Category: 29509-92-0

Synthetic Route of 29509-92-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 29509-92-0, name is 4-Chloro-6-methyl-2-phenylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: To a solution of 2-(4-bromophenyl)-4-chloro-6-methylpyrimidine (8a, 2.27 g) in acetonitrile (20 mL) was added ethanolamine (2.0 mL), and the mixture was stirred at 70 C for 14 h. To the reaction mixture was added additional ethanolamine (4.0 mL) and the mixture was stirred at 85 C for 6.5 h. The reaction mixture was cooled down to room temperature, and evaporated in vacuo. To the resulting residue was added 1 M aqueous sodium hydroxide (40 mL), and extracted with ethyl acetate. The organic layer was dried, and the desiccant was removed by filtration, and then the solvent was evaporated in vacuo. The resulting residue was purified by silica gel column chromatography (chloroform-methanol) to obtain 9a (2.03 g, 82%) as a white amorphous solid.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 29509-92-0, 4-Chloro-6-methyl-2-phenylpyrimidine.

Reference:
Article; Negoro, Kenji; Yonetoku, Yasuhiro; Maruyama, Tatsuya; Yoshida, Shigeru; Takeuchi, Makoto; Ohta, Mitsuaki; Bioorganic and Medicinal Chemistry; vol. 20; 7; (2012); p. 2369 – 2375;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 29509-92-0 ,Some common heterocyclic compound, 29509-92-0, molecular formula is C11H9ClN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A mixture of 4-chloro-6-methyl-2-phenylpyrimidine (1 g, 4.89 mmol) and piperidine-4-carboxamide (0.627 g, 4.89 mmol) and trimethylamine (1.02 mL, 7.34 mmol) in anhydrous DMF (25 mL) was heated to reflux for 4 hours, upon completion, the reaction mixture was cooled to room temperature, and then was concentrated to dry, the residue was stirred in a mixed solution of EtOAc (10 mL) and water (20 mL) for about 30 min. and then the solid product was collected by filtration to obtain 1.4 g compound, then it was re-crystallized from EtOH/H20, after dry obtained 900 mg of the title compound as a white solid in 62% yield. MS (MH+) 297.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 29509-92-0, 4-Chloro-6-methyl-2-phenylpyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; FIRMENICH INCORPORATED; SERVANT, Guy; CHEN, Qing; FOTSING, Joseph, R.; ZHANG, Lan; PATRON, Andres; WILLIAMS, Mark; BRADY, Thomas; PRIEST, Chad; DARMOHUSODO, Vincent; SIMONE, Kenneth; WONG, Melissa, S.; (204 pag.)WO2020/33669; (2020); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 29509-92-0, 4-Chloro-6-methyl-2-phenylpyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C11H9ClN2, blongs to pyrimidines compound. COA of Formula: C11H9ClN2

To a solution of 4-chloro-6-methyl-2-phenylpyrimidine (14a, 160 mg) in DMI (5 mL) were added 2-(1-oxidopyridin-3-yl)ethylamine hydrochloride (16, 480 mg) and potassium carbonate (540 mg), and the mixture was stirred at 80 C for 24 h. The reaction mixture was cooled down to room temperature and treated with water, then extracted with ethyl acetate. The organic layer was washed with brine, dried, filtered, and then the solvent was evaporated in vacuo. The resulting residue was purified by silica gel column chromatography (chloroform-methanol). The obtained solid (90 mg) was treated with ethanol (5 mL) and oxalic acid (53 mg), and the mixture was evaporated in vacuo and the resulting residue was washed with diethyl ether to give 17a (70 mg, 19%) as a white solid: 1H NMR (DMSO-d6) delta 2.31 (3H, s), 2.88 (2H, t, J = 6.6 Hz), 3.50-4.00 (2H, m), 6.30 (1H, s), 7.20-7.30 (1H, m), 7.30-7.40 (1H, m), 7.40-7.55 (3H, m), 7.55-7.75 (1H, br), 8.07 (1H, d, J = 5.8 Hz), 8.19 (1H, s), 8.24-8.35 (2H, m); FAB-MS m/z 307 [(M)+]. Anal. (C18H18N4O·1.8C2H2O4·0.4H2O): C, H, N, Br, F.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,29509-92-0, 4-Chloro-6-methyl-2-phenylpyrimidine, and friends who are interested can also refer to it.

Reference:
Article; Negoro, Kenji; Yonetoku, Yasuhiro; Misawa-Mukai, Hana; Hamaguchi, Wataru; Maruyama, Tatsuya; Yoshida, Shigeru; Takeuchi, Makoto; Ohta, Mitsuaki; Bioorganic and Medicinal Chemistry; vol. 20; 17; (2012); p. 5235 – 5246;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia