Category: 3764-01-0

Application of 3764-01-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.3764-01-0, name is 2,4,6-Trichloropyrimidine, molecular formula is C4HCl3N2, molecular weight is 183.42, as common compound, the synthetic route is as follows.

Reference Example 13 2,6-Di-morphoIin-4-yl-f4<5'lbipyrimidinvI-2'-ylamineTo a cold solution of 2,4,6-trichloropyrimidine (16g) in methanol (20OmL) was added morpholine (15.2ml). The reaction mixture was stirred for 24 hours and the solvent was then removed in vacuo. The residue was dissolved in dichloromethane, washed with water, dried (MgSO4) and the solvent removed in vacuo. The residue was purified using flash chromatography to yield 4-(6-chloro-2-morpholin-l-yl-pyrimidin-4- yl)-morpholine.Reaction of 4-(6-chloro-2-morpholin-l-yl-pyrimidin-4-yl)-morpholine with 2- aminopyrimidine-5-boronic acid, pinacol ester using standard Suzuki conditions yielded the desired title compound. 400MHz IH NMR CDC133.64-3.66 (m, 4H, 2 x CH2), 3.7-3.86 (m, 12H, 6 x CH2), 5.22 (sbr, 2H, NH2), 6.17 (s,H, ArH), 8.89 (s, 2H, 2 x ArH).

Statistics shows that 3764-01-0 is playing an increasingly important role. we look forward to future research findings about 2,4,6-Trichloropyrimidine.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; WO2009/66084; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.3764-01-0, name is 2,4,6-Trichloropyrimidine, molecular formula is C4HCl3N2, molecular weight is 183.42, as common compound, the synthetic route is as follows.Quality Control of 2,4,6-Trichloropyrimidine

The 6-chloro-4-(2-difluoromethylbenzimidazol-l-yl)-2-morpholinopyrimidine used as a starting material was prepared as follows :-; Under an atmosphere of nitrogen, a solution of morpholine (13.06 ml) in methylene chloride (100 ml) was added dropwise over 15 minutes to a stirred mixture of 2,4,6-trichloropyrimidine (27.52 g), triethylamine (22.1 ml) and methylene chloride (200 ml) that was cooled to a temperature between 5C and 15C. The resultant mixture was allowed to warm to ambient temperature and was stirred for 2 hours. The mixture was washed with an aqueous brine solution. The organic solution was dried over magnesium sulphate and evaporated. The residue was purified by column chromatography on silica using increasing proportions of ethyl acetate added to a 1 : 1 mixture of isohexane and methylene chloride as eluent. There was thus obtained 4,6-dichloro-2-morpholinopyrimidine (6.82 g); NMR Spectrum: (DMSOd6) 3.64-3.71 (m, 8H), 6.97 (s, IH); Mass Spectrum: M+H+ 234.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,3764-01-0, 2,4,6-Trichloropyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; BUTTERWORTH, Sam; GRIFFEN, Edward, Jolyon; HILL, George, Beresford; PASS, Martin; WO2008/32089; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 3764-01-0 ,Some common heterocyclic compound, 3764-01-0, molecular formula is C4HCl3N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To the solution of compound 6a (10 mmol) and Et3N (24 mmol) in EtOH (50 mL), morpholine (20 mmol) was added dropwise at 0 C. The mixture was stirred at room temperature for 24 h and a white solid was precipitated. Concentrated the reaction mixture to remove EtOH. The residue was dissolved in CH2Cl2, washed with water and brine. The organic layer was concentrated to give the residue, which was purified using flash chromatography (petroleum ether/EtOAc, 7:1) to yield a white solid, yield 78%. 1H NMR (400 MHz, Chloroform-d) delta 5.87 (s, 1H), 3.96-3.18 (m, 16H). 13C NMR (101 MHz, CDCl3) delta 163.54, 160.88, 160.60, 91.19, 66.84 (2CH2), 66.51 (2CH2), 44.44 (2CH2), 44.37 (2CH2).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,3764-01-0, its application will become more common.

Reference:
Article; Li, Wenlu; Sun, Qinsheng; Song, Lu; Gao, Chunmei; Liu, Feng; Chen, Yuzong; Jiang, Yuyang; European Journal of Medicinal Chemistry; vol. 141; (2017); p. 721 – 733;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 3764-01-0, 2,4,6-Trichloropyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 2,4,6-Trichloropyrimidine, blongs to pyrimidines compound. Safety of 2,4,6-Trichloropyrimidine

Reference Example 11; (6-Chloro-2-morpholin-4-vI-pyrimidm-4-yl)-(2-pyridin-3-yl- ethvD-amine; To a stirred solution of 2,4,6-trichloropyrimidine (10 ml; 87 mmol), and DIPEA (16 mL; 92 mmol) in dioxane (60 mL) at 5 C was added morpholine (8 ml; 91 mmol) over 5 minutes (a white solid separates during addition). The reaction mixture was stirred whilst allowing to warm to r.t. overnight (16 h). Volatiles were removed in vacuo, the resulting residue was redissolved (CH2Cl2) and evaporated onto silica and purified by flash chromatography (90:10 to 50:50 petrol/EtOAc as eluent) to afford the regioisomeric products: 4-(4,6-dichloro-pyrimidin-2-yl)-morpholine (2.46 g; 12 %); and 4-(2,6-dichloro-pyrimidin-4- yl)-morpholine (9.72 g; 48 %).

The synthetic route of 3764-01-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PIRAMED LIMITED; THE INSTITUTE OF CANCER RESEARCH; WO2008/125835; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 3764-01-0, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 3764-01-0 as follows.

2,4,6-Trichloropyrimidine (5.5 mL, 48.0 mmol) was dissolved in tetrahydrofuran (70 mL).Then, palladium acetate (0.147 g, 0.64 mmol) was sequentially added thereto.Triphenylphosphine (353 mg, 1.28 mmol),p-Methoxybenzeneboronic acid (5.01 g, 31.9 mmol)And aqueous sodium carbonate (1M, 64 mL, 64 mmol),The resulting mixture was heated to 60 C under a nitrogen atmosphere and stirred for 6 hours.Cool to room temperature, concentrate under reduced pressure to remove organic solvent.Water (100 mL) was added to the residue.The resulting mixture was extracted with ethyl acetate (100 mL¡Á3).The combined organic phases were washed with brine (100 mL).Dry anhydrous sodium sulfate, filter, and concentrate the filtrate to dryness.The residue was purified by EtOAc EtOAc EtOAc(5.58g, 68%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,3764-01-0, its application will become more common.

Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Ren Qingyun; Tang Changhua; Yin Junjun; Yi Kai; Lei Yibo; Wang Yejun; Zhang Yingjun; (138 pag.)CN108276401; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 3764-01-0, Adding some certain compound to certain chemical reactions, such as: 3764-01-0, name is 2,4,6-Trichloropyrimidine,molecular formula is C4HCl3N2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3764-01-0.

2,4,6-trichloropyrimidine (8) 10.00 g, 54.52 mmol) was added to a 250 mL three-necked flask.Add 100mL of dichloroMethane, stirred and dissolved, added DIEA (8.50 mL, 48.70 mmol), cooled to -78 C, slowly added morpholine (4.30 mL,49.40mmol), after adding, the reaction was stirred for 1 to 2 hours, TLC (petroleum ether: ethyl acetate = 6:1) was used to detect the reaction of the starting material 8 and the reaction was stopped. The reaction solution was poured into 150 mL of water, and the mixture was separated. Methyl chloride layer, the aqueous layer was extracted with 50 mL of dichloromethaneThe methylene chloride layer was combined and washed twice with saturated sodium chloride solution (80 mL¡Á2), dried over anhydrous Na 2 SO 4 , filtered and filtered.The crude product was obtained by adding a mixed solvent (petroleum ether: ethyl acetate = 50:1, 100 mL) for 2 hours, suction filtration, and drying to give a white solid.The body was 9.4 g, and the yield was 73.7%.

According to the analysis of related databases, 3764-01-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; China Pharmaceutical University; Hefei Medical Engineering Pharmaceutical Co., Ltd.; Xu Yungen; Zhu Qihua; Wang Junwei; Chu Zhaoxing; Li Hui; Ge Yiran; He Guangwei; (22 pag.)CN109810100; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 3764-01-0, Adding some certain compound to certain chemical reactions, such as: 3764-01-0, name is 2,4,6-Trichloropyrimidine,molecular formula is C4HCl3N2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3764-01-0.

[00299] To a solution of 2,4,6-trichloropyrimidine (0.29 mL, 2.5 mmol) in tetrahydrofuran (5 mL) were added palladium acetate (8 mg, 0.035 mmol), triphenylphosphine (18 mg, 0.065 mmol), phenylboronic acid (0.20 g, 1.6 mmol) and aqueous sodium carboante solution (1 M, 3.3 mL, 3.3 mmol). The mixture was stirred at 60 C for 6 h, then cooled to rt and concentrated to remove the organic solvent. To the residue was added H20 (10 mL), and the mixture was extracted with EtOAc (10 mL x 3). The combined organic layers were washed with saturated brine (30 mL), dried over anhydrous sodium sulfate and filtered. The filtrate was concentrated in vacuo to dry and the residue was purified by silica gel column chromatography (PE) to give the title compound as a white solid (0.225 g, 6 1%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 3764-01-0, 2,4,6-Trichloropyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Yingjun; REN, Qingyun; TANG, Changhua; LIN, Xiaohong; YIN, Junjun; YI, Kai; (270 pag.)WO2017/97234; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 3764-01-0, 2,4,6-Trichloropyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 3764-01-0, blongs to pyrimidines compound. Product Details of 3764-01-0

Preparation of Compound 1-4 2,4,6-trichloropyrimidine (10 g, 54.51 mmol), phenylboronic acid (16.6 g, 136,29 mmol), Pd(PPh3)4 (3.15 g, 2.72 mmol), 2M K2CO3 (50 mL), toluen (100 mL) and ethanol (30 mL) were stirred under reflux. 4 hours later, the mixture was cooled to room temperature and extracted with EA after adding distilled water. After drying with MgSO4 and distillation under reduced pressure, Compound 1-4 (7 g, 48.%) was obtained by column separation.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,3764-01-0, 2,4,6-Trichloropyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; ROHM AND HAAS ELECTRONIC MATERIALS KOREA LTD.; AHN, Hee Choon; KIM, Nam Kyun; CHO, Young Jun; KWON, Hyuck Joo; KIM, Bong Ok; KIM, Sung Min; WO2011/99718; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 3764-01-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.3764-01-0, name is 2,4,6-Trichloropyrimidine, molecular formula is C4HCl3N2, molecular weight is 183.42, as common compound, the synthetic route is as follows.

Synthetic method: 2,4,6-trichloropyrimidine (10.0 g, 54.97 mmol) was added to a 50 mL reaction flask, and CH2Cl2 (100 mL) was dissolved.DIPEA (57.72 mmol, 10.36 mL) was added and cooled to -5 ¡ã C then morpholine (54.97 mmol, 4.79 g).The reaction solution was reacted at a low temperature for 0.5 h, and then warmed to room temperature for 2 h.After the TLC reaction was completed, H 2 O (100 mL) was added, and the CH 2 Cl 2 layer was separated, and the aqueous phase was extracted once with CH 2 Cl 2 (100 mL).The organic layers were combined and washed once with saturated NaCl (100 mL).Dry with anhydrous Na2SO4.The solvent was evaporated under reduced pressure to give a crude product.Column chromatography purification (PE / EtOAc = 4 / 1) afforded white white solid: 8.43 g, yield: 65.81percent;

Statistics shows that 3764-01-0 is playing an increasingly important role. we look forward to future research findings about 2,4,6-Trichloropyrimidine.

Reference:
Patent; Guizhou Medical University; Zhang Jiquan; Li Shumin; Xu Xiaoqian; Wu Tingting; Tang Lei; (34 pag.)CN108191837; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 3764-01-0, Adding some certain compound to certain chemical reactions, such as: 3764-01-0, name is 2,4,6-Trichloropyrimidine,molecular formula is C4HCl3N2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3764-01-0.

To an ice-cold solution containing 2,4,6-t?chloropy?midine (50 g, 0.27 mol) in MeOH (500 mL) and NaHCO3 (114 g, 1.35 mol) add slowly and dropwise a methanolic solution (10 mL) of morphohne (23.7 g, 0.27 mol) Allow the mixture to warm to 250C and stir overnight. Concentrate under vacuum, extract with EtOAc (500 mL), wash with water and dry with MgSO4 Filter and evaporate under vacuum to afford a white solid. Purify the crude by flash column chromatography to afford the title product as white solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 3764-01-0, 2,4,6-Trichloropyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; NEUROGEN CORPORATION; WO2006/65872; (2006); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia