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Arvadiya, Abhishek’s team published research in World Journal of Pharmaceutical Research in 2020 | CAS: 1193-21-1

4,6-Dichloropyrimidine(cas: 1193-21-1) is a member of organic chlorides. Almost all organochlorine compounds are synthesized. It is widely used as intermediates, solvents and pesticides of chemical synthetic products.Product Details of 1193-21-1

《Synthesis, characterization and biological evaluation of some novel carboxamide derivatives of pyrazole》 was published in World Journal of Pharmaceutical Research in 2020. These research results belong to Arvadiya, Abhishek; Patel, Bony; Patel, Khyati; Zala, Mayursinh. Product Details of 1193-21-1 The article mentions the following:

A series of I [R = Ph, 4-fluorophenyl,…etc] was synthesized by using different acids. All steps were synthesized by green procedure with excellent yield. Product obtained were characterised by means of the NMR, IR and Mass spectral anal. The synthesized compounds were evaluated for their in-vitro antimicrobial activity against different bacterial and fungal strains using Mueller-Hinton Broth dilution method and also invitro antitubercular activity was performed. The results came from multiple reactions, including the reaction of 4,6-Dichloropyrimidine(cas: 1193-21-1Product Details of 1193-21-1)

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Tylinska, Beata’s team published research in International Journal of Molecular Sciences in 2021 | CAS: 1193-21-1

4,6-Dichloropyrimidine(cas: 1193-21-1) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Category: pyrimidines

Category: pyrimidinesIn 2021 ,《Novel pyrimidine derivatives as potential anticancer agents: synthesis, biological evaluation and molecular docking study》 appeared in International Journal of Molecular Sciences. The author of the article were Tylinska, Beata; Wiatrak, Benita; Czyznikowska, Zaneta; Ciesla-Niechwiadowicz, Aneta; Gebarowska, Elzbieta; Janicka-Klos, Anna. The article conveys some information:

In the present paper, new pyrimidine derivatives were designed, synthesized and analyzed in terms of their anticancer properties. The tested compounds were evaluated in vitro for their antitumor activity. The cytotoxic effect on normal human dermal fibroblasts (NHDF) was also determined According to the results, all the tested compounds exhibited inhibitory activity on the proliferation of all lines of cancer cells (colon adenocarcinoma (LoVo), resistant colon adenocarcinoma (LoVo/DX), breast cancer (MCF-7), lung cancer (A549), cervical cancer (HeLa), human leukemic lymphoblasts (CCRF-CEM) and human monocytic (THP-1)). In particular, their feature stronger influence on the activity of P-glycoprotein of cell cultures resistant to doxorubicin than doxorubicin. Tested compounds have more lipophilic character than doxorubicin, which determines their affinity for the mol. target and passive transport through biol. membranes. Moreover, the inhibitory potential against topoisomerase II and DNA intercalating properties of synthesized compounds were analyzed via mol. docking. The experimental part of the paper was very detailed, including the reaction process of 4,6-Dichloropyrimidine(cas: 1193-21-1Category: pyrimidines)

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Camacho-Hernandez, Gisela Andrea’s team published research in Journal of Medicinal Chemistry in 2019 | CAS: 1193-21-1

Safety of 4,6-DichloropyrimidineIn 2019 ,《Synthesis, pharmacological characterization, and structure-activity relationships of non-canonical selective agonists for α7 nAChRs》 appeared in Journal of Medicinal Chemistry. The author of the article were Camacho-Hernandez, Gisela Andrea; Stokes, Clare; Duggan, Brendan M.; Kaczanowska, Katarzyna; Brandao-Araiza, Stefania; Doan, Lisa; Papke, Roger L.; Taylor, Palmer. The article conveys some information:

Noncanonical 2,4,6-substituted pyrimidine analogs were prepared for a structure-activity relationship study. The new lead compounds activate selectively the α7 nAChRs with EC50’s between 30-140 nM in a PNU-120596-dependent, cell-based calcium influx assay. After characterizing the expanded lead landscape, author ranked the compounds for rapid activation using Xenopus oocytes expressing human α7 nAChR with a two-electrode voltage clamp. This approach enabled us to define the mol. determinants governing rapid activation, agonist potency, and desensitization of α7 nAChRs after exposure to pyrimidine analogs, thereby distinguishing this subclass of non-canonical agonists from previously defined types of agonists (agonists, partial agonists, silent agonists, and ago-PAMs). By NMR, author analyzed pKa values for ionization of lead candidates, demonstrating distinctive modes of interaction for this landscape of ligands. In the experiment, the researchers used 4,6-Dichloropyrimidine(cas: 1193-21-1Safety of 4,6-Dichloropyrimidine)

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Bonanno, Nico M.’s team published research in Chemical Communications (Cambridge, United Kingdom) in 2021 | CAS: 1193-21-1

Bonanno, Nico M.; Watts, Zackery; Mauws, Cole; Patrick, Brian O.; Wiebe, Christopher R.; Shibano, Yuki; Sugisaki, Kenji; Matsuoka, Hideto; Shiomi, Daisuke; Sato, Kazunobu; Takui, Takeji; Lemaire, Martin T. published their research in Chemical Communications (Cambridge, United Kingdom) in 2021. The article was titled 《Valence tautomerism in a [2 x 2] Co4 grid complex containing a ditopic arylazo ligand》.HPLC of Formula: 1193-21-1 The article contains the following contents:

The authors describe the structural and magnetic properties of a tetranuclear [2 x 2] Co4 grid complex containing a ditopic arylazo ligand. At low temperatures and in solution the complex is comprised of Co3+ and singly reduced trianion-radical ligands. In the solid state the authors demonstrate the presence of valence tautomerization via variable temperature magnetic susceptibility experiments and powder-pattern EPR spectroscopy. Valence tautomerism in polynuclear complexes is very rare and to our knowledge is unprecedented in [2 x 2] grid complexes. In the experiment, the researchers used 4,6-Dichloropyrimidine(cas: 1193-21-1HPLC of Formula: 1193-21-1)

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Pander, Piotr’s team published research in Journal of Materials Chemistry C: Materials for Optical and Electronic Devices in 2021 | CAS: 1193-21-1

4,6-Dichloropyrimidine(cas: 1193-21-1) is a member of organic chlorides. Organic chloride content in crude oil can be detected through specialized laboratory analysis. Care and attention are essential while sampling and testing.Related Products of 1193-21-1

Pander, Piotr; Zaytsev, Andrey V.; Sil, Amit; Williams, J. A. Gareth; Lanoe, Pierre-Henri; Kozhevnikov, Valery N.; Dias, Fernando B. published an article in 2021. The article was titled 《The role of dinuclearity in promoting thermally activated delayed fluorescence (TADF) in cyclometalated, N-C-N-coordinated platinum(II) complexes》, and you may find the article in Journal of Materials Chemistry C: Materials for Optical and Electronic Devices.Related Products of 1193-21-1 The information in the text is summarized as follows:

We present the synthesis and in-depth photophys. anal. of a di-Pt(II) complex with a ditopic bis-N-C-N ligand. The complex exhibits a dual luminescent behavior by emitting simultaneously delayed fluorescence and phosphorescence. By comparing with the mono-Pt(II) analog, we demonstrate that thermally activated delayed fluorescence (TADF) is turned on in the di-Pt(II) complex due to the occurrence of three main differences relative to the mono-Pt(II) analog: a larger singlet radiative rate constant (kSr), a smaller singlet-triplet energy gap (ΔEST) and a longer phosphorescence decay lifetime (τPH). We observe similar trends among other di-Pt(II) complexes and conclude that bimetallic structures promote conditions favorable for TADF to occur. The diplatinum(II) complex also shows a long wavelength-emissive excimer which yields near IR electroluminescence, λel = 805 nm, in a solution-processed OLED device with EQEmax = 0.51%. We believe this is the highest efficiency reported to date for an excimer Pt(II) emitter with λel > 800 nm in a solution-processed OLED device.4,6-Dichloropyrimidine(cas: 1193-21-1Related Products of 1193-21-1) was used in this study.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Serevicius, Tomas’s team published research in Journal of Materials Chemistry C: Materials for Optical and Electronic Devices in 2020 | CAS: 1193-21-1

《Optimization of the carbazole-pyrimidine linking pattern for achieving efficient TADF》 was published in Journal of Materials Chemistry C: Materials for Optical and Electronic Devices in 2020. These research results belong to Serevicius, Tomas; Dodonova, Jelena; Skaisgiris, Rokas; Banevicius, Dovydas; Kazlauskas, Karolis; Jursenas, Saulius; Tumkevicius, Sigitas. Formula: C4H2Cl2N2 The article mentions the following:

A high fluorescence quantum yield is essential for achieving a high OLED efficiency. Due to their typically strong charge-transfer (CT) character, thermally activated delayed fluorescence (TADF) compounds usually have a lower prompt fluorescence efficiency, and therefore the boosting of the total emission yield (ϕPL) mostly relies on the enhancement of the delayed fluorescence efficiency. In this paper, we present a less frequently used approach for achieving a high ϕPL by maximising both prompt and delayed emission yields of carbazole-pyrimidine compounds Strong decoupling of HOMO and LUMO and the subsequent emergence of TADF were achieved by introducing four carbazole units at both meta positions of the Ph unit, though was low due to the prominent nonradiative triplet decay rate. Crowding the relatively loose carbazole units together at the para position and both meta positions, conversely, was shown to diminish the nonradiative decay, enhance the radiative decay rate and subsequently boost the fluorescence yield. Efficient blue electroluminescence with a nearly 20% yield was demonstrated for the optimized compound In the experiment, the researchers used many compounds, for example, 4,6-Dichloropyrimidine(cas: 1193-21-1Formula: C4H2Cl2N2)

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Shafikov, Marsel Z.’s team published research in Journal of Materials Chemistry C: Materials for Optical and Electronic Devices in 2021 | CAS: 1193-21-1

Shafikov, Marsel Z.; Pander, Piotr; Zaytsev, Andrey V.; Daniels, Ruth; Martinscroft, Ross; Dias, Fernando B.; Williams, J. A. Gareth; Kozhevnikov, Valery N. published an article in 2021. The article was titled 《Extended ligand conjugation and dinuclearity as a route to efficient platinum-based near-infrared (NIR) triplet emitters and solution-processed NIR-OLEDs》, and you may find the article in Journal of Materials Chemistry C: Materials for Optical and Electronic Devices.Related Products of 1193-21-1 The information in the text is summarized as follows:

Near IR (NIR) emission from mol. materials is typically targeted by using more extended conjugated systems compared to visible-emitting materials. But efficiencies usually fall off due to the combined effects of increasing non-radiative and lower oscillator strengths as the energy of emissive excited states decreases. Efficient NIR-emitting organic light emitting diodes (OLEDs) are rare compared to the huge progress that has been made for visible-light devices. For organometallic emitters that contain a heavy metal ion to promote phosphorescence through the effect of enhanced spin-orbit coupling (SOC), the problem is typically exacerbated by decreased metal character in the Sn and T1 excited states as the conjugation in a bound ligand increases. Here we show how the use of a dinuclear metal complex with an extended conjugated ligand allows such effects to be mitigated compared to analogous structures with just one metal center. The complex Pt2(bis-dthpym)(dpm)2 (complex 5) is readily prepared by a double NĈ cyclometallation of 4,6-bis(dithienyl)-pyrimidine (H2bis-dthpym), with the coordination sphere of each Pt center being completed by OÔ-coordinating dipivaloylmethane (dpm). This new complex displays intense NIR emission in solution, λmax = 725 nm, with essentially no “”contamination”” by visible light <700 nm. The photoluminescence quantum yield of 0.17 in toluene at 300 K is vastly superior to that of the analogous mononuclear complex, where reduced SOC leads primarily to ligand-based fluorescence and only very weak phosphorescence. Computational results indicate that a key reason for the superior performance of the dinuclear system is a doubling of the number of higher-lying excited singlet states with which the T1 state may couple, to promote the formally forbidden phosphorescence process. Complex 5 has been evaluated as an NIR emitter in solution-processed OLEDs. An external quantum efficiency (EQE) of 3.6% is attained using 5 doped into TBP:PBD at 5% weight/weight, with a turn-on voltage of 5.6 V (at 0.01 mW cm-2). The maximum radiosity of 2.7 mW cm-2 for this device is particularly high compared to most reported NIR-emitting phosphorescent OLEDs.4,6-Dichloropyrimidine(cas: 1193-21-1Related Products of 1193-21-1) was used in this study.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The important role of 1193-21-1

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1193-21-1, 4,6-Dichloropyrimidine.

Reference of 1193-21-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1193-21-1, name is 4,6-Dichloropyrimidine, molecular formula is C4H2Cl2N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

(9) Synthesis of intermediate (c’) 298 mL of methanol is added to 387 mL (7.98 mol) of hydrazine monohydrate, followed by cooling to 10C (internal temperature). To the resulting mixture is gradually added 149 g (1.00 mol) of 4,6-dichloropyrimidine (at an internal temperature of 20C or lower), and then the ice bath is removed to allow the internal temperature to increase to room temperature, followed by stirring the mixture for 30 minutes at the same temperature. Thereafter, the mixture is further heated to an internal temperature of 60C, and stirred for 5 hours at the same temperature. After completion of the reaction, 750 mL of water is added thereto, and the reaction solution is cooled with ice to an internal temperature of 8C. Crystals precipitated are collected by filtration, spray washed with water and with isopropanol, and dried for 36 hours at room temperature to obtain 119 g (white powder; yield: 84.5%) of the intermediate (c’). Results of NMR measurement of the thus-obtained intermediate (c’) are as follows. 1H-NMR (300 MHz, d-DMSO): 7.80 (s, 1H), 7.52 (s, 2H), 5.98 (s, 1H), 4.13 (s, 4H)

Reference:
Patent; FUJIFILM Corporation; EP2474576; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Extended knowledge of 1193-21-1

According to the analysis of related databases, 1193-21-1, the application of this compound in the production field has become more and more popular.

Reference of 1193-21-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1193-21-1, name is 4,6-Dichloropyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

(c) 4,6-Diiodo-pyrimidine. A mixture of 4,6-dichloro-pyrimidine (1.0 g, 6.70 mmol, Aldrich), NaI (1.36 g, 9.00 mmol) and hydriodic acid (20 mL, 151.4 mmol) was heated at 40 C. with stirring for 1 h. The reaction mixture was stirred at room temperature for 20 h and basified with 10 N NaOH to pH 10. The resulting precipitate was filtered, washed with water, and dried in vacuo to give the title compound as a light-yellow solid. MS (ESI, pos. ion.) m/z: 332 (M+1).

According to the analysis of related databases, 1193-21-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Balan, Chenera; Chen, Ning; Doherty, Elizabeth M.; Gore, Vijay Keshav; Norman, Mark H.; Wang, Hui-Ling; US2005/182067; (2005); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

23-Sep News Extended knowledge of 1193-21-1

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1193-21-1, 4,6-Dichloropyrimidine, and friends who are interested can also refer to it.

Application of 1193-21-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1193-21-1, name is 4,6-Dichloropyrimidine. A new synthetic method of this compound is introduced below.

(a) 4-Chloro-6-[4-(trifluoromethyl)phenyl]pyrimidine. To a 500-mL, round-bottomed flask was added 4,6-dichloropyrimidine (14 g, 95 mmol, Aldrich), 4-(trifluoromethyl)phenylboronic acid (6.0 g, 32 mmol, Aldrich), acetonitrile (95 mL) and 1 M aqueous solution of sodium carbonate (95 mL). The mixture was deoxygenated by sparging with N2 for 15 min, and Pd(PPh3)4 (1.9 g, 1.6 mmol, Strem) was added. The resulting yellow mixture was heated at 80 C. with stirring for 15 h. After allowing to cool to 25 C., the mixture was evaporated under reduced pressure. The residue was diluted with 10% aqueous solution of NaHCO3 and extracted with CH2Cl2. The combined extracts were dried over Na2SO4, filtered and evaporated under reduced pressure. The residue was purified by silica gel column chromatography (gradient: 1.5-10% EtOAc/hexane) to give the title compound as a white solid. MS (ESI, pos. ion) m/z: 259 [M+1].

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1193-21-1, 4,6-Dichloropyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; Doherty, Elizabeth M.; Katon, Jodie; Norman, Mark H.; Retz, Daniel M.; Wang, Xianghong; Bo, Yunxin Y.; Tamayo, Nuria; Nishimura, Nobuko; Liao, Hongyu; US2006/241296; (2006); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia