Category: 304693-64-9

Adding a certain compound to certain chemical reactions, such as: 304693-64-9, Ethyl 2-(trifluoromethyl)pyrimidine-5-carboxylate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of Ethyl 2-(trifluoromethyl)pyrimidine-5-carboxylate, blongs to pyrimidines compound. Application In Synthesis of Ethyl 2-(trifluoromethyl)pyrimidine-5-carboxylate

To a solution of ethyl 2-(trifluoromethyl)pyrimidine-5-carboxylate (56.8 g, 252.8 mmol) dissolved in THF (500 mL) was added 1M aq. LiCH (380 mL, 379.3 mmol). The reaction mixture was stirred at RT for 16 h, concentrated under vacuum toremove the organic solvent and the remaining aqueous acidified to pH 1 with conc.HCI. The resultant precipitate was collected by vacuum filtration to afford 44.4(91 % yield) of the title compound as off-white powder.1H NMR (500 MHz, DMSO-d6): 6 [ppm] 9.44 (5, 2H).LCMS (Analytical Method A) Rt = 0.81 mm, MS (ESineg): m/z = 190.9 (M)-.

The synthetic route of 304693-64-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; EVOTEC AG; DAVENPORT, Adam James; BRAEUER, Nico; FISCHER, Oliver Martin; ROTGERI, Andrea; ROTTMANN, Antje; NEAGOE, Ioana; NAGEL, Jens; GODINHO-COELHO, Anne-Marie; (703 pag.)WO2016/91776; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 304693-64-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 304693-64-9, name is Ethyl 2-(trifluoromethyl)pyrimidine-5-carboxylate, molecular formula is C8H7F3N2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Intermediate B4-2-Trifluoromethyl-5-formylpyrimidine To a solution of ethyl 2-trifluoromethylpyrimidine-5-carboxylate (5.17 g) in toluene (120 ml) cooled in dry ice/acetone was added a solution of diisobutylaluminium hydride (25 wt %, 31 ml) over 15 min.The mixture was stirred at -78 C. for 45 min, then dilute HCl (2M, 120 ml) was added cautiously.After allowing the mixture to warm to room temperature diethyl ether was added.The organic phase was separated, washed with water, then brine, dried (MgSO4) and evaporated to give the title compound as a colourless solid (3.46 g, 84%).1H-NMR (CDCl3) delta 10.29 (1H, s), 9.37 (2H, s); 13C-NMR (CDCl3) delta 187.7, 159.6 (q, J=38 Hz), 159.1 (2C) 129.6, 119.2 (q, J=276 Hz).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 304693-64-9, Ethyl 2-(trifluoromethyl)pyrimidine-5-carboxylate.

Reference:
Patent; SmithKline Beecham p.l.c.; US2004/167142; (2004); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia