Category: 7033-39-8

Adding a certain compound to certain chemical reactions, such as: 7033-39-8, 5-Bromo-1,3-dimethylpyrimidine-2,4(1H,3H)-dione, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C6H7BrN2O2, blongs to pyrimidines compound. Formula: C6H7BrN2O2

Example 79; 5-(8-{ [(2,6-Dimethylphenyl)methyl] amino}-2,3-dimethylimidazo [1 ,2-a] pyridin-6- yl)-l,3-dimethyl-2,4(lNo.,3H)-pyrimidiiiedione hydrochlorideA mixture of iV-[(2,6-dimethylphenyl)methyl]-2,3-dimethyl-6-(4,4,5,5-tetramethyl- l,3,2-dioxaborolan-2-yl)imidazo[l,2-alpha]pyridin-8-amine ( ~1.4 mmol; crude product from Description 45) and 5-bromo-l,3-dimethyluracil (310 mg, 1.4 mmol) in 2M aqueous sodium carbonate (1.5 mL) and dimethylformamide (3 mL) was degassed with argon and then treated with [1,1 ‘- bis(diphenylphosphino)ferrocene]dichloropalladium (10 mg, 0.01 mmol). The mixture was heated in an Initiator Microwave Synthesizer at 100C for 2 hours. The resulting reaction mixture was applied to an Isolute SCX cartridge. Elution with methanol, then 2M NH3 in methanol gave, after evaporation, the crude product which was purified by silica gel chromatography eluting with ethyl acetate/hexane EPO mixtures. The product was dissolved in methanol (5 mL) and then IM HCl in diethyl ether (0.5 mL) was added. After stirring for 10 minutes, the solvents were evaporated to yield the title compound. MS (ES+ve): [M+H]+ at m/z 418 (C24H27N5O2 requires [MHhH]+ at m/z 418).

The synthetic route of 7033-39-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GLAXO GROUP LIMITED; WO2006/100119; (2006); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 7033-39-8 ,Some common heterocyclic compound, 7033-39-8, molecular formula is C6H7BrN2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: To a mixture of 1,3-dimethyluracil (0.140 g, 1 mmol), CuBr (0.057 g, 0.4 mmol, 0.4 equiv), and the aryl iodide (2 mmol, 2 equiv) in DMF (2 mL) was added LiOtBu (0.320 g, 4 mmol, 4 equiv). The reaction mixture was heated at reflux temperature for 1 h. After cooling to the room temperature, the reaction was quenched by adding saturated aqueous NH4Cl solution.The solvent was removed under reduced pressure. The residue was partitioned between EtOAc and H2O. The organic layer was washed with saturated aqueous NaCl solution, dried over anhydrous MgSO4, and then concentrated under reduced pressure to dryness. The residue was purified by flash column chromatography to give the product.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 7033-39-8, 5-Bromo-1,3-dimethylpyrimidine-2,4(1H,3H)-dione, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Cheng, Chien; Shih, Yu-Chiao; Chen, Hui-Ting; Chien, Tun-Cheng; Tetrahedron; vol. 69; 4; (2013); p. 1387 – 1396;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia