Category: 1235451-38-3

Electric Literature of 1235451-38-3 ,Some common heterocyclic compound, 1235451-38-3, molecular formula is C10H14BrN3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of compound 233-S3 (1.2 equiv) in 1,4- dioxane (10 vol) at 0 C under nitrogen atmosphere was added tert-butyl ((5-bromopyrimidin-2- yl)methyl)carbamate (1 equiv), potassium acetate (3 equiv) and PdCI2(dppf) (0.1 equiv). Thereaction mixture was stirred at 90 0C for 12 hours and concentrated. The residue was purified by column chromatography on silica gel using hexane/EtOAc to afford compound 233-S4.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1235451-38-3, tert-Butyl ((5-bromopyrimidin-2-yl)methyl)carbamate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ACHILLION PHARMACEUTICALS, INC.; WILES, Jason, Allan; PHADKE, Avinash, S.; DESHPANDE, Milind; AGARWAL, Atul; CHEN, Dawei; GADHACHANDA, Venkat, Rao; HASHIMOTO, Akihiro; PAIS, Godwin; WANG, Qiuping; WANG, Xiangzhu; BARRISH, Joel, Charles; GREENLEE, William; EASTMAN, Kyle, J.; (0 pag.)WO2018/160889; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 1235451-38-3, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 1235451-38-3 as follows.

To a mixture of compound S1 (1 equiv), AcOK (3 equiv), and compound 2 (1.2 equiv) in dioxane (10 vol) stirred at room temperature under nitrogen was added Pd(dppf)Cl2(0.05 equiv) in one portion. The resulting mixture was stirred at 90 C. under nitrogen for 3 h. After cooling the reaction mixture to room temperature and directly used in the next step.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1235451-38-3, its application will become more common.

Reference:
Patent; ACHILLION PHARMACEUTICALS, INC.; WILES, Jason, Allan; PHADKE, Avinash, S.; DESHPANDE, Milind; AGARWAK, Atul; CHEN, Dawei; GADHACHANDA, Venkat, Rao; HASHIMOTO, Akihiro; PAIS, Godwin; WANG, Qiuping; WANG, Xiangzhu; (905 pag.)WO2017/35353; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1235451-38-3, name is tert-Butyl ((5-bromopyrimidin-2-yl)methyl)carbamate, molecular formula is C10H14BrN3O2, molecular weight is 288.14, as common compound, the synthetic route is as follows.Formula: C10H14BrN3O2

A mixture of tert- butyl Af-[( 5 -brom opyri idin -2-yl )m ethyl ] curb am ate (100 mg, 347 pmol, 1.00 equiv), Pin2B2 (176 mg, 694 pmol, 2.00 equiv), KOAc (68.1 mg, 694 pmol, 2.00 equiv) and Pd(dppf)Cl2 (25.4 mg, 34.7 pmol, 0.10 equiv) in dioxane (2.00 mL) was purged with N2 and then stirred at 100 C for 2 h. The reaction mixture was filtered and concentrated in vacuo to afford [2-[(/er/-butoxycarbonylamino)methyl]pyrimidin-5-yl]boronic acid (100 mg, crude) as a red oil. LCMS [M-55]: 198.1

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1235451-38-3, tert-Butyl ((5-bromopyrimidin-2-yl)methyl)carbamate, and friends who are interested can also refer to it.

Reference:
Patent; MIRATI THERAPEUTICS, INC; MARX, Matthew, Arnold; LEE, Matthew, Randolph; BOBINSKI, Thomas, P.; BURNS, Aaron, Craig; ARORA, Nidhi; CHRISTENSEN, James, Gail; KETCHAM, John, Nichael; (225 pag.)WO2019/152419; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia