Category: 148-51-6

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 148-51-6, is researched, Molecular C8H12ClNO2, about Preconvulsive changes in brain glucose metabolism following drugs inhibiting glutamate decarboxylase, the main research direction is convulsant brain glucose glycogen; allylglycine brain glucose glycogen; deoxypyridoxine brain glucose glycogen; methionine sulfoximine brain glucose; isoniazid brain glucose glycogen; temperature brain glucose convulsant.Application In Synthesis of 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride.

DL-C-allylglycine (I) [7685-44-1], 4-deoxypyridoxine-HCl (II) [148-51-6], and DL-methionine-D-sulfoximine (III) (180, 250, and 300 mg/kg resp., i.p.) each induced preconvulsive increases in the brain glucose [50-99-7] concentration of mice at room temperature; II and III also increased brain glycogen [9005-79-2] concentrations in room-temperature mice, but only II did so in mice maintained at 33-4°. Only with I was the increase in brain glucose concentration associated with an increase in blood glucose concentration I, II, III, or isoniazid [54-85-3] (150 mg/kg) reduced rectal temperature in mice at room temperature but not those at 33-4°. Isoniazid reduced brain glucose and glycogen concentrations in mice at 33-4°, but did not affect mice at room temperature The relation between the effects of these drugs on brain carbohydrates and amino acid metabolism is discussed.

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Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《A novel BMSN (biologically synthesized mesoporous silica nanoparticles) material: synthesis using a bacteria-mediated biosurfactant and characterization》. Authors are Sharma, Raju Kumar; Wang, Shau-Chun; Maity, Jyoti Prakash; Banerjee, Pritam; Dey, Gobinda; Huang, Yi-Hsun; Bundschuh, Jochen; Hsiao, Ping-Gune; Chen, Tsung-Hsien; Chen, Chien-Yen.The article about the compound:5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloridecas:148-51-6,SMILESS:OC1=C(C)C(CO)=CN=C1C.[H]Cl).Application In Synthesis of 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride. Through the article, more information about this compound (cas:148-51-6) is conveyed.

Mesoporous materials (MMs) have recently been applied as advanced nanomaterials in different fields (separation, catalysis, adsorption etc.). Synthesis of MMs by chem. surfactants is not ecofriendly. This study focused on the biol. synthesis of a MM by sol-gel method, using a Bacillus subtilis BBK006-mediated surfactant (template) and a precursor (TEOS). The biol. synthesized mesoporous silica nanoparticles (BMSN) were formed at calcination temperatures of 450-600 °C. The BMSN comprise Si and O elements with sp. weights of 56.09% and 42.13% resp., where the at.% was detected to be 41.79% and 55.10%, resp. The phase identity of the synthesized particles (61-300 nm uniform spherical shape; surface area: 8.2616 m2 g-1; pore diameter at 550 °C: 14.8516 nm) was confirmed with wide-angle XRD (10°-81°). A typical type IV isotherm was exhibited (BET curves) following IUPAC nomenclature and confirmed the mesoporous nature. The green-synthesized biosurfactant-mediated BMSN is an environmentally promising material to apply in biomedical science (e.g., antimicrobial activity, drug delivery, CMC, anticancer activity) and oil spill management.

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Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Pyridoxine chemistry. IV. Proton magnetic resonance spectra of compounds in the vitamin B6 group》. Authors are Korytnyk, W.; Singh, R. P..The article about the compound:5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloridecas:148-51-6,SMILESS:OC1=C(C)C(CO)=CN=C1C.[H]Cl).Application of 148-51-6. Through the article, more information about this compound (cas:148-51-6) is conveyed.

cf. CA 58, 5622h. The proton magnetic resonance (p.m.r.) spectra of compounds in the vitamin B6 group have been determined in D2O solution, and the proton peaks have been assigned on the basis of comparison with several analogs of pyridoxol (I). Considerable changes in p.m.r. spectra have been observed in acid, neutral, and alk. solutions and have been rationalized on the basis of the electronic properties of the various ionic forms. A facile base-catalyzed deuterium exchange has been observed in I derivatives in which the heterocyclic N is quaternized. The nature of the aldehyde group in pyridoxal and in pyridoxal phosphate has been elucidated.

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Pyrimidine | C4H4N2 – PubChem,
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Quality Control of 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride, is researched, Molecular C8H12ClNO2, CAS is 148-51-6, about Influence of some vitamin B6 antimetabolites on the induction and development of solid IRE reticulosarcoma in rats. I. Deoxypyridoxine. Author is La Pesa, M.; Grimaldi, T.; Curci, E.; Semeraro, N..

Control and exptl. rats were inoculated s.c. in the dorsal region with solid reticulosarcoma IRE. Starting on the 2nd day, each exptl. rat received i.m. 0.35 mg/day of 4-deoxypyridoxine-HCl until death (14-32 days later). The values for latent period, survival, and daily body weight were similar for both groups.

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Pyrimidine | C4H4N2 – PubChem,
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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Synthesis of 2-ethylthioisonicotinamide, published in 1965, which mentions a compound: 148-51-6, mainly applied to , SDS of cas: 148-51-6.

2-Ethylisonicotinaldehyde diethylacetal (I), b14 125-8°, was prepared in 61% yield from EtBr 112.2, Mg 33, 2-ethyl-4-bromopyridine 62, tri-Et orthoformate 180, and NH4Cl 215 g. Hydrolysis of 15.3 g. I with 150 ml. 10% HCl gave 83% free aldehyde (II), b20 92-5°; hydrazone m. 46-8°; thiosemicarbazone m. 215-16°. Willgerodt reaction of 0.75 g. II with 0.16 g. S in 30 ml. pyridine and 20 ml. NH3 yielded 56.5% of 2-ethylthioisonicotinoylamide.

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Pyrimidine | C4H4N2 – PubChem,
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Yamashita, Junko; Hirata, Yukio published the article 《Running fits and γ-aminobutyric acid of the superior colliculus of the mouse》. Keywords: GABA brain running fit; convulsion GABA brain; vitamin B6 antagonist GABA.They researched the compound: 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride( cas:148-51-6 ).Computed Properties of C8H12ClNO2. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:148-51-6) here.

The γ-aminobutyric acid content of the superior colliculus of the mouse brain was decreased following the induction of running fits by the intracollicular injection of the antivitamin B6 compound semicarbazide. Aminooxyacetic acid hemihydrochloride, an inhibitor of 4-aminobutyrate-2-oxoglutarate aminotransferase (EC 2.6.1.19) with a resultant increase in GABA levels, has been shown to exert an antidotal effect on the induction of running fits. Therefore, this type of convulsive behavior is apparently associated with diminished levels of GABA in the superior colliculus. Running fits were also induced by the antivitamin B6 compounds thiosemicarbazide and 4-deoxypyridoxine-HCl, and presumedly this was also the result of a decrease in GABA level.

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Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Synthesis of 2-ethylthioisonicotinamide》. Authors are Gustak, E.; Koruncev, D.; Gluncic, B..The article about the compound:5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloridecas:148-51-6,SMILESS:OC1=C(C)C(CO)=CN=C1C.[H]Cl).Recommanded Product: 148-51-6. Through the article, more information about this compound (cas:148-51-6) is conveyed.

2-Ethylisonicotinaldehyde diethylacetal (I), b14 125-8°, was prepared in 61% yield from EtBr 112.2, Mg 33, 2-ethyl-4-bromopyridine 62, tri-Et orthoformate 180, and NH4Cl 215 g. Hydrolysis of 15.3 g. I with 150 ml. 10% HCl gave 83% free aldehyde (II), b20 92-5°; hydrazone m. 46-8°; thiosemicarbazone m. 215-16°. Willgerodt reaction of 0.75 g. II with 0.16 g. S in 30 ml. pyridine and 20 ml. NH3 yielded 56.5% of 2-ethylthioisonicotinoylamide.

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Pyrimidine | C4H4N2 – PubChem,
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Gao, Zengrong published the article 《Separation and identification of water-soluble vitamins and vitamin B6 analogs》. Keywords: vitamin identification chromatog spectrometry TLC; liquid chromatog vitamin identification; IR spectrometry vitamin identification; UV spectrometry vitamin identification.They researched the compound: 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride( cas:148-51-6 ).SDS of cas: 148-51-6. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:148-51-6) here.

Vitamin B12  [68-19-9], vitamin B1  [59-43-8], folic acid  [59-30-3], calcium pantothenate  [137-08-6], rutin  [153-18-4], vitamin C  [50-81-7], vitamin B2  [83-88-5], nicotinamide  [98-92-0], nicotinic acid  [59-67-6], p-aminobenzoic acid  [150-13-0], pyridoxal 5-phosphate  [54-47-7], pyridoxol-HCl  [58-56-0], pyridoxamine-2HCl  [524-36-7], pyridoxal-HCl  [65-22-5], and 4-deoxypyridoxol-HCl  [148-51-6] were identified by TLC (using various solvent systems), high-performance liquid chromatog., IR and UV spectrophotometry. Characteristics (Rf values, retention times, absorbances) of these compounds are tabulated.

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Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Preparation of 5-hydroxy-4,6-dimethyl-3-pyridinemethanol (4-deoxypyridoxine) by the use of hydrazine》. Authors are Taborsky, Robert G..The article about the compound:5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloridecas:148-51-6,SMILESS:OC1=C(C)C(CO)=CN=C1C.[H]Cl).Reference of 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride. Through the article, more information about this compound (cas:148-51-6) is conveyed.

2-Methyl-3-hydroxy-4-methoxymethyl-5-hydroxymethylpyridine-HCl (10 g.) and 50 ml. 95% N2H4 refluxed 18 hrs., most of the N2H4 removed in vacuo, and the residue extracted with 60 ml. refluxing MeOH yielded N2H4.HCl, m. 91-2°. The volume of the filtrate reduced to 20 ml., 15 ml. 11.2% MeOH-HCl added, the precipitate isolated, and 50 ml. Et2O added gave a further precipitate The total yield was 8.1 g. 2-methyl-3-hydroxy-4-methyl-5-hydroxymethylpyridine-HCl (I), m. 273° (decomposition). All conditions and isolation procedures were as above except that instead of the 4-Me ether, 5 g. pyridoxine-HCl and 25 ml. 95% N2H4 were used to give 98% I.

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Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Biological comparison of synthetic and natural adermin》. Authors are Moller, E. F.; Zima, O.; Jung, F.; Moll, Th..The article about the compound:5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloridecas:148-51-6,SMILESS:OC1=C(C)C(CO)=CN=C1C.[H]Cl).Reference of 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride. Through the article, more information about this compound (cas:148-51-6) is conveyed.

Synthetic adermin was assayed by its influence on growth and acid formation by Streptobact. plantarum (C. A. 32, 9165.1); curves of growth (turbidity) and acidity vs. time are given. The synthetic preparation is slightly more active than the vitamin preparation made from rice hulls. A growth effect upon Streptobact. plantarum is likewise exhibited by 2,4-dimethyl-3-hydroxy-5-(hydroxymethyl)pyridine (hydrochloride m. 254°) although in 50-fold dose the result was only 30-40% of that of the B6 hydrochloride. The 4-desoxyadermin in single doses of 1000 γ is inactive on dermatitic rats.

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Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia