Adding a certain compound to certain chemical reactions, such as: 1321618-96-5, 4-Chloro-5-methylfuro[2,3-d]pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 1321618-96-5, blongs to pyrimidines compound. Recommanded Product: 1321618-96-5
To a solution of 4-chloro-5-methylfuro[2,3-d]pyrimidine (12, 85 mg, 0.25 mmol) and anisole (16, 70 mg, 0.28 mmol) in 2 mL of anhydrous isopropanol (IPA) added 2 drops of concentrated HCl and the reaction mixture was stirred at room temperature overnight. The brown precipitate was collected by filtration, washed with cold isopropanol, and dried under vacuum to afford compound 13 (52 mg, 80 %) as a brown solid. 13: lH NMR (400 MHz, CD3OD) delta: 2.4 (s, 3H, CH3), 3.8 (s, 3H, CH3), 6.9 (d, 2H), 7.4 (m, 2H), 7.7 (s, IH); HRMS (EI+) calculated for: Omicron4Etaiota4Nu302: 256.1084; Found: 256.1086.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,1321618-96-5, 4-Chloro-5-methylfuro[2,3-d]pyrimidine, and friends who are interested can also refer to it.
Reference:
Patent; THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; KUMAR, Dileep; MANN, J., John; (109 pag.)WO2019/89575; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia