Synthetic Route of 785777-87-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 785777-87-9, name is 2-Bromo-4-(trifluoromethyl)pyrimidine, molecular formula is C5H2BrF3N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
[0607] Synthesis of methyl 4-(trifluoromethyl) pyrimidine-2-carboxylate: [0608] To a stirred solution of 2-bromo-4-(trifluoromethyl) pyrimidine (800 mg, 3.52 mmol) in MeOH: CH3CN (4: 1, 5 mL) under argon atmosphere was added Pd(dppf)2Cl2 (503 mg, 0.70 mmol), triethyl amine (1.0 mL, 7.04 mmol) at RT; heated to 100 C and stirred for 16 h under CO pressure. The reaction was monitored by TLC; after completion of the reaction, the volatiles were removed in vacuo to obtain the crude. The crude was purified through silica gel column chromatography using 25% EtOAc/ Hexanes to afford methyl 4-(trifluoromethyl) pyrimidine-2-carboxylate (300 mg, 41%) as Light pink solid. [0609] 1H-NMR (CDCI3, 500 MHz): delta 9.20 (d, 1H), 7.82 (d, 1H), 4.10 (s, 3H); LC-MS: 96.04%; 207 (M++l); (column; X-bridge C-18, (50 3.0 mm, 3.5 mu); RT 2.48 min. 0.05% TFA (aq.): ACN; 0.8 mL/min); TLC: 50% EtOAc/ Hexanes (R 0.3).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 785777-87-9, 2-Bromo-4-(trifluoromethyl)pyrimidine.
Reference:
Patent; ENVIVO PHARMACEUTICALS, INC.; RIPKA, Amy; SHAPIRO, Gideon; MCRINER, Andrew, J.; BURSAVICH, Matthew, Gregory; WO2013/142269; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia