Electric Literature of 74840-47-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 74840-47-4, name is 5-Chloro-2-methylpyrimidine-4-carboxylic acid. This compound has unique chemical properties. The synthetic route is as follows.
A 4 mL Wheaton scintillation vial was charged with 280 pL of a 0.6 mlvi solution of 5- chloro-2-methylpyrimidine-4-carboxylic acid in N,N-dimethylacetamide (30.0 mg, 1.2 equivalents, 0.2 mmol), a 500 pL solution of 1-[bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5- b]pyridinium 3-oxid hexafluorophosphate in N,N-dimethylacetamide (58.5 mg, 1.1 equivalents, 0.15 mmol, HATU), a 500 pL solution of methyl 5-[(3-phenylpropyl)amino]pentanoate hydrochloride in N,N-dimethylacetamide (40.0 mg, 0.14 mmol, Example 149-Step 2), neat triethylamine (58.9 pL, 3 equivalents, 0.42 mmol), and a stir bar. This was capped with a white seal and microwave cap for an Anton Paar microwave reactor. The vial was heated in an Anton Paar Synthos 3000 parallel microwave optimizer for 15 minutes at 120 C. Upon completion, the reaction mixture was filtered, and the filtrate was concentrated to dryness under reduced pressure. The residue was then dissolved in 1000 pL of dioxane. To this, 1000 pL of a 1 M LiOH aqueous solution in 75% CH3OH was added. The mixture was then heated at 60 C for 1 hour. The reaction mixture was then filtered once more and concentrated under reduced pressure. The residue was re-dissolved in dimethyl sulfoxide/methanol and purified using preparative-HPLC to give the titled compound (42.3 mg, 73.6%). ?H NMR (400 MHz, DMSO-d6) ppm 8.72 (d, J = 35.5 Hz, 1H), 7.31 -7.08 (m, 4H), 6.97(a, J = 7.4 Hz, 1H), 3.52 – 3.41 (m, 2H), 3.09 – 3.05 (m, 1H), 2.66 (t, J = 7.6 Hz, 1H), 2.59 (a, J =23.0 Hz, 3H), 2.43 (t, J = 7.3 Hz, 1H), 2.26 (t, J = 6.9 Hz, 1H), 2.06 (t, J = 7.2 Hz, 1H), 1.94 (p, J =7.5, 6.9 Hz, 1H), 1.80 (dt, J = 13.0, 6.2 Hz, 2H), 1.70- 1.56 (m, 3H), 1.50 (q, J = 8.2, 7.8 Hz, 1H),1.35 (p, J = 6.8 Hz, 1H); MS (APCf) m/z 390.0 (M+H).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 74840-47-4, 5-Chloro-2-methylpyrimidine-4-carboxylic acid.
Reference:
Patent; ABBVIE INC.; BLACK, Lawrence, A.; BUNNELLE, William, H.; CHEN, Da; CLAPHAM, Bruce; DEGOEY, David, A.; DENG, Xiangjun; FU, Liqiang; HAZELWOOD, Lisa, A.; KONG, Linglong; LANG, Qingyu; LEE, Chih-Hung; LI, Mingfeng; LUNDGAARD, Greta, L.; PATEL, Meena, V.; TAO, Ruihong; ZHANG, Lin; ZHANG, Qingwei; ZHENG, Qiangang; ZHU, Wei; (289 pag.)WO2017/177004; (2017); A1;,
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