Category: 3764-01-0

Recommanded Product: 3764-01-0In 2015 ,《Reaction of 3-aminopyrrole with chloropyrimidines to give pyrroloaminopyrimidines》 appeared in ARKIVOC (Gainesville, FL, United States). The author of the article were De Rosa, Michael; Arnold, David; Wright, Austin Cameron; Son, Young. The article conveys some information:

Reaction of 3-aminopyrrole with chloropyrimidines occurred only at the 3-amino group. The activating group(s) (Cl, NO2 or CF3), their relative positions (C4/C6, C2, or C5), and the effect of added base (DIPEA) or acetic acid on the course of the reaction, was studied. When chloro groups were present on both C4/C6 and C2, the only or major product was from the displacement of the C4/C6 chloro group. Only in the reaction of 2,4,6-trichloropyrimidine was substitution at C2 competitive with reaction at C6. Both chloro groups of 2,4-dichloro-3-nitropyrimidine were displaced to give a novel compound with three-linked heterocyclic rings. Reactions of less reactive chloropyrimidines appeared to be favored by acid catalysis. The experimental process involved the reaction of 2,4,6-Trichloropyrimidine(cas: 3764-01-0Recommanded Product: 3764-01-0)

2,4,6-Trichloropyrimidine(cas: 3764-01-0) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Recommanded Product: 3764-01-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In 2017,Leitch, Jamie A.; McMullin, Claire L.; Paterson, Andrew J.; Mahon, Mary F.; Bhonoah, Yunas; Frost, Christopher G. published 《Ruthenium-Catalyzed para-Selective C-H Alkylation of Aniline Derivatives》.Angewandte Chemie, International Edition published the findings.Safety of 2,4,6-Trichloropyrimidine The information in the text is summarized as follows:

The para-selective C-H alkylation of aniline derivatives furnished with a pyrimidine auxiliary is herein reported. This reaction is proposed to take place via an N-H-activated cyclometalate formed in situ. Exptl. and DFT mechanistic studies elucidate a dual role of the ruthenium catalyst. Here the ruthenium catalyst can undergo cyclometalation by N-H metalation (as opposed to C-H metalation in meta-selective processes) and form a redox active ruthenium species, to enable site-selective radical addition at the para position. The results came from multiple reactions, including the reaction of 2,4,6-Trichloropyrimidine(cas: 3764-01-0Safety of 2,4,6-Trichloropyrimidine)

2,4,6-Trichloropyrimidine(cas: 3764-01-0) is a member of organic chlorides. Organic chloride content in crude oil can be detected through specialized laboratory analysis. Care and attention are essential while sampling and testing.Safety of 2,4,6-Trichloropyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The author of 《Synthesis, biological profile and computational studies of some trichloropyrimidine derivatives》 were Sandeep, Thummar; Vasishta, Bhatt. And the article was published in Research Journal of Chemistry and Environment in 2019. Name: 2,4,6-Trichloropyrimidine The author mentioned the following in the article:

A series of (((oxadiazolyl-thio)(nitrophenyl-amino)pyrimidinyl)hydrazinyl)-N-phenylacetamide motifs I [R = Ph, 2-furyl, 3-pyridyl, etc.] was synthesized and studied for their antibacterial and antifungal activities as well as for mol. docking and FMO studies. All the synthesized mols. were characterized by 1H NMR and 13C NMR spectroscopic anal. Compounds I [R = 3-pyridyl, 4-pyridyl] were found to be potentially active against gram neg. and gram-pos. bacteria with MIC value between 62.5 to 500μg/mL. The mol. docking studies of compounds I [R = Ph, 3-pyridyl] were further carried out to discover the interaction with active sites. In the experimental materials used by the author, we found 2,4,6-Trichloropyrimidine(cas: 3764-01-0Name: 2,4,6-Trichloropyrimidine)

2,4,6-Trichloropyrimidine(cas: 3764-01-0) is a member of organic chlorides. Organic chloride content in crude oil can be detected through specialized laboratory analysis. Care and attention are essential while sampling and testing.Name: 2,4,6-Trichloropyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

《A novel one-pot and efficient procedure for synthesis of new fused uracil derivatives for DNA binding》 was written by Mousa, Bothaina A.; Bayoumi, Ashraf H.; Korraa, Makarem M.; Assy, Mohamed G.; El-Kalyoubi, Samar A.. Electric Literature of C4HCl3N2This research focused onxanthine arylidineaniline indenopyrrolopyrimidine indenopteridine ninhydrin DNA damage nucleobase; hydrazone oxidative cyclization thionyl chloride pyrazolopyrimidine nitrosation aminouracil; DNA uracil fused synthesis hydrazinolysis chloromethyluracil condensation aromatic aldehyde. The article conveys some information:

Hydrazinolysis of 6-chloro-1-methyluracil followed by condensation of the product with different aromatic aldehyde gives the resp. hydrazones which undergoes oxidative cyclization using thionyl chloride to obtain pyrazolo[3,4-d]pyrimidines in good yields. On the other hand, nitrosation of 6-aminouracils followed by the reaction with different arylidineanilines gives new xanthine derivatives Finally, indenopyrrolopyrimidine and indenopteridine are obtained in good yields via the reaction of 6-aminouracils and 5,6-diaminouracil with ninhydrin resp. The newly synthesized compounds show binding, chelation and fragmentation of the nucleic acid DNA. The experimental part of the paper was very detailed, including the reaction process of 2,4,6-Trichloropyrimidine(cas: 3764-01-0Electric Literature of C4HCl3N2)

2,4,6-Trichloropyrimidine(cas: 3764-01-0) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Electric Literature of C4HCl3N2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In 2016,Hammer, Sebastian G.; Gobleder, Susanne; Naporra, Franziska; Wittmann, Hans-Joachim; Elz, Sigurd; Heinrich, Markus R.; Strasser, Andrea published 《2,4-Diaminopyrimidines as dual ligands at the histamine H1 and H4 receptor-H1/H4-receptor selectivity》.Bioorganic & Medicinal Chemistry Letters published the findings.Formula: C4HCl3N2 The information in the text is summarized as follows:

Distinct diaminopyrimidines, for example, 4-(4-methylpiperazin-1-yl)-5,6-dihydrobenzo[h]quinazolin-2-amine are histamine H4 receptor (H4R) antagonists and show high affinity to the H4R, but only a moderate affinity to the histamine H1 receptor (H1R). Within previous studies it was shown that an aromatic side chain with a distinct distance to the basic amine and aromatic core is necessary for affinity to the human H1R (hH1R). Thus, a rigid aminopyrimidine with a tricyclic core was used as a lead structure. There, (1) the flexible aromatic side chain was introduced, (2) the substitution pattern of the pyrimidine core was exchanged and (3) rigidity was decreased by opening the tricyclic core. Within the present study, two compounds with similar affinity in the one digit μM range to the human H1R and H4R were identified. While the affinity at the hH1R increased about 4- to 8-fold compared to the parent diaminopyrimidine, the affinity to the hH4R decreased about 5- to 8-fold. In addition to the parent diaminopyrimidine, two selected compounds were docked into the H1R and H4R and mol. dynamic studies were performed to predict the binding mode and explain the exptl. results on a mol. level. The two new compounds may be good lead structures for the development of dual H1/H4 receptor ligands with affinities in the same range. The experimental process involved the reaction of 2,4,6-Trichloropyrimidine(cas: 3764-01-0Formula: C4HCl3N2)

2,4,6-Trichloropyrimidine(cas: 3764-01-0) is a member of organic chlorides. Almost all organochlorine compounds are synthesized. It is widely used as intermediates, solvents and pesticides of chemical synthetic products.Formula: C4HCl3N2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

《Photocatalytic trifluoromethoxylation of arenes and heteroarenes in continuous-flow》 was written by Nyuchev, Alexander V.; Wan, Ting; Cendon, Borja; Sambiagio, Carlo; Struijs, Job J. C.; Ho, Michelle; Gulias, Moises; Wang, Ying; Noe, Timothy. Computed Properties of C4HCl3N2This research focused ontrifluoromethoxy arene preparation; arene benzotriazolium trifluoromethanesulfonate photocatalytic trifluoromethoxylation; C–H functionalization; continuous-flow; organic synthesis; photoredox catalysis; trifluoromethoxylation. The article conveys some information:

The first example of photocatalytic trifluoromethoxylation of arenes and heteroarenes, e.g., I under continuous-flow conditions is described. Application of continuous-flow microreactor technol. allowed to reduce the residence time up to 16 times in comparison to the batch procedure, while achieving similar or higher yields. In addition, the use of inorganic bases was demonstrated to increase the reaction yield under batch conditions. The experimental part of the paper was very detailed, including the reaction process of 2,4,6-Trichloropyrimidine(cas: 3764-01-0Computed Properties of C4HCl3N2)

2,4,6-Trichloropyrimidine(cas: 3764-01-0) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Computed Properties of C4HCl3N2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In 2015,Sythana, Suresh Kumar; Bhagat, Pundlik R. published 《Metal free C-O bond formation in electron deficient aromatic compounds mediated by tetrabutylammonium hydroxide : application to nimesulide and paracetamol》.Journal of the Indian Chemical Society published the findings.Category: pyrimidines The information in the text is summarized as follows:

A mild and efficient method for carbon-oxygen bond formation for the synthesis of aryl ethers has been demonstrated via reaction of aromatic chloro compounds and alcs. mediated by tetrabutylammonium hydroxide (TBAH). The protocol is free from the metal alkoxides, inorganic bases or metal catalysts. This methodol. has been applied for synthesis of paracetamol and nimesulide intermediates. After reading the article, we found that the author used 2,4,6-Trichloropyrimidine(cas: 3764-01-0Category: pyrimidines)

2,4,6-Trichloropyrimidine(cas: 3764-01-0) is a member of organic chlorides. Organic chloride content in crude oil can be detected through specialized laboratory analysis. Care and attention are essential while sampling and testing.Category: pyrimidines

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

《A Predictive Model Towards Site-Selective Metalations of Functionalized Heterocycles, Arenes, Olefins, and Alkanes using TMPZnCl·LiCl》 was published in Angewandte Chemie, International Edition in 2020. These research results belong to Balkenhohl, Moritz; Jangra, Harish; Makarov, Ilya S.; Yang, Shu-Mei; Zipse, Hendrik; Knochel, Paul. Category: pyrimidines The article mentions the following:

The development of a predictive model towards site-selective deprotometalation reactions using TMPZnCl·LiCl is reported (TMP = 2,2,6,6-tetramethylpiperidinyl). The pKa values of functionalized N-, S-, and O-heterocycles, arenes, alkenes, or alkanes were calculated and compared to the exptl. deprotonation sites. Large overlap (>80%) between the calculated and empirical deprotonation sites was observed, showing that thermodn. factors strongly govern the metalation regioselectivity. In the case of olefins, calculated frozen state energies of the deprotonated substrates allowed a more accurate prediction. Addnl., various new N-heterocycles were analyzed and the metalation regioselectivities rationalized using the predictive model. After reading the article, we found that the author used 2,4,6-Trichloropyrimidine(cas: 3764-01-0Category: pyrimidines)

2,4,6-Trichloropyrimidine(cas: 3764-01-0) is a member of organic chlorides. Almost all organochlorine compounds are synthesized. It is widely used as intermediates, solvents and pesticides of chemical synthetic products.Category: pyrimidines

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In 2022,Chen, Chia-Hsun; Lin, Shih-Chun; Lin, Bo-Yen; Li, Che-Yu; Kong, Yu-Cheng; Chen, Yi-Sheng; Fang, Shao-Cheng; Chiu, Ching-Huang; Lee, Jiun-Haw; Wong, Ken-Tsung; Lin, Chi-Feng; Hung, Wen-Yi; Chiu, Tien-Lung published an article in Chemical Engineering Journal (Amsterdam, Netherlands). The title of the article was 《New bipolar host materials for high power efficiency green thermally activated delayed fluorescence OLEDs》.SDS of cas: 3764-01-0 The author mentioned the following in the article:

Four bipolar mols., namely I, II, III, and IV, with carbazole (Cz) donor and a benzonitrile-substituted pyrimidine (Pym) or triazine (Trz) acceptor core were synthesized and characterized. The electron deficiency of heteroaryl cores together with the substitution pattern of benzonitrile were employed to tune the energy levels as well as the thermally activated delayed fluorescence (TADF) characteristics. The four mols. exhibited TADF behavior with inferior photoluminescent quantum yields (PLQYs) that limit their applications as emitters. These bipolar mols. were employed as TADF host materials for the benchmark TADF emitter 4CzIPN to achieve high-performing green TADF organic light-emitting diodes (OLEDs). Among the mols., I-hosted TADF-OLEDs achieved a maximum external quantum efficiency (EQEmax) of 31.5%, maximum power efficiency (PEmax) of 95.6 lm/W, and maximum current efficiency (CEmax) of 100.2 cd/A. Notably, II-hosted TADF-OLEDs also achieved a PEmax of 116.5 lm/W, turn-on voltage of 2.5 V, and impressive low efficiency roll-off performance (>89% of EQEmax at 5000 cd/m2), representing one of the highest efficiencies ever reported in 4CzIPN-doped devices. The high device efficiency can be ascribed to the balanced ambipolar carrier-transporting character of the host materials and high PLQY as well as the outstanding light outcoupling efficiency of the emitting layer.2,4,6-Trichloropyrimidine(cas: 3764-01-0SDS of cas: 3764-01-0) was used in this study.

2,4,6-Trichloropyrimidine(cas: 3764-01-0) is a member of organic chlorides. Almost all organochlorine compounds are synthesized. It is widely used as intermediates, solvents and pesticides of chemical synthetic products.SDS of cas: 3764-01-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In 2016,Kim, Juae; Shim, Joo Young; Lee, Jihoon; Lee, Dal Yong; Chae, Sangmin; Kim, Jinwoo; Kim, Il; Kim, Hyo Jung; Park, Sung Heum; Suh, Hongsuk published 《Syntheses of pyrimidine-based polymers containing electron-withdrawing substituent with high open circuit voltage and applications for polymer solar cells》.Journal of Polymer Science, Part A: Polymer Chemistry published the findings.Related Products of 3764-01-0 The information in the text is summarized as follows:

Polymers using new electron-deficient units, 2-pyriminecarbonitrile and 2-fluoropyrimidine, were synthesized and utilized for the photovoltaics. Donor-acceptor (D-A) types of conjugated polymers (PBDTCN, PBDTTCN, PBDTF, and PBDTTF) containing 4,8-bis(2-octyldodecyloxy)benzo[1,2-b;3,4-b’]dithiophene (BDT) or 4,8-bis(5-(2-octyldodecyloxy)thiophen-2-yl)benzo[1,2-b:4,5-b’]dithiophene (BDTT) as electron rich unit and 2-pyriminecarbonitrile or 2-fluoropyrimidine as electron deficient unit were synthesized. We designed pyrimidine derivatives in which strong electron-withdrawing group (CN or fluorine) was introduced to the C2 position for the generation of strong electron-deficient property. By the combination with the electron-rich unit, the pyrimidines will provide low band gap polymers with low HOMO energy levels for higher open-circuit voltages (VOC). For the syntheses of the polymers, the electron-rich and the electron-deficient units were combined by Stille coupling reaction with Pd(0)-catalyst. Absorption spectra of the thin films of PBDTTCN and PBDTTF with BDTT unit show shift to a longer wavelength region than PBDTCN and PBDTF with BDT unit. Four synthesized polymers provided low electrochem. bandgaps of 1.56 to 1.96 eV and deep HOMO energy levels between -5.67 and -5.14 eV. © 2015 The Authors. Journal of Polymer Science Part A: Polymer Chem. Published by Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2015. The results came from multiple reactions, including the reaction of 2,4,6-Trichloropyrimidine(cas: 3764-01-0Related Products of 3764-01-0)

2,4,6-Trichloropyrimidine(cas: 3764-01-0) is a member of organic chlorides. Almost all organochlorine compounds are synthesized. It is widely used as intermediates, solvents and pesticides of chemical synthetic products.Related Products of 3764-01-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia