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Serwa, Remigiusz; Nam, Tae-gyu; Valgimigli, Luca; Culbertson, Sean; Rector, Christopher L.; Jeong, Byeong-Seon; Pratt, Derek A.; Porter, Ned A. published the article 《Preparation and Investigation of Vitamin B6-Derived Aminopyridinol Antioxidants》. Keywords: aminopyridinol preparation antioxidant.They researched the compound: 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride( cas:148-51-6 ).Reference of 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:148-51-6) here.

3-Pyridinols bearing amine substitution para to the hydroxylic moiety have previously been shown to inhibit lipid peroxidation more effectively than typical phenolic antioxidants, for example, α-tocopherol. We report here high-yielding, large-scale syntheses of mono- and bicyclic aminopyridinols from pyridoxine hydrochloride (i.e., vitamin B6). This approach provides straightforward, scaleable access to novel, potent, mol. scaffolds whose antioxidant properties have been investigated in homogeneous solutions and in liposomal vesicles. These mol. aggregates mimic cell membranes that are the targets of oxidative damage in vivo.

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Electric Literature of C8H12ClNO2. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride, is researched, Molecular C8H12ClNO2, CAS is 148-51-6, about Quantitative determination of the biological antivitamin B6 effect of pyridoxol antagonists. Author is Koerner, Wilhelm F.; Nowak, Herbert.

Rats were fed a vitamin B6-free diet for 20 days; however, during the last 10 days the diets were supplemented with 30 γ pyridoxol-HCl. During the next 5 days, the animals were loaded with daily oral doses of 200 mg. L-tryptophan/kg., and during days 26-30 of the experiment 4′-deoxypyridoxol-HCl (0.1-100 mg./kg.) was given i.p. 4′-Deoxypyridoxol-HCl had an antivitamin B6 activity (measured by xanthinuric acid excretion) beginning at the 0.3 mg./kg. dose. The antivitamin B6 activity of pyramin-HCl (10-100 mg./kg.) was 60% that of 4′-deoxypyridoxol-HCl.

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Downstream Synthetic Route Of 148-51-6

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Chang, Sue-Joan published an article about the compound: 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride( cas:148-51-6,SMILESS:OC1=C(C)C(CO)=CN=C1C.[H]Cl ).HPLC of Formula: 148-51-6. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:148-51-6) through the article.

Vitamin B6 is necessary for normal cell membrane function and stability. We studied both the function and ultrastructure of aortic and arterial endothelial cells (EC) in vitamin B6 deficiency induced by vitamin B6 antagonists 4-deoxypyridoxine HCl (dPN·HCl) and isonicotinylhydrazide (INH) given in drinking water to 1-mo-old ICR mice. The mice were fed normal laboratory chow and divided into 3 groups. Mice in group I were given distilled water (control), group II was given 0.1 mg dPN·HCl/mL water, and group III 0.4 mg INH/mL water. After 5 mo the blood plasma concentrations of B6 vitamers pyridoxal-5′-phosphate (PLP) and pyridoxal (PL) were analyzed by HPLC. With arachidonic acid (AA) as a precursor, the PGI2 production by EC was assayed by thin-layer chromatog. (TLC) as an indicator of endothelial function. Aorta and arterioles from the foot pad were removed, stained with osmium tetraoxide, and examined by transmission electron microscopy to evaluate the EC ultrastructure. The blood plasma concentrations of PLP, PL, and total B6 were lowest for mice fed INH, followed by dPN·HCl and control. The PGI2 production was paralleled by the plasma vitamin B6 status, with the lowest levels in the INH group, followed by the dPN·HCl group. Abnormalities in the EC ultrastructure were found in both dPN·HCl and INH groups, including cells detached from underlying elastic tissue, with prominent pinocytotic vesicles and swelling and/or indistinct cristae of mitochondria. Thus, vitamin B6 antagonists can induce a deficient status that alters the function and ultrastructure of EC similar to vascular disease.

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Recommanded Product: 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride, is researched, Molecular C8H12ClNO2, CAS is 148-51-6, about Gas electron diffraction and quantum chemical study of the structure of a 2-nitrobenzenesulfonyl chloride molecule. Author is Petrov, V. M.; Giricheva, N. I.; Girichev, G. V.; Bardina, A. V.; Petrova, V. N.; Ivanov, S. N..

A combined gas electron diffraction and quantum chem. (B3LYP/6-311+G**, B3LYP/cc-pVTZ, B3LYP/cc-pVTZ, midix (Cl), and MP2/cc-pVTZ) study of the structure of a 2-NO2-C6H4-SO2Cl mol. is performed. It is found exptl. that at a temperature of 345(5) K the gas phase contains two conformers of the C 1 symmetry. Conformer I with a nearly perpendicular arrangement of the S-Cl bond with respect to the benzene ring plane (the C(NO2)-C-S-Cl torsion angle is 84(3)°) is contained predominantly (69(12)%). In conformer II, the S-Cl bond is located near the benzene ring plane (the C(NO2)-C-S-Cl angle is 172(3)°). The following exptl. internuclear distances (Å) are obtained for conformer I: rh1(C-H) = 1.064(15), rh1(C-C)av = 1.397(3), rh1(C-S) = 1.761(6), rh1(S-O)av = 1.426(4), rh1(S-Cl) = 2.043(5), rh1(N-O)av = 1.222(4), rh1(C-N) = 1.485(16). In both conformers, the NO2 group is turned by more than 30° relative to the benzene ring plane.

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Synthetic Route of C8H12ClNO2. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride, is researched, Molecular C8H12ClNO2, CAS is 148-51-6, about Inhibition of ruminal degradation of L-tryptophan to 3-methylindole in vitro. Author is Hammond, Andrew C.; Carlson, James R..

A closed-system, in vitro ruminal fermentation technique was used to screen 27 compounds for their ability to reduce the conversion of L-tryptophan (TRP) [73-22-3] to 3-methylindole (3MI) [83-34-1] in order to inhibit acute bovine pulmonary edema and emphysema. 20-Desoxysalinomycin [64003-50-5], X-206 [36505-48-3], chloral hydrate [302-17-0], nigericin [28380-24-7], lasalocid [11054-70-9], monensin [17090-79-8], narasin [55134-13-9], and salinomycin [53003-10-4] all reduced 3MI production by >80% at 5 μg/mL without reducing total volatile fatty acid production All of these compounds, except chloral hydrate, are polyether antibiotics. At least part of the inhibition due to monensin and narasin occurs at the level of TRP conversion to IAA [87-51-4].

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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Ultraviolet absorption spectra of pyridoxine and related compounds》. Authors are Lund, Agnes K.; Morton, R. A..The article about the compound:5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloridecas:148-51-6,SMILESS:OC1=C(C)C(CO)=CN=C1C.[H]Cl).Recommanded Product: 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride. Through the article, more information about this compound (cas:148-51-6) is conveyed.

The absorption spectra of pyridoxine and 7 related compounds were studied at different pH values. The results permit the calculation of pH values for 2- and 3-component systems and for some 4-component systems. The study illustrates the spectrophotometric analysis of complex systems and, in addition confirms the recently established structure of codecarboxase (pyridoxal phosphate). The study was undertaken to use the vitamin B6 problem to illustrate spectrophotometric methods applied to complex systems. 12 references.

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Decrypt The Mystery Of 148-51-6

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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Anticoccidial agents. 1. Synthesis and anticoccidial activity of 4-deoxypyridoxol and its esters, published in 1974, which mentions a compound: 148-51-6, mainly applied to coccidiostat deoxypyridoxol ester; pyridoxol deoxy ester anticoccidal, SDS of cas: 148-51-6.

A series of 21 title compounds were prepared from 3,α4-O-diacetylpyridoxol-HCl [53580-90-8] by hydrogenolysis, followed by hydrolysis and ester formation. In 14 day white Leghorn chicks, moderate activity against Eimeria acervulina was observed for 4-deoxypyridoxol-HCl (I-HCl) [148-51-6], and its diacetate ester-HCl (II-HCl) [53580-95-3], dibutyrate ester-HCl (III-HCl) [53580-96-4], and dihexanoate ester-HCl (IV) [53580-97-5]. The relation of anticoccidial activity to structure and to antivitamin B6 activity was discussed.

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Why do aromatic interactions matter of compound: 148-51-6

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Related Products of 148-51-6. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride, is researched, Molecular C8H12ClNO2, CAS is 148-51-6, about Pyridoxine-derived bicyclic aminopyridinol antioxidants: synthesis and their antioxidant activities. Author is Nam, Tae-gyu; Ku, Jin-Mo; Rector, Christopher L.; Choi, Hoyoung; Porter, Ned A.; Jeong, Byeong-Seon.

A few facile synthetic pathway for bicyclic aminopyridinol antioxidants are presented. Attachment of a long alkyl chain to the bicyclic pyridinol scaffold was established using an ester linkage. Non-substituted pyrrolopyridinols and 1,3-oxazine-fused pyridinols were also synthesized as novel antioxidant scaffolds. Antioxidant activities were measured by a radical clock method and new compounds prepared are comparable to the best bicyclic aminopyridinol antioxidants.

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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride(SMILESS: OC1=C(C)C(CO)=CN=C1C.[H]Cl,cas:148-51-6) is researched.Recommanded Product: 120099-61-8. The article 《Influence of some vitamin B6 antimetabolites on the induction and development of solid IRE reticulosarcoma in rats. I. Deoxypyridoxine》 in relation to this compound, is published in Pathologica. Let’s take a look at the latest research on this compound (cas:148-51-6).

Control and exptl. rats were inoculated s.c. in the dorsal region with solid reticulosarcoma IRE. Starting on the 2nd day, each exptl. rat received i.m. 0.35 mg/day of 4-deoxypyridoxine-HCl until death (14-32 days later). The values for latent period, survival, and daily body weight were similar for both groups.

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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Smoking cessation in severe mental illness: what works?》. Authors are Banham, Lindsay; Gilbody, Simon.The article about the compound:5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloridecas:148-51-6,SMILESS:OC1=C(C)C(CO)=CN=C1C.[H]Cl).Recommanded Product: 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride. Through the article, more information about this compound (cas:148-51-6) is conveyed.

AIMS: The physical health of people with severe mental illness (SMI) is poor. Smoking-related illnesses are a major contributor to excess mortality and morbidity. An up-to-date review of the evidence for smoking cessation interventions in SMI is needed to inform clinical guidelines. METHODS: We searched bibliographic databases for relevant studies and independently extracted data. Included studies were randomized controlled trials (RCTs) of smoking cessation or reduction conducted in adult smokers with SMI. Interventions were compared to usual care or placebo. The primary outcome was smoking cessation and secondary outcomes were smoking reduction, change in weight, change in psychiatric symptoms and adverse events. RESULTS: We included eight RCTs of pharmacological and/or psychological interventions. Most cessation interventions showed moderate positive results, some reaching statistical significance. One study compared behavioural support and nicotine replacement therapy (NRT) to usual care and showed a risk ratio (RR) of 2.74 (95% CI 1.10-6.81) for short-term smoking cessation, which was not significant at longer follow-up. We pooled five trials that effectively compared bupropion to placebo giving an RR of 2.77 (95% CI 1.48-5.16), which was comparable to Hughes et al.’s 2009 figures for general population data; RR = 1.69 (95% CI 1.53-1.85). Smoking reduction data were too heterogeneous for meta-analysis, but results were generally positive. Trials suggest few adverse events. All trials recorded psychiatric symptoms and the most significant changes favoured the intervention groups over the control groups. CONCLUSIONS: Treating tobacco dependence is effective in patients with SMI. Treatments that work in the general population work for those with severe mental illness and appear approximately equally effective. Treating tobacco dependence in patients with stable psychiatric conditions does not worsen mental state.

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