Category: 3740-92-9

3740-92-9 , The common heterocyclic compound, 3740-92-9, name is 4,6-Dichloro-2-phenylpyrimidine, molecular formula is C10H6Cl2N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Under a nitrogen atmosphere, (10 g, 50 mmol) of compound 7-24-5 and (6.1 g, 50 mmol) of compound 9-12-6,(3.5 g, 3 mmol) tetrakis (triphenylphosphine) palladium, (3.2 g, 10 mmol) tetrabutylammonium bromide, (2 g, 50 mmol) sodium hydroxide,(15mL) water and (100mL) toluene were added to a 250mL three-necked flask, and the reaction was heated at 80 C with stirring for 12 hours.Most of the solvent was removed by rotary evaporation of the reaction solution, washed three times with dichloromethane and washed with water. The organic liquid was collected and mixed with silica gel.The yield is 80%

According to the analysis of related databases, 3740-92-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Guangzhou Huarui Optoelectric Materials Co., Ltd.; He Ruifeng; Lin Weijie; Wu Canjie; Pan Junyou; (40 pag.)CN109970660; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3740-92-9, name is 4,6-Dichloro-2-phenylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows. 3740-92-9

3.77g ((4-(5H-benzofuro[3,2-c]carbazol-5-yl)phenyl)boronic acid) (10mmol, 1eq) with 9g (22mmol, 4eq)4,6-Dichloro-2phenylpyrimidine, N2 was exchanged three times, and 0.16 g (0.1 mmol, 1percent eq) of tetrakistriphenylphosphine palladium was added under the protection of N2.2M K2CO3 aqueous solution, ethanol, toluene (volume ratio = 1:2:1), a total of 100ml in an anaerobic environment for 12h,The ethanol and toluene were distilled off under reduced pressure, dissolved in dichloromethane, and the organic phase was washed with water.The filtrate was subjected to column chromatography to obtain 3.12 g of (5-(4-(6-chloro-2-phenylpyrimidin-4-yl)phenyl)-5H-benzofuro[3,2-c]carbazole) (60percent);

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 3740-92-9, 4,6-Dichloro-2-phenylpyrimidine.

Reference:
Patent; Huazhong University of Science and Technology; Wang Lei; Zhang Qing; Zhuang Shaoqing; (40 pag.)CN108285452; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

3740-92-9 , The common heterocyclic compound, 3740-92-9, name is 4,6-Dichloro-2-phenylpyrimidine, molecular formula is C10H6Cl2N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

EXAMPLE VIII Two grams of 4,6-dichloro-2-phenylpyrimidine is added in small portions to 10 ml. of N-methylpiperazine with slight warming and stirring. The resulting mixture is heated on a steam bath for several minutes, then poured into 250 ml. of water. The product (2.4 g., m.p. 81¡ã-87¡ãC.) is then recrystallized from n-pentane to afford 4-chloro-6-(4-methyl-1-piperazinyl)-2-phenylpyrimidine, m.p. 91¡ã-92.5¡ãC. Anal. for C15 H17 N4 Cl: Calcd. C, 62.38; H, 5.93; N, 19.40; Cl, 12.28. Found: C, 62.32; H, 5.65; N, 19.62; Cl, 12.1.

According to the analysis of related databases, 3740-92-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; American Home Products Corporation; US3940395; (1976); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 3740-92-9, name is 4,6-Dichloro-2-phenylpyrimidine. A new synthetic method of this compound is introduced below., 3740-92-9

In a 250-mL three-neck flask, nitrogen was introduced and 0.01 mol of intermediate A20, 150 ml of DMF, 0.012 mol of intermediate B1, and 0.0001 mol of palladium acetate were added.Stir, then add 0.01mol K3PO4 aqueous solution, heated to 150 ¡ãC,The reaction was refluxed for 24 hours. Samples were taken and the reaction was complete.Cool naturally, extract with 200ml dichloromethane, layerThe extract was dried over anhydrous sodium sulfate, filtered, and the filtrate was evaporated.Purification by silica gel column to give intermediate C1, HPLC purity 99.2percentThe yield was 85.1percent.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,3740-92-9, 4,6-Dichloro-2-phenylpyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; Jiangsu March Optoelectric Technology Co., Ltd.; Wang Fang; Zhang Zhaochao; Li Chong; Zhang Xiaoqing; (53 pag.)CN107602538; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

3740-92-9 , The common heterocyclic compound, 3740-92-9, name is 4,6-Dichloro-2-phenylpyrimidine, molecular formula is C10H6Cl2N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

The following compounds presented in Examples 114-117 were prepared in accordance with Scheme 10, by a procedure analogous to that disclosed in Example 113, using starting materials with the appropriate substitution.

The synthetic route of 3740-92-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; REDDY US THERAPEUTICS, INC.; KALLEDA, Srinivas; PADAKANTI, Srinivas; KUMAR SWAMY, Nalivela; YELESWARAPU, Koteswar, Rao; ALEXANDER, Christopher, W.; KHANNA, Ish, Kumar; IQBAL, Javed; PILLARISETTI, Sivaram; PAL, Manojit; BARANGE, Deepak; WO2006/34473; (2006); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

3740-92-9 , The common heterocyclic compound, 3740-92-9, name is 4,6-Dichloro-2-phenylpyrimidine, molecular formula is C10H6Cl2N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General Method 4 Step 2C. A solution of 4-chloroaniline (127.6 mg, 1 mmol) in dry THF (2 mL) was cooled in a dry-ice/acetone bath and treated dropwise with a solution of nBuLi in cyclohexane (0.5 mL, 2M, 1 mmol). The mixture was treated with additional dry THF (2 mL) and was allowed to warm slightly (15 minutes) till the material went into solution. The material was then transferred by cannula into a solution of fenclorim (XXII) (225 mg, 1 mmol) and bis(triphenylphosphine)palladium(II) dichloride (35 mg, 0.05 mmol) in dry THF (2 mL). Rinsed with dry THF (2 mL) and stirred at room temperature for 30 minutes. The reaction was partitioned between saturated sodium bicarbonate and ethyl acetate. Added brine to help clear an emulsion. Separated layers and the aqueous layer was extracted twice with ethyl acetate. The combined organics was dried over magnesium sulfate, filtered and concentrated on a rotary evaporator to yield a film. The film was taken up in chloroform and loaded onto 100 g of silica gel. The silica gel was eluted with 10percent ethyl acetate/hexanes followed by 20percent ethyl acetate/hexanes. The appropriate fractions were concentrated to yield 6-chloro-N-(4-chlorophenyl)-2-phenylpyrimidin-4-amine (XXIII) as a film (161.87 mg). ESI/MS 315.9, 317.9 (M+H), 314.0, 316.0 (M-H).

According to the analysis of related databases, 3740-92-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Vestaron Corporation; US2012/22066; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia