Category: 69256-17-3

Evaluation of 2′-deoxy-2′-fluoro-5-methyl-1-β-D-arabinofuranosyluracil as a potential gene imaging agent for HSV-tk expression in vivo was written by Alauddin, Mian M.; Shahinian, Atranik; Gordon, Erlinda M.; Conti, Peter S.. And the article was included in Molecular Imaging on June 30,2002.Reference of 69256-17-3 The following contents are mentioned in the article:

2′-Deoxy-2′-fluoro-5-methyl-1-β-D-arabinofuranosyluracil (FMAU) has been evaluated in HT-29 cells as a potential positron emission tomog. (PET) radiotracer for imaging HSV-tk gene expression in vivo. In vitro experiments demonstrate that the accumulation of [14C]-FMAU in HSV-tk-expressing cells is 2.4-fold (p < .02), 4.0-fold (p < .001), and 5.3-fold (p < .001) higher than the wild-type cells at 1, 3, and 5 h, resp. In vivo studies revealed that the tumor uptake in HSV-tk-expressing cells was 2.3-fold (p < .001), 3.0-fold (p < .001), and 5.5-fold (p < .001) higher than the control cells at 1, 2, and 5 h, resp. FMAU was found to be more sensitive compared to our earlier studies using 9-[(3-18F-fluoro-1-hydroxy-2-propoxy)methyl]-guanine ([18F]-FHPG) and 9-(4-[18F]-fluoro-3-hydroxy-methylbutyl)guanine ([18F]-FHBG) in the same cell lines, although, the specificity was less than FHBG. These results suggest that while FMAU labeled with PET isotopes may be useful for imaging HSV-tk-expressing tumors in vivo, multitracer studies across addnl. tumor models are necessary in order to identify an optimal PET radiotracer. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3Reference of 69256-17-3).

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. Therapy for fungal infections is based mainly on four classes of antifungals: azoles, echinocandins, polyenes, and pyrimidine analogs.Reference of 69256-17-3

69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3

Comparative efficacy and selectivity of some nucleoside analogs against Epstein-Barr virus was written by Lin, Jung Chung; Smith, M. Carolyn; Pagano, Joseph S.. And the article was included in Antimicrobial Agents and Chemotherapy on June 30,1985.Product Details of 69256-17-3 The following contents are mentioned in the article:

The effects of (2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodocytosine (FIAC) [69123-90-6], 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-methyluridine (FMAU) [69256-17-3], 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodouridine (FIAU) [69123-98-4], (E)-5-(2-bromovinyl)-2′-deoxyuridine (BVdU) [69304-47-8], and 9-(1,3-dihydroxy-2-propoxymethyl)guanine (DHPG or BW B759U) [82410-32-0] on the replication of Epstein-Barr virus (EBV) in vitro were evaluated and compared with that of acyclovir (ACV). The relative potencies of these drugs, on the basis of anti-EBV activity, were: FIAC = FIAU > FMAU > DHPG > BVdU > ACV; on the basis of the therapeutic index they were: BVdU > DHPG > FIAC > ACV > FIAU > FMAU. Differential inhibition of EBV-associated polypeptides by these drugs was observed This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3Product Details of 69256-17-3).

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Product Details of 69256-17-3

69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3

In vitro and in vivo antiviral activity of 1-β-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil (BV-araU) and related compounds was written by Machida, Haruhiko; Sakata, Shinji. And the article was included in Antiviral Research on June 30,1984.Application In Synthesis of 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione The following contents are mentioned in the article:

BV-araU (I) [77181-69-2] and related compounds such as CV-araU [77181-70-5], IV-araU [87535-95-3], and BV-araUMP [86230-31-1] showed marked activity against herpes simplex virus type 1 (HSV-1) in human embryonic lung fibroblast cells. BV-araU, CB-araU, and BV-araUMP were also effective in mice infected intracerebrally with HSV-1. Especially, when mice were infected with a low dose of virus, both i.v. and oral treatment with BV-araU proved capable of increasing the mean survival time and decreasing the final mortality of the infected mice. The in vivo anti-HSV-1 activity of BV-araU was comparable to that of E-5-(2-bromovinyl)-2′-deoxyuridine  [69304-47-8]. BV-araU exhibited little toxicity for mice. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3Application In Synthesis of 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione).

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they constitute an important class of natural and synthetic compounds exhibiting diverse useful biological activities that hold attractive potential for clinical translation as therapeutic agents in alleviation of a myriad of diseases. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Application In Synthesis of 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3

4�C-Aminomethyl-2�deoxy-2�fluoroarabinonucleoside increases the nuclease resistance of DNA without inhibiting the ability of a DNA/RNA duplex to activate RNase H was written by Tsuchihira, Tatsuya; Kajino, Ryohei; Maeda, Yusuke; Ueno, Yoshihito. And the article was included in Bioorganic & Medicinal Chemistry on August 15,2020.Related Products of 69256-17-3 The following contents are mentioned in the article:

An antisense oligonucleotide is expected as an innovative drug for cancer and hereditary diseases. In this paper, we designed and synthesized DNAs containing a novel nucleoside analog, 1-(4-C-aminomethyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)thymine, and evaluated their properties. It was revealed that the analog slightly decreases the thermal stability of the DNA/RNA duplex but significantly increases the stability of DNA in a buffer containing bovine serum. Furthermore, it turned out that the DNA/RNA duplex containing the analog is a good substrate for Escherichia coli RNase H. Thus, DNAs containing the nucleoside analog would be good candidates for the development of therapeutic antisense oligonucleotides. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3Related Products of 69256-17-3).

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.Related Products of 69256-17-3

69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3

Epstein-Barr virus: inhibition of replication by three new drugs was written by Lin, Jung Chung; Smith, M. Carolyn; Cheng, Yung Chi; Pagano, Joseph S.. And the article was included in Science (Washington, DC, United States) on August 5,1983.Related Products of 69256-17-3 The following contents are mentioned in the article:

Acyclovir  [59277-89-3], the first clin. useful drug effective against replication of Epstein-Barr virus (EBV) was without effect against latent or persistent EBV infection. Three nucleoside analogs, E-5-(2-bromovinyl)-2′-deoxyuridine (I) [69304-47-8], 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodocytosine (II) [69123-90-6] and 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-methyluracil (III) [69256-17-3] were potent inhibitors of EBV replication in vitro. Moreover, in contrast to the reversibility of viral inhibition by acyclovir, these 3 drugs have prolonged effects in suppressing viral replication even after the drugs are removed from persistently infected cell cultures. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3Related Products of 69256-17-3).

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Related Products of 69256-17-3

69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3

Synthesis and anti-HIV-1 activity of 2′-“”up””-fluoro analogs of active anti-AIDS nucleosides 3′-azido-3′-deoxythymidine (AZT) and 2′,3′-dideoxycytidine (DDC) was written by Watanabe, Kyoichi A.; Harada, Kazuho; Zeidler, Joanna; Matulic-Adamic, Jasenka; Takahashi, Kiyobumi; Ren, Wu Yun; Cheng, Ling Chin; Fox, Jack J.; Chou, Ting Chao. And the article was included in Journal of Medicinal Chemistry on August 31,1990.Application In Synthesis of 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione The following contents are mentioned in the article:

1-(3-Azido-2,3-dideoxy-2-fluoro-β-D-arabinofuranosyl)thymine (I) and 1-(2,3-dideoxy-2-fluoro-β-D-threo-pentofuranosyl)cytosine (II) were synthesized from the potent antiherpes virus nucleosides 1-(2-fluoro-β-D-arabinofuranosyl)thymine and 1-(2-fluoro-β-D-arabinofuranosyl)-5-iodocytosine in the hope that introduction of a 2′-“”up””-fluoro substituent might potentiate the anti-HIV activity of 3′-azido-3′-deoxythymidine (AZT) and 2′,3′-dideoxycytidine. I did not exhibit any significant activity against the human immunodeficiency virus (HIV) in vitro. II, however, showed activity against HIV-1, but the therapeutic index was much inferior to that of AZT. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3Application In Synthesis of 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione).

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.Application In Synthesis of 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3

Inhibitors of bovine herpes mammillitis virus infections in cultured cells and in vaginally infected guinea pigs was written by Smee, D. F.; Leonhardt, J. A.; Sugiyama, S. T.; Holy, A.. And the article was included in Antiviral Chemistry & Chemotherapy on July 31,1994.COA of Formula: C10H13FN2O5 The following contents are mentioned in the article:

Bovine herpes mammillitis virus or bovine herpesvirus type 2 (BHV-2) causes ulcerative lesions on the teats and udders of infected cows. The authors investigated several nucleoside and nucleotide analogs as potential BHV-2 inhibitors. These included acyclovir, ganciclovir, 5-iodo-2′-deoxyuridine (IUdR), 1-(2′-deoxy-2′-fluoro-β-D-arabinofuranosyl) derivatives of 5-iodocytosine (FIAC), 5-iodouracil (FIAU), and 5-methyluracil (FMAU), and various 3-hydroxyphosphonylmethoxypropyl (HPMP) and 2-phosphonylmethoxyethyl (PME) derivatives of adenine (A), guanine (G), 2,6-diaminopurine (DAP), and/or cytosine (C). Of these, FIAU and FMAU were the most potent in cell culture, inhibiting 50% of BHV-2 plaques at <0.05 μM. HPMPA and HPMPG were active at 0.3 μM; FIAC, IUdR, and HPMPC at 1.3-2.3 μM; PMEDAP and ganciclovir at 20-25 μM; acyclovir and PMEA at >100 μM. The two most potent agents, FIAU and FMAU, inhibited uninfected embryonic bovine tracheal cell growth by 50% at >100 μM and 53 μM, resp., resulting in selectivity indexes (ratio of the 50% inhibitory concentration for cell growth to the 50% inhibitory concentration for plaque formation) of >2200 and 1100. Greater degrees of antiviral activity and selectivity were obtained in infected guinea pig embryo cells treated with FIAU, FMAU, and HPMPC. Infected cell extracts containing BHV-2-induced thymidine kinase activity phosphorylated FIAU, FMAU, and IUdR at nearly the same rate as thymidine, whereas FIAC, acyclovir, and ganciclovir were phosphorylated at â‰?% the rate of thymidine. Phosphorylation by this enzyme is required to generate the antivirally active nucleoside triphosphate in infected cells. In guinea pigs infected intravaginally with BHV-2, FMAU treatments of 1, 3.2, and 10 mg kg-1 per day for 5 days starting 1 day after virus challenge reduced vaginal lesion scores and virus titers in a dose-dependent manner. FIAU (10 μM) was as effective as 1 μM FMAU by the same regimen. A single treatment with 10 μM HPMPC was as active as daily treatments with 3.2 mg FMAU kg-1. These results indicate the potential of using antiviral agents to treat bovine herpes mammillitis virus infections in cattle, and the application of guinea pigs to study BHV-2 disease. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3COA of Formula: C10H13FN2O5).

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. The pyrimidine derivatives can easily interact with enzymes, genetic materials, and bio components within the cell. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.COA of Formula: C10H13FN2O5

69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3

Use of a standardized cell culture assay to assess activities of nucleoside analogs against hepatitis B virus replication was written by Korba, Brent E.; Gerin, John L.. And the article was included in Antiviral Research on July 1,1992.Name: 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione The following contents are mentioned in the article:

A cell culture system for the evaluation of compounds which inhibit hepatitis B virus (HBV) replication (Korba and Milman, Antiviral Res. 15:217, 1991) has been developed into a standardized assay. Toxicity of test compounds was assessed by the uptake of neutral red dye under cell culture and treatment conditions which were identical to those used for the antiviral assays. A total of 667 sep. cultures of 2.2.15 cells were evaluated for this study. In 86 untreated cell cultures, representing 15 experiments over a 24-mo period, the levels of extracellular HBV virion DNA and intracellular HBV DNA forms were found to vary by less than 2.5-fold overall. Virion DNA in serum and intracellular viral DNA replication intermediates [RI] are the two most reliable and commonly followed markers of hepadnavirus replication in patients and exptl. animals. In these assays, levels of extracellular HBV virion DNA and intracellular HBV RI were well correlated in 2.2.15 cells. Less correlation was observed between the levels of HBV virion DNA and the 3.2-kb episomal HBV genomes present in the cells. A threshold level of 22-37 intracellular replicating HBV genomes appeared to be required before virions were detected in the culture medium. The activities of several 2′-substituted and 3′-substituted deoxynucleoside analogs against HBV replication were compared using this standardized assay. Dideoxycytosine [ddC] and dideoxyguanosine [ddG] were the most selective 2′,3′-dideoxynucleosides against HBV in 2.2.15 cells. Substitution of fluorine at the 2′ position abolished the antiviral activity of ddC, but enhanced the selective antiviral activities of dideoxythymidine and dideoxyuracil. Several 2′-fluorinated pyrimidine arabinosyl furanosides, reported to be potent (but toxic) inhibitors of hepadnaviruses in vivo demonstrated relatively low selective antiviral activities in 2.2.15 cells. The current data base allows for validation of any given set of test evaluations through statistical anal. of both the pos. and the neg. treatment controls present in each experiment; thus, relevant comparisons of the selectivity of anti-HBV activities for different compounds examined in future experiments can be made. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3Name: 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione).

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.Name: 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3

A mammalian cell line designed to test the mutagenic activity of anti-herpes nucleosides was written by Pizer, Lewis I.; Mitchell, Dawn H.; Bentele, Beatrice; Betz, Joan L.. And the article was included in International Journal of Cancer on July 15,1987.Electric Literature of C10H13FN2O5 The following contents are mentioned in the article:

The herpes simplex virus (HSV) thymidine kinase (tk) gene was transfected into Chinese hamster ovary (CHO) 51-11 gly- cells to test its effect on the cytotoxic and mutagenic activity of anti-herpetic nucleoside analogs. Acyclovir (ACV) was somewhat more cytotoxic in the 51-D3 cell line that expresses the viral TK than in the 51-11 parent line. Growth in ACV did not increase over background mutations at the hprt locus. FIAC (2′-fluoro-5-iodo-aracytosine) was slightly cytotoxic to the parent 51-11 line and the tk-containing clone 51-D3. FMAU (2′-fluoro-5-methylarauracil) had pronounced cytotoxicity in both cell lines; the 50% survival points were 1.0 μM for 51-11 cells and 0.2 μM for 51-D3. The clone 51-D3 was more sensitive than 51-11 to low concentrations of FIAU (2′-fluoro-5-iodo-arauracil), and when treated with FIAU 51-D3 had a mutation frequency to glycine independence 5 times greater than that of 51-11 cells. With both cell lines, the mutation frequency at the hprt locus was detected after 51-D3 cells were grown with iododeoxyuridine. Trifluorothymidine was more toxic to 51-D3 than to 51-11 cells and increased the mutation frequency 2-fold. Cytosine-β-D-arabinofuranoside showed no differential cytotoxicity on the 2 cell lines and did not increase the mutation frequency at the hprt locus. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3Electric Literature of C10H13FN2O5).

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they constitute an important class of natural and synthetic compounds exhibiting diverse useful biological activities that hold attractive potential for clinical translation as therapeutic agents in alleviation of a myriad of diseases. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own.Electric Literature of C10H13FN2O5

69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3

Therapeutic activities of 1-(2-fluoro-2-deoxy-β-D-arabinofuranosyl)-5-iodocytosine and -thymine alone and in combination with acyclovir and vidarabine in mice infected intracerebrally with herpes simplex virus was written by Schinazi, Raymond F.; Peters, Jeanne; Sokol, M. Kathleen; Nahmias, Andre J.. And the article was included in Antimicrobial Agents and Chemotherapy on July 31,1983.Electric Literature of C10H13FN2O5 The following contents are mentioned in the article:

The therapeutic effectiveness of 1-(2-fluoro-2-deoxy-β-D-arabinofuranosyl)-5-iodocytosine (I) [69123-90-6] and 1-(2-fluoro-2-deoxy-β-D-arabinofuranosyl)thymine (II) [69256-17-3] was compared with that of acyclovir  [59277-89-3] and vidarabine  [5536-17-4]. In mice inoculated intracerebrally with high 50% LDs of herpes simplex virus type 2, nontoxic i.p. or oral treatments with the 2 new fluorinated antiviral agents were highly effective in reducing mortality. The 2 drugs were also effective when treatment was begun as late as 48 h after virus inoculation. The relative order of potencies of the drugs when compared on a molar basis or in terms of therapeutic index was II â‰?I > vidarabine â‰?acyclovir. The new pyrimidine analogs were also found to lack immunosuppressive activity in mice. The combination of I and vidarabine was the most effective; significantly greater reduction in mortality was achieved with this combination than with either drug alone. Thirty minutes after i.p. treatment with the fluorinated analogs, the drugs (or their metabolites) were transported to the brains of virus-inoculated and normal mice at levels about 1/3rd to 2/3rds those in the blood. The levels of II in the blood or brain were consistently higher than those found with equivalent i.p. doses of I. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3Electric Literature of C10H13FN2O5).

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.Electric Literature of C10H13FN2O5

69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3