Category: 32980-71-5

Application of 32980-71-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.32980-71-5, name is Perchloropyrimido[5,4-d]pyrimidine, molecular formula is C6Cl4N4, molecular weight is 269.9, as common compound, the synthetic route is as follows.

Connect a mineral oil valve rotating device, an impregnation thermometer, to a 4-cc bottle with a capacity of 100 cc.a vent and a drying tube, Add 7g piperidine and 30cc absolute ethanol to the bottle. Then, 2.7 g of tetrachloropyrimidopyrimidine was added with stirring. Increasing the reaction temperature to 32-35 C produces a moderate amount of basic steam. The powder reaction gradually changes from a yellow-gold-red crystal powder to a transparent granular powder.The tetrachloro compound is gradually added in 30 minutes. The reaction mixture was continuously stirred for 90 minutes and then allowed to stand for 24 hours. After the reaction was completed, it was observed that there was a bright yellow powder in the bright orange liquid, and the color of the liquid became more vivid when it was left standing. The precipitate was collected by filtration and washed with absolute ethanol to give 3.24 g of a yellow powder of unknown melting point which softened at 180 C and rapidly melted and decomposed at 240 C.The yellow powder was purified by adding 30 cc of dimethylformamide precooled at 0 C, and the dimethylformamide was turned into a deep red color. The precipitate was collected by suction filtration using a vacuum suction apparatus, and the residual dimethyl group was removed by washing with 10 cc of absolute ethanol. Formamide,The weight of the product is less than half the weight of the original material.The melting point is raised to 245 ~ 255 C, And softening occurs at 225 C. The average yield of the two chlorination reactions and subsequent reaction with piperidine is from 27 to 29%, based on the piperidine derivative, wherein the oxidized uric acid used in the chlorination reaction stage is in the form of its dried disodium salt.

Statistics shows that 32980-71-5 is playing an increasingly important role. we look forward to future research findings about Perchloropyrimido[5,4-d]pyrimidine.

Reference:
Patent; Suohao; Huan Xiaojun; Suo Hao; Qi Taotao; Jin Chunyan; Chen Yifei; (9 pag.)CN108752350; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 32980-71-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.32980-71-5, name is Perchloropyrimido[5,4-d]pyrimidine, molecular formula is C6Cl4N4, molecular weight is 269.9, as common compound, the synthetic route is as follows.

the entire chlorine pyrimido [5, 4 – d] pyrimidine (13.1 g, 48.9 mmol), piperidine, CuI (0.28 g, 1.5 mmol), Cs2 CO3 (16.0 g, 48.9 mmol) is put into the 250 in two mouth flask, add 100 ml nitrobenzene as the reaction solvent, under the protection of nitrogen, 180 C lower reaction 16 h, oil pump by reducing pressure after the reaction of the nitrobenzene solvent, PE_DCM=6:1 to column chromatography, obtaining the solid 17.0 g, yield of 95.0%, the selectivity 99%

Statistics shows that 32980-71-5 is playing an increasingly important role. we look forward to future research findings about Perchloropyrimido[5,4-d]pyrimidine.

Reference:
Patent; Dalian Wanfu Pharmaceutical Co., Ltd.; Sun Qingfa; (9 pag.)CN106946887; (2017); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 32980-71-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 32980-71-5, name is Perchloropyrimido[5,4-d]pyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

2M Ethylamine/THF (27 mL, 54.00 mmol) was added dropwise to a solution of 2,4,6,8-tetrachloro-pyrimido[5,4-djpyrimidine (1)(3.00 g, 11.15 mmol) in THF (150 mL) at 0C. The reaction mixture was stirred at room temperature for 2 h. The volatiles were removed and the residue was suspended in water (50 mL). The resultanthe precipitate were filtered, washed with water (2 x 30 mL) and dried over solid P205 to give 2,6-dichloro-N,N?-diethyl-pyrimido [5,4-djpyrimidine-4,8-diamine (160) (2.93 g, 92% yield). 300 MHz ?HNMR (DMSO-d6, ppm): 8.68 (2H, t, J=5.9 Hz) 3.52-3.40 (4H, m) 1.16 (6H, t, J7.1 Hz).ESI-MS (m/z): 287, 289, 291 [M+Hjt

According to the analysis of related databases, 32980-71-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GALLEON PHARMACEUTICALS, INC.; DAX, Scott L.; MENCEL, James Joseph; OZOLA, Vita; SUNA, Edgars; SHUBIN, Kirill; (294 pag.)WO2017/3822; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia