Reference of 155690-79-2, Adding some certain compound to certain chemical reactions, such as: 155690-79-2, name is 6-Bromopyrido[2,3-d]pyrimidin-4(1H)-one,molecular formula is C7H4BrN3O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 155690-79-2.
6-Bromopyrido[2,3-d]pyrimidin-4(3H)-one (3.Og) and POC13 (15 mL)were heated at 130 C under nitrogen for 3h. The homogeneous dark solution was concentrated under reduced pressure and diluted with EtOAc (150 mL). The heterogeneous brown slurry was poured onto mixture of ice/aq. NaHCO3 and allowed the mixture warm to room temperature. The heterogeneous brown mixture was further diluted with EtOAc (75 mL) and separated the organic layer. The organic layer was partitioned with aq. NaC1, separated, stirred with MgSO4 and filtered through a pad of Celite and silica gel. The pale yellow filtrate was concentrated and the crude solid was stirred in 50% EA/hexanes. 6-Bromo-4-chloropyrido[2,3-d]pyrimidine was obtained as a pale yellow crystalline solid (1.8 g, purity: 95%) upon filtration.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 155690-79-2, 6-Bromopyrido[2,3-d]pyrimidin-4(1H)-one, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; RIGEL PHARMACEUTICALS, INC.; SINGH, Rajinder; BHAMIDIPATI, Somasekhar; DING, Pingyu; PAYAN, Donald; GELMAN, Marina; KINSELLA, Todd; WO2015/157093; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia