Category: 7399-93-1

Electric Literature of 7399-93-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 7399-93-1, name is Methyl 6-oxo-3,6-dihydropyrimidine-4-carboxylate, molecular formula is C6H6N2O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Step 1: Methyl 1-(1-(tert-butoxycarbonyl)-2,6-dioxopiperidin-3-yl)-6-oxo-1,6- dihydropyrimidine-4-carboxylate. (1511) tert-Butyl 3-bromo-2,6-dioxopiperidine-1-carboxylate (1.0 equiv.) and methyl 6-oxo-1,6- dihydropyrimidine-4-carboxylate (1.0 equiv.) are mixed in DMF (0.2M) and cesium carbonate is added (2.0 equiv.). The reaction mixture is stirred at 60 oC for 16 hours. The reaction mixture is partitioned between brine and ethyl acetate. The organic layer is dried with sodium sulfate, filtered and evaporated under reduced pressure. The crude residue is purified by silica gel column chromatography to afford methyl 1-(1-(tert-butoxycarbonyl)-2,6-dioxopiperidin-3-yl)-6-oxo-1,6- dihydropyrimidine-4-carboxylate.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 7399-93-1, Methyl 6-oxo-3,6-dihydropyrimidine-4-carboxylate.

Reference:
Patent; C4 THERAPEUTICS, INC.; PHILLIPS, Andrew, J.; NASVESCHUK, Chris, G.; HENDERSON, James, A.; LIANG, Yanke; CHEN, Chi-li; DUPLESSIS, Martin; HE, Minsheng; LAZARSKI, Kiel; (980 pag.)WO2017/197051; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 7399-93-1 ,Some common heterocyclic compound, 7399-93-1, molecular formula is C6H6N2O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example 96-Oxo-1,6-dihydropyrimidine-4-carbohydrazide; The subtitle compound of step 9A was stirred as a slurry in anhydrous methanol and hydrazine monohydrate (3 eq.) was added. The solid first dissolved but within 5 minutes the product started to precipitate. More methanol was added and the slurry was stirred at it overnight, filtered, washed with methanol, and dried in vacuo to give the title product (91%).1H NMR (400 MHz, DMSO-d6): delta 12.36 (broad s, 1H), 9.88 (s, 1H), 8.23 (s, 1H), 6.67 (s, 1H), 4.67 (s, 2H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 7399-93-1, Methyl 6-oxo-3,6-dihydropyrimidine-4-carboxylate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; AstraZeneca AB; US2009/111821; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia