Adding a certain compound to certain chemical reactions, such as: 87591-74-0, 2-(Chloromethyl)-6-methyl-4H-pyrido[1,2-a]pyrimidin-4-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 2-(Chloromethyl)-6-methyl-4H-pyrido[1,2-a]pyrimidin-4-one, blongs to pyrimidines compound. Safety of 2-(Chloromethyl)-6-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
A solution of 1H-benzo[d]imidazole (58.9 mg, 0.499 mmol), 2-(chloromethyl)-6-methyl-4H-pyrido[1,2-a]pyrimidin-4-one (CAS 87591-74-0, 104.9 mg, 0.503 mmol), and powdered potassium carbonate (104.9 mg, 0.759 mmol) in DMF (2.50 mL) was stirred in a sealed tube at room temperature for 64 hours. The solution was diluted with methanol to 5 mL, filtered, and purified by reverse-phase HPLC to give 8 (32.07 mg, 22%) as a white solid. 1H NMR (400 MHz, DMSO-d6) ppm 2.88 (s, 3 H) 5.43 (s, 2 H) 5.81 (s, 1 H) 6.91 (d, J=6.82 Hz, 1 H) 7.19 – 7.27 (m, 2 H) 7.33 – 7.37 (m, 1 H) 7.54 – 7.59 (m, 1 H) 7.63 – 7.70 (m, 2 H) 8.35 (s, 1 H). HRMS: [M+H]+ calc. 291.124038, found 291.12374, error -1.02 ppm.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,87591-74-0, 2-(Chloromethyl)-6-methyl-4H-pyrido[1,2-a]pyrimidin-4-one, and friends who are interested can also refer to it.
Reference:
Article; Guo, Chuangxing; Linton, Angelica; Jalaie, Mehran; Kephart, Susan; Ornelas, Martha; Pairish, Mason; Greasley, Samantha; Richardson, Paul; Maegley, Karen; Hickey, Michael; Li, John; Wu, Xin; Ji, Xiaodong; Xie, Zhi; Bioorganic and Medicinal Chemistry Letters; vol. 23; 11; (2013); p. 3358 – 3363;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia