Category: 3764-01-0

In 2018,Molecules included an article by Wright, Emily W.; Nelson, Ronald A. Jr.; Karpova, Yelena; Kulik, George; Welker, Mark E.. COA of Formula: C4HCl3N2. The article was titled 《Synthesis and PI3 kinase inhibition activity of some novel trisubstituted morpholinopyrimidines》. The information in the text is summarized as follows:

A number of new substituted morpholinopyrimidines were prepared utilizing sequential nucleophilic aromatic substitution and cross-coupling reactions. One of the disubstituted pyrimidines was converted into two trisubstituted compounds which were screened as PI3K inhibitors relative to the well-characterized PI3K inhibitor ZSTK474, and were found to be 1.5-3-times more potent. A leucine linker was attached to the most active inhibitor since it would remain on any peptide-containing prodrug after cleavage by prostate-specific antigen, and it did not prevent inhibition of AKT phosphorylation and hence the inhibition of PI3K by the modified inhibitor. The experimental part of the paper was very detailed, including the reaction process of 2,4,6-Trichloropyrimidine(cas: 3764-01-0COA of Formula: C4HCl3N2)

2,4,6-Trichloropyrimidine(cas: 3764-01-0) is a member of organic chlorides. Organic chloride content in crude oil can be detected through specialized laboratory analysis. Care and attention are essential while sampling and testing.COA of Formula: C4HCl3N2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Category: pyrimidinesIn 2021 ,《Synthesis of Luminescent Fused Imidazole Bicyclic Acetic Esters by a Multicomponent Palladium Iodide-Catalyzed Oxidative Alkoxycarbonylation Approach》 appeared in ChemCatChem. The author of the article were Veltri, Lucia; Prestia, Tommaso; Russo, Patrizio; Clementi, Catia; Vitale, Paola; Ortica, Fausto; Gabriele, Bartolo. The article conveys some information:

A new multicomponent catalytic approach to important fused imidazole bicyclic acetic esters, whose core is present in many biol. active principles, is presented. It is based on the sequential cyclization-alkoxycarbonylation-isomerization of readily available N-heterocyclic propargylamine derivatives, carried out under oxidative conditions using a simple catalytic system consisting of PdI2 (1 mol%) in conjunction with KI (1 equivalent), in the presence of AcONa as additive (1 equivalent) at 100°C under 20 bar of a 4 : 1 mixture CO-air. Under the optimized conditions, several N-(prop-2-yn-1-yl)pyridin-2-amines were smoothly converted into alkyl 2-(imidazo[1,2-a]pyridin-3-yl)acetates in fair yields (51-77%). The method was also applied to the conversion of N-(prop-2-yn-1-yl)pyrimidin-2-amine into 2-(imidazo[1,2-a]pyrimidin-3-yl)acetate and of N-(prop-2-yn-1-yl)pyrazin-2-amine into 2-(imidazo[1,2-a]pyrazin-3-yl)acetate. Some of the newly synthesized bicyclic derivatives have shown promising luminescence properties. The experimental part of the paper was very detailed, including the reaction process of 2,4,6-Trichloropyrimidine(cas: 3764-01-0Category: pyrimidines)

2,4,6-Trichloropyrimidine(cas: 3764-01-0) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Category: pyrimidines

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Huang, Chen-Song; Xu, Qiong-Cong; Dai, Chunlei; Wang, Liying; Tien, Yi-Chih; Li, Fuxi; Su, Qiao; Huang, Xi-Tai; Wu, Jun; Zhao, Wei; Yin, Xiao-Yu published an article in 2021. The article was titled 《Nanomaterial-Facilitated Cyclin-Dependent Kinase 7 Inhibition Suppresses Gallbladder Cancer Progression via Targeting Transcriptional Addiction》, and you may find the article in ACS Nano.Reference of 2,4,6-Trichloropyrimidine The information in the text is summarized as follows:

Gallbladder cancer (GBC) is the most aggressive malignancy of the biliary tract cancer, and there is a lack of effective treatment. Here, we developed a nanoparticle platform (8P4 NP) that can deliver THZ1, a cyclin-dependent kinase 7 (CDK7) inhibitor, to treat GBC. Anal. of datasets demonstrated that CDK7 was pos. correlated with poor prognosis. CDK7 inhibition suppressed cell proliferation, induced apoptosis, and caused cell cycle block in GBC cells. THZ1 downregulated CDK7-mediated phosphorylation of RNA polymerase II (RNAPII), resulting in a significant downregulation of transcriptional programs, with a preferential repression of oncogenic transcription factors. To improve the tumor targeting efficiency of THZ1, 8P4 NPs were prepared and assembled with THZ1 to form THZ1@8P4 NPs. Compared with free THZ1, THZ1@8P4 NPs showed more advantages in prolonging blood circulation, escaping from lysosomes and increasing cellular uptake. Importantly, THZ1@8P4 NPs demonstrated a more significant inhibition effect on GBC cells than free THZ1 in vitro. In addition, THZ1@8P4 NPs could efficiently deliver THZ1 to tumor sites in a patient-derived xenograft model of early recurrence, leading to tumor regression and transcriptional inhibition with minimal toxicity. In summary, we conclude that THZ1@8P4 NPs provide a potent therapeutic strategy that targets CDK7-mediated transcriptional addiction in GBC.2,4,6-Trichloropyrimidine(cas: 3764-01-0Reference of 2,4,6-Trichloropyrimidine) was used in this study.

2,4,6-Trichloropyrimidine(cas: 3764-01-0) is a member of organic chlorides. Organic chloride content in crude oil can be detected through specialized laboratory analysis. Care and attention are essential while sampling and testing.Reference of 2,4,6-Trichloropyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

《Design, Synthesis and Evaluation of Triazole-Pyrimidine Analogues as SecA Inhibitors》 was written by Cui, Jianmei; Jin, Jinshan; Chaudhary, Arpana Sagwal; Hsieh, Ying-hsin; Zhang, Hao; Dai, Chaofeng; Damera, Krishna; Chen, Weixuan; Tai, Phang C.; Wang, Binghe. Recommanded Product: 2,4,6-TrichloropyrimidineThis research focused ontriazole pyrimidine analog preparation SecA inhibitors antimicrobial resistance; SecA inhibitors; antimicrobials; protein secretion; pyrimidines; triazoles. The article conveys some information:

SecA, a key component of the bacterial Sec-dependent secretion pathway, is an attractive target for the development of new antimicrobial agents. Through a combination of virtual screening and exptl. exploration of the surrounding chem. space, we identified a hit bistriazole SecA inhibitor, SCA-21, and studied a series of analogs by systematic dissections of the core scaffold. Evaluation of these analogs allowed us to establish an initial structure-activity relationship in SecA inhibition. The best compounds in this group are potent inhibitors of SecA-dependent protein-conducting channel activity and protein translocation activity at low- to sub-micromolar concentrations They also have minimal inhibitory concentration (MIC) values against various strains of bacteria that correlate well with the SecA and protein translocation inhibition data. These compounds are effective against methicillin-resistant Staphylococcus aureus strains with various levels of efflux pump activity, indicating the capacity of SecA inhibitors to null the effect of multidrug resistance. Results from studies of drug-affinity-responsive target stability and protein pull-down assays are consistent with SecA as a target for these compounds The experimental part of the paper was very detailed, including the reaction process of 2,4,6-Trichloropyrimidine(cas: 3764-01-0Recommanded Product: 2,4,6-Trichloropyrimidine)

2,4,6-Trichloropyrimidine(cas: 3764-01-0) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Recommanded Product: 2,4,6-Trichloropyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Hu, Xiaohan; Tang, Sheng; Yang, Feiyi; Zheng, Pengwu; Xu, Shan; Pan, Qingshan; Zhu, Wufu published their research in Molecules in 2021. The article was titled 《Design, synthesis, and antitumor activity of olmutinib derivatives containing acrylamide moiety》.Synthetic Route of C4HCl3N2 The article contains the following contents:

Two series of olmutinib derivatives containing an acrylamide moiety I [R1 = 3-NCC6H4NH, 3-MeOC6H4NH, 4-morpholino; R2 = C(O)CH=CH2, C(O)CH=CHMe, C(O)CH=CMe2, etc.; X = CH, N; R3 = H, CH2NMe2, CH2NEt2] were designed and synthesized and their IC50 values against cancer cell lines (A549, H1975, NCI-H460, LO2, and MCF-7) were evaluated. Most of the compounds I exhibited moderate cytotoxic activity against the five cancer cell lines. The most promising compound, I [R1 = 4-morpholinyl, R2 = C(O)CH=CHMe, X = N; R3 = CH2NMe2 (II)] showed not only excellent activity against EGFR kinase but also pos. biol. activity against PI3K kinase. The structure-activity relationship (SAR) suggested that the introduction of dimethylamine scaffolds with smaller spatial structures was more favorable for antitumor activity. Addnl., the substitution of different acrylamide side chains had different effects on the activity of compounds Generally, compounds I [R1 = 3-MeOC6H4NH, R2 = C(O)CH=CHMe, X = CH, R3 = H] and II were confirmed as promising antitumor agents. The results came from multiple reactions, including the reaction of 2,4,6-Trichloropyrimidine(cas: 3764-01-0Synthetic Route of C4HCl3N2)

2,4,6-Trichloropyrimidine(cas: 3764-01-0) is a member of organic chlorides. Almost all organochlorine compounds are synthesized. It is widely used as intermediates, solvents and pesticides of chemical synthetic products.Synthetic Route of C4HCl3N2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In 2016,Kim, Juae; Lee, Jihoon; Chae, Sangmin; Shim, Joo Young; Lee, Dal Yong; Kim, Il; Kim, Hyo Jung; Park, Sung Heum; Suh, Hongsuk published 《Conjugated polymers containing pyrimidine with electron withdrawing substituents for organic photovoltaics with high open-circuit voltage》.Polymer published the findings.Application In Synthesis of 2,4,6-Trichloropyrimidine The information in the text is summarized as follows:

Polymers using 6-(2-thienyl)-4H-thieno[3,2-b]indole (TTI) with high planarity were synthesized and utilized for the photovoltaics. Push-pull types of conjugated polymers (PTTICN, PTTICNR and PTTIFR) containing TTI as electron pushing unit and 2-pyriminecarbonitrile or 2-fluoropyrimidine as electron pulling unit were synthesized. We designed pyrimidine derivatives with strong electron-withdrawing group (CN or fluorine) for the generation of strong electron pulling property. By the combination with the electron pushing unit, the pyrimidines with strong electron pulling units will provide low HOMO (HOMO) energy levels for higher open-circuit voltages (VOC). For the syntheses of the polymers, the electron pushing and the electron pulling units were combined by Stille coupling reaction with Pd(0)-catalyst. The polymers of PTTICN and PTTICNR with CN unit show higher VOC than the polymer with fluorine unit. The device comprising PTTICNR and PCBM (1:4) with diiodooctane (DIO) additive showed a VOC of 0.82 V, a JSC of 6.38 mA/cm2, and a fill factor (FF) of 0.53, giving a power conversion efficiency of 2.81%. In the experiment, the researchers used 2,4,6-Trichloropyrimidine(cas: 3764-01-0Application In Synthesis of 2,4,6-Trichloropyrimidine)

2,4,6-Trichloropyrimidine(cas: 3764-01-0) is a member of organic chlorides. Organic chloride content in crude oil can be detected through specialized laboratory analysis. Care and attention are essential while sampling and testing.Application In Synthesis of 2,4,6-Trichloropyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The author of 《Small Polar Hits against S. aureus: Screening, Initial Hit Optimization, and Metabolomic Studies》 were Lim, Andrew S. T.; Vincent, Isabel M.; Barrett, Michael P.; Gilbert, Ian H.. And the article was published in ACS Omega in 2019. Product Details of 3764-01-0 The author mentioned the following in the article:

The global prevalence of antibacterial resistance requires new antibacterial drugs with novel chem. scaffolds and modes of action. It is also vital to design compounds with optimal physicochem. properties to permeate the bacterial cell envelope. We described an approach of combining and integrating whole cell screening and metabolomics into early antibacterial drug discovery using a library of small polar compounds Whole cell screening of a diverse library of small polar compounds against Staphylococcus aureus gave compound I. Hit expansion was carried out to determine structure-activity relationships. A selection of compounds from this series, together with other screened active compounds, was subjected to an initial metabolomics study to provide a metabolic fingerprint of the mode of action. I and its analogs have a different mode of action from some of the known antibacterial compounds tested. This early study highlighted the potential of whole cell screening using a and metabolomics in early antibacterial drug discovery, and future works will include improving potency and performing orthogonal studies to confirm the modes of action.2,4,6-Trichloropyrimidine(cas: 3764-01-0Product Details of 3764-01-0) was used in this study.

2,4,6-Trichloropyrimidine(cas: 3764-01-0) is a member of organic chlorides. Organic chloride content in crude oil can be detected through specialized laboratory analysis. Care and attention are essential while sampling and testing.Product Details of 3764-01-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In 2016,Zhang, Xiao; Lu, Guo-ping; Cai, Chun published 《Facile aromatic nucleophilic substitution (SNAr) reactions in ionic liquids: an electrophile-nucleophile dual activation by [Omim]Br for the reaction》.Green Chemistry published the findings.Recommanded Product: 2,4,6-Trichloropyrimidine The information in the text is summarized as follows:

A facile aromatic nucleophilic substitution (SNAr) reaction in recyclable [Omim]Br under relatively mild conditions has been described. An electrophile-nucleophile dual activation by [Omim]Br is also discovered based on control experiments, 1H NMR and IR spectroscopies. This chem. provides an efficient and metal-free approach for the generation of Caryl-X (X=S, N, O) bonds, many of which are significant synthetic intermediates or drugs, making this methodol. attractive to both synthetic and medicinal chem.2,4,6-Trichloropyrimidine(cas: 3764-01-0Recommanded Product: 2,4,6-Trichloropyrimidine) was used in this study.

2,4,6-Trichloropyrimidine(cas: 3764-01-0) is a member of organic chlorides. Almost all organochlorine compounds are synthesized. It is widely used as intermediates, solvents and pesticides of chemical synthetic products.Recommanded Product: 2,4,6-Trichloropyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In 2015,Manohar, Sunny; Satya Pavan, V.; Taylor, Dale; Kumar, Deepak; Ponnan, Prija; Wiesner, Lubbe; Rawat, Diwan S. published 《Highly active 4-aminoquinoline-pyrimidine based molecular hybrids as potential next generation antimalarial agents》.RSC Advances published the findings.Formula: C4HCl3N2 The information in the text is summarized as follows:

In order to overcome the problem of emerging drug resistance in malarial chemotherapy, a series of highly active 4-aminoquinoline-pyrimidine hybrids were synthesized and evaluated for their antimalarial activity against CQ-sensitive (NF54) and CQ-resistant (Dd2) strains of P. falciparum in an in vitro assay. The most active hybrid 19f exhibited 74-fold better potency than chloroquine and 4-fold better potency than artesunate against the drug-resistant strain of P. falciparum. Compound 19e, when evaluated for in vivo activity in the P. berghei-mouse malaria model showed 93.9% parasite suppression at 30 mg kg-1 dose on Day 4 with a mean survival time of 11 days. To gain insights towards the mechanism of action of these hybrids, heme binding and mol. modeling studies were performed on the most active hybrids. It was observed that inhibition of formation of β-hematin and dihydrofolate reductase-thymidylate synthase Pf-DHFR-TS enzyme could be associated with the observed antimalarial activity of these compounds After reading the article, we found that the author used 2,4,6-Trichloropyrimidine(cas: 3764-01-0Formula: C4HCl3N2)

2,4,6-Trichloropyrimidine(cas: 3764-01-0) is a member of organic chlorides. Almost all organochlorine compounds are synthesized. It is widely used as intermediates, solvents and pesticides of chemical synthetic products.Formula: C4HCl3N2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Doll, Julianna S.; Eichelmann, Robert; Hertwig, Leif E.; Bender, Thilo; Kohler, Vincenz J.; Bill, Eckhard; Wadepohl, Hubert; Rosca, Dragos-Adrian published their research in ACS Catalysis in 2021. The article was titled 《Iron-Catalyzed Trimerization of Terminal Alkynes Enabled by Pyrimidinediimine Ligands: A Regioselective Method for the Synthesis of 1,3,5-Substituted Arenes》.Name: 2,4,6-Trichloropyrimidine The article contains the following contents:

The development of pyrimidine-based analogs of the well-known pyridinediimine (PDI) iron complexes e.g., I enables access to a functional-group-tolerant methodol. for the catalytic trimerization of terminal aliphatic alkynes RCC (R = 4-fluorophenyl, Bu, cyclopropyl, thiophen-2-yl, etc.). Remarkably, in contrast to established alkyne trimerization protocols, the 1,3,5-substituted arenes 1,3,5-R3C6H3 are the main reaction products. Preliminary mechanistic investigations suggest that the enhanced π-acidity of the pyrimidine ring, combined with the hemilability of the imine groups coordinated to the iron center, facilitates this transformation. The entry point in the catalytic cycle is an isolable iron dinitrogen complex. The catalytic reaction proceeds via a 1,3-substituted metallacycle, which explains the observed 1,3,5-regioselectivity. Such a metallacycle could be isolated and represents a rare 1,3-substituted ferracycle obtained through alkyne cycloaddition In the experimental materials used by the author, we found 2,4,6-Trichloropyrimidine(cas: 3764-01-0Name: 2,4,6-Trichloropyrimidine)

2,4,6-Trichloropyrimidine(cas: 3764-01-0) is a member of organic chlorides. Almost all organochlorine compounds are synthesized. It is widely used as intermediates, solvents and pesticides of chemical synthetic products.Name: 2,4,6-Trichloropyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia