Category: 4214-85-1

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 4214-85-1, name is 2-Amino-6-methyl-5-nitro-3H-pyrimidin-4-one, molecular formula is C5H6N4O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. COA of Formula: C5H6N4O3

A suspension of 2-amino-6-methyl-5-nitropyrimidin-4-one (G. N. Mitchell et. al. J. Org. Chem . , 1974, 39, 176) (20.0 g) in acetic anhydride (120 ML) was heated under reflux for 0.5 h.. The cooled suspension was filtered and the solids washed with ether to give 2-N-acetyl-6-methyl-5-nitropyrimidin-4-one (19.7 g).. 13C NMR (d6-DMSO) delta 174.5, 161.9, 153.3, 150.9, 133.8, 24.2, 21.4.

With the rapid development of chemical substances, we look forward to future research findings about 4214-85-1.

Reference:
Patent; Industrial Research Limited; Albert Einstein College of Medicine of Yesheva University; US6693193; (2004); B1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 4214-85-1, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 4214-85-1 as follows.

In a 100 mL two-neck round-bottom flask under N2 atmosphereand molecular sieve 3 A was added 2 (2.0 g, 11.7 mmol) in dry DMF (25 mL) and DMF dimethyl acetal (7.5 mL, 70.0 mmol). The mixturewas stirred at 100 C for 24 h and then cooled. The mixturewas dried under vacuum. Acetone (15 mL) was added and theformed precipitate was filtered and washed with acetone (10 mL)furnishing 3 in 96% yield (3.16 g)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,4214-85-1, its application will become more common.

Reference:
Article; Rodrigues, Marili V.N.; Barbosa, Alexandre F.; Da Silva, Julia F.; Dos Santos, Deborah A.; Vanzolini, Kenia L.; De Moraes, Marcela C.; Correa, Arlene G.; Cass, Quezia B.; Bioorganic and Medicinal Chemistry; vol. 24; 2; (2016); p. 226 – 231;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 4214-85-1, 2-Amino-6-methyl-5-nitro-3H-pyrimidin-4-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 2-Amino-6-methyl-5-nitro-3H-pyrimidin-4-one, blongs to pyrimidines compound. Recommanded Product: 2-Amino-6-methyl-5-nitro-3H-pyrimidin-4-one

A mixture of 58 (20 g) with dry DMF (250 ml) and DMF dimethylacetal (75 ml) was stirred at 100 C. for 24 h and then cooled.. acetone (500 ml) was added and the mixture was filtered and washed with acetone affording 10 as an orange/brown solid (26.3 g, 80%).. Recrystallization from DMF gave an orange solid with mp>300 C. (dec).. 1H NMR (d6-DMSO) delta 8.59 (s, 1H), 7.81 (d, J=12.5 Hz, 1H), 5.30 (d, J=12.5 Hz, 1H), 3.12 (s, 3H), 3.00 (s, 3H), 2.93 (s, 6H).. 13C NMR delta 168.4, 166.0, 159.2, 158.5, 149.5, 129.1, 90.6, 41.8, 35.7.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,4214-85-1, 2-Amino-6-methyl-5-nitro-3H-pyrimidin-4-one, and friends who are interested can also refer to it.

Reference:
Patent; Industrial Research Limited; Albert Einstein College of Medicine of Yesheva University; US6693193; (2004); B1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.4214-85-1, name is 2-Amino-6-methyl-5-nitro-3H-pyrimidin-4-one, molecular formula is C5H6N4O3, molecular weight is 170.13, as common compound, the synthetic route is as follows.Formula: C5H6N4O3

(E)-iV.H/V-Dimethyl-Lambdarf-(4-methyl-5-nitro-6-oxo-l,6-dihydropyrimidin-2- yl)formimidamideTo a suspension of 2-Amino-6-methyl-5-nitropyrimidin-4(3H)-one (54.8 g, 0.32 mol) in CH2Cl2 (461 mL) was added DMF-dimethylacetal (103.1 mL, 0.77 mol) and stirred at room temperature for 1.5 h. The reaction mixture was filtered, washed with CH2Cl2, and used for the next step without further purification (31.9 g, 44% yield).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,4214-85-1, 2-Amino-6-methyl-5-nitro-3H-pyrimidin-4-one, and friends who are interested can also refer to it.

Reference:
Patent; VALEANT RESEARCH & DEVELOPMENT; WO2006/122003; (2006); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia