Category: 148-51-6

Sanders, L. B.; Cetorelli, J. J.; Winefordner, James D. published an article about the compound: 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride( cas:148-51-6,SMILESS:OC1=C(C)C(CO)=CN=C1C.[H]Cl ).Recommanded Product: 148-51-6. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:148-51-6) through the article.

Phosphorescence excitation and emission wavelength peaks, lifetimes, limits of detection, and concentration ranges of anal. usefulness of 37 antimetabolites in rigid (77°K.) ethanolic solution were determined Seventeen of the metabolites produced anal. useful phosphorescence, whereas the remaining 20 were of limited or no anal. use.

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Biological radiation protection. LIX. The meaning of radiation-caused changes in the content of metabolites to the survival rate of mice, published in 1964, which mentions a compound: 148-51-6, Name is 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride, Molecular C8H12ClNO2, Electric Literature of C8H12ClNO2.

After radiation, changes occur in albumin metabolism, especially in the case of tryptophan and cysteine. The changes reflect a curbing of the activity of amino acid decarboxylase with pyridoxal 5-phosphate as coenzyme. The following compounds increased the mortality rate when given with an x-ray dose of 505 r. (L.D.16/30): 4-deoxypyridoxine-HCl, isonicotinic acid hydrazide,DL-tryptophan, DL-kynurenine, and L-kynurenine. Taurine, given with 590 r. (L.D.64/30), increased the survival rate.

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Name: 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride, is researched, Molecular C8H12ClNO2, CAS is 148-51-6, about The structure of a sulfur-containing compound with vitamin B6 activity.

Pyridoxal-HCl (0.001 mole) was added to a warm solution of 0.001 mole 2,4-dinitrophenylhydrazine in 40 ml. of 95% EtOH, the mixture gently heated 5 min., after cooling the orange-yellow crystals collected and suspended 3 times in water with stirring (30 min.) (the crystal color changed to red), filtered off, dried, and recrystallized from iso-BuOH to give yellow crystals of 2,4-dinitrophenylhydrazone, m. 256-7°. To 500 mg. diacetate of bis-4-pyridoxyl disulfide (IV) (500 mg.) in 5 ml. 0.1N HCl was added acetone to a slight turbidity. After standing in the cold, 360 mg. crystals of di-HCl salt separated, m. 222°. IV.2HCl (441 mg.) dissolved in 220 ml. H2O, neutralized with 168 mg. NaHCO3, shaken with 2.0 g. Raney Ni catalyst and 3 atm. H 4 hrs. at 25°, the catalyst removed, the combined filtrates concentrated in vacuo in 10 ml., solid NaHCO3 added to pH 8.6, the solution extracted with CHCl3 30 hrs., the extract concentrated to a sirup which was dissolved in EtOH, and alc. HCl added yielded 250 mg. crystals, m. 264-5°. IV.2HCl (500 mg.), 600 mg. Sn foil, and 6 ml. 4N HCl was shaken 20 hrs. at room temperature; after diluting with H2O the Sn removed as sulfide by filtration, the filtrate dried in vacuo, and recrystallized from EtOH gave 250-300 mg. 4-pyridoxyl mercaptan (VI). VI (100 mg. in 25 ml. H2O) was adjusted to pH 8.5 with 2N NH4OH and air passed through the solution until the nitroprusside test was neg. Oxidation was accompanied by the precipitation of the free base of IV in 66% yield, m. 222°. A mixed sample of SB8.2HCl (Berhart, et al., CA 54, 19993c) and IV.2HCl did not depress the m.p. The identity of both compounds was proved by paper chromatography.

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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Postgraduate Medical Journal, Supplement called Antiviral effect of D-penicillamine, Author is Jaffe, Israeli A.; Merryman, Parvin; Ehrenfeld, Ellie, which mentions a compound: 148-51-6, SMILESS is OC1=C(C)C(CO)=CN=C1C.[H]Cl, Molecular C8H12ClNO2, HPLC of Formula: 148-51-6.

Of a series of mercaptan compounds tested, only D-penicillamine [52-67-5] possessed antiviral activity against polio virus in tissue culture. D-penicillamine produced a marked inhibition in viral directed RNA and protein synthesis, which was not dependent upon vitamin B6 antagonism. The effect was completely reversible.

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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Synthesis of 2,4-dimethyl-3-hydroxy-5-hydroxymethylpyridine, published in 1966, which mentions a compound: 148-51-6, mainly applied to , SDS of cas: 148-51-6.

2,4-Dimethyl- 3 – hydroxy-5- hydroxymethylpyridine (4- deoxypyridoxine) (I) was synthesized via the following intermediates: 2,4-dimethyl-5-cyano-6-pyridone (II), 2,4-dimethyl-3-nitro-5-cyano-6-pyridone (III), and 2,4-dimethyl-3-nitro-5-cyano-6-chloropyridine (IV). Reduction of IV was carried out in 1 step in dilute HCl over Pd-C. 2,4-Dimethyl-3-amino-5-aminomethylpyridine was converted without isolation to I by treatment with NaNO2. Thus, 33 ml. NH4OH (d20 0.9) was added with stirring to 40 g. EtO2CCH2CN, the mixture cooled with ice to 0-2° and the precipitate filtered off, washed at 0° with 20 ml. cold EtOH, and dried to yield 23.8 g. cyanoacetamide (V), m. 120-2°. The filtrate was evaporated to dryness to yield an addnl. 3.95 g. Acetylacetone (10.0 g.) was added at 70° to 8.4 g. V in 50 ml. MeOH and 1.12 ml. Me2NH to precipitate 88.1% II, m. 293.1-4.2°. A suspension of 4.44 g. II in 15 ml. Ac2O is treated with stirring with 2.3 ml. HNO3 (d20 1.4) and 2.3 ml. Ac2O at 35-40°, and the mixture stirred 2 hrs. at 18-20° and poured upon 23 g. crushed ice, to precipitate 56.4% yellow III, m. 272.0-2.6° (alc.). P2O5 (5.3 g.) is added to a suspension of 3.6 g. III in 36 ml. PhCl, the mixture heated with stirring 3 hrs. at 118-120° the solvent removed at 45-50°/10 mm., the residue treated with 3.6 ml. absolute alc., stirred, and left 8 hrs. at 0-4°, the precipitate filtered off, washed at 0° with 2 ml. alc., and dried, and the residue extracted with petr. ether (b. 60-70°) to give 62.2% yellow IV, m. 114-15°. IV (2.4 g.) in 25 ml. ice water was added to a pre-hydrogenated mixture of 0.10 g. PdCl2 with H2O, HCl, and C, the hydrogenation continued until the theoretical H absorption, the catalyst separated and washed with 2 ml. H2O, 2.4 ml. HCl (d20 1.18) added to the solution and washings, and the solution heated 1.5 hrs. at 80-5° during which 1.6 g. NaNO2 in 5 ml. H2O was added, the heating continued 30 more min. (neg. starch-iodide test), the solution evaporated in vacuo, the residue extracted with absolute alc., the extracts treated with activated C and concentrated until the appearance of crystals, the mixture kept 8 hrs. at 0-4°, and the precipitate filtered off, washed at 0° with 1 ml. alc., and dried to give 42.2% I, m. 256.1-7.2°.

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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Effects of deoxpyridoxine on the formation and development of some experimental neoplasias. I. Ascites tumor in mice, published in 1971, which mentions a compound: 148-51-6, mainly applied to vitamin B6 antagonist tumor; cancer deoxypyridoxine; pyridoxine antagonist tumor, Name: 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride.

I.p. or i.m. injection of the antivitamin B6 compound 4-deoxypyridoxine-HCl (I) [148-51-6] (0.07 mg/day) did not alter either the percentage of tumor take or the survival time of mice inoculated previously or subsequently with Ehrlich ascites tumor. The mice were not kept on a vitamin B6-deficient diet.

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Pyrimidine | C4H4N2 – PubChem,
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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Synthesis of vitamin B6 derivatives. Catalytic reduction of hydroxymethyl group substituted in pyridine ring》. Authors are Naito, Takeo; Ueno, Katsujiro.The article about the compound:5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloridecas:148-51-6,SMILESS:OC1=C(C)C(CO)=CN=C1C.[H]Cl).Electric Literature of C8H12ClNO2. Through the article, more information about this compound (cas:148-51-6) is conveyed.

Catalytic reduction of 1.64 g. pyridoxine triacetate-HCl in 32 mL. H2O with 1 g. 10% Pd-C 1.5 h. at normal pressure of H absorbed 240 mL. H and gave 0.7 g. 3,4,6,5-Me3(OH)C5HN.HCl (I), m. 209-12°. Similarly, pyridoxine 4-Et ether HCl salt yielded 52% I, m. 210-12°. The above reaction with 1 mol absorption of H yielded 18% 4,6,3,5-Me2(HOCH2)(HO)C5HN.HCl (II), m. 250° (decomposition), and the mother liquor yielded 31% 3,6,4,5-Me2(EtOCH2)(HO)C5HN.HCl; picrate m. 138°. Catalytic reduction of 0.56 g. 6,3,4,5-Me(AcOCH2)(EtOCH2)(HO)C5HN.HCl in 20 mL. MeOH with 0.8 g. 10% Pd-C showed no absorption of H, the reduction proceeded well by addition of 20 mL. H2O and absorbed 54 mL. H in 2 h., and the product in 10% HCl heated 30 min. at 100° yielded 48.8% 3,6,4,5-Me2(EtOCH2)(HO)C5HN; picrate, m. 138°. Catalytic reduction of 3.76 g. pyridoxal oxime-HCl in 170 mL. H2O and 88 mL. 10% HCl with 4.8 g. 10% Pd-C absorbed 3050 mL. H in 20 h. and yielded 62% 3,6,4,5-Me2(HCl.H2NCH2)(HO)C5HN.HCl (III), m. 262-3° (decomposition); diacetate, C12H16O3N2, m. 176-7°; ditosylate-HCl, m. 194-5°. Catalytic reduction of 0.29 g. 6,3,4,5-Me(AcOCH2)(AcNHCH2)(AcO)C5HN in 8 mL. MeOH and 2.2 mL. 10% HCl-MeOH showed no absorption H but an addition of 10 mL. H2O absorbed 28 mL. H in 2 h. and yielded 100% diacetate of III, m. 174°. Similarly, 0.51 g. pyridoxal-HCl in 20 mL. H2O and 0.5 g. 10% Pd-C yielded 30% II, m. 246-8°. Catalytic reduction of 0.58 g. pyridoxal Et hemiacetal-HCl (IV) in 20 mL. EtOH and 0.5 g. 10% Pd-C (1 mol H absorbed) yielded 79% 6,5,3,4-Me(HO)(CH2OCH2)C5HN.HCl (V), m. 233-4°; picrate m. 186-7°. Similarly, 0.58 g. IV, 20 mL. H2O and 0.5 g. Pd-C yielded 40% II, m. 248-50°; 0.58 g. IV, 20 mL. HCl, 2.7 mL. 10% HCl and 0.5 g. Pd-C yielded 68% V, m. 225-30°. Catalytic reduction of 1.09 g. 2-HOCH2C5H4 N in 15 mL. MeOH and 51 mL. 5% HCl-MeOH with 1 g. Pd-C (260 mL. H absorbed in 2 h.) yielded 90% 2-MeC5H4N (VI); picrate m. 164-5°. Similarly, 1.23 g. 2-MeOCH2C5H4N in 15 mL. MeOH and 51 mL. 5% HCl-MeOH with 0.1 g. Pd-C (255 mL. H absorbed) yielded 91% 2-MeC5H4N; or, 2-AcOCH2C5H4N, in a similar way, yielded 88% 2-MeC5H4N. 2-HOCH2C5H4N.HCl (8 g.) added dropwise into 40 g. SOCl2 with cooling, refluxed 2 h., cooled, 100 mL. C6H6 added and the product filtered off gave 8.8 g. 2-ClCH2C5H4N (VII); picrate m. 146-7°. MeONa (2.72 g. Na and 55 mL. MeOH) treated dropwise with VII in 20 mL. MeOH, refluxed 1 h., the solvent removed and the residue extracted with Et2O gave 4.7 g. 2-MeOCH2C5H4N, b18 76-8°. Similarly are prepared (product, b.p./mm. and m.p. picrate given): 3-MeOCH2C5H4N, 92-4°/20, 117-18°; 4-MeOCH2C5H4N, 91-2°/19, 108-9°.

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The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride, is researched, Molecular C8H12ClNO2, CAS is 148-51-6, about Synthesis of aflatoxins by the non-growing mycelia of Aspergillus parasiticus and the effect of inhibitors, the main research direction is aflatoxin formation metabolic inhibitor; Aspergillus aflatoxin formation.Product Details of 148-51-6.

Aflatoxins were synthesized by nongrowing mycelia of A. parasiticus, the amount and type (B or G) being dependent on the buffer used in the suspension medium. Incorporation of acetate-14C into aflatoxin was decreased by compounds that inhibit ATP production or interfere with the utilization of certain amino acids. In contrast, the specific activities of aflatoxins were increased by compounds that diverted acetate from metabolic pathways other than those leading to aflatoxin formation.

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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Derivatives of pyridine and quinoline. LII. Synthesis of 2,4-dimethyl-3-hydroxy-5-(hydroxymethyl)pyridine (4-desoxyadermine)》. Authors are van Wagtendonk, H. M.; Wibaut, J. P..The article about the compound:5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloridecas:148-51-6,SMILESS:OC1=C(C)C(CO)=CN=C1C.[H]Cl).COA of Formula: C8H12ClNO2. Through the article, more information about this compound (cas:148-51-6) is conveyed.

cf. C. A. 35, 5112.3. NCCH2CONH2 and CH2Ac2 with piperidine in EtOH at 80° give 87% of 4,6-dimethyl-3-cyano-2-pyridone (I), m. 293° (corrected); with HNO3 (d. 1.52) in Ac2O at 5°, I gives a crude yield of 40-6% of the 5-NO2 derivative which with PCl5 in PhCl gives 24-8% of 2,4-dimethyl-3-nitro-5-cyano-6-chloropyridine (II), yellow, m. 114-15°. Catalytic reduction of II with Pd-C in 96% EtOH gives 81.4% of 2,4-dimethyl-3-amino-5-cyano-6-chloropyridine, m. 149-9.2° (corrected); further reduction with Pd-C catalyst in AcOH-AcONa at room temperature gives 2,4-dimethyl-3-amino-5-(aminomethyl)pyridine, characterized as the dipicrate, m. 244° (decomposition), and the di-HCl salt (III), with 1 mol. H2O, does not m. 300°. Reaction of III in 2 N H2SO4 with NaNO2 at 80° gives 2,4-dimethyl-3-hydroxy-5-(hydroxymethyl)pyridine (4-desoxyadermine), isolated as the HCl salt, m. 257°.

Here is just a brief introduction to this compound(148-51-6)COA of Formula: C8H12ClNO2, more information about the compound(5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride) is in the article, you can click the link below.

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Anticoccidal agents. IV. Modification at the 5-position of 4-deoxypyridoxol and α4-norpyridoxol, published in 1975, which mentions a compound: 148-51-6, Name is 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride, Molecular C8H12ClNO2, Electric Literature of C8H12ClNO2.

In an attempt to relate structure to anticoccidial activity, a number of 5-modified analogs of 4-deoxypyridoxol (I) and α4-norpyridoxol (II) have been synthesized and their biol. activities examined The compounds prepared include the 5-(3-hydroxypropyl), 5-(2-hydroxyethyl), 5-(1-hydroxyethyl), formyl and acetyl analogs of I, and 5-(3-hydroxypropyl), formyl, ethoxycarbonyl, carbamoyl and hydroxyl analogs of II. Among these compounds, 4-deoxyisopyridoxal (III) and α4-norisopyridoxal (IV) exhibited anticoccidil activity.

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Pyrimidine – Wikipedia