Category: pyrimidines

Synthetic Route of C8H10N2O2On October 31, 1994 ,《The crafting of uracils with enhanced stacking potential》 appeared in Proceedings – Indian Academy of Sciences, Chemical Sciences. The author of the article were Ranganathan, Subramania; Kundu, Dinabandhu; Mehrotra, Sanjiv. The article conveys some information:

Uracils having enhanced stacking profile are of interest from diverse vantages ranging from the chem. simulation of transcription to the design of novel antiviral agents. This objective has been realized by synthetic strategies leading to uracils having, inter alia, pseudo aromatic and hydrophobic rings crafted to the 5-6 location and ionophore and hydrophobic chains affixed at the C-5 and nitrogen atoms. Endeavors to prepare a 5-2′ uracil-pyrimidine composite have led to novel uracil arising from 2-O → =CH(COOR)2 transformation and a tethered malonic acid pyrimidine complex. The results came from multiple reactions, including the reaction of Ethyl 2-(pyrimidin-2-yl)acetate(cas: 63155-11-3Synthetic Route of C8H10N2O2)

Ethyl 2-(pyrimidin-2-yl)acetate(cas: 63155-11-3) is a member of pyrimidine. Pyrimidine derivatives are an important class of N-heterocycles. They are well-known for their wide spectrum of promising biological activities such as antitumors, bactericidals, and fungicidal.Synthetic Route of C8H10N2O2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of C23H22N4OOn June 1, 2001, Banic Tomisic, Zrinka; Cempuh, Andreja; Malnar, Ivica published an article in Acta Crystallographica, Section E: Structure Reports Online. The article was 《7-Cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidine-4-ylamine, a lck tyrosine kinase inhibitor》. The article mentions the following:

The mol. and crystal structures of the potent and selective lck tyrosine kinase inhibitor, C23H22N4O, were determined by single-crystal x-ray diffraction. The pyrrolopyrimidine and Ph rings are planar while the cyclopentyl ring adopts a conformation between envelope and half-chair. The overall conformation is defined by the spatial arrangement of the ring moieties. Crystallog. data are given. In the part of experimental materials, we found many familiar compounds, such as 7-Cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine(cas: 213743-31-8Electric Literature of C23H22N4O)

7-Cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine(cas: 213743-31-8) belongs to pyrimidine. Pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Electric Literature of C23H22N4O

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In 2017,Davodian, Tayebeh; Ranjbar-Karimi, Reza; Mehrabi, Hossein published 《Synthesis of diheteroaryl sulfides via chemoselective reaction of 4,6-diaminopyrimidine-2(1H)-thione with haloheteroaryl compounds》.Chemistry of Heterocyclic Compounds (New York, NY, United States) published the findings.Recommanded Product: 3764-01-0 The information in the text is summarized as follows:

A series of substituted diheteroaryl sulfides was synthesized by the reaction of 4,6-diaminopyrimidine-2(1H)-thione with fluoro- and chloroheteroarom. compounds in the presence of Na2CO3 in acetonitrile under reflux conditions. The study indicated that 4,6-diaminopyrimidine-2(1H)-thione reacts with fluoro- and chloroheteroarom. compounds chemoselectively as S- rather than N-nucleophile. The structures of the synthesized compounds were confirmed by IR, 1H, 19F, and 13C NMR spectroscopy, as well as elemental anal. and X-ray structural anal. The experimental process involved the reaction of 2,4,6-Trichloropyrimidine(cas: 3764-01-0Recommanded Product: 3764-01-0)

2,4,6-Trichloropyrimidine(cas: 3764-01-0) is a member of organic chlorides. Organic chloride content in crude oil can be detected through specialized laboratory analysis. Care and attention are essential while sampling and testing.Recommanded Product: 3764-01-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In 2015,Esmaeilpour, Mohsen; Javidi, Jaber published 《Magnetically-recoverable Schiff Base Complex of Pd (II) Immobilized on Fe3O4@SiO2 Nanoparticles: An Efficient Catalyst for Mizoroki-Heck and Suzuki-Miyaura Coupling Reactions》.Journal of the Chinese Chemical Society (Weinheim, Germany) published the findings.Name: 2,4,6-Trichloropyrimidine The information in the text is summarized as follows:

The activity of Pd(II)-Schiff base complex mols. grafted on the surface of Fe3O4@SiO2 particles were investigated in the palladium-catalyzed coupling reactions of aryl halides with alkenes (Mizoroki-Heck reaction) and phenylboronic acids (Suzuki-Miyaura reaction) in the absence of phosphorous ligands. This method shows notable advantages such as heterogeneous nature of the catalyst, excellent yields, short reaction times, easy preparation, simplicity of operation, and cleaner reaction profiles. The catalyst can be separated from the reaction mixture by applying a permanent magnet externally and can be reused for several times without significant loss of activity. The amount of palladium leaching has been determined by ICP anal. The results came from multiple reactions, including the reaction of 2,4,6-Trichloropyrimidine(cas: 3764-01-0Name: 2,4,6-Trichloropyrimidine)

2,4,6-Trichloropyrimidine(cas: 3764-01-0) is a member of organic chlorides. Organic chloride content in crude oil can be detected through specialized laboratory analysis. Care and attention are essential while sampling and testing.Name: 2,4,6-Trichloropyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In 2015,Varalakshmi, Mavallur; Srinivasulu, Doddaga; Kotakadi, Venkata S. published 《Nano-BF3.SiO2 Catalyst-Promoted Michaelis-Arbuzov Reaction: Solvent-Free Synthesis and Antimicrobial Evaluation》.Phosphorus, Sulfur and Silicon and the Related Elements published the findings.HPLC of Formula: 3764-01-0 The information in the text is summarized as follows:

A simple, convenient synthetic route for the synthesis of novel dialkyl heteroaryl phosphonates by a reusable and green nano-BF3. SiO2 solid catalyst under solvent-free conditions through Michaelis-Arbuzov reaction with high yields is presented. All the newly synthesized compounds were characterized by spectral data and screened for their antimicrobial activity. Some of the compounds exhibited potent antibacterial activity against all the tested pathogens, and warrant further investigation. After reading the article, we found that the author used 2,4,6-Trichloropyrimidine(cas: 3764-01-0HPLC of Formula: 3764-01-0)

2,4,6-Trichloropyrimidine(cas: 3764-01-0) is a member of organic chlorides. Organic chloride content in crude oil can be detected through specialized laboratory analysis. Care and attention are essential while sampling and testing.HPLC of Formula: 3764-01-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The author of 《Repurposing strategies on pyridazinone-based series by pharmacophore- and structure-driven screening》 were Floresta, Giuseppe; Crocetti, Letizia; Giovannoni, Maria Paola; Biagini, Pierfrancesco; Cilibrizzi, Agostino. And the article was published in Journal of Enzyme Inhibition and Medicinal Chemistry in 2020. COA of Formula: C11H8N2O The author mentioned the following in the article:

We report here in silico repurposing studies on 52 new pyridazinone-based small-mols. through inverse virtual screening (iVS) methodologies. These analogs were originally designed as formyl peptide receptor (FPR) ligands. As it is sometimes the case in drug discovery programs, subsequent biol. screening demonstrated the inefficacy of the mols. in binding FPRs, failing in the identification of new hits. Through a focussed drug-repurposing approach we have defined a variety of potential targets that are suitable to interact with this library of pyridazinone-based analogs. A two-step approach has been conducted for computational anal. Specifically, the mols. were initially processed through a pharmacophore-based screening. Secondly, the resulting features of binding were investigated by docking studies and following mol. dynamic simulations, in order to univocally confirm “”pyridazinone-based ligand-target protein”” interactions. Our findings propose aspartate aminotransferase as the most favorable repurposed target for this small-mol. series, worth of addnl. medicinal chem. investigations in the field. The results came from multiple reactions, including the reaction of 3-(Pyrimidin-5-yl)benzaldehyde(cas: 640769-70-6COA of Formula: C11H8N2O)

3-(Pyrimidin-5-yl)benzaldehyde(cas: 640769-70-6) belongs to pyrimidine. Pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics. COA of Formula: C11H8N2O

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In 1970,Journal of the Chemical Society [Section] C: Organic included an article by Brown, Desmond J.; Sugimoto, T.. Application of 30561-07-0. The article was titled 《Aza analogs of pteridine. II. Novel use of silver oxide in transetherification of alkoxy-1,2,4,6,8-pentaazanaphthalenes, alkoxynitropyrimidines, and related systems》. The information in the text is summarized as follows:

Alkoxy derivatives of 1,2,4,6,8-pentaazanaphthalene (pyrimido[5,4-e]-as-triazine) (I) undergo transetherification when treated with boiling alcs. in the presence of silver oxide. Appropriate methoxy compounds give 5-ethoxy-3-methyl-, 5-propoxy-3-methyl-, and (more slowly) 5-isopropoxy-3-methyl-pentaazanaphthalene; also 5,7-diethoxy-, 5,7-dipropoxy-, 5,7-diisopropoxy-, 5,7-diethoxy-3-methyl-, and 5-ethoxy-3,7-di-methylpentaazanaphthalene. Synthetic routes to the methoxy substrates and to one of the products are reported; other structures are confirmed by uv and 1H NMR spectra. 4-Methoxypteridine undergoes transetherification similarly but simple alkoxypyrimidines and alkoxypyridines are resistant. However, the more highly activated 2-methoxy-5-nitro-, 4-methoxy-5-nitro-, and 2,4-dimethoxy-5-nitropyrimidine easily give their resp. propoxy homologs, and so does 2-methoxy-3,5-dinitropyridine. In contrast, 2,4-dimethoxy-6-methyl-5-nitropyrimidine gives only its 4-methoxy-2-propoxy homolog, and both 4,6-dimethoxy-5-nitro- and 4-methoxy-2,6-dimethyl-5-nitropyrimidine remain unchanged. The classical transetherification agent, ethanolic EtONa, reacts with 5,7-dimethoxypentaazanaphthalene to give the 7-ethoxy-5-hydroxy analog. This was identified by spectral comparison with its 5-hydroxy-7-methoxy homolog, itself synthesized by 5,6-addition of methanethiol to 7-methoxy-pentaazanaphthalene followed by dehydrogenation and selective hydrolysis. In the part of experimental materials, we found many familiar compounds, such as 2,4-Dimethoxy-5-nitropyrimidine(cas: 30561-07-0Application of 30561-07-0)

2,4-Dimethoxy-5-nitropyrimidine(cas: 30561-07-0) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Application of 30561-07-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The author of 《Pyrimidines. II. Nucleophilic substitution reactions of ethyl 4-chloro-2-methylthiopyrimidine-5-carboxylate》 were Shadbolt, Roy S.; Ulbricht, Tilo L. V.. And the article was published in Journal of the Chemical Society [Section] C: Organic in 1967. Application In Synthesis of Ethyl 2,4-diaminopyrimidine-5-carboxylate The author mentioned the following in the article:

cf. CA 56: 470b. Treatment of ethyl 4-chloro-2-(methylthio)pyrimidine-5-carboxylate (I) with dimethylamine, PhONa, PhSNa, KF, or the triethylamine salt of N-hydroxyphthalimide yielded normal substitution products. However, when the chloropyrimidine was treated with NaCN in Me2SO, or LiCN in dimethylformamide, in attempts to prepare the 4-cyano derivative, ethyl 2,4-bis(methylthio)pyridmidine-5-carboxylate was obtained. Investigation of this reaction, and of the other products, suggested that the methylthio group in ethyl-4-chloro-2-(methylthio)pyrimidine-5-carboxylate is displaced by cyanide ion. 4-Chloro-2-(methylthio)pyrimidine reacts similarly to give 2,4-bis(methylthio)pyrimidine, indicating that this reaction may be a general one. The lability of the methylthio group in ethyl 4-chloro-2-(methylthio)pyrimidine-5-carboxylate is also shown by the reaction with an excess of MeONa to give methyl 2,4-dimethoxy-pyrimidine-5-carboxylate. A number of other nucleophilic substitution products derived from ethyl 4-chloro-2-(methylthio)pyrimidine-5-carboxylate are described. 33 references. The experimental part of the paper was very detailed, including the reaction process of Ethyl 2,4-diaminopyrimidine-5-carboxylate(cas: 15400-54-1Application In Synthesis of Ethyl 2,4-diaminopyrimidine-5-carboxylate)

Ethyl 2,4-diaminopyrimidine-5-carboxylate(cas: 15400-54-1) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Application In Synthesis of Ethyl 2,4-diaminopyrimidine-5-carboxylate

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia