Category: 23256-42-0

On February 13, 2013, Wang, Bin published a patent.SDS of cas: 23256-42-0 The title of the patent was Compound veterinary drug for treating poultry colibacillosis of enteritis type. And the patent contained the following:

The drug comprises neomycin sulfate 3.25%, TMP lactate 0.81%, glutamine 10% and glucose as excipient 85.94%. The preparation method consists of pulverizing all materials resp., sieving, and mixing for 25 min. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).SDS of cas: 23256-42-0

The Article related to compound veterinary drug poultry colibacillosis enteritis, Pharmaceuticals: Formulation and Compounding and other aspects.SDS of cas: 23256-42-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On September 21, 2016, Huang, Jing; Xiao, Liping; Jiang, Wen; Wen, Qingqi; Wu, Youlin; Zhou, Shengchang; Shi, Jiancheng; Ai, Chunxiang; Liang, Shiren published a patent.SDS of cas: 23256-42-0 The title of the patent was A pharmaceutical preparation for preventing and treating sow postpartum disease and its making method. And the patent contained the following:

The present invention discloses a pharmaceutical preparation for preventing and treating sow postpartum disease and its making method. The pharmaceutical preparation for preventing and treating sow postpartum disease comprises lincomycin hydrochloride 5-10, ciprofloxacin lactate 2-6, sodium trimethoxy pyrimidine lactate 1-5, Lonicera japonica flowers 8-12, Houttuynia cordata 5-10, Liquidambar formosana infructescence 1-5, maifanite 20-30, fructooligosaccharide 2-5, and citric acid 0.5-2 weight parts. The making method includes the following steps: 1) weighing Lonicera japonica flowers, Houttuynia cordata, Liquidambar formosana infructescence, maifanite, fructooligosaccharide and citric acid, micronizing through 150 mesh; 2) weighing lincomycin hydrochloride, ciprofloxacin lactate and sodium trimethoxy pyrimidine lactate, fully mixing them uniformly; and 3) mixing the products of step 1) and 2). The present invention contains components compatible with each other, and has synergistic effect, and can cause great appetite for postpartum sows, effectively prevent postpartum diseases. decrease the incidence of mastitis, reduce dioestrus and improve sow utilization. The present invention reduces the incidence of piglet yellow-white dysentery, promotes the healthy growth of piglets, adjusts the ecol. balance of intestinal flora and greatly reduces the side effect of antibiotics disrupting the intestinal bacteria group, and has broad application prospects. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).SDS of cas: 23256-42-0

The Article related to pharmaceutical preparation sow postpartum disease making, Pharmaceuticals: Formulation and Compounding and other aspects.SDS of cas: 23256-42-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On May 2, 2019, Stockum, Werner; Lindhardt, Charlotte published a patent.Related Products of 23256-42-0 The title of the patent was Methods for performing cell culture on solid media containing different cell culture media ingredients. And the patent contained the following:

The present invention relates to methods for performing cell culture by using a solid cell culture media form prepared by a 3D printing process. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Related Products of 23256-42-0

The Article related to performing cell culture solid multilayer media, Biochemical Methods: Culture and Preservation and other aspects.Related Products of 23256-42-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On July 7, 1982, Takagishi, Yasushi; Ohsuga, Kiichiro; Ohama, Sadao published a patent.Recommanded Product: 23256-42-0 The title of the patent was Suppositories containing trimethoprim/sulfamethoxazole and a phospholipid. And the patent contained the following:

Antimicrobial pharmaceutical or veterinary compositions suitable for colonic administration comprise sulfamethoxazole-trimethoprim (I-II mixture) [8064-90-2] or their salts as the active ingredients and a phospholipid (0.5-5% by weight) for the purpose of preventing the solidification at the step of mixing I and II with a base material(s) and for solving simultaneously the delay of disintegration. Thus, a suppository containing I 20, II 4, phospholipid (soya lecithin) 2, and Witepsol 74 parts disintegrated after storage at cold and room temperature for 3 mo in 9 and 13 min, resp., compared to 35 min and not even after 60 min, resp., for controls. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Recommanded Product: 23256-42-0

The Article related to antimicrobial sulfamethoxazole trimethoprim phospholipid, veterinary sulfamethoxazole trimethoprim phospholipid, lecithin sulfamethoxazole trimethoprim suppository, Pharmaceuticals: Formulation and Compounding and other aspects.Recommanded Product: 23256-42-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On August 11, 1977, Casals, Jose Bou published a patent.Category: pyrimidines The title of the patent was Stable injection potentiated sulfonamide preparations. And the patent contained the following:

Stable injectable potentiated sulfonamide preparations comprise a sulfonamide diethanolamine salt, a sulfonamide potentiator salt, and a solvent mixture of 10-50 parts H2O, 15-30 parts propylene glycol [57-55-6], and 20-40 parts N-methylpyrrolidone [872-50-4]. The solutions have pH 5.5-7.5. For example, 30 mL N-methylpyrrolidone was added to a solution of diaveridin lactate [64191-45-3] (from 4 g diaveridin and 5 g lactic acid) in 10 mL H2O. This solution was added to a solution of sulfafurazole diethanolamine salt (I) [4299-60-9] (from 20 g sulfafurazole) in 20 mL H2O and 20 mL propylene glycol, and the pH was adjusted to 6.7-7.0. Phenylcarbazole (1 mL) was added, and the solution was diluted to 100 mL with propylene glycol, filter-sterilized, and placed in ampuls. The high H2O content decreased the tissue damage at the injection site after i.m. administration. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Category: pyrimidines

The Article related to sulfonamide potentiated injection, sulfafurazole potentiated injection, diaveridin sulfafurazole injection, trimethoprim sulfafurazole injection, Pharmaceuticals: Formulation and Compounding and other aspects.Category: pyrimidines

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On July 1, 2009, Wu, Hongyun; Li, Jianzheng; Wang, Xiuhua published a patent.Application In Synthesis of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate The title of the patent was Veterinary composition containing chinese medicines and ceftiofur for treating avian bacterial and/or viral diseases. And the patent contained the following:

The title veterinary drug contains honeysuckle 300-400, Scutellaria baicalensis 300-400, Forsythia suspensa 700-800, ceftiofur 0.5-1.5, synergists 0.5-1, antibacterial factor 20-30, and lytic factor 5-15 weight part. The synergists contain trimethoprim lactate and sulbactam sodium at ratio of 1: (0.5-1). The antibacterial factor is Pirarubicin hydrochloride. The lytic factor is mixture of N-Me pyrrolidone, propanediol, and water for injection at weight ratio of 1:1:1. The preparation method comprises of (1) decocting Scutellaria baicalensis with water three times, combining decoction liquid, filtering, concentrating filtrate, adjusting pH to 1.0-2.0 with 2 mol/L HCl at 75-80°, keeping temperature for 30 min, standing for 10-13 h, filtering, stirring sediment with 6-8 fold water, adjusting pH to 7.0 with NaOH, adding ethanol, dissolving by stirring, filtering, adjusting filtrate pH to 1.5-2 with HCl, keeping at 55-65° for 30 min, standing for 10-13 h, filtering, washing sediment with ethanol, adjusting pH to 7.0, reclaiming ethanol; processing honeysuckle and Forsythia suspensa with same methods, mixing with above Scutellaria baicalensis extract, adding water, adjusting pH to 7.0 with NaOH, stirring, preserving at 4-8° for 72 h, filtering, and adjusting filtrate pH to 7.0 to obtain solution A for further use. The preparation method also comprises (2) mixing antibacterial factor with solution A under stirring at 500 r/min, filling, sterilizing at 100° for 30 min; (3) dissolving synergists with lytic factor, filling, sterilizing at 100° for 30 min; (4) adding ceftiofur, and split charging to obtain. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Application In Synthesis of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate

The Article related to chinese medicine veterinary drug avian lonicera scutellaria forsythia, antiviral agent antibiotic ceftiofur pirarubicin, Pharmaceuticals: Formulation and Compounding and other aspects.Application In Synthesis of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On February 21, 2007, Yang, Jianbin published a patent.Quality Control of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate The title of the patent was Antibacterial compositions containing combination of florfenicol and tiamulin and doxycycline hydrochloride and trimethoprim lactate for treating mycoplasma and other bacterial infections in chicken and pig. And the patent contained the following:

The title drug is composed of (by weight parts) florfenicol 5-15, tiamulin fumarate 5-15, doxycycline hydrochloride 5-15, trimethoprim lactate 5-10 and excipient. The drug is used for treating mixed mycoplasma and other bacteria infection of chicken and pig. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Quality Control of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate

The Article related to combination chemotherapy antibacterial chicken pig, florfenicol tiamulin doxycycline hydrochloride trimethoprim lactate, Pharmaceuticals: Formulation and Compounding and other aspects.Quality Control of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On July 10, 1975, Holstius, Elvin A.; Alvan, George E. published a patent.Application of 23256-42-0 The title of the patent was Antibacterial, pharmaceutical ear and eye formulations. And the patent contained the following:

An aqueous solution or an ointment, containing sulfacetamide (I) [144-80-9] 0.1-0.5 trimethoprim hemisulfate (II) [56585-33-2] 0.1-0.5, and polymyxin 0.05-0.15 weight/volume %, was stable and possessed a wide spectrum of antibacterial activity. In an example, 100 ml aqueous solution contained 0.50 I, II corresponding to 0.10 g trimethoprim free base, 0.15 polymyxin B sulfate [1405-20-5] 0.001 thiomersal, and 0.83 g NaCl. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Application of 23256-42-0

The Article related to bactericide ear eye, sulfacetamide bactericide ear eye, trimethoprim bactericide ear eye, polymixin bactericide ear eye, Pharmaceuticals: Formulation and Compounding and other aspects.Application of 23256-42-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On March 27, 2020, Shi, Jinping; Wang, Jiaqin published a patent.Product Details of 23256-42-0 The title of the patent was A method for preparing doxycycline soluble powder for veterinary medicine. And the patent contained the following:

This article discloses about a method for preparing doxycycline soluble powder for veterinary medicine. The veterinary doxycycline soluble powder medicine is composed of doxycycline, trimethoprim lactate and anhydrous glucose. In the present invention, doxycycline, trimethoprim lactate and anhydrous glucose are resp. crushed and sieved; the sieved doxycycline and trimethoprim lactate are weighed and added to the weight of the two components. Premix with the same amount of anhydrous glucose according to the dispersion method, then add the remaining amount of anhydrous glucose to fully mix, after mixing, crush and sieve again to obtain the finished product. The veterinary doxycycline soluble powder has good drug effect, quick effect, convenient use, simple and easy preparation method, low cost, convenient large-scale industrial production, and promotion and application. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Product Details of 23256-42-0

The Article related to doxycycline trimethoprim lactate glucose solubility pharmaceutical powder veterinary medicine, Pharmaceuticals: Formulation and Compounding and other aspects.Product Details of 23256-42-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On January 1, 2014, Shao, Pu; Han, Xudong; Wang, Hongwei; Wu, Liming published a patent.Synthetic Route of 23256-42-0 The title of the patent was Veterinary compound norfloxacin nicotinate soluble powder and its preparation method. And the patent contained the following:

The invention discloses a veterinary compound norfloxacin nicotinate soluble powder and its preparation method. The powder, per 100 g, is composed of norfloxacin nicotinate 5-10 g, apramycin sulfate 5-10 g, trimethoprim lactate 2-4 g, and anhydrous glucose in balance. The product can quickly kill intestinal pathogenic microorganisms, so as to effectively control the intestinal bacterial disease in fowls and livestocks and alleviate the problem of bacterial resistance. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Synthetic Route of 23256-42-0

The Article related to norfloxacin apramycin trimethoprim powder intestinal bacterial infection diarrhea veterinary, Pharmaceuticals: Formulation and Compounding and other aspects.Synthetic Route of 23256-42-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia