Category: pyrimidines

COA of Formula: C23H22N4OOn June 14, 2016, Deschamps, Joshua D.; Ogunsola, Abiola F.; Jameson, J. Brian; Yasgar, Adam; Flitter, Becca A.; Freedman, Cody J.; Melvin, Jeffrey A.; Nguyen, Jason V. M. H.; Maloney, David J.; Jadhav, Ajit; Simeonov, Anton; Bomberger, Jennifer M.; Holman, Theodore R. published an article in Biochemistry. The article was 《Biochemical and Cellular Characterization and Inhibitor Discovery of Pseudomonas aeruginosa 15-Lipoxygenase》. The article mentions the following:

Pseudomonas aeruginosa is an opportunistic pathogen that can cause nosocomial and chronic infections in immunocompromised patients. P. aeruginosa secretes a lipoxygenase, LoxA, but the biol. role of this enzyme is currently unknown. LoxA is poorly similar in sequence to both soybean LOX-1 (s15-LOX-1) and human 15-LOX-1 (37 and 39%, resp.) yet has kinetics comparably fast vs. those of s15-LOX-1 (at pH 6.5, Kcat = 181 ± 6 s-1 and Kcat/KM = 16 ± 2 μM-1 s-1). LoxA is capable of efficiently catalyzing the peroxidation of a broad range of free fatty acid (FA) substrates (e.g., AA and LA) with high positional specificity, indicating a 15-LOX. Its mechanism includes hydrogen atom abstraction [a kinetic isotope effect (KIE) of >30], yet LoxA is a poor catalyst against phosphoester FAs, suggesting that LoxA is not involved in membrane decomposition LoxA also does not react with 5- or 15-HETEs, indicating poor involvement in lipoxin production A LOX high-throughput screen of the LOPAC library yielded a variety of low-micromolar inhibitors; however, none selectively targeted LoxA over the human LOX isoenzymes. With respect to cellular activity, the level of LoxA expression is increased when P. aeruginosa undergoes the transition to a biofilm mode of growth, but LoxA is not required for biofilm growth on abiotic surfaces. However, LoxA does appear to be required for biofilm growth in association with the host airway epithelium, suggesting a role for LoxA in mediating bacterium-host interactions during colonization. In the experimental materials used by the author, we found 7-Cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine(cas: 213743-31-8COA of Formula: C23H22N4O)

7-Cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine(cas: 213743-31-8) belongs to pyrimidine. Pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics. COA of Formula: C23H22N4O

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

《Selective and Multicyclic CO2 Adsorption with Visible Light-Driven Photodegradation of Organic Dyes in a Robust Metal-Organic Framework Embracing Heteroatom-Affixed Pores》 was written by Singh, Manpreet; Neogi, Subhadip. Quality Control of 4,6-DichloropyrimidineThis research focused onzinc MOF CSMCRI 16 preparation crystal structure adsorbent photocatalyst; carbon dioxide multicyclic selective adsorption; cationic organic dye photodegradation. The article conveys some information:

Pore environment modulation with polarizing groups is one of the essential prerequisites for selective carbon dioxide (CO2) adsorption in metal-organic frameworks (MOFs), wherein judicious installation of the photocatalytic feature can promise visible light-triggered degradation of toxic organic dye mols. However, astute amalgamation of both these attributes over a single MOF is rather rare, yet much anticipated in view of sustainable applications. Pore engineering is effectively harnessed in a Zn(II)-based three-dimensional (3D) MOF, CSMCRI-16 (CSMCRI = Central Salt and Marine Chems. Research Institute), through mixed-ligand assembly of a N-rich linker (L), 4,4′-oxybis(benzoic acid) (H2oba) ligand, and [Zn2(CO2)4N2] paddle-wheel secondary building units (SBUs). The noninterpenetrated structure contains unbound nitrogen and accessible oxygen atom-decorated porous channels and exhibits admirable stability in diverse organic solvents, open air, and at elevated temperatures The heteroatom-decorated porous channels facilitated excellent CO2 uptake in the activated MOF (16a) with high selectivity over N2 (CO2/N2: 155.3) at 273 K. The framework further exhibits reasonable CO2 affinity and multicyclic CO2 sorption recurrence without a significant loss in the uptake capacity. Benefitting from the presence of the [Zn2(CO2)4N2] cluster in conjugation with π-conjugated organic ligands, the extended 3D network revealed an optical band gap energy of 2.55 eV, which makes the MOF an efficient photocatalyst toward the degradation of the cationic dyes crystal violet (CV) and methylene blue (MB) in the presence of a simple 40 W visible light lamp without any assistance of external oxidants. The catalyst exhibits multicyclic performance and short reaction time in addition to the fact that catalytic efficiencies (CV: 97.2%, MB: 97.8%) are comparable to those of contemporary materials. In the experiment, the researchers used 4,6-Dichloropyrimidine(cas: 1193-21-1Quality Control of 4,6-Dichloropyrimidine)

4,6-Dichloropyrimidine(cas: 1193-21-1) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Quality Control of 4,6-Dichloropyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

《High-Temperature Continuous-Flow Zincations of Functionalized Arenes and Heteroarenes Using (Cy2N)2Zn·2LiCl》 was written by Becker, Matthias R.; Knochel, Paul. Electric Literature of C4HCl3N2This research focused onzincation zinc amide arene heteroarene coupling reaction. The article conveys some information:

The treatment of sensitive arenes and heteroarenes with the zinc bis-amide (Cy2N)2Zn·2LiCl (0.55 equiv), prepared in quant. yield by the reaction of Cy2NLi with ZnCl2, leads under flow conditions to a fast zincation within 10 min at temperatures between 25 and 100 °C. The resulting organozinc reagents can be trapped with various organic halides (allylic bromides, aryl iodides) in high yields. Moreover, complementary metalation regioselectivities can be obtained for several substituted pyridines compared to commonly used LiCl-activated TMP-zinc (TMP = 2,2,6,6-tetramethylpiperidyl) and -magnesium bases. After reading the article, we found that the author used 2,4,6-Trichloropyrimidine(cas: 3764-01-0Electric Literature of C4HCl3N2)

2,4,6-Trichloropyrimidine(cas: 3764-01-0) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Electric Literature of C4HCl3N2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 2,4,6-TrichloropyrimidineIn 2016 ,《Systematic synthesis, comparative studies of the optical properties, and the ICT-based sensor properties of a series of 2,4,6-tri(5-aryl-2-thienyl)pyrimidines with the D-π-A system》 was published in Tetrahedron Letters. The article was written by Muraoka, Hiroki; Obara, Takumi; Ogawa, Satoshi. The article contains the following contents:

A series of 2,4,6-tri(5-aryl-2-thienyl)pyrimidines with a star-shaped D-π-A system, which have an electron deficient pyrimidine core (A) and three donor type aryl groups (D) linked by a thiophene spacer (π-spacer), were designed and systematically synthesized. Through the characterization of the mols. by UV-vis absorption and fluorescence spectroscopies, we revealed that the mols. possess distinct absorption and emission wavelengths controlled by the donor effect of the terminal aryl groups. Interestingly, 2,4,6-tris(5-p-N,N-dibutylaminophenyl-2-thienyl)pyrimidine was found to exhibit strong fluorosolvatochromic properties and a proton-sensibility based on its intramol. charge transfer (ICT) and basic characteristics, which could allow its use as a polarity or proton sensor.2,4,6-Trichloropyrimidine(cas: 3764-01-0Reference of 2,4,6-Trichloropyrimidine) was used in this study.

2,4,6-Trichloropyrimidine(cas: 3764-01-0) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Reference of 2,4,6-Trichloropyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 2,4-DichloropyrimidineIn 2021 ,《Structure activity relationships and the binding mode of quinolinone-pyrimidine hybrids as reversal agents of multidrug resistance mediated by P-gp》 appeared in Scientific Reports. The author of the article were Laiolo, Jeronimo; Lanza, Priscila Ailin; Parravicini, Oscar; Barbieri, Cecilia; Insuasty, Daniel; Cobo, Justo; Vera, D. Mariano Adolfo; Enriz, Ricardo Daniel; Carpinella, Maria Cecilia. The article conveys some information:

P-gp-associated multidrug resistance is a major impediment to the success of chemotherapy. With the aim of finding non-toxic and effective P-gp inhibitors, we investigated a panel of quinolin-2-one-pyrimidine hybrids. Among the active compounds, two of them significantly increased intracellular doxorubicin and rhodamine 123 accumulation by inhibiting the efflux mediated by P-gp and restored doxorubicin toxicity at nanomolar range. Structure-activity relationships showed that the number of methoxy groups, an optimal length of the mol. in its extended conformation, and at least one flexible methylene group bridging the quinolinone to the moiety bearing the pyrimidine favored the inhibitory potency of P-gp. The best compounds showed a similar binding pattern and interactions to those of doxorubicin and tariquidar, as revealed by MD and hybrid QM/MM simulations performed with the recent exptl. structure of P-gp co-crystallized with paclitaxel. Anal. of the mol. interactions stabilizing the different mol. complexes determined by MD and QTAIM showed that binding to key residues from TMH 4-7 and 12 is required for inhibition. After reading the article, we found that the author used 2,4-Dichloropyrimidine(cas: 3934-20-1Reference of 2,4-Dichloropyrimidine)

2,4-Dichloropyrimidine(cas: 3934-20-1) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Reference of 2,4-Dichloropyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In 2022,Song, Peilu; Zhao, Fan; Li, Dahong; Qu, Jiqiang; Yao, Miao; Su, Yuan; Wang, Hanxun; Zhou, Miaomiao; Wang, Yujie; Gao, Yinli; Li, Feng; Zhao, Dongmei; Zhang, Fengjiao; Rao, Yu; Xia, Mingyu; Li, Haitao; Wang, Jian; Cheng, Maosheng published an article in Acta Pharmaceutica Sinica B. The title of the article was 《Synthesis of selective PAK4 inhibitors for lung metastasis of lung cancer and melanoma cells》.Reference of 2,4-Dichloropyrimidine The author mentioned the following in the article:

The p21 activated kinase 4 (PAK4) is serine/threonine protein kinase that is critical for cancer progression. Guided by X-ray crystallog. and structure-based optimization, we report a novel subseries of C-3-substituted 6-ethynyl-1H-indole derivatives that display high potential and specificity towards group II PAKs. Among these inhibitors, compound 55 exhibited excellent inhibitory activity and kinase selectivity, displayed superior anti-migratory and anti-invasive properties against the lung cancer cell line A549 and the melanoma cell line B16. Compound 55 exhibited potent in vivo antitumor metastatic efficacy, with over 80% and 90% inhibition of lung metastasis in A549 or B16-BL6 lung metastasis models, resp. Further mechanistic studies demonstrated that compound 55 mitigated TGF-β1-induced epithelial-mesenchymal transition (EMT). In the experimental materials used by the author, we found 2,4-Dichloropyrimidine(cas: 3934-20-1Reference of 2,4-Dichloropyrimidine)

2,4-Dichloropyrimidine(cas: 3934-20-1) is a member of organic chlorides. Organic chloride content in crude oil can be detected through specialized laboratory analysis. Care and attention are essential while sampling and testing.Reference of 2,4-Dichloropyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Luo, Zaoli; Liu, Yungen; Tong, Ka-Chung; Chang, Xiao-Yong; To, Wai-Pong; Che, Chi-Ming published an article in 2021. The article was titled 《Luminescent Platinum(II) Complexes with Bidentate Diacetylide Ligands: Structures, Photophysical Properties and Application Studies》, and you may find the article in Chemistry – An Asian Journal.Formula: C4H2Cl2N2 The information in the text is summarized as follows:

A series of platinum(II) m-terphenyl 2,2”-diacetylide complexes supported by diimines (2,2′-bipyridines, 1,10-phenanthroline, 2,2′-bipyrimidine) or bis-N-heterocyclic carbenes 3-RIm(CH2)nImR-3′ (R = Bu, Me; n = 1-3) ligands have been prepared The diacetylide ligands adopt a cis coordination mode featuring non-planar terphenyl moieties as revealed by X-ray crystallog. analyses. The electrochem., photophys. and photochem. properties of these platinum(II) complexes have been investigated. These platinum(II) diimine complexes show broad emission with peak maxima from 566 nm to 706 nm, with two of them having emission quantum yields >60% and lifetimes <2μs in solutions at room temperature, whereas the platinum(II) diacetylide complexes having bis-N-heterocyclic carbene instead of diimine ligand display photoluminescence with quantum yields of up to 28% in solutions and excited state lifetimes of up to 62μs at room temperature Application studies revealed that one of the complexes can catalyze photoinduced aerobic dehydrogenation of alcs. and alkenes, and a relatively non-toxic water-soluble Pt(II) complex displays anti-angiogenic activity. After reading the article, we found that the author used 2,4-Dichloropyrimidine(cas: 3934-20-1Formula: C4H2Cl2N2)

2,4-Dichloropyrimidine(cas: 3934-20-1) is a member of organic chlorides. Organic chloride content in crude oil can be detected through specialized laboratory analysis. Care and attention are essential while sampling and testing.Formula: C4H2Cl2N2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Ding, Li; Pannecouque, Christophe; De Clercq, Erik; Zhuang, Chunlin; Chen, Fen-Er published their research in Journal of Medicinal Chemistry in 2021. The article was titled 《Hydrophobic Pocket Occupation Design of Difluoro-Biphenyl-Diarylpyrimidines as Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors: from N-Alkylation to Methyl Hopping on the Pyrimidine Ring》.Application In Synthesis of 2,4-Dichloropyrimidine The article contains the following contents:

Considering the nonideal metabolic stability of the difluoro-biphenyl-diarylpyrimidine lead compound I, a series of novel alkylated difluoro-biphenyl-diarylpyrimidines were designed and synthesized based on their structure. Introducing alkyl or substituted alkyl groups on the linker region to block the potential metabolic sensitive sites generated 22 derivatives Among them, compound II with an N-Me group displayed excellent anti-HIV-1 activity and selectivity. The Me group was hopped to the central pyrimidine to occupy the small linker region and maintain the water-mediated hydrogen bond observed in the binding of compound I with RT. The resulting compound III exhibited an improved anti-HIV-1 activity, much lower cytotoxicity, and nanomolar activity toward multiple mutants. In addition, III has a better stability in human liver microsomes than I. Moreover, no apparent in vivo acute toxicity was observed in III-treated female, especially pregnant mice. This series of alkylated compounds with highly potency and safety represent a promising lead template for future discovery. The experimental process involved the reaction of 2,4-Dichloropyrimidine(cas: 3934-20-1Application In Synthesis of 2,4-Dichloropyrimidine)

2,4-Dichloropyrimidine(cas: 3934-20-1) is a member of organic chlorides. Organic chloride content in crude oil can be detected through specialized laboratory analysis. Care and attention are essential while sampling and testing.Application In Synthesis of 2,4-Dichloropyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

《Synthesis, Photophysical Properties, and Biological Profiling of Benzothieno-Fused 7-Deazapurine Ribonucleosides》 was written by Yang, Chao; Pohl, Radek; Tichy, Michal; Gurska, Sona; Pavlis, Petr; Dzubak, Petr; Hajduch, Marian; Hocek, Michal. Related Products of 1193-21-1 And the article was included in Journal of Organic Chemistry in 2020. The article conveys some information:

Two isomeric series of benzothieno-fused 7-deazapurine (benzo[4′,5′]thieno[3′,2′:4,5]- and benzo[4′,5′]thieno[2′,3′:4,5]pyrrolo[2,3-d]pyrimidine) ribonucleosides were designed and synthesized. Key steps of the synthesis included the Negishi coupling of zincated dichloropyrimidine with 2- or 3-iodobenzothiophene followed by azidation, thermal or photochem. cyclization, glycosylation, and final functionalization at position 6 through cross-couplings or nucleophilic substitutions. Deprotection gave the final nucleosides, some of which showed moderate cytotoxic and antiviral activity. Most of the free nucleosides showed moderate to strong fluorescence with emission maxima of 362-554 nm. 2′-Deoxyribonucleoside and its 5′-O-triphosphate were also prepared from benzothieno-fused 7-deazaadenine derivative, and the triphosphate was a good substrate for KOD XL DNA polymerase in primer extension synthesis of modified DNA which exerted a weak fluorescence which was slightly enhanced in double-stranded DNA as compared to single-stranded oligonucleotides. The results came from multiple reactions, including the reaction of 4,6-Dichloropyrimidine(cas: 1193-21-1Related Products of 1193-21-1)

4,6-Dichloropyrimidine(cas: 1193-21-1) is a member of organic chlorides. Organic chloride content in crude oil can be detected through specialized laboratory analysis. Care and attention are essential while sampling and testing.Related Products of 1193-21-1

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In 2019,Polymers (Basel, Switzerland) included an article by Dong, Xue; Xing, Tieling; Chen, Guoqiang. Recommanded Product: 2,4,6-Trichloropyrimidine. The article was titled 《Durable antipilling modification of cotton fabric with chloropyrimidine compounds》. The information in the text is summarized as follows:

Cotton fabric, a natural cellulose material, is widely used in the textile industry for its excellent properties. However, its application in some fields are seriously restricted because of its poor antipilling behavior. In this study, cotton fabrics were modified with 2,4,6-trichloropyrimidine (TLP), 2,4-dichloro-5-methoxypyrimidine (DMP), and 2-amino-4,6-dichloropyridine (ADP). The surface morphol. and chem. structure of the modified cotton fabric were characterized by SEM, Fourier transform IR spectroscopy (FTIR), and X-ray diffraction (XRD). Furthermore, the antipilling behavior, dyeing properties, thermal properties, and mech. properties of modified cotton fabric were evaluated. The results showed that chloropyrimidine compounds were successfully grafted onto the surface of the cotton fabric, leading to excellent and durable antipilling activity of grade 3-4 even after 10 washes. Moreover, compared with control cotton fabric, the heat release rate (HRR) and total heat release (THR) of TLP-modified cotton fabric decreased to 173.2 W/g (42.3% reduction) and 11.3 KJ/g (13.7% reduction), resp. In addition, the increased K/S value of modified cotton fabrics dyed with reactive dyes indicated that the modification can enhance the dyability of cotton fabric. This technique provides a simple and versatile method for improving the antipilling behavior of cellulosic materials and supports further preparation of functional textiles. In the experiment, the researchers used many compounds, for example, 2,4,6-Trichloropyrimidine(cas: 3764-01-0Recommanded Product: 2,4,6-Trichloropyrimidine)

2,4,6-Trichloropyrimidine(cas: 3764-01-0) is a member of organic chlorides. Almost all organochlorine compounds are synthesized. It is widely used as intermediates, solvents and pesticides of chemical synthetic products.Recommanded Product: 2,4,6-Trichloropyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia