Application of 17758-52-0 ,Some common heterocyclic compound, 17758-52-0, molecular formula is C5H6N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
A mixture of 5-methyl-3/-/-pyrimidin-4-one (0.60 g, 3.6 mmol) and phosphorous oxychloride (2.0 ml.) was heated at 90 0C for 2.5 h. The mixture was evaporated to dryness under reduced pressure and the resultant solid was purified by sublimation under reduced pressure to furnish the title compound as a white solid. This compound was unstable to air and was used immediately in the next step.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,17758-52-0, its application will become more common.
Reference:
Patent; CANCER RESEARCH TECHNOLOGY LIMITED; McDONALD, Edward; BLAGG, Julian; PICHOWICZ, Mark; CRUMPLER, Simon Ross; WO2010/41054; (2010); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia