Analyzing the synthesis route of 54-20-6

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 54-20-6.

Some common heterocyclic compound, 54-20-6, molecular formula is C5H3F3N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.54-20-6

EXAMPLE 9 Into a mixture of 5.0 g of 5-trifluoromethyluracil, 2.9 g of 2,3-dihydrofuran and 0.3 g of triethylamine in 40 ml of dioxane kept at 15 C. under agitation was added 7.5 g of dimethyldichlorosilane as a portion and the reaction was continued for about 2 hours with agitation. The treatment procedure after completion of the reaction was much the same as in Example 1 to give 5.0 g of a crystalline product of N1 -(2-tetrahydrofuryl)-5-trifluoromethyluracil having a melting point of 208 C. The yield was 72.0% of the theoretical.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 54-20-6.

Reference:
Patent; Toshin Chemical Co., Ltd.; US4159378; (1979); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Some scientific research about 62802-42-0

According to the analysis of related databases, 62802-42-0, the application of this compound in the production field has become more and more popular.

62802-42-0 ,Some common heterocyclic compound, 62802-42-0, molecular formula is C4H2ClFN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A large microwave vial was charged with potassium (2Z)-2-buten-2-yltrifluoroborate (Sigma- Aldrich, 900 mg, 5.6 mmol), potassium phosphate (3.54 g, 16.7 mmol) and 2-chloro-5- fluoro-pyrimidine (686 ^L, 5.6 mmol). DMF (10 mL) and water (2 mL) were added and the mixture was deoxygenated with an Ar stream. Tetrakis(triphenylphosphine)palladium (642 mg, 0.56 mmol) was added, and the slurry was again deoxygentaed with an Ar stream. The vial was then capped and heated in the microwave at 95 C for 12 h. The reaction mixture was then partitioned between water (60 mL) and diethyl ether (2X). The combined organic layers were washed with water (1X) and brine (1X), dried over anhydrous sodium sulfate, and concentrated in vacuo. The residue was purified by silica gel chromatography (eluent: pure DCM) to provide 403.1 (476 mg, 56% yield) as a light yellow oil. LCMS-ESI (pos.) m/z: 153.2 (M+H)+.

According to the analysis of related databases, 62802-42-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; AMGEN INC.; CHEN, Ning; CHEN, Xiaoqi; CHEN, Yinhong; CHENG, Alan C.; CONNORS, Richard V.; DEIGNAN, Jeffrey; DRANSFIELD, Paul John; DU, Xiaohui; FU, Zice; HARVEY, James S.; HEATH, Julie Anne; HEUMANN, Lars V.; HORNE, Daniel B.; HOUZE, Jonathan; KALLER, Matthew R.; KAYSER, Frank; KHAKOO, Aarif Yusuf; KOPECKY, David J.; LAI, Su-Jen; MA, Zhihua; MEDINA, Julio C.; MIHALIC, Jeffrey T.; NISHIMURA, Nobuko; OLSON, Steven H.; PATTAROPONG, Vatee; SWAMINATH, Gayathri; WANG, Xiaodong; WANSKA, Malgorzata; YANG, Kevin; YEH, Wen-Chen; (700 pag.)WO2018/97945; (2018); A1;,
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Application of 93366-88-2

At the same time, in my other blogs, there are other synthetic methods of this type of compound,93366-88-2, 7H-Pyrrolo[2,3-d]pyrimidin-2-amine, and friends who are interested can also refer to it.

93366-88-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 93366-88-2, name is 7H-Pyrrolo[2,3-d]pyrimidin-2-amine. A new synthetic method of this compound is introduced below.

7H-pyrrolo[2,3-d]pyrimidin-2-amine (388 mg, 2.90 mmol), 4-bromo-2-iodo-1-methoxybenzene (2.56 g, 8.64mmol), potassium carbonate (1.66) Mg, 12.03 mmol) and valine (83 mg, 0.72 mmol) were added to an eggplantflask, dimethyl sulfoxide was added, and the reaction solution was deoxidized. Copper iodide (60 mg, 0.31mmol) was added and the reaction solution was deoxygenated. Heat to 90C and stir for 16 hours. After the reaction was completed, it was cooled to room temperature, water and ethyl acetate were added, and the mixturewas filtered over Celite. The target compound was obtained in 60 mg.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,93366-88-2, 7H-Pyrrolo[2,3-d]pyrimidin-2-amine, and friends who are interested can also refer to it.

Reference:
Patent; Chinese Academy Of Sciences Shanghai Pharmaceutical Institute; Zhao Yujun; Li Zhiqiang; Yan Ziqin; Li Jia; Zhou Yubo; Su Mingbo; Chen Zheng; (138 pag.)CN109810110; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Brief introduction of 7504-94-1

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 7504-94-1, 2-Hydrazinylpyrimidine.

7504-94-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 7504-94-1, name is 2-Hydrazinylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

After adding 230 mg of 2-hydrazinopyrimidine and 293 mul of triethylamine to a 50 ml DMF solution containing 983 mg of {2-(3-ethoxy-4-methoxyphenyl)-2-[4-(5-methyl-[1,2,4]oxadiazol-3-yl)phenylimino]-1-methylsulfanylethylidene}carbamic acid methyl ester, the mixture was stirred at 85 C. for 10 hours under a nitrogen atmosphere. The reaction mixture was concentrated, and the residue was dissolved in 30 ml of a methanol_THF=1:1 mixed solvent. After adding 420 mul of acetic acid and 657 mg of sodium cyanotrihydroborate to the reaction mixture, it was stirred at room temperature for 5 hours. Ethyl acetate was added to the reaction mixture which was then filtered through a small amount of NAM silica gel, and the silica gel was washed with ethyl acetate-methanol. The filtrate was concentrated under reduced pressure, and the residue was purified by NAM silica gel column chromatography (methanol-ethyl acetate) to give the title compound (400 mg) as a light yellow solid. 1H-NMR (CDCl3) delta 1.32 (t, J=7.2 Hz, 3H) 2.58 (s, 3H) 3.80 (s, 3H) 3.90 (q, J=7.2 Hz, 2H) 5.77 (d, J=7.2 Hz, 1H) 6.77 (d, J=8.8 Hz, 1H) 6.83 (d, J=8.8 Hz, 2H) 7.12-7.17 (m, 3H) 7.81 (d, J=8.8 Hz, 2H) 8.69 (d, J=4.8 Hz, 2H)

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 7504-94-1, 2-Hydrazinylpyrimidine.

Reference:
Patent; Eisai R&D Management Co., Ltd.; US2008/15199; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The origin of a common compound about 3934-20-1

The chemical industry reduces the impact on the environment during synthesis 3934-20-1, I believe this compound will play a more active role in future production and life.

3934-20-1, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 3934-20-1 as follows.

Phenylboronic acid (1 eq) and 2,4-dichloropyrimidine (1 eq) were added to tetrahydrofuran, to which 10% sodium bicarbonate (1 eq) was added. Nitrogen was bubbled into the mixture to remove oxygen while the reaction mixture was well stirred. 0.05 equivalent of palladium tetrakis was added to the mixture and stirred well. The mixture was then refluxed under a stream of nitrogen for 24 hours. After the reaction was complete, the mixture was worked up with ethyl acetate and water to give a crude yellow solid. The solid was purified by column chromatography to give white solid crystals. TLC was observed at Rf: 05 (ethyl acetate: hexane)

The chemical industry reduces the impact on the environment during synthesis 3934-20-1, I believe this compound will play a more active role in future production and life.

Reference:
Patent; CHUNGNAM NATIONAL UNIVERSITY INDUSTRY & ACADEMIC COOPERATION (IAC); JUNG, SANG HUN; WOO, SUN HEE; KIM, SANG KYUM; JEON, EUN SEOK; LEE, YOU JUNG; MANICKAM, MANOJ; JALANI HITESHKUMAR, HITESHKUMAR; SHARMA, NITI; (234 pag.)KR2015/111825; (2015); A;,
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Sources of common compounds: 871254-61-4

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 871254-61-4.

Adding some certain compound to certain chemical reactions, such as: 871254-61-4, name is 2,4-Dichloropyrimidine-5-carbaldehyde, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 871254-61-4. 871254-61-4

Example 18 6-Chloro-1H-pyrazolo[3,4-d]pyrimidine To a stirred solution of hydrazine (Aldrich, 64 mg, 2 mmol) in THF (5 mL), 2,4-Dichloro-pyrimidine-5-carbaldehyde (Example 17, 176 mg, 1 mmol) was added and the mixture was stirred at room temperature for 30 min. The mixture was poured into water and extracted with EtOAc. The extract was dried with sodium sulfate and the solvent was removed to give an orange solid. 128 mg, 82%. MS (M+H)+, 155.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 871254-61-4.

Reference:
Patent; Ding, Qingjie; Jiang, Nan; Roberts, John Lawson; US2005/277655; (2005); A1;,
Pyrimidine | C4H4N2 – PubChem,
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A new synthetic route of 934524-10-4

At the same time, in my other blogs, there are other synthetic methods of this type of compound,934524-10-4, 2,4-Dichloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine, and friends who are interested can also refer to it.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 934524-10-4, name is 2,4-Dichloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine. A new synthetic method of this compound is introduced below., 934524-10-4

To a solution of the 2,4-dichloro-N-tosylpyrrolopyrimidine 3 (1.00 g, 2.92 mmol) in 1,4-dioxane (40 mL) and H2O (10 mL) was added phenylboronic acid (430 mg, 3.50 mmol) and Na2CO3 (620 mg, 5.84 mmol), and the mixture was degassed under argon. To this mixture was added Pd(PPh3)4 (100 mg, 6 mol %) and the reaction mixture was heated at reflux for 1 h, then cooled to room temperature and the solvent was removed in vacuo. The residue was dissolved in EtOAc (50 mL) and washed with H2O (2 * 30 mL), brine (2 * 30 mL), dried, filtered and the solvent was removed in vacuo to give a yellow residue. The residue was purified by flash chromatography (10% EtOAc/Hexanes) and recrystallised from EtOH to give 5d (600 mg, 55%) as a white solid; mp 151-155 C; deltaH (CDCl3): 8.14 (2H, d, J 8.0 Hz), 7.97 (2H, dd, J 6.0, 2.0 Hz), 7.75 (1H, d, J 4.0 Hz), 7.52-7.51 (3H, m), 7.34 (2H, d, J 8.0 Hz), 6.87 (1H, d, J 4.0 Hz), 2.41 (3H, s); deltaC (CDCl3): 160.6, 155.3, 152.9, 146.3, 136.0, 134.2, 131.1, 129.9, 129.0, 128.8, 127.1, 116.3, 104.1, 21.7; m/z (ESI): 384.0 (M[35Cl]H+), 386.0 (M[37Cl]H+); HRMS (ESI): M[35Cl]H+, found 384.0567. C19H15ClN3O2S+ requires 384.0569.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,934524-10-4, 2,4-Dichloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine, and friends who are interested can also refer to it.

Reference:
Article; O’Brien, Nathan J.; Brzozowski, Martin; Buskes, Melissa J.; Deady, Leslie W.; Abbott, Belinda M.; Bioorganic and Medicinal Chemistry; vol. 22; 15; (2014); p. 3879 – 3886;,
Pyrimidine | C4H4N2 – PubChem,
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Application of 5413-85-4

According to the analysis of related databases, 5413-85-4, the application of this compound in the production field has become more and more popular.

5413-85-4 , The common heterocyclic compound, 5413-85-4, name is 5-Amino-4,6-dichloropyrimidine, molecular formula is C4H3Cl2N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

2C. 5,6-Diamino-4-chloropyrimidine; A mixture of 4,6-dichloro-5-aminopyrimidine (Aldrich Chemical Co.) (2.0 g, 12.2 mmol) and concentrated aqueous ammonia (20 ml) was heated to 100 0C in a sealed glass tube with vigorous stirring for 18 hours. The cooled tube was recharged with concentrated aqueous ammonia (8 ml), aggregates were broken up, and the mixture was reheated at 100 0C for a further 28 hours. The mixture was evaporated to dryness and the solids were washed with water (20 ml) and dried to give the product as yellow crystals (1.71 g, 97percent). LC/MS (LCTl): Rt 1.59 [M+H]+ 147, 145.

According to the analysis of related databases, 5413-85-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ASTEX THERAPEUTICS LIMITED; THE INSTITUTE OF CANCER RESEARCH:ROYAL CANCER HOSPITAL; CANCER RESEARCH TECHNOLOGY LIMITED; ASTRAZENECA AB; WO2008/75110; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Analyzing the synthesis route of 135481-57-1

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,135481-57-1, its application will become more common.

135481-57-1, Adding a certain compound to certain chemical reactions, such as: 135481-57-1, 6-Benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 135481-57-1, blongs to pyrimidines compound.

6-Benzyl-5,6,7,8-tetrahydropyrido-[4,3-d]pyrimidine-2,4 (1H, 3H) -dione (30.0 g, 0.116 mol) prepared according to Process Step 1 was mixed with phosphorus oxychloride (300 mL), followed by stirring with heating for five hours. After checking the completion of the reaction by thin layer chromatography, excess phosphorus oxychloride was distilled off under reduced pressure. The residue was mixed with isopropyl alcohol (300 mL) for crystallization. The suspension containing the precipitated crystals was stirred under reflux for one hour and was further stirred at room temperature for one hour. The precipitated crystals were collected by filtration, were dried under reduced pressure and thereby yielded 6-benzyl-2,4-dichloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimid ine hydrochloride (33 g, in a yield of 85%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,135481-57-1, its application will become more common.

Reference:
Patent; KYOWA HAKKO KOGYO CO., LTD.; EP1552842; (2005); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

A new synthetic route of 2435-50-9

According to the analysis of related databases, 2435-50-9, the application of this compound in the production field has become more and more popular.

2435-50-9 ,Some common heterocyclic compound, 2435-50-9, molecular formula is C5H4N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: SI, Figure 4. General procedure of the reductive amination reactions: synthesis of AA9-AA24 compounds (Tables 1 and 2). The ethyl 3-amino-4-(cyclohexylamino)benzoate (AA1) and derivatives (1 equiv.)and benzaldehyde (1 equiv) were heated in DCE for 1h at 80 oC in the presence of molecular sieves (4 A), then the mixture was cooled down to room temperature before addition of the NaBH(OAc)3 (1.6 equiv.) in small portions over 3h. The reaction mixture was stirred at room temperature under a nitrogen atmosphere for 17h. The reaction mixture was quenched with aqueous saturated NaHCO3, and the product was extracted with EtOAc. The EtOAc extract was dried (MgSO4), and the solvent was evaporated. The residue was purified by flash-column chromatography on silica gel, using a mixture of solvent of DCM: MeOH (50:1), to provide the desired AA9-AA24 compounds (Tables 1-2).

According to the analysis of related databases, 2435-50-9, the application of this compound in the production field has become more and more popular.

Reference:
Article; Iniguez, Eva A.; Perez, Andrea; Maldonado, Rosa A.; Skouta, Rachid; Bioorganic and Medicinal Chemistry Letters; vol. 25; 22; (2015); p. 5315 – 5320;,
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