Category: 69256-17-3

Alterations in the recognition of nucleoside analogs as substrates by the deoxythymidine kinase of a 5-methoxymethyldeoxyuridine-resistant mutant of herpes simplex virus type 1 was written by Veerisetty, V.; Veerisetty, Indira K.; Gentry, Glenn A.. And the article was included in Journal of General Virology on December 31,1983.HPLC of Formula: 69256-17-3 The following contents are mentioned in the article:

Inhibition constants (Kis) were used as an estimate of the ability of various nucleoside analogs to be recognized as substrates by the deoxythymidine kinases (dTKs) of a 5-methoxymethyldeoxyuridine-resistant (MMdUr) mutant of herpes simplex virus type 1 (HSV-1) and its parent wild-type (wt). The Kis for the 5-position analogs MMdU, [E]-5-(2-bromovinyl)deoxyuridine, bromodeoxyuridine, and iododeoxyuridine were increased approx. 3-5-fold, suggesting that they were poorer substrates for the MMdUr dTK than for the wt dTK. With the 2′ analogs arabinosylthymine and 2′-fluoro-5-methylarabinosyluracil, however, the Kis were increased to a much greater extent, 80- and 240-fold, resp. These findings suggest that the resistance of the mutant MMdUr to these analogs may be due to a mutation(s) in the viral dTK that directly affects binding at the 2′ recognition site and indirectly at the 5, while still allowing substantial activity with the natural substrate deoxythymidine. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3HPLC of Formula: 69256-17-3).

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.HPLC of Formula: 69256-17-3

69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3

Synthesis and some properties of modified oligonucleotides. 2. Oligonucleotides containing 2′-deoxy-2′-fluoro-β-D-arabinofuranosylpyrimidine nucleotides was written by Kois, Pavol; Tocik, Zdenek; Spassova, Maria; Ren, Wu Yun; Rosenberg, Ivan; Soler, Jaume Farras; Watanabe, Kyoichi A.. And the article was included in Nucleosides & Nucleotides on December 31,1993.Application of 69256-17-3 The following contents are mentioned in the article:

In order to find the effects of unnatural nucleosides on the stability of duplex, several oligonucleotides containing 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-uracil (FAU), -cytosine (FAC) and -thymine (FMAU) were synthesized by two alternative approaches: phosphoramidite method on an ABI 392 synthesizer and H-phosphonate procedure on the authors’ GeneSyn I universal module synthesizer. It was shown from the melting profiles that the presence of FMAU has a large stabilizing effect on the duplex. Replacement of thymidine with FAU, or deoxycytidine with FAC resulted in the formation of less stable duplexes. Temperature-dependent CD spectroscopy demonstrated that the structures of the fluorine containing oligomers are very similar to those of unmodified oligomers. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3Application of 69256-17-3).

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. The pyrimidine derivatives can easily interact with enzymes, genetic materials, and bio components within the cell. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Application of 69256-17-3

69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3

Structures of metabolites isolated from urine of mice treated with the antiviral agent, 1-(2-fluoro-2-deoxy-β-D-arabinofuranosyl)-5-methyluracil was written by Feinberg, Aaron; Vidal, Pedro M.; Fox, Jack J.; Watanabe, Kyoichi A.; Chun, Moon Woo; Field, F. H.; Bencsath, Aladar; Chait, Brian; Philips, Frederick S.. And the article was included in Drug Metabolism and Disposition on December 31,1984.Name: 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione The following contents are mentioned in the article:

Mice were treated i.v. with 2-14C-labeled 1-(2-fluoro-2-deoxy-β-D-arabinofuranosyl)-5-methyluracil (I) [69256-17-3] (501 μCi/365 mg/kg). The 24 h urine collection contained 93% of the radioactivity administered. HPLC anal. of the urine showed 97.2, 1.5, 0.2, and 0.6% of the recovered radioactivity as I and as metabolites A, B, and C, resp. Fractionation of the urine by HPLC yielded 0.98 mg of metabolite A and 0.3 mg of metabolite C. UV, NMR, HPLC, and mass spectral analyses were used to elucidate the structures of metabolites A and C. The spectra for metabolite A were identical to those of the synthesized compound 1-(2-fluoro-2-deoxy-β-D-arabinofuranosyl)-5-hydroxymethyluracil  [94817-51-3]. A postulated structure for metabolite C is given. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3Name: 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione).

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.Name: 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3

The parallel and antiparallel triplex formation and stability of self complementary oligonucleotides containing 2′-fluoro-arabinosyl thymine and 5-methyl-2′-deoxycytidine was written by Ren, Wu Yun; Watanabe, Kyoichi A.. And the article was included in Nucleosides & Nucleotides on November 30,1998.Electric Literature of C10H13FN2O5 The following contents are mentioned in the article:

We examined the effects of 1-(2-deoxy -2-fluoro-β-D-arabinofuranosyl)-thymine (or FMAU, a potent antiviral nucleoside) on the stability of duplex and triplexes. When compared the stability of the self-complementary 5′-A5T5 duplex with 5′-A5X5 (X = FMAU), duplex containing FMAU has much higher melting temperature (Tm). 5-A6T5T3X3T5F3X3 and T3X3T5A6T5F3X3 form the parallel and antiparallel triplexes T3X3:A6:X3T3, resp. The former exhibited the typical T:A:T triplex behavior with only one melting temperature at 70 °C and 45 °C in 1.0 M and 0.2 M NaCl solution, resp., whereas the latter has two Tm values at 56 °C and 28 °C in 1.0 M solution FMAU clearly stabilize the triplex structure as A6T22 which forms the parallel triplex T6:A6:T6 has also only one Tm at 54 °C and 37 °C and 37 °C in high and low salt concentration solutions, resp. A 31mer 5′-TCCTCCTTTTTTAGGAGGATTTTTTGGTGGT and 5′-TCCTCCTTTTTTAGGAGGATTTTTTX’X’TX’X’T (X’ = 2′-deoxy-5-methylcytidine) were prepared to study their triplex forming potential. The former was found to have a weak interaction of the Watson-Crick duplex with the mismatched third-strand at all pH. The latter formed a stable triplex at lower pH consistent with required protonation on the 5-methylcytosine base. For these studies we developed a simple PC desktop spreadsheet program to calculate the first derivative profile of the melting curve data. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3Electric Literature of C10H13FN2O5).

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Electric Literature of C10H13FN2O5

69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3

Comparison of antiviral effects of mismatched double-stranded RNA and 1-(2′-deoxy-2′-fluoro-β-D-arabinofuranosyl)-5-methyl-uracil (D-FMAU) against duck hepatitis B virus in vitro was written by Ijichi, K.; Ida, S.; Machida, H.; Shimada, K.. And the article was included in Antiviral Chemistry & Chemotherapy on November 30,1997.COA of Formula: C10H13FN2O5 The following contents are mentioned in the article:

The effects of mismatched double-stranded RNA (mdsRNA) and 1-(2′-deoxy-2′-fluoro-β-D-arabinofuranosyl)-5-methyl-uracil (D-FMAU) on the replication of duck hepatitis B virus (DHBV) were examined in duck primary hepatocytes infected with DHBV. The 50% inhibitory doses of m-dsRNA and D-FMAU for the replication of DHBV DNA were 0.34±0.06 and 0.007±0.001 μg mL-1, resp. Mismatched dsRNA slightly inhibited the intermediate DHBV DNA at a concentration as high as 1.0 μg mL-1, whereas the DHBV replicative form was markedly suppressed in the presence of 0.1 μg mL-1 of D-FMAU. On the other hand, m-dsRNA inhibited DHBV DNA replication even after the compound was removed from the culture medium, while the efficacy of D-FMAU did not persist after the cessation of treatment. The anal. of DHBV RNA revealed that m-dsRNA markedly inhibited DHBV RNA transcription, while D-FMAU only marginally suppressed the transcription of viral RNA. These results indicate that m-dsRNA inhibits DHBV RNA transcription rather than DHBV DNA replication and that this suppression of DHBV RNA transcription may produce persistent inhibition of DHBV replication. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3COA of Formula: C10H13FN2O5).

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. Pyrimidine derivatives have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.COA of Formula: C10H13FN2O5

69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3

Biochemical effects of 2′-fluoro-5-methyl-1-β-D-arabinofuranosyluracil and 2′-fluoro-5-iodo-1-β-D-arabinofuranosylcytosine in mouse leukemic cells sensitive and resistant to 1-β-D-arabinofuranosylcytosine was written by Chou, Ting Chao; Burchenal, Joseph H.; Schmid, Franz A.; Braun, Thomas J.; Su, Tsann Long; Watanabe, Kyoichi A.; Fox, Jack J.; Philips, Frederick S.. And the article was included in Cancer Research on October 31,1982.Recommanded Product: 69256-17-3 The following contents are mentioned in the article:

2′-fluoro-5-methyl-1-β-D-arabinofuranosyluracil (FMAU)(I) [69256-17-3], like 2′-fluoro-5-iodo-1-β-D-arabinofuranosylcytosine (FIAC)(II) [69123-90-6], has potent antiviral activity, but unlike FIAC, it also has antileukemic effects. The 2 agents and 1-β-D-arabinofuranosylcytosine (ara-C) [147-94-4] are compared herein. Concentrations inhibiting thymidine (dThd) incorporation into DNA by 50% are for FMAU, FIAC, and ara-C, resp., in L1210/0, 32, 353, and 0.2 μm and in L1210/ara-C, 17, <10,000, and 3900 μM. Other FMAU analogs, 2'-fluoro-5-ethyl-1-β-D-arabinofuranosyluracil  [69123-98-4], inhibit dThd incorporation equally in ara-C-sensitive and -resistant cells; however, their potencies are weaker than that of FMAU. Similar results are obtained when [3H]deoxyadenosine is used as a precursor of incorporation. In L1210/0 cells, incorporation of [2-14C]FMAU radioactivity into DNA is completely inhibited by dThd and deoxycytidine (dCyd), whereas the incorporation of [2-14C]FIAC radioactivity is competitively inhibited by dCyd but not appreciably by dThd. In L1210/0 cells, FMAU has little inhibitory effect on the tritium release from [5-3H]deoxyuridine but markedly inhibits the incorporation of [2-14C]deoxyuridine into DNA. FIAC, by contrast, predominately inhibits the release of tritium from [5-3H]deoxyuridine but has little effect on subsequent incorporation into DNA. Apparently, (1) FIAC, but not FMAU, is cross-resistant to ara-C; (2) FMAU is particularly effective against L1210/ara-C cells; (3) FIAC behaves metabolically like dCyd, and FMAU like dThd and dCyd; (4) dCyd and dThd may be used as chemotherapeutic modulators; and (5) FIAC predominately inhibits dThd kinase and(or) thymidine monophosphate synthetase, whereas FMAU predominately inhibits DNA polymerase and(or) nucleotide kinases. Similar conclusions were obtained when P815/0 and P815/ara-C cells were used. The relative potencies of FIAC and FMAU in inhibiting dThd incorporation into DNA in leukemic sublines correlate with cytotoxicity in vitro and chemotherapeutic effects in vivo. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3Recommanded Product: 69256-17-3).

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they constitute an important class of natural and synthetic compounds exhibiting diverse useful biological activities that hold attractive potential for clinical translation as therapeutic agents in alleviation of a myriad of diseases. Pyrimidine derivatives have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.Recommanded Product: 69256-17-3

69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3

An Escherichia coli system expressing human deoxyribonucleoside salvage enzymes for evaluation of potential antiproliferative nucleoside analogs was written by Wang, Jianghai; Neuhard, Jan; Eriksson, Staffan. And the article was included in Antimicrobial Agents and Chemotherapy on October 31,1998.Product Details of 69256-17-3 The following contents are mentioned in the article:

Deoxyribonucleoside salvage in animal cells is mainly dependent on two cytosolic enzymes, thymidine kinase (TK1) and deoxycytidine kinase (dCK), while Escherichia coli expresses only one type of deoxynucleoside kinase, i.e., TK. A bacterial whole-cell system based on genetically modified E. coli was developed in which the relevant bacterial deoxypyrimidine metabolic enzymes were mutated, and the cDNA for human dCK or TK1 under the control of the lac promoter was introduced. The TK level in extract from induced bacteria with cDNA for human TK1 was found to be 20,000-fold higher than that in the parental strain, and for the strain with human dCK, the enzyme activity was 160-fold higher. The in vivo incorporation of deoxythymidine (Thd) and deoxycytidine (dCyd) into bacterial DNA by the two recombinant strains was 20 and 40 times higher, resp., than that of the parental cells. A number of nucleoside analogs, including cytosine arabinoside, 5-fluoro-dCyd, difluoro-dCyd, and several 5-halogenated deoxyuridine analogs, were tested with the bacterial system, as well as with human T-lymphoblast CEM cells. The results showed a close correlation between the inhibitory effects of several important cytostatic and antiviral analogs on the recombinant bacteria and the cellular system. Thus, E. coli expressing human salvage kinases is a rapid and convenient model system which may complement other screening methods in drug discovery projects. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3Product Details of 69256-17-3).

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Product Details of 69256-17-3

69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3

Efficacy and selectivity of some nucleoside analogs as antihuman cytomegalovirus agents was written by Colacino, Joseph M.; Lopez, Carlos. And the article was included in Antimicrobial Agents and Chemotherapy on October 31,1983.Name: 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione The following contents are mentioned in the article:

1-(2′-Deoxy-2′-fluoro-β-D-arabinofuranosyl)-5-iodocytosine (FIAC) [69123-90-6], 1-(2′-deoxy-2′-fluoro-β-D-arabinofuranosyl)-5-methyluridine (FMAU) [69256-17-3], 1-(2′-deoxy-2′-fluoro-β-D-arabinofuranosyl)-5-iodouridine (FIAU) [69123-98-4], and 1-(2′-deoxy-2′-fluoro-β-D-arabinofuranosyl)-5-ethyluridine (FEAU) [83546-42-3] were evaluated for antiviral activities against human cytomegalovirus (HCMV) and compared with 9-[(2-hydroxyethoxy)methyl]guanine (acylovir) [59277-89-3] and E-5-(2′-bromovinyl)-2′-deoxyuridine (BVDU) [69304-47-8]. The relative anti-HCMV potencies of these compounds, as determined by calculating the dose of drug which inhibited 50% plaque formation, were in order of decreasing potency: FIAC > FIAU > FMAU > acyclovir > FEAU > BVDU. The antiviral activity of FIAC occurred at levels much lower than those that caused cytotoxic or cytostatic effects in uninfected fibroblasts. Neither thymidine nor deoxycytidine reversed the anti-HCMV activity of FIAC, indicating that this drug was not acting as an analog of the natural nucleosides. FIAC was not phosphorylated by cytosols of HCMV-infected cells to a greater extent that by those of uninfected cells, indicating that, unlike the antiviral activity against herpes simplex virus type 1, the selectivity of this drug is probably not based on a virus-specified pyrimidine kinase. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3Name: 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione).

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Name: 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3

Cell-specific antiviral activity of 1-(2-fluoro-2-deoxy-β-D-arabinofuranosyl)-5-iodocytosine (FIAC) against Marek’s disease herpesvirus and turkey herpesvirus was written by Schat, Karel A.; Schinazi, Raymond F.; Calnek, Bruce W.. And the article was included in Antiviral Research on October 31,1984.Related Products of 69256-17-3 The following contents are mentioned in the article:

Three new fluoroarabinosylpyrimidine nucleosides [1-(2-fluoro-2-deoxy-β-D-arabinofuranosyl-5-iodocytosine (FIAC)(I) [69123-90-6], 1-(2-fluoro-2-deoxy-β-D-arabinofuranosyl)-5-iodouracil (FIAU)(II) [69123-98-4], and 1-(2-fluoro-2-deoxy-β-D-arabinofuranosyl)-5-methyluracil (FMAU)(III) [69256-17-3]] were tested for in vitro activity against oncogenic and nononcogenic strains of Marek’s disease virus (MDV) and herpesvirus of turkeys (HVT). Marek’s disease is a herpesvirus-induced lymphoma in chickens. Nononcogenic strains of MDV and HVT can protect against this disease. All viruses were inhibited by 1 μM of these drugs in chick kidney cell (CKC) cultures, but only FMAU and FIAU were active in chicken embryo fibroblast (CEF) and spleen cell cultures. It was determined that whereas CKC produced the enzyme 2′-deoxycytidine-deaminase  [37259-56-6] which is needed to deaminate FIAC to FIAU, CEF were devoid of this enzyme activity. In addition, the deaminase inhibitor 3,4,5,6-tetrahydrouridine prevented the antiviral activity of FIAC and CKC. FMAU was not active against two Marek’s disease-derived lymphoblastoid tumor cell lines. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3Related Products of 69256-17-3).

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own.Related Products of 69256-17-3

69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3

Comparative anti-herpesvirus activities of 9-(1,3-dihydroxy-2-propoxymethyl)guanine, acyclovir, and two 2′-fluoropyrimidine nucleosides was written by Smee, Donald F.; Campbell, Nancy L.; Matthews, Thomas R.. And the article was included in Antiviral Research on October 31,1985.HPLC of Formula: 69256-17-3 The following contents are mentioned in the article:

9-(1,3-Dihydroxy-2-propoxymethyl)guanine (DHPG) [82410-32-0], was evaluated in cell culture and in animals for its inhibitory effect on herpes simplex viruses. Compounds used for comparison included acyclovir  [59277-89-3], 2′-fluoro-2′-deoxy-5-iodoarabinofuranosylcytosine (FIAC) [69123-90-6], and 2′-fluoro-2′-deoxy-5-methylarabinofuranosyluracil (FMAU) [69256-17-3]. In plaque-reduction assays DHPG, acyclovir, FIAC, and FMAU were inhibitory to 6 herpes types 1 and 2 virus strains at concentrations of 0.2-2.4 μM. These concentrations were much lower than those required to inhibit Vero cell proliferation. In guinea pig vaginal infections, DHPG provided significantly greater inhibition of herpetic lesions than did acyclovir. In a herpes type 2 infection model in mice, DHPG, and FMAU were active at 5 mg/kg, whereas acyclovir and FIAC showed no statistically significant effect at 80 mg/kg. In a herpes type 1 encephalitis model, DHPG and FMAU were active at doses <10 mg/kg, with FMAU being about 4 times more potent than DHPG in that model. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3HPLC of Formula: 69256-17-3).

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they constitute an important class of natural and synthetic compounds exhibiting diverse useful biological activities that hold attractive potential for clinical translation as therapeutic agents in alleviation of a myriad of diseases. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.HPLC of Formula: 69256-17-3

69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3