Category: pyrimidines

《Reaction of 4-chloropyrimidines with alkylisothioureas》 was written by Hurst, Derek T.. Application of 52854-14-5 And the article was included in Journal of Heterocyclic Chemistry on April 30 ,1995. The article conveys some information:

Reaction of 4,6-dichloro-5-nitropyrimidine with S-methylisothiouronium sulfate gave 1-(4-chloro-5-nitropyrimidinium-6-yl)-S-methylisothiourea by an unusual nucleophilic attack involving an isothiouronium nitrogen atom. Rearrangement of S-Methylisothiuronium sulfate with 4,6-dichloro-5-nitropyrimidine gave [4-(methylthio)-1,3,5-triazin-2(1H)-ylidene]nitroacetonitrile (>70% yield) and 4,6-bis(methylthio)-5-nitropyrimidine (6% yield). In the experiment, the researchers used many compounds, for example, 4-Chloro-6-methoxy-5-nitropyrimidine(cas: 52854-14-5Application of 52854-14-5)

4-Chloro-6-methoxy-5-nitropyrimidine(cas: 52854-14-5) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Application of 52854-14-5

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

《Pyrimidine reactions. XVI. Thermal rearrangement of substituted 2- and 4-alkoxyprimidines》 was published in Australian Journal of Chemistry in 1968. These research results belong to Brown, Desmond J.; Lee, Tzoong-Chyh. Category: pyrimidines The article mentions the following:

Thermal rearrangement of methyl, bromo, and nitro derivatives of 2- and 4- alkoxypyrimidines produced their N-alkyl isomers, identified by proton magnetic resonance spectral comparison with synthetic specimens of unambiguous or proven structure. The rates for such isomerizations were measured by changes in uv spectra. The C-methyl derivatives rearranged more slowly than the parent alkoxypyrimidines, but the bromo, and especially the nitro derivatives did so much more quickly. Among the derivatives of each methoxypyrimidine, the rate of rearrangement increased as the basic pKa value fell and as the methoxyl protons moved downfield, thus affording a qual. correlation with properties reflecting the electronic effect of each substituent. 32 references. The experimental process involved the reaction of 2-Methoxy-4-methylpyrimidine(cas: 14001-60-6Category: pyrimidines)

2-Methoxy-4-methylpyrimidine(cas: 14001-60-6) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Category: pyrimidines

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

《Pyrimidine reactions. XIV. The butylaminolysis of substituted methoxy- and methylthiopyrimidines》 was published in Australian Journal of Chemistry in 1966. These research results belong to Brown, Desmond J.; Foster, Roy V.. COA of Formula: C6H8N2O The article mentions the following:

cf. CA 65, 15374e Aminolyses of 2- and 4-methoxy (or methylthio) pyrimidines bearing C-methyl, CC’-dimethyl, 5-bromo, or 5-intro substituents have proved of value, in the absence of added solvent, for preparing the corresponding n- and tert-butylamino-pyrimidines. When these displacements are followed spectro-metrically, the apparent 1st-order rate constants indicate mild deactivation by addnl. methyl substituents, moderate activation by a bromo substituent, and profound activation by a nitro substituent. Ionization constants and uv spectra of relevant pyrimidines are recorded. 31 references. In addition to this study using 2-Methoxy-4-methylpyrimidine, there are many other studies that have used 2-Methoxy-4-methylpyrimidine(cas: 14001-60-6COA of Formula: C6H8N2O) was used in this study.

2-Methoxy-4-methylpyrimidine(cas: 14001-60-6) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.COA of Formula: C6H8N2O

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

《Design and optimization leading to an orally active TTK protein kinase inhibitor with robust single agent efficacy》 was written by Riggs, Jennifer R.; Elsner, Jan; Cashion, Dan; Robinson, Dale; Tehrani, Lida; Nagy, Mark; Fultz, Kimberly E.; Krishna Narla, Rama; Peng, Xiaohui; Tran, Tam; Kulkarni, Ashutosh; Bahmanyar, Sogole; Condroski, Kevin; Pagarigan, Barbra; Fenalti, Gustavo; LeBrun, Laurie; Leftheris, Katerina; Zhu, Dan; Boylan, John F.. Application of 90213-66-4This research focused ontriple neg breast cancer antitumor TTK protein kinase pharmacokinetics. The article conveys some information:

Triple neg. breast cancer (TNBC) is an aggressive disease with high relapse rates and few treatment options. Outlined in previous publications, we identified a series of potent, dual TTK/CLK2 inhibitors with strong efficacy in TNBC xenograft models. Pharmacokinetic properties and kinome selectivity were optimized, resulting in the identification of a new series of potent, selective, and orally bioavailable TTK inhibitors. We describe here the structure-activity relationship of the 2,4-disubstituted-7H-pyrrolo[2,3-d]pyrimidine series, leading to significant single agent efficacy in a TNBC xenograft model without body weight loss. The design effort evolving an iv-dosed TTK/CLK2 inhibitor to an orally bioavailable TTK inhibitor is described. The results came from multiple reactions, including the reaction of 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine(cas: 90213-66-4Application of 90213-66-4)

2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine(cas: 90213-66-4) belongs to pyrimidine. Pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics. Application of 90213-66-4

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Quality Control of 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidineIn 2009 ,《Novel Class of LIM-Kinase 2 Inhibitors for the Treatment of Ocular Hypertension and Associated Glaucoma》 appeared in Journal of Medicinal Chemistry. The author of the article were Harrison, Bryce A.; Whitlock, N. Andrew; Voronkov, Michael V.; Almstead, Zheng Y.; Gu, Kun-Jian; Mabon, Ross; Gardyan, Michael; Hamman, Brian D.; Allen, Jason; Gopinathan, Suma; McKnight, Beth; Crist, Mike; Zhang, Yulian; Liu, Ying; Courtney, Lawrence F.; Key, Billie; Zhou, Julia; Patel, Nita; Yates, Phil W.; Liu, Qingyun; Wilson, Alan G. E.; Kimball, S. David; Crosson, Craig E.; Rice, Dennis S.; Rawlins, David B.. The article conveys some information:

The discovery of a pyrrolopyrimidine class of LIM-kinase 2 (LIMK2) inhibitors is reported. These LIMK2 inhibitors show good potency in enzymic and cellular assays and good selectivity against ROCK. After topical dosing to the eye in a steroid induced mouse model of ocular hypertension, the compounds reduce intraocular pressure to baseline levels. The compounds also increase outflow facility in a pig eye perfusion assay. These results suggest LIMK2 may be an effective target for treating ocular hypertension and associated glaucoma. In the experiment, the researchers used many compounds, for example, 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine(cas: 90213-66-4Quality Control of 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine)

2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine(cas: 90213-66-4) belongs to pyrimidine. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives, including the nucleotides cytosine, thymine and uracil, thiamine (vitamin B1) and alloxan. Quality Control of 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

COA of Formula: C6H3Cl2N3In 2017 ,《Novel pyrrolopyrimidines as Mps1/TTK kinase inhibitors for breast cancer》 appeared in Bioorganic & Medicinal Chemistry. The author of the article were Sugimoto, Yasuro; Sawant, Dwitiya B.; Fisk, Harold A.; Mao, Liguang; Li, Chenglong; Chettiar, Somsundaram; Li, Pui-Kai; Darby, Michael V.; Brueggemeier, Robert W.. The article conveys some information:

New targeted therapy approaches for certain subtypes of breast cancer, such as triple-neg. breast cancers and other aggressive phenotypes, are desired. High levels of the mitotic checkpoint kinase Mps1/TTK have correlated with high histol. grade in breast cancer, suggesting a potential new therapeutic target for aggressive breast cancers (BC). Novel small mols. targeting Mps1 were designed by computer assisted docking analyses, and several candidate compounds were synthesized. These compounds were evaluated in anti-proliferative assays of a panel of 15 breast cancer cell lines and further examined for their ability to inhibit a variety of Mps1-dependent biol. functions. The results indicate that the lead compounds have strong anti-proliferative potential through Mps1/TTK inhibition in both basal and luminal BC cell lines, exhibiting IC50 values ranging from 0.05 to 1.0 μM. In addition, the lead compounds 1 and 13 inhibit Mps1 kinase enzymic activity with IC50 values from 0.356 μM to 0.809 μM, and inhibited Mps1-associated cellular functions such as centrosome duplication and the spindle checkpoint in triple neg. breast cancer cells. The most promising analog, compound 13, significantly decreased tumor growth in nude mice containing Cal-51 triple neg. breast cancer cell xenografts. Using drug discovery technologies, computational modeling, medicinal chem., cell culture and in vivo assays, novel small mol. Mps1/TTK inhibitors have been identified as potential targeted therapies for breast cancers. In the experimental materials used by the author, we found 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine(cas: 90213-66-4COA of Formula: C6H3Cl2N3)

2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine(cas: 90213-66-4) belongs to pyrimidine. Pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics. COA of Formula: C6H3Cl2N3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Recommanded Product: 1193-21-1In 2021 ,《Design, synthesis, and structure-activity relationships study of N-pyrimidyl/pyridyl-2-thiazolamine analogues as novel positive allosteric modulators of M3 muscarinic acetylcholine receptor》 appeared in Chemical & Pharmaceutical Bulletin. The author of the article were Tanaka, Hiroaki; Akaiwa, Michinori; Negoro, Kenji; Kawaminami, Eiji; Mihara, Hisashi; Fuji, Hideyoshi; Okimoto, Risa; Ino, Katsutoshi; Ishizu, Kenichiro; Takahashi, Taisuke. The article conveys some information:

The M3 muscarinic acetylcholine receptor (mAChR) plays an essential pharmacol. role in mediating a broad range of actions of acetylcholine (ACh) released throughout the periphery and central nerve system (CNS). Nevertheless, its agonistic functions remain unclear due to the lack of available subtype-selective agonists or pos. allosteric modulators (PAMs). Based on the extended structure-activity relationships (SARs) study on a previously reported PAM of the M3 mAChR, 2-acylaminothiazole I, aa series of N-azinyl-2-thiazolamine analogs II (X = pyridine-2,6-diyl, pyrimidine-2,4-diyl, 5-fluoropyrimidine-4,6-diyl, pyrazine-3,6-diyl, etc.) were identified as new scaffolds. The SARs study was rationalized using conformational analyses based on intramol. interactions. A comprehensive study of a series of analogs described in this paper suggests that a unique sulfur-nitrogen nonbonding interaction in the N-azinyl-2-thiazolamine moiety enables conformations that are essential for activity. Further, a SARs study around the N-pyrimidyl/pyridyl-2-thiazolamine core culminated in the discovery of the compound II (X = 5-fluoro-2-methylpyrimidine-4,6-diyl), which showed potent in vitro PAM activity for the M3 mAChR with excellent subtype selectivity. Compound II (X = 5-fluoro-2-methylpyrimidine-4,6-diyl) also showed a distinct pharmacol. effect on isolated smooth muscle tissue from rat bladder and favorable pharmacokinetics profiles, suggesting its potential as a chem. tool for probing the M3 mAChR in further research. In addition to this study using 4,6-Dichloropyrimidine, there are many other studies that have used 4,6-Dichloropyrimidine(cas: 1193-21-1Recommanded Product: 1193-21-1) was used in this study.

4,6-Dichloropyrimidine(cas: 1193-21-1) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Recommanded Product: 1193-21-1

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

《1,2,3-Thiadiazolo[5,4-b]pyrimidin-4(5H)ones》 was published in Journal of Heterocyclic Chemistry in 1976. These research results belong to Hymans, William E.. Related Products of 6237-96-3 The article mentions the following:

Potential herbicides I (R = Et, Pr, CHMe2, Bu, CH2CHMe2, CMe3, CH2CMe3) were prepared in 6 steps from RC(:NH)NH2 and CH2(CO2Et)2. In addition to this study using 4,6-Dichloro-2-ethylpyrimidin-5-amine, there are many other studies that have used 4,6-Dichloro-2-ethylpyrimidin-5-amine(cas: 6237-96-3Related Products of 6237-96-3) was used in this study.

4,6-Dichloro-2-ethylpyrimidin-5-amine(cas: 6237-96-3) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Related Products of 6237-96-3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 1193-21-1In 2020 ,《Achieving Submicrosecond Thermally Activated Delayed Fluorescence Lifetime and Highly Efficient Electroluminescence by Fine-Tuning of the Phenoxazine-Pyrimidine Structure》 was published in ACS Applied Materials & Interfaces. The article was written by Serevicius, Tomas; Skaisgiris, Rokas; Dodonova, Jelena; Jagintavicius, Laimis; Banevicius, Dovydas; Kazlauskas, Karolis; Tumkevicius, Sigitas; Jursenas, Saulius. The article contains the following contents:

Thermally activated delayed fluorescence (TADF) materials, combining high fluorescence quantum efficiency and short delayed emission lifetime, are highly desirable for application in organic light-emitting diodes (OLEDs) with negligible external quantum efficiency (EQE) roll-off. Here, we present the pathway for shortening the TADF lifetime of highly emissive 4,6-bis[4-(10-phenoxazinyl)phenyl]pyrimidine derivatives Tiny manipulation of the mol. structure with Me groups was applied to tune the singlet-triplet energy-level scheme and the corresponding coupling strengths, enabling the boost of the reverse intersystem crossing (rISC) rate (from 0.7 to 6.5) × 106 s-1 and shorten the TADF lifetime down to only 800 ns in toluene solutions An almost identical TADF lifetime of roughly 860 ns was attained also in solid films for the compound with the most rapid TADF decay in toluene despite the presence of inevitable conformational disorder. Concomitantly, the boost of fluorescence quantum efficiency to near unity was achieved in solid films due to the weakened nonradiative decay. Exceptional EQE peak values of 26.3-29.1% together with adjustable emission wavelength in the range of 502-536 nm were achieved in TADF OLEDs. Reduction of EQE roll-off was demonstrated by lowering the TADF lifetime. In the experiment, the researchers used many compounds, for example, 4,6-Dichloropyrimidine(cas: 1193-21-1Related Products of 1193-21-1)

4,6-Dichloropyrimidine(cas: 1193-21-1) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Related Products of 1193-21-1

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Quality Control of 4,6-DichloropyrimidineIn 2020 ,《Ruthenium, rhodium and iridium complexes containing pyrimidine based thienyl pyrazoles: Synthesis and antibacterial studies》 was published in Journal of Organometallic Chemistry. The article was written by Lapasam, Agreeda; Mawnai, Ibaniewkor L.; Banothu, Venkanna; Kaminsky, Werner; Kollipara, Mohan Rao. The article contains the following contents:

The reaction of pyrimidine based electron-rich heterocyclic thiophene pyrazoles and halide bridged arene d6 metal precursors yielded a series of mononuclear and dinuclear half sandwich d6 metal complexes. Mononuclear and dinuclear complexes formed by the ratio-based reaction between ligand and metal precursor. All these cationic complexes have been characterized by IR, UV-Vis, 1H NMR, 13C NMR spectroscopic techniques. Complex 5 has been established by single-crystal anal. X-ray diffraction studies revealed the formation of mononuclear and dinuclear complexes and suggest that the vicinity around the metal atom is distorted octahedral. An in vitro study to screen the antibacterial potential of these complexes against pathogenic bacteria, S. aureus, K. pneumoniae, and E. coli was addressed. All the complexes display a better zone of inhibitions for both Gram-pos. (S. aureus) and Gram-neg. strains (K. pneumoniae, and E. coli). The min. inhibitory concentrations (MICs) for the most active complex ranged from 0.125 to 0.25 mg/mL for S. aureus and Klebsiella Pneumoniae and 0.25-0.5 mg/mL for E. coli. The experimental part of the paper was very detailed, including the reaction process of 4,6-Dichloropyrimidine(cas: 1193-21-1Quality Control of 4,6-Dichloropyrimidine)

4,6-Dichloropyrimidine(cas: 1193-21-1) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Quality Control of 4,6-Dichloropyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia