Category: 111196-81-7

Adding a certain compound to certain chemical reactions, such as: 111196-81-7, 2-Chloro-5-ethylpyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 111196-81-7, blongs to pyrimidines compound. Computed Properties of C6H7ClN2

Step B: Preparation of 4-((lr,4r)-4-((l-(5-Ethylpyrimidin-2-yl)piperidin-4- yl)methoxy)cyclohexyl)-3-fluoro-N,N-dimethylbenzamide.; A mixture of 3-fluoro-N,N-dimethyl-4-(((lr,4r)-4-(piperidin-4- ylmethoxy)cyclohexyl)benzamide hydrochloride (14.0 mg, 0.035 mmol), prepared in Step A above, 2-chloro-5-ethylpyrimidine (20 mu, 0.165 mmol), and triethylamine (30 muEpsilon, 0.220 mmol) in iPrOH (1.3 mL) was heated under microwave irradiation at 120 C for 2 h. The mixture was purified by HPLC (5-95% CH3CN). Fractions containing the title compound were partly concentrated and the residue was extracted with 1M NaOH and CH2C12. The organic phase was dried over MgS04, filtered, and concentrated to give the title compound (10.2 mg, 0.022 mmol, 62.0% yield) as a white solid. Exact mass calculated for C27H37FN4O2: 468.2, found: LCMS m/z= 469.4 [M+H]+; lU NMR (400 MHz, CDC13) delta ppm 1.18 (t, = 7.6 Hz, 3H), 1.19-1.26 (m, 2H), 1.34-1.58 (m, 4H), 1.83-1.93 (m, 5H), 2.15-2.17 (m, 2H), 2.45 (q, = 7.6 Hz, 2H), 2.81- 2.91 (m, 3H), 2.99 (s, 3H), 3.09 (s, 3H), 3.23-3.30 (m, IH), 3.36 (d, = 5.8 Hz, 2H), 4.69-4.76 (m, 2H), 7.06-7.09 (m, IH), 7.12-7.14 (m, IH), 7.20-7.25 (m, IH), 8.16 (s, 2H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,111196-81-7, its application will become more common.

Reference:
Patent; ARENA PHARMACEUTICALS, INC.; JONES, Robert M.; HAN, Sangdon; LEHMANN, Juerg; THORESEN, Lars; WO2012/135570; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.111196-81-7, name is 2-Chloro-5-ethylpyrimidine, molecular formula is C6H7ClN2, molecular weight is 142.59, as common compound, the synthetic route is as follows.Quality Control of 2-Chloro-5-ethylpyrimidine

[0761] A mixture of (S)-3-((4-bromophenoxy)methyl)pyrrolidine hydrochloride (1.15 g, 3.9 mmol), 2- chloro-5-ethylpyrimidine (0.62 g, 4.3 mmol) and diisopropylethylamine (1.27 g, 9.7 mmol) in dimethylformamide (50 mL) was stirred at 130oC overnight. After cooling to ambient temperature, dimethylformamide was removed under reduced pressure and the residue was treated with water (200 mL). A brown precipitate was formed and then the mother liquor was decanted. The precipitate was re- dissolved in dichloromethane, dried over sodium sulfate and purified on a 3 cm silica gel pad eluted with hexanes: ethyl acetate mixture gradient (4:1 to 2:1) to afford the title product (0.73 g, 51 %) as colorless powder.1H-NMR (400 MHz, DMSO-d6) delta 8.21 (s, 2H), 7.44 (d, J = 9.0 Hz, 2H), 6.94 (d, J = 9.0 Hz, 2H), 4.12- 3.87 (m, 2H), 3.75- 3.55 (m, 2H), 3.52- 3.39 (m, 1H), 3.37- 3.26 (m, 1H), 2.79 – 2.64 (m, 1H), 2.41 (q, J = 7.5 Hz, 2H), 2.20- 2.05 (m, 1H), 1.91- 1.75 (m, 1H), 1.11 (t, J = 7.6 Hz, 3H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,111196-81-7, 2-Chloro-5-ethylpyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; PRAMANA PHARMACEUTICALS INC.; CHAFEEV, Mikhail; (240 pag.)WO2019/104418; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 111196-81-7, name is 2-Chloro-5-ethylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Quality Control of 2-Chloro-5-ethylpyrimidine

General procedure: Add in the reaction bottleBoc-based disubstituted pyrimidopyrimidine (50 mg, 0.09 mmol),2-chloro-5-ethylpyrimidine (18 mg, 0.13 mmol),TEA (27 mg, 0.45 mmol) and DCM (2 mL).The reaction was stirred at room temperature overnight, and the reaction mixture was diluted with dichloromethane.The organic phase was washed with brine, dried over anhydrous sodiumThe crude product using silica gel column chromatography (petroleum ether: ethyl acetate = 1: 1) to give a pale yellow solid, yield 45% reaction.

With the rapid development of chemical substances, we look forward to future research findings about 111196-81-7.

Reference:
Patent; Jiangxi University of Traditional Chinese Medicine; Yang Zunhua; Fang Yuanying; Liu Ronghua; He Mingzhen; Wang Qi; Li Zhifeng; (13 pag.)CN109761990; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia