pyrimidines | Page 155 of 1124

Rezaei, Saghar’s team published research in RSC Advances in 2016 | CAS: 36847-11-7

RSC Advances published new progress about Aryl alkenes Role: SPN (Synthetic Preparation), PREP (Preparation). 36847-11-7 belongs to class pyrimidines, name is 2,4,6-Tribromopyrimidine, and the molecular formula is C4HBr3N2, Computed Properties of 36847-11-7.

Rezaei, Saghar published the artcileMono- and multifold C-C coupling reactions catalyzed by a palladium complex encapsulated in MIL-Cr as a three dimensional nano reactor, Computed Properties of 36847-11-7, the main research area is phenylboronic acid halobenzene chromium MOF encapsulated palladium Suzuki reaction; biaryl preparation green chem; styrene halobenzene chromium MOF encapsulated palladium Heck reaction; styrylbenzene preparation green chem; reusable chromium MOF encapsulated palladium complex catalyst preparation.

The organic palladium complex (trans-dichlorobis(4-iodoaniline-κN)palladium(II)) was encapsulated into a porous metal-organic framework MIL-Cr (Pd complex@MIL-Cr) using ship-in-a-bottle strategy. The novel catalyst as a three dimensional nanoreactor was fully characterized using different techniques such as XRD, BET, XPS, SEM, EDX, TEM and ICP. The Pd complex@MIL-Cr was isostructural to the parent MIL-Cr framework, with a high surface area and pore volume of ca. 1418 m2 g-1 and 0.87 cm3 g-1, resp. The nanoreactor was highly efficient in the catalytic conversion of aryl halides, showing extraordinarily higher activity than the homogeneous Pd counterparts. Surprisingly, high yields were achieved in Suzuki-Miyaura and Heck coupling reactions of chloroarenes bearing a wide range of substituents. Besides, this protocol could be extended to the cross-couplings of 2-bromo and 2,6-dibromopyridine with arylboronic acids in excellent yields at room temperature The Pd complex@MIL-Cr was also used as an efficient and convenient catalyst for the preparation of a series of C3-sym. mols. with benzene, pyridine or pyrimidine units as the central core. Moreover, the catalyst could be recovered easily and reused several times without any considerable loss of its catalytic activity. Investigation of the nature of the recovered catalyst showed that the catalyst was converted to Pd nanoparticles.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Cowden, William B. et al. published their research in Australian Journal of Chemistry in 1981 | CAS: 35139-67-4

2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.HPLC of Formula: 35139-67-4

Can nitrogen-15 NMR be used to determine the site of N-oxidation of pyrimidine-2,4-diamine? was written by Cowden, William B.; Waring, Paul. And the article was included in Australian Journal of Chemistry in 1981.HPLC of Formula: 35139-67-4 The following contents are mentioned in the article:

An examination of the products of N-oxidation of pyrimidine-2,4-diamine demonstrated that 15N spectroscopy is an unreliable technique for the determination of the site of N-oxidation The 15N shifts caused by N-oxidation were small and downfield and of no diagnostic value. This study involved multiple reactions and reactants, such as 2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4HPLC of Formula: 35139-67-4).

35139-67-4;2,6-Diamino-4-chloropyrimidine-1-oxide;The future of 35139-67-4;New trend of C4H5ClN4O;function of 35139-67-4

Cowden, William B. et al. published their research in Australian Journal of Chemistry in 1984 | CAS: 35139-67-4

2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4) belongs to pyrimidine derivatives. Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.Application of 35139-67-4

Pyrimidine N-oxides. VI. The ionization constants of pyrimidine-2,4-diamine N-oxides was written by Cowden, William B.; Jacobsen, Noel W.. And the article was included in Australian Journal of Chemistry in 1984.Application of 35139-67-4 The following contents are mentioned in the article:

The ionization constants of some pyrimidine-2,4-diamines and their N-oxides, including the drugs trimethoprim and minoxidil, are reported. The syntheses of several pyrimidine-2,4-diamine N-oxides are described. This study involved multiple reactions and reactants, such as 2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4Application of 35139-67-4).

35139-67-4;2,6-Diamino-4-chloropyrimidine-1-oxide;The future of 35139-67-4;New trend of C4H5ClN4O;function of 35139-67-4

von Angerer, S. et al. published their research in Science of Synthesis in 2004 | CAS: 35139-67-4

2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.Quality Control of 2,6-Diamino-4-chloropyrimidine-1-oxide

Product class 12: pyrimidines was written by von Angerer, S.. And the article was included in Science of Synthesis in 2004.Quality Control of 2,6-Diamino-4-chloropyrimidine-1-oxide The following contents are mentioned in the article:

A review. Methods for preparing pyrimidines are reviewed including cyclization, ring transformation, aromatization and substituent modification. This study involved multiple reactions and reactants, such as 2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4Quality Control of 2,6-Diamino-4-chloropyrimidine-1-oxide).

35139-67-4;2,6-Diamino-4-chloropyrimidine-1-oxide;The future of 35139-67-4;New trend of C4H5ClN4O;function of 35139-67-4

Vorbrueggen, Helmut et al. published their research in Organic Reactions (Hoboken, NJ, United States) in 2000 | CAS: 56632-83-8

4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Reference of 56632-83-8

Synthesis of nucleosides was written by Vorbrueggen, Helmut; Ruh-Pohlenz, Carmen. And the article was included in Organic Reactions (Hoboken, NJ, United States) in 2000.Reference of 56632-83-8 The following contents are mentioned in the article:

A review of the article Synthesis of nucleosides. This study involved multiple reactions and reactants, such as 4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8Reference of 56632-83-8).

56632-83-8;4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one;The future of 56632-83-8;New trend of C9H12FN3O4;function of 56632-83-8

Machida, Haruhiko et al. published their research in Microbiology and Immunology in 1990 | CAS: 69256-17-3

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.SDS of cas: 69256-17-3

Antiviral potencies of BV-araU and related nucleoside analogs against varicella-zoster virus in different cell lines was written by Machida, Haruhiko; Ijichi, Katsushi; Ohta, Arihito; Honda, Mariko; Niimura, Michihito. And the article was included in Microbiology and Immunology in 1990.SDS of cas: 69256-17-3 The following contents are mentioned in the article:

The nucleoside analog 1-β-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil (BV-araU) and 9 other anti-herpes nucleoside analogs were compared for their potencies against 4 strains of varicella-zoster virus (VZV) on 3 different cell lines: HEL cells, Vero cells, and MS cells established from a human malignant schwannoma. In contrast to the activity against herpes simplex virus type 1 previously reported, BV-araU showed extremely marked antiviral activity against VZV even on Vero cells. ED50, 50% plaque reduction dose, of BV-araU for VZV was 0.20-3.1 and 0.14-0.63 ng/mL on Vero cells and on HEL cells, resp. Potency of BV-araU on MS cells was similar to that on these cell lines. There was no variation in anti-VZV activity of the other nucleoside analogs on these 3 different cell lines except for a few combinations of VZV strain and test compound This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3SDS of cas: 69256-17-3).

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.SDS of cas: 69256-17-3

69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3

Ding, Cungang et al. published their research in Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences in 2012 | CAS: 69256-17-3

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they constitute an important class of natural and synthetic compounds exhibiting diverse useful biological activities that hold attractive potential for clinical translation as therapeutic agents in alleviation of a myriad of diseases. Pyrimidine derivatives have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.Formula: C10H13FN2O5

Normal-phase liquid chromatography coupled with electrospray ionization mass spectrometry for chiral separation and quantification of clevudine and its enantiomer in human plasma was written by Ding, Cungang; Ge, Qinghua; Wang, Yemu; Zhou, Zhen; Zhi, Xiaojin; Liu, Xiaofen; Li, Zhou. And the article was included in Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences in 2012.Formula: C10H13FN2O5 The following contents are mentioned in the article:

A new, simple, and enantioselective normal-phase liquid chromatog.-mass spectrometry method was presented for the quantification of clevudine and its enantiomer in human blood plasma. A C18 cartridge was used in this method to extract the enantiomers in 200 μL plasma followed by a chiral separation on a cellulose-based LC column with mobile phase consisted of hexane, MeOH, and EtOH (62:28:10, V/V/V). The eluate was directed to a mass spectrometry through an electrospray ionization interface. A transition of m/z 261.0 to m/z 126.8 was used for monitoring of clevudine and its enantiomer. This method showed good linearity (R > 0.997), precision (<9.6%), and accuracy (within 95.48-105.9%) within a range of 10-1000 ng/mL for the enantiomers and was applied to the pharmacokinetics study of clevudine capsules in human plasma. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3Formula: C10H13FN2O5).

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they constitute an important class of natural and synthetic compounds exhibiting diverse useful biological activities that hold attractive potential for clinical translation as therapeutic agents in alleviation of a myriad of diseases. Pyrimidine derivatives have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.Formula: C10H13FN2O5

69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3

Lin, J. C. et al. published their research in International Congress Series in 1985 | CAS: 69256-17-3

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.SDS of cas: 69256-17-3

Effects of nucleoside analogs in inhibition of Epstein-Barr virus was written by Lin, J. C.; Nelson, D. J.; Lambe, C. U.; Choi, E. I.; Pagano, J. S.. And the article was included in International Congress Series in 1985.SDS of cas: 69256-17-3 The following contents are mentioned in the article:

The relative antiviral potency of several nucleoside analogs against Epstein-Barr virus infection in P3HR-1 cells was 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodocytosine (I) [69123-90-6] = 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodouracil (II) [69123-98-4] > 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-thymine (III) [69256-17-3] > BW B759U (IV) [82410-32-0] > E-5-(2-bromovinyl)-2′-deoxyuridine (V) [69304-47-8] > acyclovir (VI); the relative therapeutic efficacy (ratio of cytotoxicity to antiviral potency) was V > IV > I > VI > II > III. IV was rapidly and markedly phosphorylated by virus-infected Raji cells; this effect was 100-fold greater than for VI. The results are discussed with respect to the prolonged inhibitory action of the nucleoside analogs against Epstein-Barr virus replication. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3SDS of cas: 69256-17-3).

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.SDS of cas: 69256-17-3

69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3

McLaren, C. et al. published their research in International Congress Series in 1985 | CAS: 69256-17-3

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Computed Properties of C10H13FN2O5

Preclinical investigations of FIAU, an anti-herpes agent was written by McLaren, C.; Chen, M. S.; Barbhaiya, R. H.; Buroker, R. A.; Oleson, F. B.. And the article was included in International Congress Series in 1985.Computed Properties of C10H13FN2O5 The following contents are mentioned in the article:

The pharmacol. of FIAU (I) [69123-98-4] as an anti-herpes agent is described in relation to that of FIAC (II) [69123-90-6] and FMAU (III) [69256-17-3]. The mechanism of action of I is dependent on selective inhibition of viral thymidine kinase [9002-06-6]. The I monophosphate [99891-31-3] and III monophosphate [94344-82-8] had better affinities for cellular thymidylate kinase [9014-43-1] than for herpes simplex virus thymidine/thymidylate kinases. However, II monophosphate [99876-43-4] had poor affinities for either the cellular or herpes simplex virus enzymes. In cells exposed to 14C-labeled II, I monophosphate was the major metabolite, indicating that II is converted to the more active agent, I. I appeared to have good activity, but it had cardiotoxic and myelosuppressive activities. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3Computed Properties of C10H13FN2O5).

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Computed Properties of C10H13FN2O5

69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3

Fox, J. J. et al. published their research in International Congress Series in 1985 | CAS: 69256-17-3

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Application of 69256-17-3

Antiviral activities of some newer 2′-fluoro-5-substituted arabinosylpyrimidine nucleosides was written by Fox, J. J.; Watanabe, K. A.; Schinazi, R. F.; Lopez, C.. And the article was included in International Congress Series in 1985.Application of 69256-17-3 The following contents are mentioned in the article:

The inhibitory activity of the title compounds I (R = Me, Et, CH:CHBr, CH:CHI, I; X = NH or O) against herpes simplex virus in in vitro assays in Vero cells was determined Cytotoxicity was also determined The uracil nucleosides showed better therapeutic indexes than the corresponding cytosine analogs. The 5-Me analogs were more effective but also more cytotoxic than the corresponding 5-Et analogs. In mice with herpes simplex virus infections, 2′-fluoro-5-ethylarabinosyluracil [83546-42-3] and 2′-fluoro-5-methylarabinosyluracil [69256-17-3] were effective in decreasing mortality without any toxic effects. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3Application of 69256-17-3).

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Application of 69256-17-3

69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3