Category: 3764-01-0

Reference of 2,4,6-TrichloropyrimidineIn 2016 ,《Systematic synthesis, comparative studies of the optical properties, and the ICT-based sensor properties of a series of 2,4,6-tri(5-aryl-2-thienyl)pyrimidines with the D-π-A system》 was published in Tetrahedron Letters. The article was written by Muraoka, Hiroki; Obara, Takumi; Ogawa, Satoshi. The article contains the following contents:

A series of 2,4,6-tri(5-aryl-2-thienyl)pyrimidines with a star-shaped D-π-A system, which have an electron deficient pyrimidine core (A) and three donor type aryl groups (D) linked by a thiophene spacer (π-spacer), were designed and systematically synthesized. Through the characterization of the mols. by UV-vis absorption and fluorescence spectroscopies, we revealed that the mols. possess distinct absorption and emission wavelengths controlled by the donor effect of the terminal aryl groups. Interestingly, 2,4,6-tris(5-p-N,N-dibutylaminophenyl-2-thienyl)pyrimidine was found to exhibit strong fluorosolvatochromic properties and a proton-sensibility based on its intramol. charge transfer (ICT) and basic characteristics, which could allow its use as a polarity or proton sensor.2,4,6-Trichloropyrimidine(cas: 3764-01-0Reference of 2,4,6-Trichloropyrimidine) was used in this study.

2,4,6-Trichloropyrimidine(cas: 3764-01-0) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Reference of 2,4,6-Trichloropyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In 2019,Polymers (Basel, Switzerland) included an article by Dong, Xue; Xing, Tieling; Chen, Guoqiang. Recommanded Product: 2,4,6-Trichloropyrimidine. The article was titled 《Durable antipilling modification of cotton fabric with chloropyrimidine compounds》. The information in the text is summarized as follows:

Cotton fabric, a natural cellulose material, is widely used in the textile industry for its excellent properties. However, its application in some fields are seriously restricted because of its poor antipilling behavior. In this study, cotton fabrics were modified with 2,4,6-trichloropyrimidine (TLP), 2,4-dichloro-5-methoxypyrimidine (DMP), and 2-amino-4,6-dichloropyridine (ADP). The surface morphol. and chem. structure of the modified cotton fabric were characterized by SEM, Fourier transform IR spectroscopy (FTIR), and X-ray diffraction (XRD). Furthermore, the antipilling behavior, dyeing properties, thermal properties, and mech. properties of modified cotton fabric were evaluated. The results showed that chloropyrimidine compounds were successfully grafted onto the surface of the cotton fabric, leading to excellent and durable antipilling activity of grade 3-4 even after 10 washes. Moreover, compared with control cotton fabric, the heat release rate (HRR) and total heat release (THR) of TLP-modified cotton fabric decreased to 173.2 W/g (42.3% reduction) and 11.3 KJ/g (13.7% reduction), resp. In addition, the increased K/S value of modified cotton fabrics dyed with reactive dyes indicated that the modification can enhance the dyability of cotton fabric. This technique provides a simple and versatile method for improving the antipilling behavior of cellulosic materials and supports further preparation of functional textiles. In the experiment, the researchers used many compounds, for example, 2,4,6-Trichloropyrimidine(cas: 3764-01-0Recommanded Product: 2,4,6-Trichloropyrimidine)

2,4,6-Trichloropyrimidine(cas: 3764-01-0) is a member of organic chlorides. Almost all organochlorine compounds are synthesized. It is widely used as intermediates, solvents and pesticides of chemical synthetic products.Recommanded Product: 2,4,6-Trichloropyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Name: 2,4,6-TrichloropyrimidineIn 2019 ,《Resonance enhanced multiphoton ionisation (REMPI) detection of Cl(2Pj) atom in the photodissociation of halogenated pyrimidines at 235 nm: role of triplet states》 appeared in Molecular Physics. The author of the article were Srinivas, Doddipatla; Kawade, Monali; Upadhyaya, Hari P.. The article conveys some information:

The dynamics of chlorine atom (2Pj) formation in the photodissociation process of halogen substituted pyrimidines, namely, 2,4,6-trichloropyrimidine and 5-chloro-2,4,6-trifluoropyrimidine have been studied around 235 nm using Resonance Enhanced Multiphoton Ionisation Time-of-Flight Mass Spectrometry technique. For the chlorine atom dissociation channel, we have determined the translational energy distribution, the recoil anisotropy parameter, β, and the spin-orbit branching ratio. In both the mols., the TOF profiles for Cl (2P3/2) and Cl* (2P1/2) are found to be independent of laser polarisation suggesting a zero value for β, within the exptl. uncertainties. For 2,4,6-trichloropyrimidine, the average translational energies for Cl and Cl* elimination channels are determined to be 6.0 ± 1.2 and 7.0 ± 1.5 kcal/mol, resp. Similarly, for 5-chloro-2,4,6-trifluoropyrimidine, the average translational energies for Cl and Cl* elimination channels are determined to be 6.5 ± 1.2 and 7.9 ± 1.6 kcal/mol, resp. Computational calculations are performed to generate the potential energy curves along the dissociating C-Cl bond using equation of motion coupled cluster with single and double excitations (EOM-CCSD) method. Computational studies suggest the role of triplet states in the photodissociation process forming the Cl atom. The experimental part of the paper was very detailed, including the reaction process of 2,4,6-Trichloropyrimidine(cas: 3764-01-0Name: 2,4,6-Trichloropyrimidine)

2,4,6-Trichloropyrimidine(cas: 3764-01-0) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Name: 2,4,6-Trichloropyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

《Design, synthesis and antibacterial activities of triazole-pyrimidine derivatives as SecA inhibitors》 was written by Bamba, Fante; Etienne, Camara Tchambaga; Siomenan, Coulibali; Jacques, Akpa Sagne; Souleymane, Coulibaly; Ane, Adjou. Recommanded Product: 3764-01-0This research focused ontriazole pyrimidine preparation antibacterial activity. The article conveys some information:

Background: To highlight the magnitude of the important challenge now facing scientists, drug resistance needs exploration of novel antimicrobial agents. The identification of new and vital target in bacteria and then designing their inhibitors can be explored. Thus, targeting SecA, a central component of the bacterial general secretion system, is a promising strategy for the development of novel antimicrobials. Objective: To evaluate new compounds as SecA inhibitors synthesized by structural modification of bistriazole SCA-21. Method: A new compounds were synthesized and evaluated for antibacterial activity against Escherichia coli NR698 (E. coli a leaky mutant), Staphylococcus aureus (S. aureus) and Bacillus anthracis (B. anthracis). Results: Some novel triazole-pyrimidine derivatives by structural modification of known SecA inhibitor SCA 21 were synthesized and their structures were confirmed by 1H NMR, 13C NMR and Mass spectral anal. The synthesized compound showed antimicrobial activity against E. coli NR698 (a leaky mutant), S. aureus and B. anthracis Sterne. Conclusion: Five novel triazole-pyrimidine derivatives were designed, synthesized and evaluated as SecA inhibitors. At the end of this study, compound SCA 259 with azide pentyl group was found as the most potent inhibitor. It expressed better inhibitory activity against SecA ATPase than else known inhibitor SCA 21. The experimental part of the paper was very detailed, including the reaction process of 2,4,6-Trichloropyrimidine(cas: 3764-01-0Recommanded Product: 3764-01-0)

2,4,6-Trichloropyrimidine(cas: 3764-01-0) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Recommanded Product: 3764-01-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In 2017,Kamijo, Shin; Kamijo, Kaori; Murafuji, Toshihiro published 《Synthesis of Alkylated Pyrimidines via Photoinduced Coupling Using Benzophenone as a Mediator》.Journal of Organic Chemistry published the findings.Formula: C4HCl3N2 The information in the text is summarized as follows:

Alkylated pyrimidines such as I (R = Cl, MeO) were prepared regioselectively by photochem. coupling of cyclic ethers, carbamates, γ-butyrolactam, and tetrahydrothiophene (THT) with methanesulfonylpyrimidines such as II (R = Cl, MeO) using benzophenone as the sole photochem. mediator. The heterocyclic substituents were selectively introduced at the nonacidic C(sp3)-H bond proximal to their heteroatoms, and at the methanesulfonyl-substituted position of the pyrimidines. This method was used to prepare an analog of the Aurora kinase inhibitor MK-0457. The experimental process involved the reaction of 2,4,6-Trichloropyrimidine(cas: 3764-01-0Formula: C4HCl3N2)

2,4,6-Trichloropyrimidine(cas: 3764-01-0) is a member of organic chlorides. Organic chloride content in crude oil can be detected through specialized laboratory analysis. Care and attention are essential while sampling and testing.Formula: C4HCl3N2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In 2022,Dannheim, Friederike M.; Walsh, Stephen J.; Orozco, Carolina T.; Hansen, Anders Hoejgaard; Bargh, Jonathan D.; Jackson, Sophie E.; Bond, Nicholas J.; Parker, Jeremy S.; Carroll, Jason S.; Spring, David R. published an article in Chemical Science. The title of the article was 《All-in-one disulfide bridging enables the generation of antibody conjugates with modular cargo loading》.Product Details of 3764-01-0 The author mentioned the following in the article:

Antibody-drug conjugates (ADCs) are valuable therapeutic entities which leverage the specificity of antibodies to selectively deliver cytotoxins to antigen-expressing targets such as cancer cells. However, current methods for their construction still suffer from a number of shortcomings. For instance, using a single modification technol. to modulate the drug-to-antibody ratio (DAR) in integer increments while maintaining homogeneity and stability remains exceptionally challenging. Herein, we report a novel method for the generation of antibody conjugates with modular cargo loading from native antibodies. Our approach relies on a new class of disulfide rebridging linkers, which can react with eight cysteine residues, thereby effecting all-in-one bridging of all four interchain disulfides in an IgG1 antibody with a single linker mol. Modification of the antibody with the linker in a 1 : 1 ratio enabled the modulation of cargo loading in a quick and selective manner through derivatization of the linker with varying numbers of payload attachment handles to allow for attachment of either 1, 2, 3 or 4 payloads (fluorescent dyes or cytotoxins). Assessment of the biol. activity of these conjugates demonstrated their exceptional stability in human plasma and utility for cell-selective cytotoxin delivery or imaging/diagnostic applications. The results came from multiple reactions, including the reaction of 2,4,6-Trichloropyrimidine(cas: 3764-01-0Product Details of 3764-01-0)

2,4,6-Trichloropyrimidine(cas: 3764-01-0) is a member of organic chlorides. Organic chloride content in crude oil can be detected through specialized laboratory analysis. Care and attention are essential while sampling and testing.Product Details of 3764-01-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In 2018,Wang, Hui-Yan; Shen, Ying; Zhang, Hao; Hei, Yuan-Yuan; Zhao, Hong-Yi; Xin, Minhang; Lu, She-Min; Zhang, San-Qi published 《Discovery of 2-(aminopyrimidin-5-yl)-4-(morpholin-4-yl)-6- substituted triazine as PI3K and BRAF dual inhibitor》.Future Medicinal Chemistry published the findings.Safety of 2,4,6-Trichloropyrimidine The information in the text is summarized as follows:

The discovery and development of novel agents simultaneously targeting PI3K/AKT/mammalian target of rapamycin and Ras/RAF/MEK, two signaling pathways, are urgent to improve the curative effect of kinase inhibitors and overcome acquired resistance. In the present study, 2-(2-aminopyrimidin-5-yl)-4-(morpholin-4-yl)-6-(N-cyclopropyl-N- (1-benzoylpiperidin-4-yl))triazines/pyrimidines were designed as PI3K and BRAF dual inhibitors. The synthesized 20 compounds exhibited potent antiproliferative effects in vitro against HCT116, A375, MCF-7, Colo205, A549 and LOVO cancer cell lines. The tested compounds A6, A7, A9 and A11 remarkably displayed inhibitory activities toward both PI3Kα and BRAFV600E. These results indicated that our design compounds can serve as potent PI3Kα and BRAFV600E dual inhibitors and effective antiproliferative agents, which can be further optimized to discover more potent PI3Kα and BRAFV600E dual inhibitors.2,4,6-Trichloropyrimidine(cas: 3764-01-0Safety of 2,4,6-Trichloropyrimidine) was used in this study.

2,4,6-Trichloropyrimidine(cas: 3764-01-0) is a member of organic chlorides. Almost all organochlorine compounds are synthesized. It is widely used as intermediates, solvents and pesticides of chemical synthetic products.Safety of 2,4,6-Trichloropyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

《Second-generation tricyclic pyrimido-pyrrolo-oxazine mTOR inhibitor with predicted blood-brain barrier permeability》 was written by Borsari, Chiara; Keles, Erhan; Treyer, Andrea; De Pascale, Martina; Hebeisen, Paul; Hamburger, Matthias; Wymann, Matthias P.. Computed Properties of C4HCl3N2This research focused ontricyclic pyrimido pyrrolooxazine mTOR inhibitor blood brain barrier permeability. The article conveys some information:

Highly selective mTOR inhibitors have been discovered through the exploration of the heteroaromatic ring engaging the binding affinity region in mTOR kinase. Compound 11 showed predicted BBB permeability in a MDCK-MDR1 permeability in vitro assay, being the first pyrimido-pyrrolo-oxazine with potential application in the treatment of neurol. disorders. In addition to this study using 2,4,6-Trichloropyrimidine, there are many other studies that have used 2,4,6-Trichloropyrimidine(cas: 3764-01-0Computed Properties of C4HCl3N2) was used in this study.

2,4,6-Trichloropyrimidine(cas: 3764-01-0) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Computed Properties of C4HCl3N2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Quality Control of 2,4,6-TrichloropyrimidineIn 2015 ,《Design, synthesis, and biological evaluation of pyrimidine-2-carboxamide analogs: investigation for novel RAGE inhibitors with reduced hydrophobicity and toxicity》 appeared in Archives of Pharmacal Research. The author of the article were Kim, Seok-Ho; Han, Young Taek. The article conveys some information:

This paper describes an investigation of novel RAGE inhibitors with improved drug-like properties. To identify the improved drug-like RAGE inhibitor, the authors designed and synthesized pyrimidine-2-carboxamide analogs based on the previous work. Several potent analogs with improved hydrophilicity were identified by evaluation of RAGE inhibitory activity. In particular, one of the potent (diethylamino)ethoxymethoxy analogs did not exhibit undesired cytotoxicity in contrast with the parent RAGE inhibitors. In the experimental materials used by the author, we found 2,4,6-Trichloropyrimidine(cas: 3764-01-0Quality Control of 2,4,6-Trichloropyrimidine)

2,4,6-Trichloropyrimidine(cas: 3764-01-0) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Quality Control of 2,4,6-Trichloropyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

《Discovery of Novel Dual Poly(ADP-ribose)polymerase and Phosphoinositide 3-Kinase Inhibitors as a Promising Strategy for Cancer Therapy》 was published in Journal of Medicinal Chemistry in 2020. These research results belong to Wang, Junwei; Li, Hui; He, Guangchao; Chu, Zhaoxing; Peng, Kewen; Ge, Yiran; Zhu, Qihua; Xu, Yungen. Safety of 2,4,6-Trichloropyrimidine The article mentions the following:

Concomitant inhibition of PARP and PI3K pathways has been recognized as a promising strategy for cancer therapy, which may expand the clin. utility of PARP inhibitors. Herein, we report the discovery of dual PARP/PI3K inhibitors that merge the pharmacophores of PARP and PI3K inhibitors. Among them, compound 15 stands out as the most promising candidate with potent inhibitory activities against both PARP-1/2 and PI3Kα/δ with pIC50 values greater than 8. Compound 15 displayed superior antiproliferative profiles against both BRCA-deficient and BRCA-proficient cancer cells in cellular assays. The prominent synergistic effects produced by the concomitant inhibition of the two targets were elucidated by comprehensive biochem. and cellular mechanistic studies. In vivo, 15 showed more efficacious antitumor activity than the corresponding drug combination (Olaparib + BKM120) in the MDA-MB-468 xenograft model with a tumor growth inhibitory rate of 73.4% without causing observable toxic effects. All of the results indicate that 15, a first potent dual PARP/PI3K inhibitor, is a highly effective anticancer compound In addition to this study using 2,4,6-Trichloropyrimidine, there are many other studies that have used 2,4,6-Trichloropyrimidine(cas: 3764-01-0Safety of 2,4,6-Trichloropyrimidine) was used in this study.

2,4,6-Trichloropyrimidine(cas: 3764-01-0) is a member of organic chlorides. Almost all organochlorine compounds are synthesized. It is widely used as intermediates, solvents and pesticides of chemical synthetic products.Safety of 2,4,6-Trichloropyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia