Category: pyrimidines

Differential mechanism of the cytostatic effect of (E)-5-(2-bromovinyl)-2′-deoxyuridine, 9-(1,3-dihydroxy-2-propoxymethyl)guanine, and other antiherpetic drugs on tumor cells transfected by the thymidine kinase gene of herpes simplex virus type 1 or type 2 was written by Balzarini, Jan; Bohman, Christina; De Clercq, Erik. And the article was included in Journal of Biological Chemistry on March 25,1993.Name: 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione The following contents are mentioned in the article:

After they have been transfected with the herpes simplex virus type 1 (HSV-1) or type 2 (HSV-2) thymidine kinase (TK) gene murine mammary carcinoma (FM3A) cells become highly sensitive to the growth inhibitory properties of the antiherpetic agents (E)-5-(2-bromovinyl)-2′-deoxyuridine (BVDU), 9-[(2-hydroxyethoxy)methyl]guanine (acyclovir, ACV), 9-[(1,3-dihydroxy-2-propoxy)methyl]guanine (DHPG, ganciclovir), and 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-methyluracil (FMAU). BVDU was 100-fold more potent an inhibitor of HSV TK gene-transfected tumor cell growth (50% inhibitory concentration (IC50), 0.0020-0.0047 μM) than FMAU or DHPG (IC50, 0.051-0.277 μM) and 1000-fold more potent than ACV (IC50, 0.42-4.9 μM). As a rule, the test compounds were more cytostatic to HSV-2 TK than HSV-1 TK gene-transfected FM3A cells. This may be ascribed to the higher phosphorylating capacity (Vmax/Km) of HSV-2 TK than HSV-1 TK and/or to the higher TK enzyme levels of the HSV-2 TK gene-transfected FM3A cells than the HSV-1 TK gene-transfected FM3A cells. Thymidylate synthase of the HSV TK gene-transfected FM3A cells appears to be the target enzyme for the cytostatic action of BVDU, but not FMAU, DHPG, or ACV. Instead, the cytostatic activity of DHPG seems to be correlated with its conversion to the triphosphate form and subsequent incorporation into the DNA of HSV TK gene-transfected FM3A cells. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3Name: 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione).

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they constitute an important class of natural and synthetic compounds exhibiting diverse useful biological activities that hold attractive potential for clinical translation as therapeutic agents in alleviation of a myriad of diseases. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Name: 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3

Deglycosylation of antiherpesviral 5-substituted arabinosyluracil derivatives by rat liver extract and enterobacteria cells was written by Machida, Haruhiko; Watanabe, Yohko; Kano, Fumitaka; Sakata, Shinji; Kumagai, Masao; Yamaguchi, Toyofumi. And the article was included in Biochemical Pharmacology on March 15,1995.COA of Formula: C10H13FN2O5 The following contents are mentioned in the article:

A number of antiherpesviral 5-substituted derivatives of 1-β-D-arabinofuranosyluracil (araU) were significantly resistant to phosphorolysis by rat liver extract (S-9), but were gradually deglycosylated in a 2% enterobacteria cell suspension. The relative order of the resistance conferred by the different C-5 substituents was: 5-propynyl > 5-(E)-2-bromovinyl > 5-(E)-2-chlorovinyl > 5-Me > 5-iodo. The 2′-fluoro derivatives of araU were completely resistant to phosphorolysis by both liver extract and enterobacteria, whereas the corresponding ribofuranosyl and 2′-deoxyribofuranosyl nucleosides were easily phosphorolyzed by S-9, and were immediately cleaved in a 1% enterobacteria cell suspension. These findings suggest that antiherpesviral 5-substituted araU analogs can be relatively stable in vivo, when injected i.v., and that degradation of 1-β-D-arabinofuranosyl-5-(E-2-bromovinyl)uracil (sorivudine) following oral administration is due primarily to the action of enterobacteria. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3COA of Formula: C10H13FN2O5).

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own.COA of Formula: C10H13FN2O5

69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3

Effect of 2′-fluoro-5-methyl-ara-uracil and cyclophosphamide on herpes simplex virus infection in guinea pigs was written by Zheng, Zhiming; Landry, M. L.; Mayo, D. R.; Hsiung, G. D.. And the article was included in Zhongguo Yaoli Xuebao on March 31,1987.Application In Synthesis of 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione The following contents are mentioned in the article:

2′-Fluoro-5-methylarauracil (FMAU) (50 mg/kg, i.p. daily for 3 days) starting 1 day post-vaginal inoculation of herpes simplex virus-2 (HSV-2) in guinea pigs almost completely inhibited the appearance of primary genital lesions (GL) but did not reduce the establishment of HSV latency. When cyclophosphamide (Cy) (50 mg/kg, i.p. daily for 7 days) was simultaneously given, mild delayed GL were occasionally noticed in FMAU-treated animals. During HSV-2 latent infection, i.p. Cy 50 mg/kg, for 10 d could induce genital herpes recurrence in FMAU-treated animals. Cy, 300 mg/kg 3 times at weekly intervals could increase the incidence of recurrent GL, suggesting that the reactivation of latent HSV by Cy was dosage related. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3Application In Synthesis of 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione).

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. Pyrimidine derivatives have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.Application In Synthesis of 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3

Inhibitory effects of 2′-fluorinated arabinosylpyrimidine nucleosides on woodchuck hepatitis virus replication in chronically infected woodchucks was written by Fourel, I.; Hantz, O.; Watanabe, K. A.; Jacquet, C.; Chomel, B.; Fox, J. J.; Trepo, C.. And the article was included in Antimicrobial Agents and Chemotherapy on March 31,1990.Computed Properties of C10H13FN2O5 The following contents are mentioned in the article:

The treatment of woodchuck hepatitis virus infections with 1-(2′-deoxy-2′-fluoro-β-D-arabinofuranosyl)-5-iodocytosine and 1-(2′-deoxy-2′-fluoro-β-D-arabinofuranosyl)-5-methyluracil given i.p. caused complete and permanent decrease of serum virus endogenous DNA polymerase and viral DNA in all treated woodchucks but was associated with severe toxicity. By contrast, 1-(2′-deoxy-2′-fluoro-β-D-arabinofuranosyl)-5-ethyluracil (FEAU) induced a sustained, although less dramatic, decrease of viral replication without apparent toxic effect. FEAU was also effective when given orally, but in both cases the inhibitory effect was transient. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3Computed Properties of C10H13FN2O5).

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. Pyrimidine derivatives have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.Computed Properties of C10H13FN2O5

69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3

Incorporation of metabolites of 2′-fluoro-5-iodo-1-β-D-arabinofuranosylcytosine into deoxyribonucleic acid of neoplastic and normal mammalian tissues was written by Grant, Alan J.; Feinberg, Aaron; Chou, Ting-Chao; Watanabe, Kyoichi A.; Fox, Jack J.; Philips, Frederick S.. And the article was included in Biochemical Pharmacology on March 15,1982.Reference of 56632-83-8 The following contents are mentioned in the article:

Following treatment of mice with 2-14C-labeled 2′-fluoro-5-iodo-1-β-D-arabinofuranosylcytosine (I) [69123-90-6], a new and potent antiherpetic agent, enzyme degradation of highly purified DNA from the small intestine and anal. of the resulting nucleosides failed to reveal the presence of unchanged I. Three metabolites were found, namely the 2′-fluoro-1-β-D-arabinofuranosyl nucleosides of cytosine, thymine, and 5-iodouracil. Labeled metabolites of I were also found in the DNA isolated from P815 leukemia cells of mice given I-2-14C. These metabolites are also potent antiherpetic agents. This study involved multiple reactions and reactants, such as 4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8Reference of 56632-83-8).

4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8) belongs to pyrimidine derivatives. The pyrimidine derivatives can easily interact with enzymes, genetic materials, and bio components within the cell. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Reference of 56632-83-8

56632-83-8;4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one;The future of 56632-83-8;New trend of C9H12FN3O4;function of 56632-83-8

Can nitrogen-15 NMR be used to determine the site of N-oxidation of pyrimidine-2,4-diamine? was written by Cowden, William B.; Waring, Paul. And the article was included in Australian Journal of Chemistry in 1981.HPLC of Formula: 35139-67-4 The following contents are mentioned in the article:

An examination of the products of N-oxidation of pyrimidine-2,4-diamine demonstrated that 15N spectroscopy is an unreliable technique for the determination of the site of N-oxidation The 15N shifts caused by N-oxidation were small and downfield and of no diagnostic value. This study involved multiple reactions and reactants, such as 2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4HPLC of Formula: 35139-67-4).

2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.HPLC of Formula: 35139-67-4

35139-67-4;2,6-Diamino-4-chloropyrimidine-1-oxide;The future of 35139-67-4;New trend of C4H5ClN4O;function of 35139-67-4

Pyrimidine N-oxides. VI. The ionization constants of pyrimidine-2,4-diamine N-oxides was written by Cowden, William B.; Jacobsen, Noel W.. And the article was included in Australian Journal of Chemistry in 1984.Application of 35139-67-4 The following contents are mentioned in the article:

The ionization constants of some pyrimidine-2,4-diamines and their N-oxides, including the drugs trimethoprim and minoxidil, are reported. The syntheses of several pyrimidine-2,4-diamine N-oxides are described. This study involved multiple reactions and reactants, such as 2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4Application of 35139-67-4).

2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4) belongs to pyrimidine derivatives. Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.Application of 35139-67-4

35139-67-4;2,6-Diamino-4-chloropyrimidine-1-oxide;The future of 35139-67-4;New trend of C4H5ClN4O;function of 35139-67-4

Product class 12: pyrimidines was written by von Angerer, S.. And the article was included in Science of Synthesis in 2004.Quality Control of 2,6-Diamino-4-chloropyrimidine-1-oxide The following contents are mentioned in the article:

A review. Methods for preparing pyrimidines are reviewed including cyclization, ring transformation, aromatization and substituent modification. This study involved multiple reactions and reactants, such as 2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4Quality Control of 2,6-Diamino-4-chloropyrimidine-1-oxide).

2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.Quality Control of 2,6-Diamino-4-chloropyrimidine-1-oxide

35139-67-4;2,6-Diamino-4-chloropyrimidine-1-oxide;The future of 35139-67-4;New trend of C4H5ClN4O;function of 35139-67-4

Synthesis of nucleosides was written by Vorbrueggen, Helmut; Ruh-Pohlenz, Carmen. And the article was included in Organic Reactions (Hoboken, NJ, United States) in 2000.Reference of 56632-83-8 The following contents are mentioned in the article:

A review of the article Synthesis of nucleosides. This study involved multiple reactions and reactants, such as 4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8Reference of 56632-83-8).

4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Reference of 56632-83-8

56632-83-8;4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one;The future of 56632-83-8;New trend of C9H12FN3O4;function of 56632-83-8

Antiviral potencies of BV-araU and related nucleoside analogs against varicella-zoster virus in different cell lines was written by Machida, Haruhiko; Ijichi, Katsushi; Ohta, Arihito; Honda, Mariko; Niimura, Michihito. And the article was included in Microbiology and Immunology in 1990.SDS of cas: 69256-17-3 The following contents are mentioned in the article:

The nucleoside analog 1-β-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil (BV-araU) and 9 other anti-herpes nucleoside analogs were compared for their potencies against 4 strains of varicella-zoster virus (VZV) on 3 different cell lines: HEL cells, Vero cells, and MS cells established from a human malignant schwannoma. In contrast to the activity against herpes simplex virus type 1 previously reported, BV-araU showed extremely marked antiviral activity against VZV even on Vero cells. ED50, 50% plaque reduction dose, of BV-araU for VZV was 0.20-3.1 and 0.14-0.63 ng/mL on Vero cells and on HEL cells, resp. Potency of BV-araU on MS cells was similar to that on these cell lines. There was no variation in anti-VZV activity of the other nucleoside analogs on these 3 different cell lines except for a few combinations of VZV strain and test compound This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3SDS of cas: 69256-17-3).

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.SDS of cas: 69256-17-3

69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3