Category: 799842-07-2

Synthetic Route of 799842-07-2 , The common heterocyclic compound, 799842-07-2, name is N-[5-Bromomethyl-4-(4-fluorophenyl)-6-isopropylpyrimidine-2-yl]-N-methylmethane sulfonamide, molecular formula is C16H19BrFN3O2S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example-3Preparation of N-[4-(4-FIuoro-phenyl)-6-isopropyI-5-(pyridin-2-ylsulfanylmethyl)- pyrimidin-2-yI]-N-methyl-methanesulfonamide (III)2-mercaptopyridine (II) 3.23g was taken in 16mL tetrahydrofuran and chilled to -25 to -30 C and added 30% n-butyl lithium(l 1.OmL) drop wise at -5 to -10 C and stirred at the same temperature for one hour. Added N-[5-Bromomethyl-4-(4-fluoro-phenyl)-6- isopropyl-pyrimidin-2-yl]-N-methyl-methanesulfonamide (11. Og) dissolved in 22 mL THF at -60 C to -700C drop wise and stirred for 15 minutes at -60 to-70 C. Slowly brought the temperature to 250C and stirred for 2 h. Adjusted the pH of the reaction mixture to 7-8 with saturated ammonium chloride and added 5OmL ethyl acetate and separated the layers. Organic layer was given water washes and a brine wash. Organic layer was dried over anhydrous sodium sulphate and concentrated to get solid N-[4-(4- Fluoro-phenyl)-6-isopropyl-5-(pyridin-2-ylsulfanylmethyl)-pyrimidin-2-yl]-N-methyl- methanesulfonamide (V) Yield: 11. Og

The synthetic route of 799842-07-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BIOCON LIMITED; ANEGONDI, Sreenivasa, Prasad; RAJMAHENDRA, Shanmughasamy; JOSEPH, Jibin; SRINIVAS, Pullela, Venkata; WO2010/23678; (2010); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 799842-07-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 799842-07-2, name is N-[5-Bromomethyl-4-(4-fluorophenyl)-6-isopropylpyrimidine-2-yl]-N-methylmethane sulfonamide. A new synthetic method of this compound is introduced below.

Example 3: Preparation of N-[4-(4-fluoro-phcnyl)-6-isopropyl-5-(4-mcthyl-4i1-[1,2,41 triazol-3-ylsulfanylmethyl)pyrimidin-2-yll -N-methyl-methane-sulfonamide Method A: To a solution of 4-methyl-4H-{l,2,4triazole-3-thiol (7.62g) in ethyl acetate (250ml), potassium carbonate (20g) was added and the reaction rnixtur was stirred for 30minutes at 25 to 30C. N-[5-Bromomethyl-4-(4-fluorophnyl)-6?-isopropylpyrimidin-2-yl]-N-methyl-methane sulfonamide (25g) was added and temperature was raised to 30 to 35C and stirred for 4 hours; After completion of reaction, the reaction mass was quenched with water (200m1). The organic-layer was separated and aqueous layer was extracted with ethyl acetate. The combined organic layer was washed with brine, dried on anhydrous sodium sulphate andconcentrated. Isopropyl ether (SUm) was added to the residue and stirred for 30 minutes at 25-30C and the resulting solid was filtered, washed with diisopropyl ether and dried to give (27g)of title compound which is characterizedby ?H-NMR and mass spectra.1H-NMR, (400 MHz, CDCI3, ppm): 1.34 (d, 6H), 3.50 (s, 4H), 3.53 (s, 6H), 4.50 (s, 2H), 7.12(dd, 2H), 7.65 (dd, 2H), 8.19 (s, 1H);Mass (M+1)45l amu

At the same time, in my other blogs, there are other synthetic methods of this type of compound,799842-07-2, N-[5-Bromomethyl-4-(4-fluorophenyl)-6-isopropylpyrimidine-2-yl]-N-methylmethane sulfonamide, and friends who are interested can also refer to it.

Reference:
Patent; IND-SWIFT LABORATORIES LIMITED; NAIK RAJESH VINODRAI; JAIN ANSHUL KUMAR; SARIN GURDEEP SINGH; SAINI VINAY KUMAR; KUMAR VIJAY; WO2015/37018; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia