Category: 1119280-68-0

Adding a certain compound to certain chemical reactions, such as: 1119280-68-0, 2-Chlorothieno[3,2-d]pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 2-Chlorothieno[3,2-d]pyrimidine, blongs to pyrimidines compound. Recommanded Product: 2-Chlorothieno[3,2-d]pyrimidine

2-chlorothieno[3,2-d]pyrimidine (4, 0.9 g, 5 mmol) was taken up in acetonitrile (10 mL) to form a mixture. Bromine (0.450 mL, 8 mmol), followed by HI04 (0.558 g, 2 mmol) were added to the mxiture and the mixture was refluxed for 2 h. Thin layer chromatography (TLC) of the reaction mixture showed complete conversion of compound 4 to compound 5. The reaction mixture was then cooled and poured in ethyl acetate to form a mixture. Water, followed by saturated sodium thiosulfate were added to the mixture to form a biphasic mixture having an organic layer and an aqueous layer. The organic layer was separated from the aqueous layer, washed sucessively with bicarbonate and brine, dried over Na2S04 and concentrated to obtain 7-bromo-2-chlorothieno[3,2-d]pyrimidine (5, l g, 68.96%). ‘HNMR (CDCl3): 9.18 (s, 1 H), 8.10 (s, 1 H).

The synthetic route of 1119280-68-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GATEKEEPER PHARMACEUTICAL, INC.; GRAY, Nathanael, S.; ZHOU, Wenjun; WO2011/79231; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 1119280-68-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1119280-68-0, name is 2-Chlorothieno[3,2-d]pyrimidine, molecular formula is C6H3ClN2S, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

The intermediate 8 (1 equiv) and N-iodosuccinimide (3 equiv)were mixed in acetic acid and heated at 80 C for 24 h. The reactionwas then partitioned between water and EtOAc, and the aqueouslayer was extracted twice with EtOAc. The combined organic fractionswere washed with saline, dried over anhydrous Na2SO4, andfiltered. The filtrate was concentrated and purified using chromatographyto yield the intermediate 9.1H NMR (600 MHz, DMSO-d6)d 9.49 (s, 1H), 8.85 (s, 1H). MS (ESI) m/z(%): 296.5 [MH].

According to the analysis of related databases, 1119280-68-0, the application of this compound in the production field has become more and more popular.

Reference:
Article; Chen, Yixuan; Cheng, Maosheng; Hao, Chenzhou; Wang, Ruifeng; Wu, Tianxiao; Yang, Bowen; Yu, Sijia; Zhao, Dongmei; Zhao, Xiangxin; European Journal of Medicinal Chemistry; vol. 188; (2020);,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 1119280-68-0, Adding some certain compound to certain chemical reactions, such as: 1119280-68-0, name is 2-Chlorothieno[3,2-d]pyrimidine,molecular formula is C6H3ClN2S, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1119280-68-0.

To a solution of 2-chlorothieno[3,2-d]pyrimidine (150mg, 0.87mmol) and 4- morpholinoaniline (188mg, 1.05mmol) in NMP (5mL) was added diisopropylethylamine (337muL, 1.93mmol). The reaction was heated at 25O 0C in a microwave reactor for 20min, then diluted with EtOAc and 5%aq. citric acid. The aqueous layer was extracted twice further with EtOAc and the combined organic fractions washed with sat. aq. NaHCO3, dried (Na2SO4) filtered and concentrated to afford the crude product. Purification by silica gel chromatography using 30-70% EtOAc/DCM as eluent then afforded the product as an orange gum. Trituration with EtOAc three times and collection of the fine solid afforded compound 7 as a dark yellow solid (26mg, 10%).

According to the analysis of related databases, 1119280-68-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; CYTOPIA RESEARCH PTY LTD; WO2009/62258; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 1119280-68-0 , The common heterocyclic compound, 1119280-68-0, name is 2-Chlorothieno[3,2-d]pyrimidine, molecular formula is C6H3ClN2S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

2-Methoxythieno[3,2-i/]pyrimidine (17).; To a solution of 16 (146 mg, 0.86 mmol) in MeOH (20 mL) was added NaOMe (130 mg, 2.41 mmol). The solution was heated at reflux for 37 h. An additional 1.4 equiv of NaOMe (65.0 mg) was added after 24 h (Note: The reaction was complete in 7 h with comparable yields when 4.2 equiv of NaOMe were added at the start of the reaction). The reaction mixture was cooled to room temperature, quenched with 1 N aq. HC1 (2.0 mL), and extracted with DCM (4 x 10 mL). The combined organic layers were washed with H20 (10 mL), dried (MgS04), and concentrated under reduced pressure to provide 17 (125 mg, 88%) as an off-white solid: Mp 167.0-168.5 C (DCM); IR (ATR, neat) 3071, 3025, 2917, 1558, 1528, 1478, 1379, 1295, 1249, 1031, 796, 677 cm”1; 1H NMR (DMSO- 6, 300 MHz) delta 9.30 (d, 1 H, J= 0.6 Hz), 8.45 (d, 1 H, J= 5.4 Hz), 7.47 (dd, 1 H, J= 5.4, 0.7 Hz), 3.96 (s, 3 H); 13C NMR (DMSO-d6, 75 MHz) delta 163.4, 162.4, 154.8, 139.9, 124.8, 122.9, 54.6; MS (EI) m/z 166 (M+, 29), 84 (100); HRMS (EI) m/z calcd for C7H6N2OS 166.0201, found 166.0201.

The synthetic route of 1119280-68-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; UNIVERSITY OF PITTSBURGH – OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION; WIPF, Peter; WANG, Qiming, Jan; WO2012/78859; (2012); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia