63931-21-5 | Page 2 of 2

Zhang, Zhaochao et al. published their patent in 2017 |CAS: 63931-21-5

The Article related to pyridine benzimidazole oled, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Electric Literature of 63931-21-5

On July 21, 2017, Zhang, Zhaochao; Li, Chong; Tang, Dandan; Jin, Weixin; Wang, Miao published a patent.Electric Literature of 63931-21-5 The title of the patent was Organic compounds based on pyridine and benzimidazole use as OLED device. And the patent contained the following:

The present invention provides chem. structural formula I of the organic compound, in which X1-X6 independently represents N or C atom, the number of N atoms is 2; p is 0, 1, 2, 3 or 4; m or n independently represents 0, 1, 2 or 3, m+n+z=4, Ar1-3 independently represents C1-10 linear chain or branched chain alkyl, halogen atom, protinium, deuterium, triterium atom substituted or unsubstituted Ph, naphthyl, anthracyl or pyridyl; pyrimidyl, pyrazinyl, pyridazinyl, dibenzopyrane, 9,9-di-Me fluorene, N-Ph carbazole, quinolyl, isoquinolyl or naphthyridinyl, Ar1 also represents single bond etc. The compound of this invention has higher glass transition temperature and mol. heat endurance; and it has low absorptivity and high refractive index in visible light domain. After applied to the CPL layer of OLED device, title compound can effectively enhance the light extraction efficiency of OLED device. The compound of this invention also has deep HOMO energy level and high electron mobility, so it can be used as material of hole barrier/electron transport layer of OLED device, and can effectively stop the conveyance of hole or energy from luminescent layer to electronic shell side, so as to enhance the compounding efficiency of hole and electron in luminescent layer, and enhance the luminous efficiency and service life of OLED device. The experimental process involved the reaction of 5-Bromo-2,4,6-trichloropyrimidine(cas: 63931-21-5).Electric Literature of 63931-21-5

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

9/27 News Sources of common compounds: 63931-21-5

Statistics shows that 63931-21-5 is playing an increasingly important role. we look forward to future research findings about 5-Bromo-2,4,6-trichloropyrimidine.

Synthetic Route of 63931-21-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.63931-21-5, name is 5-Bromo-2,4,6-trichloropyrimidine, molecular formula is C4BrCl3N2, molecular weight is 262.3192, as common compound, the synthetic route is as follows.

5-Bromo-2,4,6-trichloropyrimidine (1.28 g, 4.88 mmol) and 3,3-difluorocyclobutan- amine hydrochloride (715 mg, 4.98 mmol) were suspended in acetonitrile (6 mL) and N,N- diisopropylethylamine (1.55 g, 2.1 mL, 12 mmol) was added at room temperature. The resulting yellow solution was stirred for 7 h at room temperature. After that, the reaction mixture was concentrated in vacuo and the residue was purified by column chromatography (silica gel, 80 g, eluting with ethyl acetate / n-heptane, gradient 0: 100 to 10:90) to yield, after drying in vacuo (40C, 5 mbar), the title compound as a pale yellow oil (1.188 g, 73%). HPLC (method (0254) LCMS_fastgradient) tR = 1.31 min. 1H NMR (CDC13, 300 MHz): delta 2.48-2.67 (m, 2 H), 3.08-3.25 (m, 2 H), 4.39-4.53 (m, 1 H), 5.78-5.90 (m, 1 H). MS (ES+) m/z 330.0, 332.0, 334.0 [M+H, Br & 2 CI isotopes] .

Statistics shows that 63931-21-5 is playing an increasingly important role. we look forward to future research findings about 5-Bromo-2,4,6-trichloropyrimidine.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; BARTELS, Bjoern; JAKOB-ROETNE, Roland; LIMBERG, Anja; NEIDHART, Werner; RATNI, Hasane; REUTLINGER, Michael; STEINER, Sandra; (89 pag.)WO2018/11164; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

17-Sep-21 News Extended knowledge of 63931-21-5

At the same time, in my other blogs, there are other synthetic methods of this type of compound,63931-21-5, 5-Bromo-2,4,6-trichloropyrimidine, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 63931-21-5, 5-Bromo-2,4,6-trichloropyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyrimidines, blongs to pyrimidines compound. category: pyrimidines

5-Bromo-2,4,6-trichloropyrimidine (3.00 g, 10.9 mmol) was dissolved in THF (18 mL) and water (9 mL), and sodium acetate (2.67 g, 32.6 mmol), followed by 3,4-difluoroaniline (1.43 g, 1.10 mL, 11.1 mmol) were added. The mixture was stirred at room temperature for 18 h. After that, a saturated aqueous solution of sodium hydrogencarbonate (30 mL) was added and the resulting mixture was extracted with ethyl acetate (2 x 150 mL). The combined organic layers were dried (sodium sulfate) and concentrated in vacuo. The crude was purified by column chromatography (silica gel, 120 g, eluting with ethyl acetate / n-heptane, gradient 0: 100 to 10:90) to afford, after drying in vacuo (40C, 5 mbar), the title compound as a light yellow solid (3.32 g, 86%). HPLC (method LCMS_fastgradient) tR = 1.37 min. 1H NMR (CDC13, 300 MHz): delta 7.17- 7.24 (m, 2 H), 7.43 (br s, 1 H), 7.59-7.68 (m, 1 H). MS (ES+) m/z 353.9, 355.9, 357.8 [M+H, Br & 2 CI isotopes] .

At the same time, in my other blogs, there are other synthetic methods of this type of compound,63931-21-5, 5-Bromo-2,4,6-trichloropyrimidine, and friends who are interested can also refer to it.

Some tips on 5-Bromo-2,4,6-trichloropyrimidine

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 63931-21-5, 5-Bromo-2,4,6-trichloropyrimidine.

Related Products of 63931-21-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 63931-21-5, name is 5-Bromo-2,4,6-trichloropyrimidine, molecular formula is C4BrCl3N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

5-Bromo-2,4,6-trichloropyrimidine (1.880 g, 6.81 mmol) was dissolved in THF (11 mF) and water (5 mF), and sodium acetate (1.68 g, 20.4 mmol), followed by 4-fluoroaniline (787 mg, (0231) 0.68 mF, 6.87 mmol) were added. The mixture was stirred at room temperature for 18 h. After that, a saturated aqueous solution of sodium hydrogenocarbonate (15 mF) was added and the resulting mixture was extracted with ethyl acetate (2 x 150 mF). The combined organic layers were dried (sodium sulfate) and concentrated in vacuo. The crude was purified by column chromatography (silica gel, 40 g, eluting with ethyl acetate / n-heptane, gradient 0:100 to 10:90) to afford, after drying in vacuo (40C, 5 mbar), the title compound as a light brown solid (2.07 g, 90%). MS (ES+) m/z 335.9, 337.9, 339.9 [M+H, Br & 2 Cl isotopes].

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; BARTELS, Bjoern; COOK, Xinlan Aloise Ford; RATNI, Hasane; REUTLINGER, Michael; VIFIAN, Walter; (46 pag.)WO2019/101984; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Extracurricular laboratory: Synthetic route of 5-Bromo-2,4,6-trichloropyrimidine

According to the analysis of related databases, 63931-21-5, the application of this compound in the production field has become more and more popular.

Electric Literature of 63931-21-5, Adding some certain compound to certain chemical reactions, such as: 63931-21-5, name is 5-Bromo-2,4,6-trichloropyrimidine,molecular formula is C4BrCl3N2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 63931-21-5.

5-Bromo-2,4,6-trichloropyrimidine (1.30 g, 4.96 mmol) and 3-(trifluoromethyl)- bicyclo[l.l. l]pentan-l- amine hydrochloride (985 mg, 4.99 mmol) were suspended in acetonitrile (6.5 mL) and N,N-diisopropylethylamine (1.55 g, 2.1 mL, 12 mmol) was added at room temperature. The resulting yellow solution was stirred for 7 h at room temperature. After that, the reaction mixture was concentrated in vacuo and the residue was purified by column chromatography (silica gel, 80 g, eluting with ethyl acetate / n-heptane, gradient 0: 100 to 10:90) to yield, after drying in vacuo (40C, 5 mbar), the title compound as an off-white solid (1.487 g, 80%). HPLC (method LCMS_fastgradient) tR = 1.50 min. 1H NMR (CDC13, 300 MHz): delta 2.46 (s, 6 H), 6.10 (br s, 1 H). MS (ES+) m/z 375.9, 377.9, 379.8 [M+H, Br & 2 CI isotopes].

According to the analysis of related databases, 63931-21-5, the application of this compound in the production field has become more and more popular.

Some tips on 63931-21-5

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,63931-21-5, its application will become more common.

Electric Literature of 63931-21-5 ,Some common heterocyclic compound, 63931-21-5, molecular formula is C4BrCl3N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

5-Bromo-2,4,6-trichloropyrimidine (1.880 g, 6.81 mmol) was dissolved in THF (11 mL) and water (5 mL), and sodium acetate (1.68 g, 20.4 mmol), followed by 4-fluoroaniline (787 mg, 0.68 mL, 6.87 mmol) were added. The mixture was stirred at room temperature for 18 h. After that, a saturated aqueous solution of sodium hydrogencarbonate (15 mL) was added and the resulting mixture was extracted with ethyl acetate (2 x 150 mL). The combined organic layers were dried (sodium sulfate) and concentrated in vacuo. The crude was purified by column chromatography (silica gel, 40 g, eluting with ethyl acetate / n-heptane, gradient 0: 100 to 10:90) to afford, after drying in vacuo (40C, 5 mbar), the title compound as a light brown solid (2.07 g, 90%). HPLC (method LCMS_fastgradient) tR = 1.36 min. 1H NMR (CDC13, 300 MHz): delta 7.12 (dd, / = 8.3, 9.1 Hz, 2 H), 7.43 (br s, 1 H), 7.52 (dd, / = 4.6, 8.9 Hz, 2 H). MS (ES+) m/z 335.9, 337.9, 339.9 [M+H, Br & 2 CI isotopes] .

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,63931-21-5, its application will become more common.