Category: 69256-17-3

Effects of nucleoside analogs in inhibition of Epstein-Barr virus was written by Lin, J. C.; Nelson, D. J.; Lambe, C. U.; Choi, E. I.; Pagano, J. S.. And the article was included in International Congress Series in 1985.SDS of cas: 69256-17-3 The following contents are mentioned in the article:

The relative antiviral potency of several nucleoside analogs against Epstein-Barr virus infection in P3HR-1 cells was 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodocytosine (I) [69123-90-6] = 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodouracil (II) [69123-98-4] > 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-thymine (III) [69256-17-3] > BW B759U (IV) [82410-32-0] > E-5-(2-bromovinyl)-2′-deoxyuridine (V) [69304-47-8] > acyclovir (VI); the relative therapeutic efficacy (ratio of cytotoxicity to antiviral potency) was V > IV > I > VI > II > III. IV was rapidly and markedly phosphorylated by virus-infected Raji cells; this effect was 100-fold greater than for VI. The results are discussed with respect to the prolonged inhibitory action of the nucleoside analogs against Epstein-Barr virus replication. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3SDS of cas: 69256-17-3).

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.SDS of cas: 69256-17-3

69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3

Preclinical investigations of FIAU, an anti-herpes agent was written by McLaren, C.; Chen, M. S.; Barbhaiya, R. H.; Buroker, R. A.; Oleson, F. B.. And the article was included in International Congress Series in 1985.Computed Properties of C10H13FN2O5 The following contents are mentioned in the article:

The pharmacol. of FIAU (I) [69123-98-4] as an anti-herpes agent is described in relation to that of FIAC (II) [69123-90-6] and FMAU (III) [69256-17-3]. The mechanism of action of I is dependent on selective inhibition of viral thymidine kinase  [9002-06-6]. The I monophosphate [99891-31-3] and III monophosphate [94344-82-8] had better affinities for cellular thymidylate kinase  [9014-43-1] than for herpes simplex virus thymidine/thymidylate kinases. However, II monophosphate [99876-43-4] had poor affinities for either the cellular or herpes simplex virus enzymes. In cells exposed to 14C-labeled II, I monophosphate was the major metabolite, indicating that II is converted to the more active agent, I. I appeared to have good activity, but it had cardiotoxic and myelosuppressive activities. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3Computed Properties of C10H13FN2O5).

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Computed Properties of C10H13FN2O5

69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3

Antiviral activities of some newer 2′-fluoro-5-substituted arabinosylpyrimidine nucleosides was written by Fox, J. J.; Watanabe, K. A.; Schinazi, R. F.; Lopez, C.. And the article was included in International Congress Series in 1985.Application of 69256-17-3 The following contents are mentioned in the article:

The inhibitory activity of the title compounds I (R = Me, Et, CH:CHBr, CH:CHI, I; X = NH or O) against herpes simplex virus in in vitro assays in Vero cells was determined Cytotoxicity was also determined The uracil nucleosides showed better therapeutic indexes than the corresponding cytosine analogs. The 5-Me analogs were more effective but also more cytotoxic than the corresponding 5-Et analogs. In mice with herpes simplex virus infections, 2′-fluoro-5-ethylarabinosyluracil  [83546-42-3] and 2′-fluoro-5-methylarabinosyluracil  [69256-17-3] were effective in decreasing mortality without any toxic effects. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3Application of 69256-17-3).

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Application of 69256-17-3

69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3

Nucleosides. 123. Synthesis of antiviral nucleosides: 5-substituted 1-(2-deoxy-2-halogeno-β-D-arabinofuranosyl)cytosines and -uracils. Some structure-activity relationships was written by Watanabe, Kyoichi A.; Su, Tsann Long; Klein, Robert S.; Chu, Chung K.; Matsuda, Akira; Chun, Moon Woo; Lopez, Carlos; Fox, Jack J.. And the article was included in Journal of Medicinal Chemistry in 1983.Category: pyrimidines The following contents are mentioned in the article:

Several 2′-deoxy-2′-halogenoarabinofuranosylcytosines and -uracils substituted at C-5 of the aglycon with Br or I were prepared and evaluated for antiherpetic activity against both herpes virus type 1 and 2 on monolayers of Vero cells by the plaque reduction assay. A dose that reduced the number of virus plaques by 50% (ED50) was determined The 2′-F function showed better antiviral activity than the corresponding 2′-Br or Cl congeners. 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodocytosine (I) [69123-90-6] had the most potent activity in vitro. Structure-activity relations are discussed. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3Category: pyrimidines).

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Category: pyrimidines

69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3

Evaluation of antivirals in preventing herpes simplex virus-induced cataracts in a murine model was written by Schinazi, Raymond F.; Scott, R. Taylor; Gammon, J. Allen; Stulting, R. Doyle; Kuck, John F. R.; Wright, John D.; Nahmias, Andre J.. And the article was included in International Congress Series in 1985.Formula: C10H13FN2O5 The following contents are mentioned in the article:

In mice inoculated intracerebrally with herpes simplex virus type 2, 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)thymine (FMAU) [69256-17-3] and FMAC  [78636-53-0] treatment completely inhibited cataract formation; although acyclovir  [59277-89-3], ara-A  [5536-17-4], 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-S-iodocytosine (FIAC) [69123-90-6], and other drugs were effective in reducing mortality, they were unable to prevent cataractogenesis. Results on the optimization of virally-induced cataract formation and virol., immunol., and pathol. findings are presented. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3Formula: C10H13FN2O5).

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Formula: C10H13FN2O5

69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3

Susceptibility of several strains of varicella-zoster virus to 5-substituted derivatives of 2′-deoxyuridine and 1-β-D-arabinofuranosyluracil was written by Machida, Haruhiko; Kuninaka, Akira; Yoshino, Hiroshi. And the article was included in International Congress Series in 1982.Product Details of 69256-17-3 The following contents are mentioned in the article:

In confluent monolayers of human embryonic lung fibroblast cells infected with varicella-zoster virus, 5-bromovinylarabinosyluracil (I) [77181-69-2] and 5-chlorovinylarabinosyluracil  [77181-70-5] were the most potent of the 9 thymidine analogs in inhibiting plaque formation. There was some variability in the susceptibility of different strains of varicella-zoster virus to the thymidine analogs. The susceptibility of varicella-zoster virus to these compounds was different than that of herpes simplex virus type 1 and type 2. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3Product Details of 69256-17-3).

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.Product Details of 69256-17-3

69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3

Nucleosides. 110. Synthesis and antiherpes virus activity of some 2′-fluoro-2′-deoxyarabinofuranosylpyrimidine nucleosides was written by Watanabe, Kyoichi A.; Reichman, Uri; Hirota, Kosaku; Lopez, Carlos; Fox, Jack J.. And the article was included in Journal of Medicinal Chemistry in 1979.Electric Literature of C10H13FN2O5 The following contents are mentioned in the article:

The title compounds were prepared by condensation of 3-O-acetyl-5-O-benzoyl-2-deoxy-2-fluoro-D-arabinosyl bromide [56632-81-6] with the appropriate trimethylsilylated pyrimidines followed by saponification of the protected nucleosides, and evaluated for antiherpes virus activity. 1-(2′-Deoxy-2′-fluoro-β-D-arabinofuranosyl)-5-iodocytosine (I) [69123-90-6] was the most effective showing 99.5% suppression of viral replication even at concentrations of 0.1 μg/mL. Structure-activity relations are discussed. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3Electric Literature of C10H13FN2O5).

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they constitute an important class of natural and synthetic compounds exhibiting diverse useful biological activities that hold attractive potential for clinical translation as therapeutic agents in alleviation of a myriad of diseases. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Electric Literature of C10H13FN2O5

69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3

Comparison of 2′-fluoroarabinosylpyrimidine nucleosides and 1-β-D-arabinofuranosylcytosine on immunological parameters in vitro was written by Merluzzi, V. J.; Last-Barney, K.; Fox, J. J.. And the article was included in International Journal of Immunopharmacology in 1983.Synthetic Route of C10H13FN2O5 The following contents are mentioned in the article:

Ara C  [147-94-4], 2′-fluoro-5-iodo-arabinofuranosylcytosine (FIAC) [69123-90-6], and 2′-fluoro-5-methylarabinofuranosyluracil (FMAU) [69256-17-3] were analyzed for immunosuppressive activity in vitro. In assay systems quantifying both humoral and cellular immune reactivity of mice, FMAU and FIAC were less immunosuppressive than Ara C by several orders of magnitude. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3Synthetic Route of C10H13FN2O5).

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Synthetic Route of C10H13FN2O5

69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3

Inhibition of B virus (Macacine herpesvirus 1) by conventional and experimental antiviral compounds was written by Krug, P. W.; Schinazi, R. F.; Hilliard, J. K.. And the article was included in Antimicrobial Agents and Chemotherapy in 2009.Synthetic Route of C10H13FN2O5 The following contents are mentioned in the article:

B virus infection of humans results in high morbidity and mortality in as many as 80% of identified cases. The main objective of this study was to conduct a comparative anal. of conventional and exptl. antiviral drug susceptibilities of B virus isolates from multiple macaque species and zoonotically infected humans. We used a plaque reduction assay to establish the effective inhibitory doses of acyclovir, ganciclovir, and vidarabine, as well as those of a group of exptl. nucleoside analogs with known anti-herpes simplex virus activity. Four of the exptl. drugs tested were 10- to 100-fold more potent inhibitors of B virus replication than conventional antiviral agents. Drug efficacies were similar for multiple B virus isolates tested, with variations within 2-fold of the median effective concentration (EC50) for each drug, and each EC50 was considerably lower than those for B virus thymidine kinase (TK) mutants. We observed no differences in the viral TK amino acid sequence between B virus isolates from rhesus monkeys and those from human zoonoses. Differences in the TK protein sequence between cynomolgus and pigtail macaque B virus isolates did not affect drug sensitivity except in the case of one compound Taken together, these data suggest that future B virus zoonoses will respond consistently to conventional antiviral treatment. Further, the considerably higher potency of FEAU (2′-fluoro-5-ethyl-Ara-U) than of conventional antiviral drugs argues for its compassionate use in advanced human B virus infections. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3Synthetic Route of C10H13FN2O5).

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. Therapy for fungal infections is based mainly on four classes of antifungals: azoles, echinocandins, polyenes, and pyrimidine analogs.Synthetic Route of C10H13FN2O5

69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3

Different antiviral potencies of BV-araU and related nucleoside analogs against herpes simplex virus type 1 in human cell lines and Vero cells was written by Machida, Haruhiko; Nishitani, Makiko; Suzutani, Tatsuo; Hayashi, Kozaburo. And the article was included in Microbiology and Immunology in 1991.Quality Control of 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione The following contents are mentioned in the article:

Antiviral potencies against herpes simplex virus type 1 (HSV-1) of 1-β-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil (BV-araU) and 10 other nucleoside analogs in human embryonic lung fibroblast (HEL) cells were compared with those in Vero cells. 5-Halogenovinylarabinosyluracils, highly active in HEL cells, were inactive against all 3 laboratory-stocked strains of HSV-1 but exerted moderate antiviral effects on 3 clin. isolates in Vero cells. The reduction in anti-HSV-1 potencies of other representative nucleoside analogs in Vero cells was much less than those of 5-halogenovinylarabinosyluracils. However, significant antiviral potencies of BV-araU against laboratory strains were observed in other human and monkey fibroblast cells including an immortalized cell line. Significant enhancement of antiviral activity of BV-araU against a laboratory strain and a clin. isolate was demonstrated in Vero cells by the addition of 0.1 μM aminopterin or FUdR, an inhibitor of thymidylate synthesis. The potentiated anti-HSV-1 activity in Vero cells was comparable to the potency in HEL cells without the inhibitor. These results suggested that high activity of thymidylate synthesis and a large thymidylate pool size in Vero cells seem to be related to loss of anti-HSV-1 potency of BV-araU. Original tissue type, species, and the immortality may not be responsible for the reduced antiviral activity of BV-araU in Vero cells. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3Quality Control of 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione).

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. Pyrimidine derivatives have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.Quality Control of 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3