73418-88-9 | Pyrimidines

A new synthetic route of 73418-88-9

At the same time, in my other blogs, there are other synthetic methods of this type of compound,73418-88-9, Methyl 5-aminopyrimidine-2-carboxylate, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 73418-88-9, Methyl 5-aminopyrimidine-2-carboxylate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of Methyl 5-aminopyrimidine-2-carboxylate, blongs to pyrimidines compound. Application In Synthesis of Methyl 5-aminopyrimidine-2-carboxylate

Methyl 5-aminopyrimidine-2-carboxylate (0.065 g, 0.425 mmol) and pyridine (0.172 mL, 2.123 mmol) were dissolved in DCM (2 mL). To this solution was added Intermediate I-141A (0.072 g, 0.212 mmol) as a solution in DCM (1 mL). The reactionmixture was allowed to stir for lh. The reaction mixture was concentrated under reducedpressure. Purified on ISCO using 0-100% EtOAc in hexanes to yield Intermediate 1-141(0.066 g, 0.145 mmol, 68.2 % yield) as a white solid. ?H NMR (400MHz, CDC13) 9.04(s, 2H), 7.87 (d, J=9.7 Hz, 1H), 6.94 (s, 1H), 5.56 (dd, J=6.5, 2.8 Hz, 1H), 5.38-5.17 (m,1H), 4.09 (s, 3H), 1.47 (d, J=6.4 Hz, 6H). LC-MS: method H, RT = 0.93 mm, MS (ESI)m/z: 456.0 (M+H)

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; ZHANG, Xiaojun; PRIESTLEY, Eldon Scott; BATES, J. Alex; HALPERN, Oz Scott; REZNIK, Samuel Kaye; RICHTER, Jeremy M.; (1137 pag.)WO2018/13774; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Brief introduction of Methyl 5-aminopyrimidine-2-carboxylate

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,73418-88-9, its application will become more common.

Reference of 73418-88-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 73418-88-9, name is Methyl 5-aminopyrimidine-2-carboxylate. A new synthetic method of this compound is introduced below.

Methyl 5-aminopyrimidine-2-carboxylate (10.29 mg, 0.067 mmol) and pyridine (0.049 mL, 0.611 mmol) were dissolved in DCM (2 mL) Intermediate 816C (0.030 g, 0.06 1 mmol) was added as a solution in DCM (1 mL). The reaction mixture was allowedto stir for 1 hour. The reaction mixture was concentrated under reduced pressure and purified on ISCO using 24 g column eluting with 0-100% EtOAc over 15 mm to yield Intermediate 816D (24.6 mg, 0.040 mmol, 66.3 % yield) as a pale yellow solid. ?HNIVIR (400MHz, CDC13) 8.47 (d, J=1.8 Hz, 3H), 8.44 (s, 1H), 7.91 (d, J10.3 Hz, 1H), 7.66 (s, 1H), 7.13 (s, 1H), 5.70-5.60 (m, 1H), 5.31 (br. s., 1H), 2.56 (s, 3H), 1.41 (d, J=6.8 Hz,5H), 1.17 (s, 3H), 0.07-0.11 (m, 6H). LC-MS. method H, RT = 1.27 mm, MS (ESI)m/z:608.0 (M+H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,73418-88-9, its application will become more common.