Category: 2927-71-1

The nomenclature of pyrimidines is straightforward. However, like other heterocyclics, tautomeric hydroxyl groups yield complications since they exist primarily in the cyclic amide form. 2927-71-1, formula is C4HCl2FN2, Name is 2,4-Dichloro-5-fluoropyrimidine. For example, 2-hydroxypyrimidine is more properly named 2-pyrimidone. A partial list of trivial names of various pyrimidines exists. Application In Synthesis of 2927-71-1.

Chan, Shingpan;Han, Kun;Qu, Rong;Tong, Linjiang;Li, Yingjun;Zhang, Zhang;Cheng, Huimin;Lu, Xiaoyun;Patterson, Adam;Smaill, Jeff;Ren, Xiaomei;Ding, Jian;Xie, Hua;Ding, Ke research published 《 2,4-Diarylamino-pyrimidines as kinase inhibitors co-targeting IGF1R and EGFR^L858R/T790M》, the research content is summarized as follows. IGF1R amplification was recently implied to be related to the secondary acquired resistance against the 2nd or 3rd generation EGFR inhibitor therapies. The authors have successfully identified a series of 2,4-diarylamino-pyrimidines as new IGF1R/EGFR^L858R/T790M cotargeting agents. One of the most promising compounds I potently inhibits both kinases with low nanomolar IC₅₀ values, but is significantly less potent in inhibiting the wild type EGFR. The compound also displays a good kinase selectivity profile against a panel of 468 kinases. Moreover, I strongly suppresses the proliferation of CO-1686-resistant H1975-IGF1R cancer cells, suggesting its promising potential as a new lead compound for future anticancer drug discovery.

Application In Synthesis of 2927-71-1, 2,4-Dichloro-5-fluoropyrimidine is a useful research compound. Its molecular formula is C4HCl2FN2 and its molecular weight is 166.97 g/mol. The purity is usually 95%.
2,4-Dichloro-5-fluoropyrimidine is an aromatic hydrocarbon that has been shown to inhibit the growth of mouse tumor cells in vitro. It also inhibits the production of amines by reacting with industrial chemicals and sodium carbonate. This compound has potent inhibitory activity against autoimmune diseases and cytotoxic potency on mcf-7 cells. Furthermore, 2,4-Dichloro-5-fluoropyrimidine has been shown to have a chlorinating effect on cancer cells., 2927-71-1.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The systematic study of pyrimidines began in 1884 with Pinner, who synthesized derivatives by condensing ethyl acetoacetate with amidines. Pinner first proposed the name “pyrimidin” in 1885. 2927-71-1, formula is C4HCl2FN2, Name is 2,4-Dichloro-5-fluoropyrimidine. The parent compound was first prepared by Gabriel and Colman in 1900, by conversion of barbituric acid to 2,4,6-trichloropyrimidine followed by reduction using zinc dust in hot water. Related Products of 2927-71-1.

Chen, Lingfeng;Fu, Weitao;Feng, Chen;Qu, Rong;Tong, Linjiang;Zheng, Lulu;Fang, Bo;Qiu, Yinda;Hu, Jie;Cai, Yuepiao;Feng, Jianpeng;Xie, Hua;Ding, Jian;Liu, Zhiguo;Liang, Guang research published 《 Structure-based design and synthesis of 2,4-diaminopyrimidines as EGFR L858R/T790M selective inhibitors for NSCLC》, the research content is summarized as follows. Mutated epidermal growth factor receptor (EGFR) is a major driver of non-small cell lung cancer (NSCLC). The EGFRT790M secondary mutation has become a leading cause of clin.-acquired resistance to gefitinib and erlotinib. Herein, structure-based design approach to increase the potency and selectivity of the previously reported reversible EGFR inhibitor I, at the kinase and cellular levels has been reported. Three-step structure-activity relationship exploration led to promising compounds II (R¹ = Br; R² = 1-methyl-1H-indol-6-yl, 2,3-dihydro-1H-inden-5-yl; R³ = OMe; R⁴ = 4-methyl-1-piperazinyl) with unique chem. structure and binding mode from the other third-generation tyrosine kinase inhibitors. In a human NSCLC xenograft model, the above compounds exhibited dose-dependent tumor growth suppression without toxicity. These selective inhibitors are promising drug candidates for EGFRT790M-driven NSCLC.

Related Products of 2927-71-1, 2,4-Dichloro-5-fluoropyrimidine is a useful research compound. Its molecular formula is C4HCl2FN2 and its molecular weight is 166.97 g/mol. The purity is usually 95%.
2,4-Dichloro-5-fluoropyrimidine is an aromatic hydrocarbon that has been shown to inhibit the growth of mouse tumor cells in vitro. It also inhibits the production of amines by reacting with industrial chemicals and sodium carbonate. This compound has potent inhibitory activity against autoimmune diseases and cytotoxic potency on mcf-7 cells. Furthermore, 2,4-Dichloro-5-fluoropyrimidine has been shown to have a chlorinating effect on cancer cells., 2927-71-1.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Pyrimidine is a nitrogenous base similar to benzene (a six-membered ring) and includes cytosine, thymine, and uracil as bases used for DNA or RNA. 2927-71-1, formula is C4HCl2FN2, Name is 2,4-Dichloro-5-fluoropyrimidine. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. Recommanded Product: 2,4-Dichloro-5-fluoropyrimidine.

Boyd, Michael J.;Bandarage, Upul K.;Bennett, Hamilton;Byrn, Randal R.;Davies, Ioana;Gu, Wenxin;Jacobs, Marc;Ledeboer, Mark W.;Ledford, Brian;Leeman, Joshua R.;Perola, Emanuele;Wang, Tiansheng;Bennani, Youssef;Clark, Michael P.;Charifson, Paul S. research published 《 Isosteric replacements of the carboxylic acid of drug candidate VX-787: Effect of charge on antiviral potency and kinase activity of azaindole-based influenza PB2 inhibitors [Erratum to document cited in CA162:570090]》, the research content is summarized as follows. On page 1992, the first paragraph contained inaccurate text describing the activity of the enantiomer of 1; the corrected text is given.

Recommanded Product: 2,4-Dichloro-5-fluoropyrimidine, 2,4-Dichloro-5-fluoropyrimidine is a useful research compound. Its molecular formula is C4HCl2FN2 and its molecular weight is 166.97 g/mol. The purity is usually 95%.
2,4-Dichloro-5-fluoropyrimidine is an aromatic hydrocarbon that has been shown to inhibit the growth of mouse tumor cells in vitro. It also inhibits the production of amines by reacting with industrial chemicals and sodium carbonate. This compound has potent inhibitory activity against autoimmune diseases and cytotoxic potency on mcf-7 cells. Furthermore, 2,4-Dichloro-5-fluoropyrimidine has been shown to have a chlorinating effect on cancer cells., 2927-71-1.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives, 2927-71-1, formula is C4HCl2FN2, Name is 2,4-Dichloro-5-fluoropyrimidine. including the nucleotides cytosine, thymine and uracil, thiamine (vitamin B1) and alloxan. SDS of cas: 2927-71-1.

Bronner, Sarah M.;Merrick, Karl A.;Murray, Jeremy;Salphati, Laurent;Moffat, John G.;Pang, Jodie;Sneeringer, Christopher J.;Dompe, Nicholas;Cyr, Patrick;Purkey, Hans;Boenig, Gladys de Leon;Li, Jun;Kolesnikov, Aleksandr;Larouche-Gauthier, Robin;Lai, Kwong Wah;Shen, Xiaoli;Aubert-Nicol, Samuel;Chen, Yi-Chen;Cheong, Jonathan;Crawford, James J.;Hafner, Marc;Haghshenas, Pouyan;Jakalian, Araz;Leclerc, Jean-Philippe;Lim, Ngiap-Kie;O’Brien, Tom;Plise, Emile G.;Shalan, Hadil;Sturino, Claudio;Wai, John;Xiao, Yang;Yin, Jianping;Zhao, Liang;Gould, Stephen;Olivero, Alan;Heffron, Timothy P. research published 《 Design of a brain-penetrant CDK4/6 inhibitor for glioblastoma》, the research content is summarized as follows. CDK4 and CDK6 are kinases with similar sequences that regulate cell cycle progression and are validated targets in the treatment of cancer. Glioblastoma is characterized by a high frequency of CDKN2A/CCND2/CDK4/CDK6 pathway dysregulation, making dual inhibition of CDK4 and CDK6 an attractive therapeutic approach for this disease. Abemaciclib, ribociclib, and palbociclib are approved CDK4/6 inhibitors for the treatment of HR+/HER2- breast cancer, but these drugs are not expected to show strong activity in brain tumors due to poor blood brain barrier penetration. Herein, we report the identification of a brain-penetrant CDK4/6 inhibitor derived from a literature mol. with low mol. weight and topol. polar surface area (MW = 285 and TPSA = 66 Ų), but lacking the CDK2/1 selectivity profile due to the absence of a basic amine. Removal of a hydrogen bond donor via cyclization of the pyrazole allowed for the introduction of basic and semi-basic amines, while maintaining in many cases efflux ratios reasonable for a CNS program. Ultimately, a basic spiroazetidine (cpK_a = 8.8) was identified that afforded acceptable selectivity over anti-target CDK1 while maintaining brain-penetration in vivo (mouse K_p,uu = 0.20-0.59). To probe the potency and selectivity, our lead compound was evaluated in a panel of glioblastoma cell lines. Potency comparable to abemaciclib was observed in Rb-wild type lines U87MG, DBTRG-05MG, A172, and T98G, while Rb-deficient cell lines SF539 and M059J exhibited a lack of sensitivity.

SDS of cas: 2927-71-1, 2,4-Dichloro-5-fluoropyrimidine is a useful research compound. Its molecular formula is C4HCl2FN2 and its molecular weight is 166.97 g/mol. The purity is usually 95%.
2,4-Dichloro-5-fluoropyrimidine is an aromatic hydrocarbon that has been shown to inhibit the growth of mouse tumor cells in vitro. It also inhibits the production of amines by reacting with industrial chemicals and sodium carbonate. This compound has potent inhibitory activity against autoimmune diseases and cytotoxic potency on mcf-7 cells. Furthermore, 2,4-Dichloro-5-fluoropyrimidine has been shown to have a chlorinating effect on cancer cells., 2927-71-1.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The systematic study of pyrimidines began in 1884 with Pinner, who synthesized derivatives by condensing ethyl acetoacetate with amidines. Pinner first proposed the name “pyrimidin” in 1885. 2927-71-1, formula is C4HCl2FN2, Name is 2,4-Dichloro-5-fluoropyrimidine. The parent compound was first prepared by Gabriel and Colman in 1900, by conversion of barbituric acid to 2,4,6-trichloropyrimidine followed by reduction using zinc dust in hot water. Recommanded Product: 2,4-Dichloro-5-fluoropyrimidine.

Bandarage, Upul K.;Clark, Michael P.;Perola, Emanuele;Gao, Huai;Jacobs, Marc D.;Tsai, Alice;Gillespie, Jeffery;Kennedy, Joseph M.;Maltais, Francois;Ledeboer, Mark W.;Davies, Ioana;Gu, Wenxin;Byrn, Randal A.;Nti Addae, Kwame;Bennett, Hamilton;Leeman, Joshua R.;Jones, Steven M.;O’Brien, Colleen;Memmott, Christine;Bennani, Youssef;Charifson, Paul S. research published 《 Novel 2-Substituted 7-Azaindole and 7-Azaindazole Analogues as Potential Antiviral Agents for the Treatment of Influenza》, the research content is summarized as follows. JNJ-63623872 (2) is a first-in-class, orally bioavailable compound that offers significant potential for the treatment of pandemic and seasonal influenza. Early lead optimization efforts in our 7-azaindole series focused on 1,3-diaminocyclohexyl amide and urea substitutions on the pyrimidine-7-azaindole motif. In this work, we explored two strategies to eliminate observed aldehyde oxidase (AO)-mediated metabolism at the 2-position of these 7-azaindole analogs. Substitution at the 2-position of the azaindole ring generated somewhat less potent analogs, but reduced AO-mediated metabolism Incorporation of a ring nitrogen generated 7-azaindazole analogs that were equipotent to the parent 2-H-7-azaindole, but surprisingly, did not appear to improve AO-mediated metabolism Overall, we identified multiple 2-substituted 7-azaindole analogs with enhanced AO stability and we present data for one such compound (12) that demonstrate a favorable oral pharmacokinetic profile in rodents. These analogs have the potential to be further developed as anti-influenza agents for the treatment of influenza.

Recommanded Product: 2,4-Dichloro-5-fluoropyrimidine, 2,4-Dichloro-5-fluoropyrimidine is a useful research compound. Its molecular formula is C4HCl2FN2 and its molecular weight is 166.97 g/mol. The purity is usually 95%.
2,4-Dichloro-5-fluoropyrimidine is an aromatic hydrocarbon that has been shown to inhibit the growth of mouse tumor cells in vitro. It also inhibits the production of amines by reacting with industrial chemicals and sodium carbonate. This compound has potent inhibitory activity against autoimmune diseases and cytotoxic potency on mcf-7 cells. Furthermore, 2,4-Dichloro-5-fluoropyrimidine has been shown to have a chlorinating effect on cancer cells., 2927-71-1.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The systematic study of pyrimidines began in 1884 with Pinner, who synthesized derivatives by condensing ethyl acetoacetate with amidines. Pinner first proposed the name “pyrimidin” in 1885. 2927-71-1, formula is C4HCl2FN2, Name is 2,4-Dichloro-5-fluoropyrimidine. The parent compound was first prepared by Gabriel and Colman in 1900, by conversion of barbituric acid to 2,4,6-trichloropyrimidine followed by reduction using zinc dust in hot water. Application In Synthesis of 2927-71-1.

Adam, Catherine;Bray, Thomas L.;Perez-Lopez, Ana M.;Tan, Ee Hong;Rubio-Ruiz, Belen;Baillache, Daniel J.;Houston, Douglas R.;Salji, Mark J.;Leung, Hing Y.;Unciti-Broceta, Asier research published 《 A 5-FU Precursor Designed to Evade Anabolic and Catabolic Drug Pathways and Activated by Pd Chemistry In Vitro and In Vivo》, the research content is summarized as follows. 5-Fluorouracil (5-FU) is an antineoplastic antimetabolite that is widely administered to cancer patients by bolus injection, especially to those suffering from colorectal and pancreatic cancer. Because of its suboptimal route of administration and dose-limiting toxicities, diverse 5-FU prodrugs have been developed to confer oral bioavailability and increase the safety profile of 5-FU chemotherapy regimens. Our contribution to this goal is presented herein with the development of a novel palladium-activated prodrug designed to evade the metabolic machinery responsible for 5-FU anabolic activation and catabolic processing. The new prodrug is completely innocuous to cells and highly resistant to metabolization by primary hepatocytes and liver S9 fractions (the main metabolic route for 5-FU degradation), whereas it is rapidly converted into 5-FU in the presence of a palladium (Pd) source. In vivo pharmokinetic anal. shows the prodrug is rapidly and completely absorbed after oral administration and exhibits a longer half-life than 5-FU. In vivo efficacy studies in a xenograft colon cancer model served to prove, for the first time, that orally administered prodrugs can be locally converted to active drugs by intratumorally inserted Pd implants.

Application In Synthesis of 2927-71-1, 2,4-Dichloro-5-fluoropyrimidine is a useful research compound. Its molecular formula is C4HCl2FN2 and its molecular weight is 166.97 g/mol. The purity is usually 95%.
2,4-Dichloro-5-fluoropyrimidine is an aromatic hydrocarbon that has been shown to inhibit the growth of mouse tumor cells in vitro. It also inhibits the production of amines by reacting with industrial chemicals and sodium carbonate. This compound has potent inhibitory activity against autoimmune diseases and cytotoxic potency on mcf-7 cells. Furthermore, 2,4-Dichloro-5-fluoropyrimidine has been shown to have a chlorinating effect on cancer cells., 2927-71-1.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2927-71-1, name is 2,4-Dichloro-5-fluoropyrimidine. This compound has unique chemical properties. The synthetic route is as follows. category: pyrimidines

Nitrogen was bubbled into a solution of compound 13 (1 g, 6 mmol, 1.1 eq), Pd(dppf)2Cl2 (0.38 g, 0.05 mmol, 0.1 eq) and 2 N Na2C03 (8.4 mL, 16.8 mmol, 3 eq) in DME (17 mL) for 5 minutes. The mixture was warmed to 80 C and a solution of compound 12 (1.8 g, 5.4 mmol, 1 eq) in DME (18 mL) was added dropwise. After addition, the mixture was stirred at 84 C for 1 h. After cooling down to rt, the mixture was diluted with ethyl acetate (100 mL) and washed with brine (50 mL x 2), dried over sodium sulfate, concentrated and purified by column chromatography to give the desired product (1.8 g, 60%). LCMS: (M+H)+: 334.8.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 2927-71-1, 2,4-Dichloro-5-fluoropyrimidine.

Reference:
Patent; BEIJING XUANYI PHARMASCIENCES CO., LTD.; SONG, Yuntao; CHEN, Xiaoqi; (188 pag.)WO2019/35008; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2927-71-1, name is 2,4-Dichloro-5-fluoropyrimidine. This compound has unique chemical properties. The synthetic route is as follows. category: pyrimidines

Nitrogen was bubbled into a solution of compound 13 (1 g, 6 mmol, 1.1 eq), Pd(dppf)2Cl2 (0.38 g, 0.05 mmol, 0.1 eq) and 2 N Na2C03 (8.4 mL, 16.8 mmol, 3 eq) in DME (17 mL) for 5 minutes. The mixture was warmed to 80 C and a solution of compound 12 (1.8 g, 5.4 mmol, 1 eq) in DME (18 mL) was added dropwise. After addition, the mixture was stirred at 84 C for 1 h. After cooling down to rt, the mixture was diluted with ethyl acetate (100 mL) and washed with brine (50 mL x 2), dried over sodium sulfate, concentrated and purified by column chromatography to give the desired product (1.8 g, 60%). LCMS: (M+H)+: 334.8.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 2927-71-1, 2,4-Dichloro-5-fluoropyrimidine.

Reference:
Patent; BEIJING XUANYI PHARMASCIENCES CO., LTD.; SONG, Yuntao; CHEN, Xiaoqi; (188 pag.)WO2019/35008; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 2927-71-1, Adding some certain compound to certain chemical reactions, such as: 2927-71-1, name is 2,4-Dichloro-5-fluoropyrimidine,molecular formula is C4HCl2FN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2927-71-1.

title compound (81%) as an orange solid, which was used without further purification.LRMS (m/z): 163 (M+1)+.1H-NMR delta (CDCl3): 4.11 (s, 3H), 8.20 (d, 1 H)

According to the analysis of related databases, 2927-71-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Almirall, S.A.; Eastwood, Paul Robert; Gonzalez Rodriguez, Jacob; Bach Tana, Jordi; Pages Santacana, Lluis Miquel; Taltavull Moll, Joan; Caturla Javaloyes, Juan Francisco; EP2338888; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 2927-71-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 2927-71-1, name is 2,4-Dichloro-5-fluoropyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: To a solution of 2,4-dichloro-5-fluoropyrimidine 7a (0.83g, 5mmol) in THF (10mL) at 0C was slowly added THF solution of cyclopentylamine (0.74mL, 7.5mmol). The resulting mixture was stirred at 0C for 3h (monitored by TLC). The solvent was removed in vacuo and water (20mL) was added and extracted with CH2Cl2 (3×10mL). Combined organic phase was washed with brine, dried over anhydrous Na2SO4, filtered and concentrated. The crude product was purified by column chromatography on silica gel (dichloromethane/methanol 50:1) to give 8a (0.83g, 77%) as a solid.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 2927-71-1, 2,4-Dichloro-5-fluoropyrimidine.

Reference:
Article; Qin, Wen-Wen; Sang, Chun-Yan; Zhang, Lin-Lin; Wei, Wei; Tian, Heng-Zhi; Liu, Huan-Xiang; Chen, Shi-Wu; Hui, Ling; European Journal of Medicinal Chemistry; vol. 95; (2015); p. 174 – 184;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia