17326-27-1 | Pyrimidines

Simple exploration of 17326-27-1

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 17326-27-1, 2-Chloro-9-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carbaldehyde, other downstream synthetic routes, hurry up and to see.

Reference of 17326-27-1, Adding some certain compound to certain chemical reactions, such as: 17326-27-1, name is 2-Chloro-9-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carbaldehyde,molecular formula is C10H7ClN2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 17326-27-1.

To a stirred solution of G2 (1.0 mmol) in THF (2.0 mL) was added Et3N (2.0 mmol). The mixture was cooled to 0C. After 5 min, an amine (1.0 mmol) was added dropwise and the mixture was stirred at room temperature overnight. The reaction mixture was diluted with CH2C12 (10 mL) and washed with brine (10 mL). The organic layer was dried over anhydrous MgS04 and concentrated in vacuo. The crude product was purified by flash column chromatography to give G3.; 9-Methyl-4-oxo-2-(phenylamino)-4H-pyrido[l ,2-a1pyrimidine-3-carbaldehyde (132)NMR (400 MHz, CDC13) delta 2.44 (s, 3H), 6.89 (t, J- 6.8 Hz, 1H), 7.11 (t, J= 7.2 Hz, 1H), 7.34 (t, J= 7.6 Hz, 2H), 7.62 (d, J= 6.4 Hz, 1H), 7.76 (d, J= 8.0 Hz, 2H), 8.80 (d, J= 6.8 Hz, 1H), 10.27 (s, 1H), 1 1.67 (brs, 1H); 13C NMR (100 MHz, CDC13) delta 18.1 , 94.6, 1 13.6, 121.8, 124.2, 125.9, 128.7, 133.6, 138.1, 138.9, 152.5, 153.8, 160.2, 190.2.

Reference:
Patent; INSTITUT PASTEUR KOREA; INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (EPST); NO, Zaesung; KIM, Jaeseung; BRODIN, Priscille; SEO, Min Jung; PARK, Eunjung; CECHETTO, Jonathan; JEON, Heekyoung; GENOVESIO, Auguste; LEE, Saeyeon; KANG, Sunhee; EWANN, Fanny, Anne; NAM, Ji, Youn; FENISTEIN, Denis, Philippe, Cedric; CHRISTOPHE, Thierry; CONTRERAS DOMINGUEZ, Monica; KIM, EunHye; HEO, Jamung; WO2011/85990; (2011); A1;,
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The important role of 17326-27-1

The synthetic route of 17326-27-1 has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 17326-27-1, name is 2-Chloro-9-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carbaldehyde, the common compound, a new synthetic route is introduced below. Recommanded Product: 17326-27-1

G2 (0.5 mmol) was dissolved in 10.4 mL of tert-butyl alcohol and 2.5 mL of 2-methyl-2- butene. A solution of sodium chlorite (4.59 mmol) and sodium dihydrogenphosphate (3.46 mmol) in 4.2 mL of water was added dropwise. The reaction mixture was stirred at room temperature overnight. Volatile components were then removed under vacuum, and the residue was dissolved in 10 ml of water and extracted with two 10 ml portions of hexane. The aqueous layer was acidified to pH=3 with HCl(aq) and extracted with 10 mL portions of methylene chloride. The combined organic layers were washed with 20 mL of cold water, dried and concentrated to give G4.; 2-Chloro-9-methyl-4-oxo-4H-pyrido Gamma 1.2-a1pyrimidine-3 -carboxylic acid ( 144) NMR (400 MHz, OMSO-d6) delta 2.58 (s, 3H), 7.53 (t, J = 7.0 Hz, 1H), 8.14 (d, J = 7.2 Hz, 1H), 8.97 (d. J= 6.8 Hz, 1H), 13.53 (brs, 1H); 13C NMR (100 MHz, DMSO-i/6) delta 16.7, 108.1, 1 17.1, 125.6, 133.3, 138.7, 148.2, 152.0, 154.6, 163.9.

The synthetic route of 17326-27-1 has been constantly updated, and we look forward to future research findings.

Sources of common compounds: 2-Chloro-9-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carbaldehyde

With the rapid development of chemical substances, we look forward to future research findings about 17326-27-1.

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 17326-27-1, name is 2-Chloro-9-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carbaldehyde, molecular formula is C10H7ClN2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. COA of Formula: C10H7ClN2O2

G2 (0.5 mmol) was dissolved in 10.4 mL of tert-butyl alcohol and 2.5 mL of 2-methyl-2-butene. A solution of sodium chlorite (4.59 mmol) and sodium dihydrogenphosphate (3.46 mmol) in 4.2 mL of water was added dropwise. The reaction mixture was stirred at room temperature overnight. Volatile components were then removed under vacuum, and the residue was dissolved in 10 ml of water and extracted with two 10 ml portions of hexane. The aqueous layer was acidified to pH=3 with HCl(aq) and extracted with 10 mL portions of methylene chloride. The combined organic layers were washed with 20 mL of cold water, dried and concentrated to give G4. 1H NMR (400 MHz, DMSO-d6) delta 2.58 (s, 3H), 7.53 (t, J=7.0 Hz, 1H), 8.14 (d, J=7.2 Hz, 1H), 8.97 (d. J=6.8 Hz, 1H), 13.53 (brs, 1H); 13C NMR (100 MHz, DMSO-d6) delta 16.7, 108.1, 117.1, 125.6, 133.3, 138.7, 148.2, 152.0, 154.6, 163.9.

With the rapid development of chemical substances, we look forward to future research findings about 17326-27-1.

Reference:
Patent; Brodin, Priscille; Christophe, Thierry; No, Zaesung; Kim, Jaeseung; Genovesio, Auguste; Fenistein, Denis Philippe Cedric; Jeon, Heekyoung; Ewann, Fanny Anne; Kang, Sunhee; Lee, Saeyeon; Seo, Min Jung; Park, Eunjung; Contreras Dominguez, Monica; Nam, Ji Youn; Kim, Eun Hye; US2011/178077; (2011); A1;,
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Extracurricular laboratory: Synthetic route of 17326-27-1

Electric Literature of 17326-27-1, Adding some certain compound to certain chemical reactions, such as: 17326-27-1, name is 2-Chloro-9-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carbaldehyde,molecular formula is C10H7ClN2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 17326-27-1.

General procedure: To a stirred solution of 2-chloro-4-oxo-4H-pyrido [1,2-a]pyrimidine-3-carbaldehyde (100mg, 0.479mmol) in THF (3mL) was added benzylamine (0.058mL, 0.527mmol) and TEA (0.1mL, 0.719mmol). The reaction mixture was stirred at 70C for 3h. after the mixture was concentrated, 1N aqueous HCl solution in THF (1/3 ratio, 4mL). The reaction mixture was stirred at 70C for 1h. after reaction was completed, the mixture was evaporated and neutralized to approximately pH 7 by adding 1N NaOH. The pale solid was collected by filtration and washed with H2O to give 5a (117mg, 87%) as a brown solid.

Reference:
Article; Park, Dong-Sik; Jo, Eunji; Choi, Jihyun; Lee, MyungEun; Kim, Soohyun; Kim, Hee-Young; Nam, Jiyon; Ahn, Sujin; Hwang, Jong Yeon; Windisch, Marc Peter; European Journal of Medicinal Chemistry; vol. 140; (2017); p. 65 – 73;,
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Introduction of a new synthetic route about 2-Chloro-9-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carbaldehyde

The synthetic route of 17326-27-1 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 17326-27-1, 2-Chloro-9-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carbaldehyde, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C10H7ClN2O2, blongs to pyrimidines compound. Formula: C10H7ClN2O2

To a stirred solution of G2 (1.0 mmol) in THF (2.0 mL) was added Et3N (2.0 mmol). The mixture was cooled to 0 C. After 5 min, an amine (1.0 mmol) was added dropwise and the mixture was stirred at room temperature overnight. The reaction mixture was diluted with CH2Cl2 (10 mL) and washed with brine (10 mL). The organic layer was dried over anhydrous MgSO4 and concentrated in vacuo. The crude product was purified by flash column chromatography to give G3. 1H NMR (400 MHz, CDCl3) delta 2.44 (s, 3H), 6.89 (t, J=6.8 Hz, 1H), 7.11 (t, J=7.2 Hz, 1H), 7.34 (t, J=7.6 Hz, 2H), 7.62 (d, J=6.4 Hz, 1H), 7.76 (d, J=8.0 Hz, 2H), 8.80 (d, J=6.8 Hz, 1H), 10.27 (s, 1H), 11.67 (brs, 1H); 13C NMR (100 MHz, CDCl3) delta 18.1, 94.6, 113.6, 121.8, 124.2, 125.9, 128.7, 133.6, 138.1, 138.9, 152.5, 153.8, 160.2, 190.2.

The synthetic route of 17326-27-1 has been constantly updated, and we look forward to future research findings.

New learning discoveries about 17326-27-1

The synthetic route of 17326-27-1 has been constantly updated, and we look forward to future research findings.

Application of 17326-27-1 , The common heterocyclic compound, 17326-27-1, name is 2-Chloro-9-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carbaldehyde, molecular formula is C10H7ClN2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

222.6mg (1mmol) 2- chloro-3-aldehyde-4-carbonyl methylpyridine -4H-9- [1,2-alpha] pyrimidine 5mL of absolute ethanol was added a solution of 484.7mg (4mmol ) phenethylamine, rt 12h, after the reaction was filtered, the solid washed thoroughly with ethanol to give a pale yellow solid 320.2mg, 78% yield.

The synthetic route of 17326-27-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Chinese Academy Of Sciences Shanghai Pharmaceutical Institute; Chinese Academy Of Sciences Beijing Genome Institute; Yang Caiguang; Liu Jiang; Luo Cheng; Guo Zhongqiang; Gong Shouzhe; Li Jiafei; Zheng Tong; Jiang Hualiang; (46 pag.)CN107141287; (2017); A;,
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