Category: 69256-17-3

Activities of 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodocytosine and its metabolites against herpes simplex virus types 1 and 2 in cell culture and in mice infected intracerebrally with herpes simplex virus type 2 was written by Schinazi, Raymond F.; Fox, Jack J.; Watanabe, Kyoichi A.; Nahmias, Andre J.. And the article was included in Antimicrobial Agents and Chemotherapy on January 31,1986.Electric Literature of C10H13FN2O5 The following contents are mentioned in the article:

As measured by plaque and yield reduction assays, several metabolites of 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodocytosine (FIAC) were highly active against herpes simplex virus types 1 and 2. These metabolites included the 2′-deoxy-2′-fluoroarabinosyl derivatives of 5-iodouracil, cytosine, uracil, and thymine. In mice inoculated intracerebrally with herpes simplex virus type 2, the relative order of potency of these compounds and known antiviral drugs were as follows: 2′-fluoro-5-methylarabinosyluracil (FMAU) [69256-17-3] ≫ 2′-fluoro-5-iodoarabinosylcytosine (FIAC) [69123-90-6] ≈ 2′-fluoro-5-iodoarabinosyluracil (FIAU) [69123-98-4] > acyclovir ≈ vidarabine ≫ 2′-fluoroarabinosylcytosine (FAC) [56632-83-8] ≈ 2′-fluoroarabinosyluracil (FAU) [69123-94-0]. One of the main metabolites of FMAU, 2′-fluoro-5-hydroxymethylarabinosyluracil  [94817-51-3], was essentially inactive in vivo. FIAC-, FIAU-, FMAU-, FAC-, and FAU-resistant herpes simplex virus variants prepared in cell culture were found to be (i) devoid of viral thymidine kinase  [9002-06-6], (ii) cross-resistant to one another and resistant to drugs requiring viral thymidine kinase for activation, and (iii) sensitive to vidarabine or phosphonoformate. These results indicate that FIAC, FIAU, and FMAU require the virally encoded thymidine kinase for activation and suggest that the antiviral activity of FAU and FAC in cell cultures is also mediated by this enzyme. The interaction of the fluoroarabinosylpyrimidine nucleosides with herpes simplex virus thymidine kinase in a cell-free system is also described. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3Electric Literature of C10H13FN2O5).

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Electric Literature of C10H13FN2O5

69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3

Mutagenic potential of anti-herpes agents was written by De Clercq, E.; Cassiman, J. J.. And the article was included in Life Sciences on January 20,1986.Reference of 69256-17-3 The following contents are mentioned in the article:

A number of anti-herpes agents which are either licensed for clin. use (acyclovir  [59277-89-3]) or subject to clin. studies ((E)-5-(2-bromovinyl)-2′-deoxyuridine  [69304-47-8], 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl-5-iodocytosine  [69123-90-6], and 9-(1,3-dihydroxy-2-propoxymethyl)guanine  [82410-32-0]) or under preclin. investigation (1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodouracil (FIAU) [69123-98-4], 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-methyluracil  [69256-17-3], 9-(3,4-dihydroxybutyl)guanine  [83470-64-8], (E)-5-(2-bromovinyl)-2′-deoxycytidine  [74131-09-2], (E)-5-(bromovinyl)-1-β-D-arabinofuranosyluracil  [77181-69-2], carbocyclic bromovinyldeoxyuridine  [95463-56-2], (E)-5-(2-bromovinyl)uracil  [69304-49-0], and (E)-5-(2-bromovinyl)uridine  [86391-68-6]) were evaluated for their ability to induce sister chromatid exchange (SCE), an indicator of mutagenesis. SCE was scored on metaphasic chromosomes of human lymphocytes which had been exposed to 5-bromo-2-deoxyuridine and varying concentrations of the test compounds The antiviral assays were based on the inhibition of the cytopathogenicity of herpes simplex virus for human diploid fibroblasts. Most compounds, e.g., acyclovir, bromovinyldeoxyuridine, or carbocyclic bromovinyldeoxyuridine, either did not induce SCE or only did so at concentrations far above their min. antiviral concentrations However, FIAU and dihydroxypropoxymethylguanine affected the SCE rate at a concentration (≥4.5 μg/mL) that is readily achievable in blood following i.v. injection. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3Reference of 69256-17-3).

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. Therapy for fungal infections is based mainly on four classes of antifungals: azoles, echinocandins, polyenes, and pyrimidine analogs.Reference of 69256-17-3

69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3

Activity of 1-(2′-deoxy-2′-fluoro-β-D-arabinofuranosyl)-5-iodouracil against simian varicella virus infections in African green monkeys was written by Soike, Kenneth F.; Cantrell, Connie; Gerone, Peter J.. And the article was included in Antimicrobial Agents and Chemotherapy on January 31,1986.Category: pyrimidines The following contents are mentioned in the article:

The fluorinated pyrimidines 1-(2′-deoxy-2′-fluoro-β-D-arabinofuranosyl)-5-iodouracil (FIAU) [69123-98-4] and 1-(2′-deoxy-2′-fluoro-β-D-arabinofuranosyl)-5-methyluracil (FMAU) [69256-17-3] are highly effective inhibitors of herpesvirus infections in vitro and in vivo. This report is concerned with an evaluation of their activities in African green monkeys (Cercopithecus aethiops) infected with simian varicella virus, a herpesvirus closely related to human varicella-zoster virus. Oral or i.v. administration of FIAU at 50 mg/kg daily as divided doses beginning 48 h after virus inoculation prevented the development of evidences of clin. infection. Oral treatment with FIAU at 30 mg/kg daily deferred as late as 7 days after virus inoculation modified the course of the disease. When treatment was started 48 h after virus inoculation, daily doses of FIAU as small as 1 mg/kg inhibited development of infections; daily doses of 0.2 mg/kg were ineffective. At the latter dose, FMAU prevented development of clin. disease, suggesting that it was more active than FIAU. No signs of FIAU toxicity were observed, with the single exception of an early but transitory elevation in aspartate aminotransferase activity in serum. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3Category: pyrimidines).

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Category: pyrimidines

69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3

Comparative efficacy of three 2′-fluoropyrimidine nucleosides and 9-(1,3-dihydroxy-2-propoxymethyl)guanine (BW B759U) against pseudorabies and equine rhinopneumonitis virus infection in vitro and in laboratory animals was written by Rollinson, Elizabeth A.. And the article was included in Antiviral Research on January 31,1987.Product Details of 69256-17-3 The following contents are mentioned in the article:

The 3 2′-fluoropyrimidine nucleosides 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodocytosine (FIAC) [69123-90-6], 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodouracil (FIAU) [69123-98-4], and 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-methyluracil (FMAU) [69256-17-3], showed high activity in RK13 monolayers against equine rhinopneumonitis virus, (EHV-1), Aujeszky’s disease virus (SHV-1, pseudorabies), and infectious bovine rhinotracheitis virus (1BR, BHV-1). The activity of these compounds was compared with 9-(1,3-dihydroxy-2-propoxymethyl)guanine (BW B759U, DHPG) in 2 laboratory animal disease models: EHV-1-induced hepatitis in hamsters and SHV-1-induced encephalitis in mice. All the compounds, provided from 3 to 5 h pre-infection for 5 days, were effective in preventing EHV-1 mortality (at 3-5 mg/kg per day) and in significantly reducing SHV-1 mortality (at 60 mg/kg per day). While FIAU had the greatest activity in vitro, FMAU tended to be more potent in vivo. The reasons for these differences between relative in vitro and in vivo activities are briefly discussed. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3Product Details of 69256-17-3).

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. Therapy for fungal infections is based mainly on four classes of antifungals: azoles, echinocandins, polyenes, and pyrimidine analogs.Product Details of 69256-17-3

69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3

Effects of certain nucleoside analogs on human cytomegalovirus replication in vitro was written by Mar, Engchun; Patel, Pravin C.; Cheng, Yungchi; Fox, Jack J.; Watanabe, Kyoichi A.; Huang, Engshang. And the article was included in Journal of General Virology on January 31,1984.COA of Formula: C10H13FN2O5 The following contents are mentioned in the article:

Four nucleoside analogs, 1-(2′-deoxy-2′-fluoro-β-D-arabinofuranosyl)-5-methyluracil (I), -5-iodouracil (II), -5-methylcytosine (III) and -5-iodocytosine (IV), were studied for their effect on human cytomegalovirus (HCMV) replication in vitro. I, II, III, and IV showed antiviral activities for 4 strains of HCMV (Major, Clegg, D550 and Towne) in a plaque reduction assay, with ED50s in the range of 0.1-0.65 μM. At 1 μM I or IV, the synthesis of 5 virus-specific late polypeptides was entirely blocked. Quantification of Towne viral DNA synthesis, using complementary RNA-DNA hybridization with a Towne-specific cRNA probe, demonstrated a complete inhibition of HCMV DNA replication at 1 μM I or IV. After the removal of the inhibitors, however, viral DNA synthesis resumed, and infectious virus reappeared, indicating that the inhibition of HCMV replication by these nucleoside analogs was of a virostatic reversible type. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3COA of Formula: C10H13FN2O5).

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. The pyrimidine derivatives can easily interact with enzymes, genetic materials, and bio components within the cell. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.COA of Formula: C10H13FN2O5

69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3

Phosphorylation of the anti-hepatitis B nucleoside analog 1-(2′-deoxy-2′-fluoro-1-β-D-arabinofuranosyl)-5-iodouracil (FIAU) by human cytosolic and mitochondrial thymidine kinase and implications for cytotoxicity was written by Wang, Jianghai; Eriksson, Staffan. And the article was included in Antimicrobial Agents and Chemotherapy on June 30,1996.Related Products of 69256-17-3 The following contents are mentioned in the article:

The capacity of recombinant human cytosolic thymidine kinase (TK1) and bovine mitochondrial thymidine kinase (TK2) to phosphorylate the antiviral analogs 1-(2;-deoxy-2′-fluoro-1-β-D-arabinofuranosyl)-5-iodouracil (FIAU) and 1-(2′-deoxy-2′-fluoro-1-β-D-arabinofuranosyl)-5-methyluracil (FMAU) has been analyzed. The Vmax/Km ratios for FIAU and FMAU with TK2 are about 30% of that for deoxythymidine, while the corresponding values for TK1 are 2 and 5%, resp. Thus, these two analogs are more efficient substrates for TK2 than for TK1, which may be part of the explanation for the mitochondrial toxicity associated with FIAU during treatment of hepatitis B infection. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3Related Products of 69256-17-3).

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they constitute an important class of natural and synthetic compounds exhibiting diverse useful biological activities that hold attractive potential for clinical translation as therapeutic agents in alleviation of a myriad of diseases. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Related Products of 69256-17-3

69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3

Structural study of pyrimidine nucleoside analogs. I: molecular mechanics and semiempirical calculations of 2′-deoxy-2′-fluoroarabinofuranosyluracils was written by Molina Molina, J.; Rodriguez Espinosa, M.. And the article was included in Structural Chemistry on June 30,1994.Application In Synthesis of 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione The following contents are mentioned in the article:

Mol. mechanics (MM) calculations have been performed on the title compounds For the MM min. energy conformation obtained by conformational anal., MO calculations MNDO and AM1 have also been performed. The geometries obtained have been compared with the exptl. ones extracted from the Cambridge Structural Database (CSD). A qual. structure-activity relationship has been pointed out based on the electrostatic potentials calculated at different positions on the electronic surface. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3Application In Synthesis of 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione).

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. The pyrimidine derivatives can easily interact with enzymes, genetic materials, and bio components within the cell. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own.Application In Synthesis of 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3

Separation of 2-fluoro-2-deoxyarabinofuranosylpyrimidine nucleosides by high-performance liquid chromatography was written by Feinberg, Aaron. And the article was included in Journal of Chromatography on June 19,1981.Computed Properties of C10H13FN2O5 The following contents are mentioned in the article:

Six 2-fluoro-2-deoxyarabinofuranosylpyrimidine nucleotides were separated using reversed-phase high-performance liquid chromatog. with Partisil ODS-1 and ODS-3. Separation was obtained by eluting isocratically with 0.01M sodium phosphate, pH 5.3, containing 4% MeOH for 5 min, followed by isocratic elution with the same buffer in 20% MeOH. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3Computed Properties of C10H13FN2O5).

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. The pyrimidine derivatives can easily interact with enzymes, genetic materials, and bio components within the cell. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.Computed Properties of C10H13FN2O5

69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3

Crystal structures of B-DNA with incorporated 2′-deoxy-2′-fluoro-arabino-furanosyl thymines: implications of conformational preorganization for duplex stability was written by Berger, Imre; Tereshko, Valentina; Ikeda, Hisafumi; Marquez, Victor E.; Egli, Martin. And the article was included in Nucleic Acids Research on May 15,1998.Quality Control of 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione The following contents are mentioned in the article:

The fundamental conformational states of right-handed double helical DNA, the A- and B-forms, are associated with distinct puckers of the sugar moieties. The furanose conformation itself is affected by the steric and electronic nature of the ring substituents. For example, a strongly electroneg. substituent at the C2′ position, such as in the 2′-deoxy-2′-fluororibofuranosyl analog, will drive the conformational equilibrium toward the C3′-endo type (north). Conversely, the 2′-deoxy-2′-fluoroarabinofuranosyl modification with opposite stereochem. at C2′ appears to have a preference for a C2′-endo type pucker (south). Incorporation of 2′-fluoroarabinofuranosyl thymines was previously shown to enhance the thermodn. stability of B-DNA duplexes. We have determined the crystal structures of the B-DNA dodecamer duplexes [d(CGCGAASSCGCG)]2 and [d(CGCGAASTCGCG)]2 with incorporated 2′-deoxy-2′-fluoroarabinofuranosyl thymines S (south) at 1.55 Å resolution In the crystal structures, all S residues adopt an O4′-endo conformation (east), well compatible with an overall B-form duplex geometry. In addition to the increased rigidity of S nucleosides, a clathrate-like ordered water structure around the 2′-fluorines may account for the observed larger thermodn. stability of DNA duplexes containing 2′-deoxy-2′-fluoroarabino thymidines. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3Quality Control of 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione).

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Quality Control of 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3

Enzymology and pathogenicity in mice of a herpes simplex virus type 1 mutant resistant to 2′-fluoro-2′-deoxy-1-β-D-arabinofuranosyl-5-iodocytosine was written by Colacino, Joseph; Brownridge, Elizabeth; Greenberg, Nancy; Lopez, Carlos. And the article was included in Antimicrobial Agents and Chemotherapy on May 31,1986.Recommanded Product: 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione The following contents are mentioned in the article:

The deoxypyrimidine nucleoside analog 2-fluoro-2′-deoxy-1-β-D-arabinofuranosyl-5-iodocytosine (FIAC) [69123-90-6] is a potent and selective inhibitor of herpes simplex virus type I in vitro. Isopycnog. anal. demonstrated that 1 μM FIAC inhibited herpes simplex virus DNA replication by more than 95% but inhibited cellular DNA replication by only 32%. Mutant herpes simplex virus type 1 selected resistant to FIAC displayed linked resistance to other nucleoside analogs, including arabinosylthymine  [605-23-2] and acyclovir  [59277-89-3]. Lysates derived from Vero cells infected with FIAC-resistant virus showed markedly lower levels of thymidine kinase  [9002-06-6] activity and were unable to phosphorylate selectively arabinosylthymine or FIAC, in contrast to lysates from the cells infected with wild-type herpes simplex virus type 1. Drug-resistant virus displayed a 6,000-fold decrease in pathogenicity when inoculated i.p. into genetically susceptible A/J mice. These results indicate that resistance to deoxypyrimidine nucleoside analogs is due, at least in part, to alterations in viral thymidine kinase and is accompanied by decreased pathogenicity in vivo. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3Recommanded Product: 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione).

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they constitute an important class of natural and synthetic compounds exhibiting diverse useful biological activities that hold attractive potential for clinical translation as therapeutic agents in alleviation of a myriad of diseases. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Recommanded Product: 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3