to XII(Me), m. 312-13° (decomposition), and XI(H) is reduced to XII(H), m. 268-9° (decomposition). While XII(OH) (like III) gives a blue-violet color on treatment with 1% FeCl3 and a few drops of concentrated NH4OH, XII (R = NH2, H, and Me) give brown colors.

Scientia Sinica (English Edition) published new progress about Color reaction. 15837-41-9 belongs to class pyrimidines, and the molecular formula is C4H4N2O2, Recommanded Product: 5-Hydroxypyrimidin-4(3H)-one.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Gruessner, A.; Montavon, M.; Schnider, O. published the artcile< Disubstituted 4-sulfanilamidopyrimidines>, Formula: C5H4Cl2N2O, the main research area is .

A series of 5,6-dialkoxy-4-sulfanilamidopyrimidines was prepared and tested for chemotherapeutic activity. Thus, to a mixture of 1 mole ROCH2CO2Me, 1200 ml. benzene, and 1.5 moles oxalic acid dialkyl ester was added in small portions at 22° during 3 hrs. with cooling and stirring 60 g. NaOMe. The mixture was stirred overnight, worked up, the crude product heated with 3 g. glass powder and 5 mg. Fe powder at 210°/400 mm. for 3 hrs. followed by distillation at 11 mm. After distillation was complete the residue was heated with an addnl. 5 g. glass powder and 5 mg. iron powder for 3 hrs. at 210° and then distilled at 11 mm. The successive distillations gave ROCH(CO2Me)2 (I). I was converted to the diamide ROCH(CONH2)2 (II) by treatment with liquid NH3 for 14 hrs. at room temperature The table lists the methyl esters and amides prepared I, II; R, b11, % yield, M.p. (H2O), % yield; Me, 103-4°, 78, 217-18°, 97; Et, 114-16°, 80, 202°, 97; iso-Pr, 118-21°, 72, 218-19°, 94; Pr, 124-8°, 65, –, –; Bu, 128-30°, 63, 174-6°, 85; To a solution of 20.4 g. Na in 410 ml. absolute alc. was added 42 g. II (R = Me) followed by 20.4 ml. formamide. The solution was heated for 3 hrs. After cooling the Na salt of 4,6-dihydroxypyrimidine was filtered off, washed with absolute alc., and dried in vacuo at 50°. The crude Na salt (72.4 g.) was added slowly to 314 ml. POCl3 below 30°, followed by 31 ml. PhNMe2. The mixture was heated at 130° for 3 hrs. to give 4,6-dichloro-5-methoxypyrimidine (III), m. 57-8°. Similarly prepared were the following IV (R and b12 given): Et, 102-7°; iso-Pr, 108-13°; Bu, 128-33°. A mixture of 48 g. III and 170 ml. liquid NH3 under N at 20 atm. was shaken in an autoclave overnight to give 82% 4-amino-5-methoxy-6-chloropyrimidine (V), m. 176-8°. The 5-ethoxy, m. 119-20° (MeCN), 5-isopropoxy, m. 139-41° (MeCN), and 5-butoxy, m. 103-4°, analogs were prepared To a solution of 29.4 g. Na in 1 l. MeOH was added 170 g. V and the solution heated 18 hrs. to yield 94% 4-amino-5,6-dimethoxypyrimidine (VI), m. 88-9° (isopropyl ether). Similarly prepared were the following VIa (R, R1, and m.p. given): Me, Et, 64-58°; Me, iso-Pr, 111-12°; Me, Pr, 70-1°; Me, CH2CH:CH2, 41-2°; Me, C10H21, 53-4°; Et, Et, 83-4°; Bu, C10H21, 32-3°; Bu, CH2CH2OCH2Me, 98-9°. To a solution of 62 g. VI in 160 ml. absolute pyridine was added over 3 hrs. 130 g. 4-acetamidobenzenesulfonyl chloride at 3-4° and the solution kept overnight to yield 89.5% VII (R = Me, R1 = OMe, X = Ac), m. 230-1° (HOAc), hydrolysis of which with 2N NaOH gave VII (R = Me, R1 = OMe, X = H), m. 201-2°. The following VII (R = Me) were similarly prepared (R1, X, and m.p. given): EtO, Ac, 201-2°; EtO, H, 170-1°; PrO, Ac, 186-7°; PrO, H, 142-3°; iso-PrO, Ac, 195-7°; iso-PrO, H, 136-7°; MeO, HCO, 194-5°. Also prepared were the following VII (X = H) (R, R1, and m.p. given): Me, OC10H21, 94-6°; Me, OPr-iso, 136-7°; Et, Cl, 215-16°; Et, OMe, 228-9°; Et, OEt, 173-4°; Et, OCH2CH:CH2, 152°; Et, OPr, 162°; Et, OPr-iso, 181-3°; Me, OCH2CH:CH2, 145-6°; iso-Pr, OMe, 193-5°; iso-Pr, OEt, 183-4°; iso-Pr, OPr-iso, 170-1°; Bu, Cl, 172-4°; iso-Pr, OCH2CH:CH2, 146-8°; Bu, OMe, 192-3°; H, OC10H21, 142-4°; Cl, OPr-iso, 172-4°. To a solution of 155 g. Na sulfanilamide in 500 ml. Me2NCHO was added slowly 71.6 g. III at 100°. Work-up gave 82% 4-sulfanilamido-5-methoxy-6-chloropyrimidine (VIII), m. 200-2° (alc.-H2O). To a solution of 5.75 g. Na in 200 ml. allyl alc. was added 31.4 g. VIII to give 4-sulfanilamido-5-methoxy-6-allyloxypyrimidine, m. 145 (BuOAc). To 31 g. VI in 140 ml. absolute pyridine was added 88 g. p-nitrobenzenesulfonyl chloride to give 105 g. 4-[bis(4-nitrophenylsulfonyl)amino]-5,6-dimethoxypyrimidine (IX), m. 216-17° (glacial HOAC). Partial hydrolysis of IX with NaOH in absolute MeOH gave 4-(4-nitrobenzenesulfonamido)-5,6-dimethoxypyrimidine (X), m. 136-8° (MeCN). Treatment of X with Ac2O in absolute pyridine for 3 hrs. on a steam bath gave 4-(N-acetyl-4-nitrobenzenesulfonamido)-5,6-dimethoxypyrimidine (XI), m. 160-2° (MeCN). Reduction of 13 g. XI in 540 ml. HOAc in the presence of 13 g. 5% Pd-C at room temperature gave 8.5 g. 4-(N’-acetylsulfanilamido)-5,6-dimethoxypyrimidine, m. 196-8 (MeCN). The following XII were similarly prepared (R, R1, X, and m.p. given): OMe, C10H21, 4-O2NC6H4SO2, 112-13°; OMe, C10H21, H, 114-15°; OBu, OCH2CH2OEt, 4-O2NC6H4SO2, 124-5°; OBu, OCH2CH2OEt, H, 96-8°.

Monatshefte fuer Chemie published new progress about 5018-38-2. 5018-38-2 belongs to class pyrimidines, and the molecular formula is C5H4Cl2N2O, Formula: C5H4Cl2N2O.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Picazo, Edwige M. H.; Heptinstall, Amy B.; Wilson, David M.; Cano, Celine; Golding, Bernard T.; Waring, Michael J. published the artcile< Cyclizations and fragmentations in the alkylation of 6-chloro-5-hydroxy-4-aminopyrimidines with aminoalkyl chlorides>, Electric Literature of 5018-38-2, the main research area is polysubstituted aminopyrimidine preparation; chlorohydroxyaminopyrimidine aminoalkyl chloride alkylation.

Substituted aminopyrimidines are an important class of compounds, in part because they frequently show biol. activity. Facile synthesis of polysubstituted aminopyrimidines is highly desirable for the synthesis of screening libraries. Authors describe a route to 4,6-diamino-5-alkoxypyrimidines via a SNAr-alkylation-SNAr sequence from readily available 4,6-dichloro-5-methoxypyrimidine, which allows the synthesis of such compounds with regiochem. control. The extension of this approach to alkylating agents bearing amino substituents led to unexpected and, in some cases, unprecedented products resulting from intramol. SNAr cyclization and subsequent fragmentation.

Journal of Heterocyclic Chemistry published new progress about Alkylation. 5018-38-2 belongs to class pyrimidines, and the molecular formula is C5H4Cl2N2O, Electric Literature of 5018-38-2.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Feng, Da; Wei, Fenju; Sun, Yanying; Sharma, Prem Prakash; Zhang, Tao; Lin, Hao; Rathi, Brijesh; De Clercq, Erik; Pannecouque, Christophe; Kang, Dongwei; Zhan, Peng; Liu, Xinyong published the artcile< Boronic acid-containing diarylpyrimidine derivatives as novel HIV-1 NNRTIs: Design, synthesis and biological evaluation>, HPLC of Formula: 18740-39-1, the main research area is boronic acid diarylpyrimidine preparation human immunodeficiency virus 1 inhibitor; acid boronic diarylpyrimidine preparation HIV1 nonnucleoside reverse transcriptase inhibitor; mol dynamics simulation boronic acid diarylpyrimidine HIV 1 inhibitor.

Drug resistance remains to be a serious problem with type I human immunodeficiency virus (HIV-1) non-nucleoside reverse transcriptase inhibitors (NNRTIs). A series of novel boronic acid-containing diarylpyrimidine (DAPY) derivatives were designed via bioisosterism and scaffold-hopping strategies, taking advantage of the ability of a boronic acid group to form multiple hydrogen bonds. The target compounds were synthesized and evaluated for their anti-HIV activities and cytotoxicity in MT-4 cells. Compound 10j yielded the most potent activity and turned out to be a single-digit nanomolar inhibitor towards the HIV-1 IIIB [wild-type (WT) strain], L100I and K103N strains, with 50% effective concentration (EC50) values of 7.19-9.85 nmol/L. Moreover, 10j inhibited the double-mutant strain RES056 with an EC50 value of 77.9 nmol/L, which was 3.3-more potent than that of EFV (EC50 = 260 nmol/L) and comparable to that of ETR (EC50 = 32.2 nmol/L). 10J acted like classical NNRTIs with high affinity for WT HIV-1 reverse transcriptase (RT) with 50% inhibition concentration (IC50) value of 0.1837μmol/L. Furthermore, mol. dynamics simulation indicated that 10j was proposed as a promising mol. for fighting against HIV-1 infection through inhibiting RT activity. Overall, the results demonstrated that 10j could serve as a lead mol. for further modification to address virus-drug resistance.

Chinese Chemical Letters published new progress about Anti-HIV agents. 18740-39-1 belongs to class pyrimidines, and the molecular formula is C6H2Cl2N2S, HPLC of Formula: 18740-39-1.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Chang, P.; Wu, Shao-Lan published the artcile< 5-Hydroxypyrimidines. I. Synthesis of 2-substituted 4,5,6-trihydroxypyrimidines>, Application In Synthesis of 15837-41-9, the main research area is .

Et benzyloxymalonate (I) condenses with various amidine derivatives to 2-substituted 5-benzyloxy-4,6-dihydroxypyrimidines (II, R, PhCH2O), converted to the corresponding 4,5,6-(HO)3 analogs (III, R, HO) by Pd-catalyzed hydrogenation; Raney Ni converts II (SH, PhCH2O) to II (H, PhCH2O) the PhCH2 group being unaffected. [In this abstract N:CR.N:C(OH).CR’:COH (II) and N:CR.N:C(OH).C(OH):COH (III) are designated by the Roman numeral, followed by R and R’, and by R, resp.] All III give pos. color reactions with FeCl3-NH4OH (blue-violet), Ba(OH)2 (violet-blue), and phosphomolybdic acid (deep blue), and decolorize (reduce) 2,6-dichlorophenolindophenol at various rates. PhCH2OCH2CO2H (IV) [20 g., b0.4 142-4°, prepared in 84% yield according to Fischer and Gohlke (C.A. 28, 1337) except that the mixture is acidified immediately with cooling instead of after removing the large excess of PhCH2OH], refluxed 2 hrs. with 25 ml. EtOH, 30 ml. C6H6, and 2 ml. concentrated H2SO4, the volatiles distilled, the residue neutralized with aqueous Na2CO3, extracted with Et2O, and the extract dried and distilled gives 74% PhCH2OCH2CO2Et (V), b8 135-7°, also prepared via PhCH2OCH2CN (VI); 50 ml. each of MeOH and 40% aqueous HCHO ice-cooled, stirred with 32.5 g. KCN until homogeneous, 57 g. PhCH2Cl in 100 ml. MeOH slowly stirred in at room temperature, the mixture heated 4 hrs. at 40°, cooled, poured into 100 ml. H2O, and the organic layer worked up give some PhCH2Cl, a small unidentified fraction, b. 110-25°, n25D 1.5073, d2020 1.081, and crude VI, b. 130-45°, redistilled to give 58-60% purified VI, b14 136-7°, which becomes progressively yellower on exposure to air, analyzes 1% low for N, and always leaves on redistillation a black residue shown to contain PhCH2OCONH2 [also prepared (m. 90.5-1.0°) by mixing 1 g. V with 5 ml. concentrated NH4OH and recrystallizing the product from hot H2O], and IV, b6 180°. Redistilled VI (74 g.) treated at 0° with 55 g. 95% EtOH previously saturated with HCl (33 g.), refluxed 4 hrs., yields 70% V, b5 125-6°, b10 138°, b12 145-6°; if the crude VI is only freed of more volatile materials and alcoholized undistd., 48% V (based on unrecovered PhCH2Cl) is obtained. No IV was obtained by dissolving 9.2 g. Na in 100 ml. hot PhCH2OH, adding 46.6 g. ClCH2CO2Na, and heating 5 hrs. at 160°, nor was VI identified among the products of reaction of 18 g. CuCN in 40 ml. anhydrous Et2O with 35 g. PhCH2OCH2Cl at 30°. Na (6.9 g.) in 90 ml. anhydrous EtOH treated with 68.7 g. (CO2Et)2 at room temperature, stirred 10 min., 58.2 g. V added dropwise, the mixture heated 4-5 hrs. at 50-60°, kept overnight at room temperature, acidified with glacial HOAc, poured into H2O, extracted with Et2O, the extracts dried, freed of Et2O, the residual liquid heated at 180-200°/15-20 mm. until evolution of CO ceases (2-3 hrs.), and the residue distilled gives 49% I, b0.4 127-9°, n20D 1.4900. I with concentrated NH4OH gives PhCH2OCH(CONH2)2, needles from H2O, m. 222°. Na (1.4 g.) in 30 ml. anhydrous EtOH treated with 16 g. I, then 8 g. EtBr, refluxed until neutral to litmus, cooled, poured into H2O, extracted with Et2O, and the extract dried and distilled gives 56% PhCH2OCEt(CO2Et)2 (VII), b0.4 133-4°, n20D 1.4862. Urea (3 g.) dissolved in a solution of 1.5 g. Na in 40 ml. anhydrous EtOH, 9 g. I added, the mixture refluxed 6 hrs. at 105-7°, cooled, the Na salt dissolved in a small amount of H2O, and the solution acidified with concentrated HCl precipitates 67% II (OH, PhCH2O), needles from H2O or 50% aqueous EtOH, decompose 202-3° after turning red at 180°. II (OH, PhCH2O) also gradually reddens on standing exposed to air, recrystallization of the red material from H2O yielding a colorless, air-stable, more H2O-soluble product (VIII), decompose 202-55°, believed to be II(OH, HO). VII condenses with NH2CONH2 in the presence of NaOEt to give 20% II(OH, Et), needles from EtOH, m 186-7°, stable in air. Similarly, 6.6 g. I, 3 g. NH2C(:NH)NH2.HNO3 (IX), and 1.2 g. Na in 30 ml. EtOH react (6 hrs.) to give 83% II(NH2, PhCH2O), needles from EtOH, m. 220-1° (decomposition); which also reddens in air, but is stabilized by recrystallization VII condenses with IX to 68% II(NH2, Et), recrystallized from EtOH, stable, m. 308-9° (decomposition). I condenses similarly with CH3C(:NH)NH2.HCl to give 54% II(Me, PhCH2O), needles from H2O, m. 263-4° (decomposition); with NH2CSNH2 to give 78% II(SH, PhCH2O), needles from EtOH, m. 140-1° (decomposition), reddens in air; and with NH2C(:NH)SEt.HBr to give 51% II(SEt, PhCH2O), needles from EtOH, m. 164-5° (decomposition), turning red-violet in air. II(SH, PhCH2O) (1 g.) in hot dilute NH4OH (2 ml. concentrated NH4OH cut with 16 ml. H2O) is heated 2 hrs. on steam with 3 g. Raney Ni, the mixture filtered hot, concentrated until crystals appear, and cooled gives 86% II(H, PhCH2O), m. 223-4° (decomposes) (from H2O). II(OH, PhCH2O) (1 g.) in 60 ml. HCO2H shaken with 0.1 g. PdO and H at room temperature and atm. pressure until 1 mol. equivalent H is taken up (20 min.) and the filtered mixture concentrated gives 98% dialuric acid (III, HO), m. 213-14° (decomposition) after reddening from 180°, readily air-oxidized. Similarly, II (NH2, PhCH2O) gives a quant. yield of III(NH2), which turns brown at 293-4° but remains solid up to 320°; this substance also turns red in air. Hydrogenation of II(Me, PhCH2O) in glacial HOAc gives 100% III(Me), stable in air, blackens at 290-1°, but is not molten at 320°. Similarly, II(H, PhCH2O) is reduced to III(H), air-stable, blackens at 284-5°, but does not m. at 320°.

Scientia Sinica (English Edition) published new progress about Color reaction. 15837-41-9 belongs to class pyrimidines, and the molecular formula is C4H4N2O2, Application In Synthesis of 15837-41-9.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

von Angerer, S. published the artcile< Product class 12: pyrimidines>, Synthetic Route of 99469-85-9, the main research area is review pyrimidine preparation cyclization ring transformation aromatization.

A review. Methods for preparing pyrimidines are reviewed including cyclization, ring transformation, aromatization and substituent modification.

Science of Synthesis published new progress about Aromatization. 99469-85-9 belongs to class pyrimidines, and the molecular formula is C5H4Cl2N2S, Synthetic Route of 99469-85-9.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Yu, Lide; Wang, Qinqin; Wang, Caolin; Zhang, Binliang; Yang, Zunhua; Fang, Yuanying; Zhu, Wufu; Zheng, Pengwu published the artcile< Design, Synthesis and biological evaluation of novel thienopyrimidine derivatives as PI3Kα inhibitors>, Electric Literature of 18740-39-1, the main research area is morpholinyl diphenyldihydropyrazolyl thienopyrimidine preparation; diphenyldihydropyrazolyl morpholinyl tetrahydrobenzothienopyrimidine preparation; antitumor activity mTOR PI3Ka kinase inhibition SAR mol docking; PI3Kα inhibitor; Pyrazole; Thienopyrimidine.

Three series of novel thienopyrimidine derivatives I [R1 = H, 4-F, 4-Br, 3,4-di-Cl; R2 = H, 4-Me, 4-Br, etc.], II and III [R3 = H, 4-F, 4-Br, 3,4-di-Cl; R4 = H, 4-Me, 4-Br, etc.] were synthesized and their IC50 values against four cancer cell lines HepG-2, A549, PC-3 and MCF-7 were evaluated. Most compounds showed moderate cytotoxicity against the tested cancer cell lines. The most promising compound I [R1 = R2 = H (IV)] showed moderate activity with IC50 values of 12.32 ± 0.96, 11.30 ± 1.19, 14.69 ± 1.32 and 9.80 ± 0.93μM, resp. The inhibitory activities of compounds IV and II [R1 = R2 = H (V)] against PI3Kα and mTOR kinase were further evaluated. Compound IV exhibited PI3Kα kinase inhibitory activity with IC50 of 9.47 ± 0.63μM. In addition, docking studies of compounds IV and V were also investigated.

Molecules published new progress about Acetophenones Role: RCT (Reactant), RACT (Reactant or Reagent). 18740-39-1 belongs to class pyrimidines, and the molecular formula is C6H2Cl2N2S, Electric Literature of 18740-39-1.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia