At the same time, in my other blogs, there are other synthetic methods of this type of compound,52522-99-3, 5-Iodo-2,4-dimethoxypyrimidine, and friends who are interested can also refer to it.
Adding a certain compound to certain chemical reactions, such as: 52522-99-3, 5-Iodo-2,4-dimethoxypyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 52522-99-3, blongs to pyrimidines compound. Product Details of 52522-99-3
Preparation 70: 5-(2-Chloro-5-fluoro-pyridin-3-yl)-2,4-dimethoxy-pyrimidine (Prep70); 5-lodo-2,4-dimethoxy-pyrimidine (868 mg, 3.3 mmol) was dissolved in degassed n-PrOH (30 ml) and then 2-chloro-5-fluoropyridine-3-boronic acid (858 mg, 4.9 mmol), Na2CO3 (700 mg, 6.6 mmol), PPh3 (88 mg, 0.33 mmol) and Pd(OAc)2 (90 mg) were added. The suspension was stirred at reflux for 4 hours. The solvent was evaporated under vacuum and the crude was partitioned between brine and ethyl acetate. The organic phase was dried (Na2SO4) and evaporated. The crude was purified by flash chromatography with ethyl acetate-petroleum ether 2-8 affording 240 mg of the title compound (27% yield). MS (ES) (m/z): 270 [M+H]+.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,52522-99-3, 5-Iodo-2,4-dimethoxypyrimidine, and friends who are interested can also refer to it.
Reference:
Patent; Glaxo Group Limited; WO2007/113232; (2007); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia