Category: pyrimidines

《Synthesis and biological evaluation of aurora kinases inhibitors based on N-trisubstituted pyrimidine scaffold》 was written by Long, Liang; Luo, Yu; Hou, Zhi-Jie; Ma, Hua-Juan; Long, Zi-Jie; Tu, Zheng-Chao; Huang, Lin-Jie; Liu, Quentin; Lu, Gui. Formula: C4HCl3N2This research focused ontrisubstituted pyrimidine preparation aurora kinase inhibitor antitumor human SAR; Anticancer drug; Aurora kinase inhibitor; Leukemia; N-trisubstituted pyrimidines; Synthesis. The article conveys some information:

The inhibition of the members of aurora kinase family using ATP-competitive small mols. was an effective method for anticancer therapeutics. Based on this concept, synthesis of new N-trisubstituted pyrimidine derivatives I [Ar = 4-FC6H4, 3-F-4-CO2MeC6H3, 3,4,5-MeO3C6H2, etc.] and evaluation of their biol. activities and stabilities were done. Among them, compound I [Ar = 3-Cl-4-FC6H3] showed the best inhibition against aurora A kinase (IC50 = 7.1 nM), human leukemia cell line U937 (IC50 = 12.2 nM) and the growth of U937 xenograft tumors in vivo. By flow cytometry and immunofluorescence anal. of U937, it was found that compound I [Ar = 3-Cl-4-FC6H3] could induced polyploidy formation including (4N, 8N and 16N) and induced defects in both chromosome alignment and spindle formation. Furthermore, compound I [Ar = 3-Cl-4-FC6H3] exhibited good chem., phys., and thermal stabilities. All these results suggested that compound I [Ar = 3-Cl-4-FC6H3] was a promising lead compound for further development of anticancer drugs.2,4,6-Trichloropyrimidine(cas: 3764-01-0Formula: C4HCl3N2) was used in this study.

2,4,6-Trichloropyrimidine(cas: 3764-01-0) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Formula: C4HCl3N2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

《Improvement of aqueous solubility of lapatinib-derived analogues: identification of a quinolinimine lead for human African trypanosomiasis drug development》 was written by Bachovchin, Kelly A.; Sharma, Amrita; Bag, Seema; Klug, Dana M.; Schneider, Katherine M.; Singh, Baljinder; Jalani, Hitesh B.; Buskes, Melissa J.; Mehta, Naimee; Tanghe, Scott; Momper, Jeremiah D.; Sciotti, Richard J.; Rodriguez, Ana; Mensa-Wilmot, Kojo; Pollastri, Michael P.; Ferrins, Lori. Quality Control of 2,4-DichloropyrimidineThis research focused ontrypanosomiasis parasiticide quinolinimine lapatinib pharmacokinetics Trypanosoma brucei. The article conveys some information:

Lapatinib, an approved epidermal growth factor receptor inhibitor, was explored as a starting point for the synthesis of new hits against Trypanosoma brucei, the causative agent of human African trypanosomiasis (HAT). Previous work culminated in I, which was part of a series typically associated with poor aqueous solubility In this report, we present various medicinal chem. strategies that were used to increase the aqueous solubility and improve the physicochem. profile without sacrificing antitrypanosomal potency. To rank trypanocidal hits, a new assay (summarized in a cytocidal effective concentration (CEC50)) was established, as part of the lead selection process. Increasing the sp3 carbon content of I resulted in II (0.19 μM EC50 against T. brucei and 990 μM aqueous solubility). Further chem. exploration of II yielded III, a trypanocidal quinolinimine (EC50: 0.013 μM; aqueous solubility: 880 μM; and CEC50: 0.18 μM). Compound III reduced parasitemia 109 fold in trypanosome-infected mice; it is an advanced lead for HAT drug development. The experimental part of the paper was very detailed, including the reaction process of 2,4-Dichloropyrimidine(cas: 3934-20-1Quality Control of 2,4-Dichloropyrimidine)

2,4-Dichloropyrimidine(cas: 3934-20-1) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Quality Control of 2,4-Dichloropyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

《Discovery of uracil-bearing DAPYs derivatives as novel HIV-1 NNRTIs via crystallographic overlay-based molecular hybridization》 was written by Zhang, Heng; Tian, Ye; Kang, Dongwei; Huo, Zhipeng; Zhou, Zhongxia; Liu, Huiqing; De Clercq, Erik; Pannecouque, Christophe; Zhan, Peng; Liu, Xinyong. Category: pyrimidinesThis research focused onuracil containing diarylpyrimidine preparation anti HIV QSAR; DAPYs; Drug design; Molecular hybridization; NNRTIs; Physicochemical properties; Uracil. The article conveys some information:

A novel series of uracil-bearing DAPYs derivatives were designed and synthesized via structure-based mol. hybridization to discover compounds with improved anti-resistance profiles. Anti-HIV activity of the designed compounds was tested in MT-4 cell cultures. The most promising compound I showed excellent activity with EC50 value of 5.6 nM against wide-type HIV-1 and low cytotoxicity (SI > 50000). Activity against the clinic prevalent mutant strains was also tested, suggesting that I was sensitive to E138K (EC50 = 34.2 nM). Primary drug-like properties, such as water solubility and logP, were evaluated by experiment or calculation, which indicated that introducing an uracil can improve solubility The mol. modeling accompanied with the preliminary SAR correlations paved the way for the next round of rational design of potent anti-HIV agents. The experimental part of the paper was very detailed, including the reaction process of 2,4,6-Trichloropyrimidine(cas: 3764-01-0Category: pyrimidines)

2,4,6-Trichloropyrimidine(cas: 3764-01-0) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Category: pyrimidines

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

《Coordination Polymers from Functionalized Bipyrimidine Ligands and Silver(I) Salts》 was written by Beaulieu-Houle, Guillaume; White, Nicholas G.; MacLachlan, Mark J.. Formula: C9H6N4O2 And the article was included in Crystal Growth & Design on April 4 ,2018. The article conveys some information:

Readily functionalizable bipyrimidine compounds were prepared for the first time, and their coordination chem. with silver salts was explored. Solution 1H NMR spectroscopy experiments indicated that the ligands rapidly form complexes with silver(I) salts, and coordination at a first site inhibits coordination of a second cation to the ligand, thus favoring 1:1 complexes in solution These 1:1 units self-assemble into one-dimensional chains in the solid state, even in the presence of excess Ag(I). Structurally diverse coordination polymers exhibiting different coordination numbers and geometry were characterized by single crystal X-ray crystallog. Our results demonstrate that a modification to the ligand, distal from the binding site, affects the coordination chem. and supramol. structure of these complexes. The results came from multiple reactions, including the reaction of 2-(Pyrimidin-2-yl)pyrimidine-5-carboxylic acid(cas: 933191-25-4Formula: C9H6N4O2)

2-(Pyrimidin-2-yl)pyrimidine-5-carboxylic acid(cas: 933191-25-4) belongs to pyrimidine. Pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics. Formula: C9H6N4O2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Product Details of 90213-66-4In 2021 ,《Synthesis and evaluation of FAK inhibitors with a 5-fluoro-7H-pyrrolo[2,3-d]pyrimidine scaffold as anti-hepatocellular carcinoma agents》 appeared in European Journal of Medicinal Chemistry. The author of the article were Tan, Hanyi; Liu, Yue; Gong, Chaochao; Zhang, Jiawei; Huang, Jian; Zhang, Qian. The article conveys some information:

Focal adhesion kinase (FAK) is a ubiquitous intracellular non-receptor tyrosine kinase, which is involved in multiple cellular functions, including cell adhesion, migration, invasion, survival, and angiogenesis. In this study, a series of 7H-pyrrolo[2,3-d]pyrimidines were designed and synthesized according to the E-pharmacophores generated by docking a library of 667 fragments into the ATP pocket of the co-crystal complex of FAK and PF-562271 (PDB ID: 3BZ3). The 5-fluoro-7H-pyrrolo[2,3-d]pyrimidine derivatives demonstrated excellent activity against FAK and the cell lines SMMC7721 and YY8103. 2-((2-((3-(Acetamidomethyl)phenyl)amino)-5-fluoro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-methylbenzamide (I) was selected for further bioactivity evaluations in vivo, including preliminary pharmacokinetic profiling in rats and toxicity assays in mice, and tumor growth inhibition studies in a xenograft tumor model. The results showed that I did not affect the body weight gain of the animals up to a dose of 200 mg/kg, and significantly inhibited tumor growth with a tumor growth inhibition rate of 78.6% compared with the neg. control group. Furthermore, phosphoantibody array analyses of a sample of the tumor suggested that I inhibited the malignant proliferation of hepatocellular carcinoma (HCC) cells through decreasing the phosphorylation in the FAK cascade. In the experimental materials used by the author, we found 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine(cas: 90213-66-4Product Details of 90213-66-4)

2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine(cas: 90213-66-4) belongs to pyrimidine. Pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics. Product Details of 90213-66-4

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Quality Control of 2,4-DichloropyrimidineIn 2021 ,《Optimization of WZ4003 as NUAK inhibitors against human colorectal cancer》 appeared in European Journal of Medicinal Chemistry. The author of the article were Yang, Huali; Wang, Xiaobing; Wang, Cheng; Yin, Fucheng; Qu, Lailiang; Shi, Cunjian; Zhao, Jinhua; Li, Shang; Ji, Limei; Peng, Wan; Luo, Heng; Cheng, Maosheng; Kong, Lingyi. The article conveys some information:

NUAK, the member of AMPK (AMP-activated protein kinase) family of protein kinases, is phosphorylated and activated by the LKB1 (liver kinase B1) tumor suppressor protein kinase. Recent work has indicated that NUAK1 is a key component of the antioxidant stress response pathway, and the inhibition of NUAK1 will suppress the growth and survival of colorectal tumors. As a promising target for anticancer drugs, few inhibitors of NUAK were developed. With this goal in mind, based on NUAK inhibitor WZ4003, a series of derivatives has been synthesized and evaluated for anticancer activity. Compound I, a derivative of WZ4003 by removing a methoxy group, was found to be the most potential one with stronger inhibitory against NUAK1/2 enzyme activity, tumor cell proliferation and inducing apoptosis of tumor cells. By in vivo efficacy evaluations of colorectal SW480 xenografts, I suppresses tumor growth more effectively with an excellent safety profile in vivo and is therefore seen as a suitable candidate for further investigation. The results came from multiple reactions, including the reaction of 2,4-Dichloropyrimidine(cas: 3934-20-1Quality Control of 2,4-Dichloropyrimidine)

2,4-Dichloropyrimidine(cas: 3934-20-1) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Quality Control of 2,4-Dichloropyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Patterson, Jaclyn R.; Graves, Alan P.; Stoy, Patrick; Cheung, Mui; Desai, Tina A.; Fries, Harvey; Gatto, Gregory J. Jr.; Holt, Dennis A.; Shewchuk, Lisa; Totoritis, Rachel; Wang, Liping; Kallander, Lara S. published their research in Journal of Medicinal Chemistry in 2021. The article was titled 《Identification of Diarylurea Inhibitors of the Cardiac-Specific Kinase TNNI3K by Designing Selectivity Against VEGFR2, p38α, and B-Raf》.Product Details of 3934-20-1 The article contains the following contents:

A series of diarylurea inhibitors of the cardiac-specific kinase TNNI3K were developed to elucidate the biol. function of TNNI3K and evaluate TNNI3K as a therapeutic target for the treatment of cardiovascular diseases. Utilizing a structure-based design, enhancements in kinase selectivity were engineered into the series, capitalizing on the established X-ray crystal structures of TNNI3K, VEGFR2, p38α, and B-Raf. Our efforts culminated in the discovery of an in vivo tool compound 47 (GSK329), which exhibited desirable TNNI3K potency and rat pharmacokinetic properties as well as promising kinase selectivity against VEGFR2 (40-fold), p38α (80-fold), and B-Raf (>200-fold). Compound 47 demonstrated pos. cardioprotective outcomes in a mouse model of ischemia/reperfusion cardiac injury, indicating that optimized exemplars from this series, such as 47, are favorable leads for discovering novel medicines for cardiac diseases. In addition to this study using 2,4-Dichloropyrimidine, there are many other studies that have used 2,4-Dichloropyrimidine(cas: 3934-20-1Product Details of 3934-20-1) was used in this study.

2,4-Dichloropyrimidine(cas: 3934-20-1) is a member of organic chlorides. Organic chloride content in crude oil can be detected through specialized laboratory analysis. Care and attention are essential while sampling and testing.Product Details of 3934-20-1

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

《Triptycene based and nitrogen rich hyper cross linked polymers (TNHCPs) as efficient CO2 and iodine adsorbent》 was written by Hassan, Atikur; Goswami, Santu; Alam, Akhtar; Bera, Ranajit; Das, Neeladri. Application In Synthesis of 2,4-DichloropyrimidineThis research focused ontriptycene pyrazine copolymer crosslinked radioactive waste iodine adsorbent; carbon dioxide adsorption air pollution reusable recyclable. The article conveys some information:

Triptycene based polymeric networks are rapidly emerging as porous organic polymers (POPs) for efficient capture of small gas mols. Further, such triptycene based frameworks are also being explored as adsorbents for radioactive iodine. Herein, a group of three unique “”Triptycene based and Nitrogen-rich Hyper Crosslinked Polymers”” (TNHCPs) have been easily obtained via the well-known Friedel-Craft alkylation reactions of triptycene with six-membered N-rich heterocycles. In these TNHCPs, the presence of triptycene motifs yields contorted and rigid polymeric frameworks with plenty of micropores and ultramicropores. Further, the presence of N-rich heterocycles increases their efficiency to selectively capture carbon dioxide and adsorb iodine vapors as well as iodide ions from aqueous solutions Comparison with data in recent literature reveals that TNHCPs are better in these domains than several previously reported POPs in general and HCPs in particular. In the experiment, the researchers used 2,4-Dichloropyrimidine(cas: 3934-20-1Application In Synthesis of 2,4-Dichloropyrimidine)

2,4-Dichloropyrimidine(cas: 3934-20-1) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Application In Synthesis of 2,4-Dichloropyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

《Discovery of Clinical Development Candidate GDC-0084, a Brain Penetrant Inhibitor of PI3K and mTOR》 was written by Heffron, Timothy P.; Ndubaku, Chudi O.; Salphati, Laurent; Alicke, Bruno; Cheong, Jonathan; Drobnick, Joy; Edgar, Kyle; Gould, Stephen E.; Lee, Leslie B.; Lesnick, John D.; Lewis, Cristina; Nonomiya, Jim; Pang, Jodie; Plise, Emile G.; Sideris, Steve; Wallin, Jeffrey; Wang, Lan; Zhang, Xiaolin; Olivero, Alan G.. Quality Control of 4-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-amine And the article was included in ACS Medicinal Chemistry Letters on April 14 ,2016. The article conveys some information:

Inhibition of phosphoinositide 3-kinase (PI3K) signaling is an appealing approach to treat brain tumors, especially glioblastoma multiforme (GBM). The authors previously disclosed the successful approach to prospectively design potent and blood-brain barrier (BBB) penetrating PI3K inhibitors. The previously disclosed mols. were ultimately deemed not suitable for clin. development due to projected poor metabolic stability in humans. The authors, therefore, extended the studies to identify a BBB penetrating inhibitor of PI3K that was also projected to be metabolically stable in human. These efforts required identification of a distinct scaffold for PI3K inhibitors relative to the authors’ previous efforts and ultimately resulted in the identification of GDC-0084. The discovery and preclin. characterization of this mol. are described within. In addition to this study using 4-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-amine, there are many other studies that have used 4-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-amine(cas: 944401-55-2Quality Control of 4-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-amine) was used in this study.

4-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-amine(cas: 944401-55-2) belongs to pyrimidine. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own. Quality Control of 4-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-amineThey have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

《Decomposition of thiamine in alcohol solution. II》 was published in Chemical & Pharmaceutical Bulletin in 1974. These research results belong to Shimahara, Noboru; Asakawa, Hiroyuki; Kawamatsu, Yutaka; Hirano, Hiroshi. COA of Formula: C6H8ClN3 The article mentions the following:

Thiamine mononitrate I was decomposed in MeOH solution to produce the pentamer II and the thiazole III. II was converted to 9-amino-2,7,10-trimethyl-5H-dipyrimido[1,6-a:4′,5′-d]pyrimidine. Decomposition of thiamine monochloride in MeOH followed by AgNO3 gave II. II in aqueous solution reacted with acidic sodium sulfite to give 4-amino-2-methylpyrimidinyl-5-methanesulfonic acid. In the experiment, the researchers used many compounds, for example, 6-Chloro-2,5-dimethylpyrimidin-4-amine(cas: 18260-92-9COA of Formula: C6H8ClN3)

6-Chloro-2,5-dimethylpyrimidin-4-amine(cas: 18260-92-9) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.COA of Formula: C6H8ClN3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia