Category: 4595-59-9

The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives, 4595-59-9, formula is C4H3BrN2, Name is 5-Bromopyrimidine. including the nucleotides cytosine, thymine and uracil, thiamine (vitamin B1) and alloxan. Recommanded Product: 5-Bromopyrimidine.

Lin, Wenhua;Zhang, Liping;Ma, Yanping;Liang, Tongling;Sun, Wen-Hua research published 《 Sterically enhanced 2-iminopyridylpalladium chlorides as recyclable ppm-palladium catalyst for Suzuki-Miyaura coupling in aqueous solution》, the research content is summarized as follows. Sterically hindered 2-iminopyridine derivatives and their palladium chlorides complexes were designed and prepared, which efficiently promoted the Suzuki-Miyaura coupling (SMC) reaction in aqueous solution Besides the good to excellent yields and broad substrate scope, these catalysts could be reused for at least four new batches of the substrates. Spontaneous separation of coupling products RR¹ [R = Ph, 4-BrC₆H₄, 1-naphthyl, etc.; R¹ = Ph, 4-NCC₆H₄, 1-naphthyl, 4-PhCH₂OC₆H₄, 9-anthryl] in the aqueous reaction medium was the addnl. striking feature of this catalytic process. Furthermore, catalytic performance of palladium complexes bearing the azo-bridged Ph groups was greatly influenced by the UV irradiation due to the cis/trans photoisomerization of azo unit of the catalysts. In conclusion, titled palladium complexes provided a green, sustainable, cost-effective and convenient process to synthesize SMC products at multi-gram-scale reaction.

Recommanded Product: 5-Bromopyrimidine, 5-Bromopyrimidine is a reactive intermediate that is used in the synthesis of 4-methoxyphenylboronic acid. 5-Bromopyrimidine has been shown to be nucleophilic, reacting with β-amino acids under basic conditions to form the corresponding 2-bromo amide. It also undergoes cross-coupling reactions with halides and can be used as a building block for other organic compounds. 5-Bromopyrimidine has optical properties that are characteristic of aromatic molecules, including strong absorption bands in the ultraviolet region and visible light region.
5-Bromopyrimidine undergoes direct metallation with lithuium diisopropylamide to yield 4-lithio-5-bromopyrimidine., 4595-59-9.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The systematic study of pyrimidines began in 1884 with Pinner, who synthesized derivatives by condensing ethyl acetoacetate with amidines. Pinner first proposed the name “pyrimidin” in 1885. 4595-59-9, formula is C4H3BrN2, Name is 5-Bromopyrimidine. The parent compound was first prepared by Gabriel and Colman in 1900, by conversion of barbituric acid to 2,4,6-trichloropyrimidine followed by reduction using zinc dust in hot water. Reference of 4595-59-9.

Li, Bowen;Luo, Bangke;Blakemore, Caroline A.;Smith, Aaron C.;Widlicka, Daniel W.;Berritt, Simon;Tang, Wenjun research published 《 Synthesis of α-Heteroaryl Propionic Esters by Palladium-Catalyzed α-Heteroarylation of Silyl Ketene Acetals》, the research content is summarized as follows. A practical and efficient synthesis of α-heteroaryl propionic esters was developed by employing palladium-catalyzed α-heteroarylation of silyl ketene acetals, forming a wide variety of α-heteroaryl propionic esters with various substituents and functionalities in high yields. The success of this transformation was credited to the development of the bulky P,P=O ligand. This method provided an efficient synthesis of α-heteroaryl propionic acids.

Reference of 4595-59-9, 5-Bromopyrimidine is a reactive intermediate that is used in the synthesis of 4-methoxyphenylboronic acid. 5-Bromopyrimidine has been shown to be nucleophilic, reacting with β-amino acids under basic conditions to form the corresponding 2-bromo amide. It also undergoes cross-coupling reactions with halides and can be used as a building block for other organic compounds. 5-Bromopyrimidine has optical properties that are characteristic of aromatic molecules, including strong absorption bands in the ultraviolet region and visible light region.
5-Bromopyrimidine undergoes direct metallation with lithuium diisopropylamide to yield 4-lithio-5-bromopyrimidine., 4595-59-9.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives, including the nucleotides cytosine, thymine and uracil, thiamine (vitamin B1) and alloxan. 4595-59-9, formula is C4H3BrN2, Name is 5-Bromopyrimidine. It is also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. Electric Literature of 4595-59-9.

Li, Dong-Hui;Lan, Xiao-Bing;Song, A-Xiang;Rahman, Mahbubur Md.;Xu, Chang;Huang, Fei-Dong;Szostak, Roman;Szostak, Michal;Liu, Feng-Shou research published 《 Buchwald-Hartwig Amination of Coordinating Heterocycles Enabled by Large-but-Flexible Pd-BIAN-NHC Catalysts》, the research content is summarized as follows. A new class of large-but-flexible Pd-BIAN-NHC catalysts (BIAN=acenaphthoimidazolylidene, NHC=N-heterocyclic carbene) has been rationally designed to enable the challenging Buchwald-Hartwig amination of coordinating heterocycles. This robust class of BIAN-NHC catalysts permits cross-coupling under practical aerobic conditions of a variety of heterocycles with aryl, alkyl, and heteroarylamines, including historically challenging oxazoles and thiazoles as well as electron-deficient heterocycles containing multiple heteroatoms with BIAN-INon (N,N’-bis(2,6-di(4-heptyl)phenyl)-7H-acenaphtho[1,2-d]imidazol-8-ylidene) as the most effective ligand. Studies on the ligand structure and electronic properties of the carbene center are reported. The study should facilitate the discovery of even more active catalyst systems based on the unique BIAN-NHC scaffold.

Electric Literature of 4595-59-9, 5-Bromopyrimidine is a reactive intermediate that is used in the synthesis of 4-methoxyphenylboronic acid. 5-Bromopyrimidine has been shown to be nucleophilic, reacting with β-amino acids under basic conditions to form the corresponding 2-bromo amide. It also undergoes cross-coupling reactions with halides and can be used as a building block for other organic compounds. 5-Bromopyrimidine has optical properties that are characteristic of aromatic molecules, including strong absorption bands in the ultraviolet region and visible light region.
5-Bromopyrimidine undergoes direct metallation with lithuium diisopropylamide to yield 4-lithio-5-bromopyrimidine., 4595-59-9.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives, 4595-59-9, formula is C4H3BrN2, Name is 5-Bromopyrimidine. including the nucleotides cytosine, thymine and uracil, thiamine (vitamin B1) and alloxan. COA of Formula: C4H3BrN2.

Li, Haoyu;Liu, Yuliang;Chiba, Shunsuke research published 《 Anti-Markovnikov hydroarylation of alkenes via polysulfide anion photocatalysis》, the research content is summarized as follows. A protocol for anti-Markovnikov hydroarylation of alkenes, e.g., 2,3-dihydrofuran with aryl halides ArX (Ar = (4-CO₂CH₃)C₆H₄, 2-naphthyl, 5-cyanothiophen-2-yl, etc.; X = Br, Cl) has been developed using polysulfide anions as photocatalysts in the presence of the Hantzsch ester and water under irradiation with visible light.

COA of Formula: C4H3BrN2, 5-Bromopyrimidine is a reactive intermediate that is used in the synthesis of 4-methoxyphenylboronic acid. 5-Bromopyrimidine has been shown to be nucleophilic, reacting with β-amino acids under basic conditions to form the corresponding 2-bromo amide. It also undergoes cross-coupling reactions with halides and can be used as a building block for other organic compounds. 5-Bromopyrimidine has optical properties that are characteristic of aromatic molecules, including strong absorption bands in the ultraviolet region and visible light region.
5-Bromopyrimidine undergoes direct metallation with lithuium diisopropylamide to yield 4-lithio-5-bromopyrimidine., 4595-59-9.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives, including the nucleotides cytosine, thymine and uracil, thiamine (vitamin B1) and alloxan. 4595-59-9, formula is C4H3BrN2, Name is 5-Bromopyrimidine. It is also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. Quality Control of 4595-59-9.

Kralova, Veronika;Soural, Miroslav;Horak, Radim;Hradil, Pavel research published 《 Convenient Synthesis of Furo[3,2-b]quinolin-4(1H)-ones》, the research content is summarized as follows. The simple synthesis of furo[3,2-b]quinolin-4(1H)-ones I (R = H, 4-methoxyphenyl, thiophen-2-yl, etc.) from readily available 4-ethynyl-[1,3]dioxolo[4,5-c]quinolone as the key starting material was reported. After Sonogashira (hetero)arylation, formation of the furoquinoline scaffold I was accomplished using methanesulfonic acid and metal-free conditions. Although the cyclization was affected by the substitution of reaction intermediates II, the method allowed the preparation of derivatives varying at the C3-position.

4595-59-9, 5-Bromopyrimidine is a reactive intermediate that is used in the synthesis of 4-methoxyphenylboronic acid. 5-Bromopyrimidine has been shown to be nucleophilic, reacting with β-amino acids under basic conditions to form the corresponding 2-bromo amide. It also undergoes cross-coupling reactions with halides and can be used as a building block for other organic compounds. 5-Bromopyrimidine has optical properties that are characteristic of aromatic molecules, including strong absorption bands in the ultraviolet region and visible light region.
5-Bromopyrimidine undergoes direct metallation with lithuium diisopropylamide to yield 4-lithio-5-bromopyrimidine., Quality Control of 4595-59-9

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. 4595-59-9, formula is C4H3BrN2, Name is 5-Bromopyrimidine. In nucleic acids, three types of nucleobases are pyrimidine derivatives: cytosine (C), thymine (T), and uracil (U). Related Products of 4595-59-9.

Kumada, Kengo;Sasabe, Hisahiro;Nakao, Kohei;Matsuya, Misaki;Noda, Taito;Arai, Hiroki;Kido, Junji research published 《 Controlling the electronic structures of triphenylene based sky blue TADF emitters by chemical modifications for high efficiency with shorter emission lifetimes》, the research content is summarized as follows. Chem. modified triphenylene derivatives are one of the attractive candidates as an acceptor unit for realizing efficient blue thermally activated delayed fluorescence (TADF) emitters due to the rigid structure and the high triplet energy of 2.9 eV however, only a limited number of examples with low external quantum efficiency (EQE) below 10% are reported to date. Here, we developed three types of blue TADF emitters based on modified triphenylene acceptor units. These emitters showed sky blue emission with the emission peak wavelength around 470 nm, high photoluminescent quantum yield (PLQY) of ∼88%, and a short delayed lifetime (τd) of ∼7.7 μs. These emitters realized efficient sky blue organic light-emitting device with high EQE of over 20%.

4595-59-9, 5-Bromopyrimidine is a reactive intermediate that is used in the synthesis of 4-methoxyphenylboronic acid. 5-Bromopyrimidine has been shown to be nucleophilic, reacting with β-amino acids under basic conditions to form the corresponding 2-bromo amide. It also undergoes cross-coupling reactions with halides and can be used as a building block for other organic compounds. 5-Bromopyrimidine has optical properties that are characteristic of aromatic molecules, including strong absorption bands in the ultraviolet region and visible light region.
5-Bromopyrimidine undergoes direct metallation with lithuium diisopropylamide to yield 4-lithio-5-bromopyrimidine., Related Products of 4595-59-9

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. 4595-59-9, formula is C4H3BrN2, Name is 5-Bromopyrimidine. In nucleic acids, three types of nucleobases are pyrimidine derivatives: cytosine (C), thymine (T), and uracil (U). COA of Formula: C4H3BrN2.

Kwak, Minjoon;Bok, Jinsol;Lee, Byoung-Hoon;Kim, Jongchan;Seo, Youngran;Kim, Sumin;Choi, Hyunwoo;Ko, Wonjae;Hooch Antink, Wytse;Lee, Chan Woo;Yim, Guk Hee;Seung, Hyojin;Park, Chansul;Lee, Kug-Seung;Kim, Dae-Hyeong;Hyeon, Taeghwan;Yoo, Dongwon research published 《 Ni single atoms on carbon nitride for visible-light-promoted full heterogeneous dual catalysis》, the research content is summarized as follows. Visible-light-driven organic transformations are of great interest in synthesizing valuable fine chems. under mild conditions. The merger of heterogeneous photocatalysts and transition metal catalysts has recently drawn much attention due to its versatility for organic transformations. However, these semi-heterogenous systems suffered several drawbacks, such as transition metal agglomeration on the heterogeneous surface, hindering further applications. Here, we introduce heterogeneous single Ni atoms supported on carbon nitride (NiSAC/CN) for visible-light-driven C-N functionalization with a broad substrate scope. Compared to a semi-heterogeneous system, high activity and stability were observed due to metal-support interactions. Furthermore, through systematic exptl. mechanistic studies, we demonstrate that the stabilized single Ni atoms on CN effectively change their redox states, leading to a complete photoredox cycle for C-N coupling.

COA of Formula: C4H3BrN2, 5-Bromopyrimidine is a reactive intermediate that is used in the synthesis of 4-methoxyphenylboronic acid. 5-Bromopyrimidine has been shown to be nucleophilic, reacting with β-amino acids under basic conditions to form the corresponding 2-bromo amide. It also undergoes cross-coupling reactions with halides and can be used as a building block for other organic compounds. 5-Bromopyrimidine has optical properties that are characteristic of aromatic molecules, including strong absorption bands in the ultraviolet region and visible light region.
5-Bromopyrimidine undergoes direct metallation with lithuium diisopropylamide to yield 4-lithio-5-bromopyrimidine., 4595-59-9.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Pyrimidine is a nitrogenous base similar to benzene (a six-membered ring) and includes cytosine, thymine, and uracil as bases used for DNA or RNA. 4595-59-9, formula is C4H3BrN2, Name is 5-Bromopyrimidine. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. Related Products of 4595-59-9.

Lai, Samson;Takaesu, Noah;Lin, Wen Xuan;Perrin, David M. research published 《 Suzuki coupling of aroyl-MIDA boronate esters – A preliminary report on scope and limitations》, the research content is summarized as follows. The production of benzophenones by C-C cross coupling between a benzoyl-MIDA boronate ester and a multitude of aryl bromide substrates in adequate yields following optimization under ambient conditions outside of a glove box were reported. Under these standard conditions, none of several acyl-MIDA boronate esters (in an alkyl series) served as a competent coupling partner. The substrate scope was also limited by the finding that the corresponding trifluoroborates of both acyl- and aroyltrifluroborates were not suitable substrates. For reasons of availability and synthetic difficulty in procuring other aroyl-MIDA boronates, this preliminary study examined the reactivity of benzoyl-MIDA boronate with several aryl bromide substrates.

4595-59-9, 5-Bromopyrimidine is a reactive intermediate that is used in the synthesis of 4-methoxyphenylboronic acid. 5-Bromopyrimidine has been shown to be nucleophilic, reacting with β-amino acids under basic conditions to form the corresponding 2-bromo amide. It also undergoes cross-coupling reactions with halides and can be used as a building block for other organic compounds. 5-Bromopyrimidine has optical properties that are characteristic of aromatic molecules, including strong absorption bands in the ultraviolet region and visible light region.
5-Bromopyrimidine undergoes direct metallation with lithuium diisopropylamide to yield 4-lithio-5-bromopyrimidine., Related Products of 4595-59-9

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The nomenclature of pyrimidines is straightforward. However, like other heterocyclics, tautomeric hydroxyl groups yield complications since they exist primarily in the cyclic amide form. 4595-59-9, formula is C4H3BrN2, Name is 5-Bromopyrimidine. For example, 2-hydroxypyrimidine is more properly named 2-pyrimidone. A partial list of trivial names of various pyrimidines exists. Safety of 5-Bromopyrimidine.

Khan, Ilham;Khalid, Muhammad;Adeel, Muhammad;Niaz, Shah Irum;Shafiq, Iqra;Muhammad, Shabbir;Braga, Ataualpa Albert Carmo research published 《 Palladium-catalyzed synthesis of 5-(arylated) pyrimidines, their characterization, electronic communication, and non-linear optical evaluations》, the research content is summarized as follows. In this study, new derivatives of pyrimidines I [R¹ = 4-methylsulfanyl, 4-Ph, 4-trifluoromethoxy, 2,3-dichloro] were synthesized through Suzuki-Miyaura coupling and assessed by ¹H NMR, ¹³C NMR, FT-IR and UV/Visible anal. Furthermore, computational study such as spectroscopic, frontier MO (FMO), natural bond orbital (NBO) and the mol. electrostatic potential (MEP) was performed at M06/6-311G** to obtain comprehensive insights into electronic communications and the structural property relationship for synthesized compounds I. The maximum exptl. absorption (λ_Exp) for compounds I [R¹ = 4-Ph, 4-methylsulfanyl, 4-trifluoromethoxy, 2,3-dichloro] was obtained at 260, 301, 248, and 233 nm, resp. in methanol, which displayed good agreement with theor. (λ_DFT) result 279, 298, 247, and 233 nm, resp. Moreover, different functional(s) such as HF, M06, M062X, CAM-B3LYP, and LC-BLYP with basis sets 6-311G** were utilized to compute the average polarizability α, total dipole moment (μ_tot) and hyperpolarizability (β_tot) values. Among the tested methods, highest μ_tot value (3.5465 D) was observed for compoundI [R¹ = 2,3-dichloro] and the lowest value (0.2680 D) for compound I [R¹ = 4-trifluoromethoxy] through HF method. Consequently, the LC-BLYP method also showed the highest μ_tot value (3.4689 D) for compound I [R¹ = 2,3-dichloro] and the lowest value (0.3123 D) of compound I [R¹ = 4-trifluoromethoxy]. Moreover, other methods: CAM-B3LYP, M062X, and M06 showed almost similar values for all compounds I with similar trends. The M06 method showed the largest α values (190.779, 149.331, 130.430 and 138.964 a.u.) for compounds I [R¹ = 4-Ph, 4-methylsulfanyl, 4-trifluoromethoxy, 2,3-dichloro] resp. In contrast, the HF method showed the least α values (178.166, 140.356, 121.848, and 128.994 a.u.) for compounds I [R¹ = 4-Ph, 4-methylsulfanyl, 4-trifluoromethoxy, 2,3-dichloro] resp. The other methods (CAMB3LYP, M062X, and LC-BLYP) indicated nearly parallel (α) values. Moreover, the (β_tot) values (604.898, 344.234, 41.628, and 299.958 a.u.) obtained with M06 method for compounds I [R¹ = 4-Ph, 4-methylsulfanyl, 4-trifluoromethoxy, 2,3-dichloro] resp., were higher compared with urea (β_tot = 69.399 a.u.).

Safety of 5-Bromopyrimidine, 5-Bromopyrimidine is a reactive intermediate that is used in the synthesis of 4-methoxyphenylboronic acid. 5-Bromopyrimidine has been shown to be nucleophilic, reacting with β-amino acids under basic conditions to form the corresponding 2-bromo amide. It also undergoes cross-coupling reactions with halides and can be used as a building block for other organic compounds. 5-Bromopyrimidine has optical properties that are characteristic of aromatic molecules, including strong absorption bands in the ultraviolet region and visible light region.
5-Bromopyrimidine undergoes direct metallation with lithuium diisopropylamide to yield 4-lithio-5-bromopyrimidine., 4595-59-9.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives, including the nucleotides cytosine, thymine and uracil, thiamine (vitamin B1) and alloxan. 4595-59-9, formula is C4H3BrN2, Name is 5-Bromopyrimidine. It is also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. Related Products of 4595-59-9.

Khan, Ilham;Khalid, Muhammad;Adeel, Muhammad;Khan, Muhammad Usman;Khan, Muhammad Sohail;Ahmad, Naseeb;Ali, Akbar;Akram, Muhammad research published 《 Palladium-catalyzed synthesis of pyrimidine substituted diaryl ethers through Suzuki Miyaura coupling reactions: Experimental and DFT studies》, the research content is summarized as follows. Aryl and hetero-aryl substituted pyrimidine derivatives demonstrate widespread applications in nonlinear optics (NLO), agrochem. and therapeutic drugs. Therefore, 2-(4-phenoxyphenyl)pyrimidine (2-PPP) and 5-(4-phenoxyphenyl) pyrimidine (5-PPP) were synthesized by palladium-catalyzed Suzuki coupling approach. The structure elucidation of synthesized products was done by ¹H-NMR, ¹³C-NMR, and UV-vis spectroscopic analyses. The natural bond orbital (NBO) anal. was performed using d. functional theory (DFT) assisted M06/6-311G** functional, which confirmed the existence of delocalization process and the hyper-conjugative interaction with representative transitions as π(C10-N16)→π*(C14-N17) and π(C26-N30)→π*(C9-N31) having stabilization energies of 36.30 and 36.55 kcal/mol for 2-PPP and 5-PPP, resp. The small energy ΔE LUMO HOMO gap as 5.330 eV in 2-PPP and 4.975 eV in 5-PPP was evident from the frontier MO (FMO) anal., computed at TD-DFT/M06/6-311G** level, Both the NBO and the FMO anal. predicted promising NLO mol. response. Furthermore, HF, LC-BLYP, CAM-B3LYP, M06-2X, and M06 methods, along with the 6-311G** basis set, were utilized to acquire the NLO findings of 2-PPP and 5-PPP. M06 and HF methods indicated the largest and lowest values of average polarizability α and first hyperpolarizability (β_tot), resp. for both the compounds 2-PPP and 5-PPP. The α and β_tot values of 2-PPP and 5-PPP were observed as 7.0 and 7.3 times and 15 and 36 times higher than the urea mol., resp. Both compounds hold fine NLO characteristics, thus recommended for future NLO applications.

Related Products of 4595-59-9, 5-Bromopyrimidine is a reactive intermediate that is used in the synthesis of 4-methoxyphenylboronic acid. 5-Bromopyrimidine has been shown to be nucleophilic, reacting with β-amino acids under basic conditions to form the corresponding 2-bromo amide. It also undergoes cross-coupling reactions with halides and can be used as a building block for other organic compounds. 5-Bromopyrimidine has optical properties that are characteristic of aromatic molecules, including strong absorption bands in the ultraviolet region and visible light region.
5-Bromopyrimidine undergoes direct metallation with lithuium diisopropylamide to yield 4-lithio-5-bromopyrimidine., 4595-59-9.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia