Category: 831203-15-7

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 831203-15-7, name is 2-(5-Bromopyrimidin-2-yl)acetonitrile. This compound has unique chemical properties. The synthetic route is as follows. name: 2-(5-Bromopyrimidin-2-yl)acetonitrile

General procedure: The title compound of this step was prepared by the method described in Example 1, Step 3,2- (5-bromopyrimidin-2-yl) acetonitrile (0.724 g, 3.66 mmol), 4-chloro-2-fluorophenylboronic acid (0.829 g, 4.75 mmol)Potassium carbonate (1.517 g, 10.98 mmol),Tetrakis (triphenylphosphine) palladium (0.338 g, 0.292 mmol)In toluene (15 mL) with nitrogen at 100 C for 15 hours.The crude product was directly purified by silica gel column chromatography (petroleum ether / ethyl acetate (v / V) = 5/1)The compound (orange solid, 563 g, 62.2%)

With the rapid development of chemical substances, we look forward to future research findings about 831203-15-7.

Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Jin Chuanfei; Wei Dehuo; Xue Yaping; Zhang Yingjun; (44 pag.)CN106674207; (2017); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 831203-15-7, name is 2-(5-Bromopyrimidin-2-yl)acetonitrile. This compound has unique chemical properties. The synthetic route is as follows. name: 2-(5-Bromopyrimidin-2-yl)acetonitrile

At room temperature, under a nitrogen atmosphere,(5-bromopyrimidin-2-yl) acetonitrile (150 mg, 0.76 mmol),1-octyne (167 mg, 1.51 mmol),PdCl2 (13 mg, 0.08 mmol),Triphenylphosphine (40 mg, 0.15 mmol),CuI (7 mg, 0.04 mmol),Triethylamine (0.81 ml) and THF (1.8 ml) were added and the mixture was stirred at 40 C. for 3 hours.Thereafter, filtration with celite was carried out, and the filtrate was concentrated under reduced pressure to obtain a crude product. The obtained crude product was purified using thin layer column chromatography (hexane: ethyl acetate = 2: 1) to obtain [5- (1-octynyl) pyrimidin-2-yl] acetonitrile. Yield 138 mg, yield 80%, yellow liquid.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 831203-15-7, 2-(5-Bromopyrimidin-2-yl)acetonitrile.

Reference:
Patent; NIPPON STEEL & SUMIKIN CHEMICAL COMPANY LIMITED; KYUSHU INSTITUTE OF TECHNOLOGY; NAGAHAMA, TAKUO; KAWADA, ATSUSHI; TAKASHIMA, WATARU; OKAUCHI, TATSUO; NAGAMATSU, SHUICHI; (69 pag.)JP2017/178911; (2017); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 831203-15-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.831203-15-7, name is 2-(5-Bromopyrimidin-2-yl)acetonitrile, molecular formula is C6H4BrN3, molecular weight is 198.02, as common compound, the synthetic route is as follows.

To a solution of 2-(5-bromopyrimidin-2-yl)acetonitrile (S2, 1 equiv) in DMF/H2O (9:1, 10 vol) was added compound S1 (1 equiv), K2CO3(2 equiv), and tetrakis(triphenylphosphine)palladium (0.1 equiv). The reaction mixture was stirred at 90 C. for 5 h and then concentrated under reduced pressure. The remaining residue was purified by column chromatography on silica gel to give compound S3.

Statistics shows that 831203-15-7 is playing an increasingly important role. we look forward to future research findings about 2-(5-Bromopyrimidin-2-yl)acetonitrile.

Reference:
Patent; ACHILLION PHARMACEUTICALS, INC.; WILES, Jason, Allan; PHADKE, Avinash, S.; DESHPANDE, Milind; AGARWAK, Atul; CHEN, Dawei; GADHACHANDA, Venkat, Rao; HASHIMOTO, Akihiro; PAIS, Godwin; WANG, Qiuping; WANG, Xiangzhu; (905 pag.)WO2017/35353; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 831203-15-7 ,Some common heterocyclic compound, 831203-15-7, molecular formula is C6H4BrN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Add acetic anhydride (2.50 g, 23.7 mmol) to a solution of2-(5-bromopyrimidin-2yl)acetonitrile (950 mg, 4.75 mmol) and triethyl orthoformate (3 mL, 17.7 mmol), the reaction mixture is stirred at 120 oc for 5 h. The reaction mixture is concentrated to afford 10 title compound (0.96 g, 79.6%) as brown crude. LCMS (m/z): 255.9 [M+Ht.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 831203-15-7, 2-(5-Bromopyrimidin-2-yl)acetonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ELI LILLY AND COMPANY; LILLY CHINA RESEARCH AND DEVELOPMENT CO., LTD.; MA, Tianwei; WU, Liang; ZHANG, Xuejun; (109 pag.)WO2019/41340; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 831203-15-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 831203-15-7, name is 2-(5-Bromopyrimidin-2-yl)acetonitrile. This compound has unique chemical properties. The synthetic route is as follows.

A solution of 2- (5-bromopyrimidin-2-yl) acetonitrile (0.1 (^, 0.50%)4-fluorophenylboronic acid (0.088, 0.601111111)Potassium carbonate (0.21 g, 1.50 mmol),Tetrakis (triphenylphosphine) palladium (0.3 g, 0.30 mmol)And toluene (10 mL) were successively added to a 50 mL reaction flask,The reaction was carried out with nitrogen and the reaction was carried out at 100 C for 8 hours.The reaction was quenched and the solvent was removed by distillation under reduced pressure. The remaining solid was extracted with dichloromethane (10 mL X), washed with organic phase, saturated brine (20 mL) and dried over anhydrous sodium sulfate. The solvent was removed by distillation under reduced pressure. The title compound (white solid, 0.088, 80.1%) was obtained by silica gel column chromatography (petroleum ether / acetone (nu / nu) = 20/1)

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 831203-15-7, 2-(5-Bromopyrimidin-2-yl)acetonitrile.

Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Jin Chuanfei; Wei Dehuo; Xue Yaping; Zhang Yingjun; (44 pag.)CN106674207; (2017); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia