Category: 129872-81-7

Application of 129872-81-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 129872-81-7, name is 2,4-Dichloro-5-methyl-5H-pyrrolo[3,2-d]pyrimidine. A new synthetic method of this compound is introduced below.

4-(2-Chloro-5-methyl-5H-pyrrolo[3,2-Patent; VALEANT RESEARCH & DEVELOPMENT; WO2006/122003; (2006); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 129872-81-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 129872-81-7, name is 2,4-Dichloro-5-methyl-5H-pyrrolo[3,2-d]pyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: An oven-dried 15 mL pressure tube cooled under nitrogen, charged with 123 mg (0.61 mmol) of 2,6 dichloro-7-methyl-7H-purine (See US 20110086840 A1 for synthesis) and anhydrous ethanol/ DMF (0.5 mL/0.3 mL, 0.76M). N,N-diisopropylethylamine (0.130 mL,0.73mmol) was added via syringe followed by morpholine (0.064 mL, 0.73 mmol). The pressure tube was flushed with nitrogen and the septa replaced by a Teflon screw cap. The reaction mixture stirred overnight at room temperature. The reaction mixture was poured into 50 % ether/ethyl acetate and washed 1x with 50% brine and 1x with brine.The organic layer was dried (MgSO4), filtered , concentrated to yield 119 mg of crude product (77.6%) which was taken directly into the next step. 1H NMR (400MHz, DMSO d6) d 8.44 (s, 1H), 3.96 (s, 3H), 3.80 – 3.71(m, 4H), 3.53 – 3.44 (m, 4H). LC/MS-m/z FontWeight=”Bold” FontSize=”10″ 254.5 (M+H)+.

According to the analysis of related databases, 129872-81-7, the application of this compound in the production field has become more and more popular.

Reference:
Article; Lee, Wendy; Ortwine, Daniel F.; Bergeron, Philippe; Lau, Kevin; Lin, Lichuan; Malek, Shiva; Nonomiya, Jim; Pei, Zhonghua; Robarge, Kirk D.; Schmidt, Stephen; Sideris, Steve; Lyssikatos, Joseph P.; Bioorganic and Medicinal Chemistry Letters; vol. 23; 18; (2013); p. 5097 – 5104;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 129872-81-7, 2,4-Dichloro-5-methyl-5H-pyrrolo[3,2-d]pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of 2,4-Dichloro-5-methyl-5H-pyrrolo[3,2-d]pyrimidine, blongs to pyrimidines compound. Application In Synthesis of 2,4-Dichloro-5-methyl-5H-pyrrolo[3,2-d]pyrimidine

General procedure: Pd(PPh3)2Cl2 (23 mg, 0.03 mmol), 4-trifluoromethoxyphenylboronic acid (73 mg, 0.35 mmol), compound 15 (100 mg, 0.32 mmol) and TEA (91 mg, 0.90 mmol) were added to a solution of DMF (5 mL) and H2O (0.5 mL). The mixture was stirred at 80 oC for 4 h. Water (10 mL) and EtOAc (30 mL) were added to the reaction. The layers were separated. The aqueous layer was extracted using EtOAc (10 mL). The combined organic extracts were dried over anhydrous Na2SO4. The solvent was removed under reduced pressure, and the resulting residue was purified via silica gel column chromatography using petroleum ether/EtOAc (5/1) to give 16 (67 mg, 48 %) as a yellow solid.

The synthetic route of 129872-81-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Zhang, Liandi; Xin, Minhang; Shen, Han; Wen, Jun; Tang, Feng; Tu, Chongxing; Zhao, Xinge; Wei, Ping; Bioorganic and Medicinal Chemistry Letters; vol. 24; 15; (2014); p. 3486 – 3492;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia