Synthetic Route of 90905-31-0 ,Some common heterocyclic compound, 90905-31-0, molecular formula is C6H6N2OS, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Step 1 To a solution of Intermediate 2 (400 mg, 1.39 mmol) in dry THF (10.0 mL) under nitrogen at -78 °C was added nBuLi (1.5 mL, 3.76 mmol, 2.7 eq.) dropwise and the solution stirred at -78 °C for 1h. 2-(methylsulfanyl)pyrimidine-5-carbaldehyde (236 mg, 1.53 mmol, 1.1 eq.) was dissolved in dry THF (2.0 mL) and then added. Reaction left at -78 °C for 45 minutes and was then quenched with water (~20 mL). Concentrated and then partitioned between EtOAc (30 mL) and water (30 mL). Organic phase was washed with water (30 mL) and brine (10 mL) before it was dried (MgS04), filtered and concentrated to give crude material (~520 mg), which was used in Step 2 without further purification, m/z: 441 .
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 90905-31-0, 2-(Methylthio)pyrimidine-5-carbaldehyde, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ASTEX THERAPEUTICS LIMITED; WOODHEAD, Andrew James; HAMLETT, Christopher Charles Frederick Hamlett; BESONG, Gilbert Ebai; CHESSARI, Gianni; CARR, Maria Grazia; MILLEMAGGI, Alessia; NORTON, David; SAALAU-BETHELL, Susanne Maria; WILLEMS, Hendrika Maria Gerarda; THOMPSON, Neil Thomas; HISCOCK, Steven Douglas; WO2013/64543; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia